Explore every episode of the podcast ICU Ed and Todd-Cast
| Title | Pub. Date | Duration | |
|---|---|---|---|
| New/Old: RATE and CESAR | 06 Oct 2026 | 00:49:07 | |
Send us a Text Message (please include your email so we can respond!) Episode 102! In this episode we talk about ECMO anticoagulation strategies with RATE and go back in time to talk about the original landmark trial for ECMO in CESAR RATE: https://pubmed.ncbi.nlm.nih.gov/42413523/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| Old/New: TTM2 and ICECAP | 22 Sep 2026 | 00:44:22 | |
Send us a Text Message (please include your email so we can respond!) Episode 101! In this episode we talk about targeted temperature management starting with TTM2 to set the stage and moving towards ICECAP published by Muerer et al in JAMA August 2026! TTM2: https://pubmed.ncbi.nlm.nih.gov/34133859/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: Olanzapine vs Dex and a look back | 08 Sep 2026 | 00:45:50 | |
Send us a Text Message (please include your email so we can respond!) Episode 100! Can't believe we made it here. 100 episode of trying to fit into Todd's triple booked schedule. This episode we do a little reminiscing about the past 3 years of podcasting but not after talking about a trial published in the form of a research letter about olanzapine versus dexmedetomidine for delirium by Liu et al published in the Blue Journal May 2026 Olanzapine vs Dex: https://pubmed.ncbi.nlm.nih.gov/42118124/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| NEXIS and Mailbag | 25 Aug 2026 | 00:38:55 | |
Send us a Text Message (please include your email so we can respond!) Episode 99! In this episode we talk about Nutrition and Exercise in Critical Illness published in AJRCCM June 2026 by Needham et al. A shorter episode today as we're dealing with end-of-summer travel schedules so we add a mailbag segment to this one. NEXIS: https://pubmed.ncbi.nlm.nih.gov/42438140/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| Old/New: EUPHRATES and Tigris | 11 Aug 2026 | 00:55:09 | |
Send us a Text Message (please include your email so we can respond!) Episode 98! We talk about polymyxin B filtration of endotoxin for patients with septic shock in EUPHRATES which sets the stage for Tigris. We also butcher Mesopotamian history (sorry!) EUPHRATES: https://pubmed.ncbi.nlm.nih.gov/30304428/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New: MARCH and Tele-Rehab | 28 Jul 2026 | 00:56:17 | |
Send us a Text Message (please include your email so we can respond!) Episode 97! In this episode we talk about mucolytics for patients with difficult to clear secretions on the ventilator and the effects of a tele ICU rehabilitation intervention! We also have some emails following up on scurvy and the taste of chalk. Scurvy History:https://pmc.ncbi.nlm.nih.gov/articles/PMC1276007/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New: ARISE-FLUIDS and VICTORY (+mail) | 14 Jul 2026 | 01:05:28 | |
Send us a Text Message (please include your email so we can respond!) Episode 96. In this episode we talk about ARISE FLUIDS (early pressors vs early fluids) and VICTORY (high dose Vitamin C in severe burn) both simultaneously presented and published at the CCR26 conference. Then we start digging out form our ever growing mailbag ARISE-FLUIDS: https://pubmed.ncbi.nlm.nih.gov/42274006/ VICTORY: https://pubmed.ncbi.nlm.nih.gov/42267875/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New: BiHCA and SODa-BIC | 30 Jun 2026 | 00:52:01 | |
Send us a Text Message (please include your email so we can respond!) Episode 95! In this episode we talk about "Sodium Bicarbonate for In-Hospital Cardiac Arrest" by Granfeldt et al and "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock" published by the ANZICS group both presented at the CCR26 conference. BiHCA: https://pubmed.ncbi.nlm.nih.gov/42273960/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR26 and the unpublished results presentations | 16 Jun 2026 | 00:55:00 | |
Send us a Text Message (please include your email so we can respond!) Episode 94! In this episode we give some general reactions to the CCR conference, discuss our impact on the critical care world, and talk briefly about 3 of the presentations from the conference that did NOT have a simultaneous publication (REMAP-CAP oseltamivir, FISSH, and SAVE-ICU) If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| NEW: ATS 2026 and Hantavirus? | 02 Jun 2026 | 01:02:29 | |
