Explore every episode of the podcast Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

When is the best time to take L-theanine—for daytime anxiety, before bed, or when you wake during the night?

In this short Q&A episode of The Histamine Well Podcast, Joanne discusses how she uses L-theanine to support relaxation and explains how timing may differ depending on your symptoms. She also explores combining L-theanine with magnesium and the options she discusses when magnesium glycinate isn’t tolerated.

In this episode, you’ll learn:

• How Joanne uses L-theanine for daytime anxiety and nervous system hyperarousal.
• When she considers taking it before bed for difficulty falling asleep.
• How she approaches L-theanine timing for waking during the night.
• The doses and supplement combinations discussed in her clinical approach.
• Why individual tolerance matters when choosing magnesium.

If you’ve been wondering when to take L-theanine for anxiety or sleep, this quick episode explores the timing options Joanne considers in practice.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture?

In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small intestinal bacterial overgrowth (SIBO), exploring persistent digestive symptoms, a methane-positive breath test, and suspected histamine-related reactions.

The patient had experienced significant bloating, nausea, reflux, constipation and brain fog, with probiotics making her bloating worse. Despite seeing several practitioners, she had not been assessed for SIBO.

Joanne shares the clues that prompted testing, why she prioritised a SIBO breath test over stool microbiome testing in this case, and how she introduced a SIBO low-histamine diet and personalised digestive support.

At her first follow-up, the patient reported an 80% reduction in bloating, alongside improvements in nausea, reflux and heartburn. With constipation still an issue, Joanne explains the next adjustments to her care and why retesting remained part of the plan.

In this episode, you’ll hear:

• The patient’s symptom history following food poisoning.
• Joanne’s reasoning behind targeted SIBO testing.
• How the methane-positive result informed her approach to constipation.
• The dietary changes and digestive support used initially.
• How Joanne adjusted the plan as symptoms improved.
• Her plans for follow-up, retesting and food reintroduction.

Whether you’re experiencing ongoing gut symptoms or supporting patients in clinical practice, this episode offers a practical look at Joanne’s assessment and treatment decisions.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration.

In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement.

If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could your gut help explain why you’re reacting to foods you once tolerated?

In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact.

A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters.

What you’ll learn:

• How the intestinal barrier and secretory IgA help protect your gut.
• Why microbial diversity, butyrate and immune tolerance matter.
• How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms.
• How mast cells and certain gut bacteria produce histamine.
• Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine.
• How stress, the nervous system, and gut motility can influence digestive symptoms.
• Why gut support needs to be personalised to your symptoms and tolerance.

Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one?

In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating.

In this episode:

• How food swaps on a low FODMAP diet may increase your sulfur or oxalate intake
• Symptoms Joanne suggests watching for alongside bloating
• Why the migrating motor complex may matter when bloating persists
• Why a SIBO test can help clarify what may be going on

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night.

Joanne and Melanie talk about the signals that can disrupt your body clock, from spending the day indoors to bright lights, screens and late meals at night. They share practical ways to support a more consistent rhythm, including morning daylight, time outdoors during the day and a darker evening routine.

In this episode, you’ll learn:

• What circadian rhythm is and why it matters beyond sleep
• How light and darkness influence cortisol and melatonin
• Why meal timing may matter for digestion and gut motility
• How histamine activity follows a daily pattern
• Simple ways to support your body clock within your routine

If you’re navigating histamine intolerance, sleep difficulties, hormone concerns or persistent gut symptoms, this conversation offers another piece of the picture to discuss with your healthcare practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it.

In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects.

You’ll also learn why feeling worse doesn’t necessarily mean NAC is working—and why a lower dose, slower introduction or different approach may be needed.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Why do SIBO, Candida, and other gut infections sometimes return—even after treatment initially seems successful?

In this episode of The Histamine Well Podcast, Joanne explains how biofilms may contribute to persistent bacterial and fungal overgrowths. Biofilms are organised microbial communities surrounded by a protective matrix that can help microorganisms survive antimicrobial treatment and resist immune defences.

Joanne explores the role biofilms may play in recurring SIBO, Candida overgrowth, gut dysbiosis, chronic sinus infections and MARCoNS. She also explains how bacteria and fungi can communicate, share resources and coexist within mixed-species biofilms.

You’ll discover:

• What biofilms are and why microorganisms create them
• Why SIBO, Candida and gut infections may keep returning
• How biofilms can protect bacteria and fungi
• The connection between biofilms, chronic sinus infections and MARCoNS
• How Candida and Aspergillus form fungal biofilms
• The difference between mould, mycotoxins and biofilms
• What the biofilm matrix is made from
• How enzymes and N-acetylcysteine may support biofilm disruption
• Why biofilm support should be introduced gradually during antimicrobial treatment

If you’re dealing with recurring digestive symptoms or want to better understand persistent microbial overgrowths, this episode offers a clear and practical introduction to biofilms and their potential role in gut and sinus health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves.

In this short Q&A episode of The Histamine Well Podcast, Joanne explores possible reasons for feeling sick after an Epsom salt bath, including bath temperature, changes in blood pressure, histamine intolerance, mast cell activation and sensitivity to sulfur compounds.

Epsom salts are magnesium sulfate. Joanne explains the role of sulfate in a detoxification pathway called sulfation and discusses why people use Epsom salt baths as part of their detox routines. She also shares why feeling unwell afterwards should not automatically be interpreted as a sign that a treatment is working—or a reason