Send us a Text Message (please include your email so we can respond!) Episode 93! In this episode we go over TOWAR or "Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage" by Sperry et all published in NEJM and "Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors" published by O'Neill et al in JAMA both in May 2026 and presented at the ATS International Conference! Then we talk a little bit about some current events with Hantavirus and sepsis that has hit the news cycles TOWAR (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2602167 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: R2D2 | 19 May 2026 | 00:41:53 | |
Send us a Text Message (please include your email so we can respond!) Episode 92! In this episode we talk about "Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients" published in JAMA by Sonneville et al April 2026! R2D2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/41841304/ R2D2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2846726 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: 4D | 05 May 2026 | 00:44:09 | |
Send us a Text Message (please include your email so we can respond!) Episode 91! In this episode we talk about "Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients" published by Godet et al in Intensive Care Medicine October of 2025! We are going to be on a one article per episode kick for a while but hope to get back to normal programming soon! 4D: https://pubmed.ncbi.nlm.nih.gov/41160116/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: 2026 Sepsis Guidelines | 21 Apr 2026 | 01:02:00 | |
Send us a Text Message (please include your email so we can respond!) Episode 90! In this episode we talk about the 2026 Surviving Sepsis Campaign Guidelines lead by Prescott et all and published in Critical Care Medicine in March of 2026! We review all that's new and all that's changed If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: Hi-PEITHO | 07 Apr 2026 | 00:48:05 | |
Send us a Text Message (please include your email so we can respond!) Episode 89! In this episode we talk about HI-PEITHO or catheter directed thrombolysis versus conventional anticoagulation for intermediate risk pulmonary embolism. This was published in the New England Journal of Medicine by Rosenfield et al. HI-PEITHO: http://nejm.org/doi/full/10.1056/NEJMoa2516567 HI-PEITHO (pubmed): https://pubmed.ncbi.nlm.nih.gov/41910345/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New: PE and CPR Guidelines | 24 Mar 2026 | 00:46:55 | |
Send us a Text Message (please include your email so we can respond!) Episodes 88! In this episode we talk about guidelines recently released for the management of pulmonary embolism and cardiac arrest! A little hap hazard of an episode as we jump around from topic to topic but good to highlight things that are new and things that are changing! PE: https://pubmed.ncbi.nlm.nih.gov/41712898/ CPR: https://pubmed.ncbi.nlm.nih.gov/41122893/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| Old/New: ALBIOS and ARISS | 10 Mar 2026 | 00:47:12 | |
Send us a Text Message (please include your email so we can respond!) Episode 87! In this episode we talk about Albumin with two related studies, ALBIOS ("Albumin replacement in patients with severe sepsis or septic shock" by Caironi et al) and ARISS ("Albumin Replacement Therapy in Septic Shock" by Sakr et al) ALBIOS: https://pubmed.ncbi.nlm.nih.gov/24635772/ ARISS: https://pubmed.ncbi.nlm.nih.gov/41712212/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: PreVent2 | 24 Feb 2026 | 00:47:51 | |
Send us a Text Message (please include your email so we can respond!) Episode 86! In this episode we talk about endotracheal tubes or "Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation" published in Lancet Respiratory Medicine February 2026 by Treggiari et al. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41319662/ LRM: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00294-2/abstract If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: LIBERATE-D with Eddie Siew | 10 Feb 2026 | 00:58:20 | |
Send us a Text Message (please include your email so we can respond!) Episode 85! In this episode we go over LIBERATE-D or "A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury" by Liu et al in JAMA 2026. We have the second author, Eddie Siew, on with us to discuss! LIBERATE-D (pubmed): https://pubmed.ncbi.nlm.nih.gov/41201895/ LIBERATE-D (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2841171 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR Down Under: ACTiVE and CLIP2 | 27 Jan 2026 | 00:36:02 | |
Send us a Text Message (please include your email so we can respond!) Episode 84! In this episode we finish up our discussion of the articles presented with the CCR Down Under Conference with ACTiVE (close loop ventilation) and CLIP2 (cryopreserved platelets for surgical bleeding). Both are neutral trials at best, so we took them both pretty short. ACTiVE: https://pubmed.ncbi.nlm.nih.gov/41361939/ ACTiVE (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842610 CLIP2: https://pubmed.ncbi.nlm.nih.gov/41360717/ CLIP2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842479 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR Down Under: ImmunoSep | 13 Jan 2026 | 00:46:56 | |
Send us a Text Message (please include your email so we can respond!) Episode 83! Only one article this episode since Todd is feeling a little under the weather, but still a good discussion! ImmunoSep (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842634 ImmunoSep (pubmed): https://pubmed.ncbi.nlm.nih.gov/41359996/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| 2025 Year in Review | 30 Dec 2025 | 00:45:56 | |
Send us a Text Message (please include your email so we can respond!) Back by popular demand, year in review! Or probably better titled "Our Favorite Articles of the Year" but I kept the title from last year. A smattering of papers and topics in this one ranging from avalanche survival, to intubation, to cardiac resuscitation and more. Happy New Year everyone! We will see you in 2026, thanks for listening and spending sometime with us. If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: MODS with Yonathan Freund | 16 Dec 2025 | 01:03:00 | |
Send us a Text Message (please include your email so we can respond!) Episode 81! In this episode we talk to Yonathan Fruend the senior author on the MODS study looking at a single questions approach to ruling out pulmonary embolism in the emergency department. This is not our typical patient population but this is a good episode, don't miss this one! MODS: https://pubmed.ncbi.nlm.nih.gov/41135553/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR Down Under: RSI with Jon Casey | 10 Dec 2025 | 01:06:45 | |
Send us a Text Message (please include your email so we can respond!) We start our Critical Care Reviews Down Under coverage with RSI talking with the first author of the "Ketamine versus Etomidate for Adults Receiving Emergency Endotrachael Intubation", Jonathan Casey! We will pick up the rest of our CCR Down Under Coverage after the holiday break! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New: EVERDAC and ANDROMEDA SHOCK 2 | 02 Dec 2025 | 00:57:44 | |
Send us a Text Message (please include your email so we can respond!) Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/ EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136 ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/ ANDROMEDA SHOCK 2(JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840823 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New: BICAR ICU 2 and SOFA 2 | 18 Nov 2025 | 00:51:15 | |
Send us a Text Message (please include your email so we can respond!) Episode 78! We start our discussion of the trials that drop with ESICM with the much anticipated BICAR-ICU 2! Then we talk briefly about some changes to the SOFA score with the new SOFA-2 score. BICAR-ICU2: https://pubmed.ncbi.nlm.nih.gov/41159812/ BICAR-ICU 2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840824 SOFA-2: https://pubmed.ncbi.nlm.nih.gov/41159833/ SOFA-2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840822 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: WFIT with Carla Sevin | 04 Nov 2025 | 01:09:20 | |
Send us a Text Message (please include your email so we can respond!) Episode 77! We will start on ESICM coverage next episode. In this episode we talk about WFIT or "A Randomized Controlled Trial of a Post-ICU Telehealth Care Model" by Bakhru et al published in the blue journal September 2025! A long discussion but a good one! WFIT: https://pubmed.ncbi.nlm.nih.gov/40532205/ Editorial: https://pubmed.ncbi.nlm.nih.gov/40700738/ ICU Recovery Pilot: https://pubmed.ncbi.nlm.nih.gov/31385881/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| LIVE @ CHEST2025: Oscillation, Glucose, and more! | 22 Oct 2025 | 00:44:07 | |
Send us a Text Message (please include your email so we can respond!) We were LIVE from the CHEST Annual Meeting 2025! Thanks to everyone who came out and stuck around to chat afterwards. We cover a lot of ground including some conference and Chicago related banter (~8 minutes if you wanted to skip to the learning!) High frequency oscillation: https://pubmed.ncbi.nlm.nih.gov/40983167/ MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/ Continuous glucose monitoring: https://pubmed.ncbi.nlm.nih.gov/39956190/ SAFE-ECMO: https://pubmed.ncbi.nlm.nih.gov/40081660/ BASE: https://pubmed.ncbi.nlm.nih.gov/39971001/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: MELLOW, Melatonin, and Mailbag | 07 Oct 2025 | 00:41:03 | |
Send us a Text Message (please include your email so we can respond!) Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag! MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/ DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/ Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| Old/New: SBT and SBT Timing | 23 Sep 2025 | 00:44:29 | |
Send us a Text Message (please include your email so we can respond!) Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM. SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/ SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502 SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/ SBT Timing (Annals ATS): https://www.atsjournals.org/doi/10.1513/AnnalsATS.202502-188OC If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| LIVE @ CC Bootcamp 2025: PIC | 09 Sep 2025 | 00:25:43 | |
Send us a Text Message (please include your email so we can respond!) We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale et al published in the Lancet Respiratory Medicine September 2025 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR25: UK-ROX and TARGET-Protein (with Mail bag!) | 26 Aug 2025 | 00:44:27 | |
Send us a Text Message (please include your email so we can respond!) Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018. UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/ UK-ROX (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835384 TARGET-Protein: https://pubmed.ncbi.nlm.nih.gov/40495743/ TARGET-Protein (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835302 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR24/Old: FLUID and BICAR-ICU | 12 Aug 2025 | 00:53:35 | |
Send us a Text Message (please include your email so we can respond!) Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018. FLUID: https://pubmed.ncbi.nlm.nih.gov/40503714/ FLUID (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2416761 BICAR-ICU: https://pubmed.ncbi.nlm.nih.gov/29910040/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: A2B with Wes Ely | 29 Jul 2025 | 00:58:30 | |
Send us a Text Message (please include your email so we can respond!) Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one! Pubmed: https://pubmed.ncbi.nlm.nih.gov/40388916/ JAMA: https://jamanetwork.com/journals/jama/article-abstract/2834276 Editorial: https://jamanetwork.com/journals/jama/article-abstract/2834277 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR25: RESCUE-3 and PROMIZING | 15 Jul 2025 | 00:44:57 | |
Send us a Text Message (please include your email so we can respond!) Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM. RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/ PROMIZING (pubmed): https://pubmed.ncbi.nlm.nih.gov/40513024/ PROMIZING (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2505708 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: MODE with Kevin Seitz | 01 Jul 2025 | 00:50:22 | |
Send us a Text Message (please include your email so we can respond!) Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial". Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode! Pubmed: https://pubmed.ncbi.nlm.nih.gov/40189043/ CHEST: https://journal.chestnet.org/article/S0012-3692(25)00417-9/fulltext If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR25 Recap | 17 Jun 2025 | 00:42:57 | |
Send us a Text Message (please include your email so we can respond!) Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: TASC with Benjamin Tillman | 03 Jun 2025 | 00:46:05 | |
Send us a Text Message (please include your email so we can respond!) Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/ AJRCCM: https://www.atsjournals.org/doi/10.1164/rccm.202409-1727OC If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/Old: Risk factors for Stress Ulcers and Transfusions in GIB | 20 May 2025 | 00:35:14 | |
Send us a Text Message (please include your email so we can respond!) Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding! Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New: REMAP-CAP Steroids | 06 May 2025 | 00:40:02 | |
Send us a Text Message (please include your email so we can respond!) Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/Old: PEERLESS and PEITHO | 22 Apr 2025 | 00:50:27 | |
Send us a Text Message (please include your email so we can respond!) Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmonary embolism" by Meter et al in NEJM 2014. PEERLESS: https://pubmed.ncbi.nlm.nih.gov/39470698/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| ISICEM Review and SESAR | 08 Apr 2025 | 00:48:46 | |
Send us a Text Message (please include your email so we can respond!) Episode 62! We talk briefly about two of the analyses that dropped with the ISICEM conference and then talk in depth about SESAR or "Inhaled Sedation in Acute Respiratory Distress Syndrome" by Jabudon et al in JAMA 2025. Then was answer a question on sleep in the ICU. Eddie did misspeak when he said one of the dexmedetomidine articles was in Lancet Respiratory medicine, rather, it was published in eClinical Medicine part of the Lancet network. SESAR (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2831857 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/Review: Extubating to HFNC | 25 Mar 2025 | 00:46:47 | |
Send us a Text Message (please include your email so we can respond!) Episode 61! We talk about HFNC including extubation to HFNC in "Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure" by Ayyawar et al published in Critical Care Science. Then we talk about weaning HFNC from the "How I do it" series from CHEST. Auto-PEEP (NEJM): https://www.nejm.org/doi/full/10.1056/NEJM199307153290322 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| SCCM: PROACTIVE and ASA in sepsis | 11 Mar 2025 | 00:45:15 | |
Send us a Text Message (please include your email so we can respond!) Episode 60! We jump to SCCM where we talk about 2 late breakers - PROACTIVE or "Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation" by Downar et al and "Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock" by Almeida et al both published in CCM in 2025. If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| TRAUMOX2, SAHARA, and mailbag | 25 Feb 2025 | 00:57:02 | |
Send us a Text Message (please include your email so we can respond!) Episode 59! We finish our CCR down under coverage with TRAUMOX2 or "Early Restrictive vs Liberal Oxygen for Trauma Patients" published in JAMA by Arleth et al and then switch to SAHARA or "Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage" by English et al published in NEJM. We then frustrate Todd with questions from our mailbag, a good episode! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| Old/New: FLORALI and RENOVATE | 11 Feb 2025 | 00:56:42 | |
Send us a Text Message (please include your email so we can respond!) Episode 58! We talk about non-invasive oxygen support and RENOVATE or "High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure" published in JAMA December 2024 and presented at the CCR Down Under Conference. We supplement this by first talking about FLORALI or "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure" published in NEJM May 2015 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR Down Under: SCREEN with Adam Wright | 28 Jan 2025 | 01:06:27 | |
Send us a Text Message (please include your email so we can respond!) Episode 57! We were excited to have on this episode Dr. Adam Wright who is a PhD in Bioinformatics to discuss SCREEN or "Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial" published by Arabi et al in JAMA 2024 and presented at the CCR Down Under Conference. A long episode but a lot of good discussion If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| CCR Down Under: ADAPT-Sepsis | 14 Jan 2025 | 00:46:03 | |
Send us a Text Message (please include your email so we can respond!) Episode 56! In this episode we spend a few minutes talking about making decisions on ECMO initiation but spend most of the episode talking about ADAPT-Sepsis or "Biomarker-Guided Antibiotic Duration for Hospitalized Patients If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| 2024 Year in Review and CCR Down Under | 31 Dec 2024 | 00:59:58 | |
Send us a Text Message (please include your email so we can respond!) Episode 55 and Happy New Year! In this episode we talk broad strokes about the CCR Down Under Conference and the trials that were presented, then Todd and Eddie go over a bunch of articles from the year 2024 that they didn't have time to go over or want to re-emphasize for whatever reason. Big show and we hope you enjoy! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/Old: BALANCE and iDIAPASON | 17 Dec 2024 | 00:52:01 | |
Send us a Text Message (please include your email so we can respond!) Episode 54! In this episode we talk about antibiotic duration in bacteremia (BALANCE) and also antibiotic duration in Pseudomonas Ventilator associated pneumonia (iDIAPASON). If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||
| New/New-ish: IVIO and PARAMEDIC-3 | 03 Dec 2024 | 00:34:16 | |
Send us a Text Message (please include your email so we can respond!) Episode 53! In this episode we talk about access in patients with out of hospital cardiac arrest. Both articles are similar so we talk in depth about IVIO and then bringing PARAMEDIC-3 to round out our discussion. A good acronym discussion too, don't miss it! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music! | |||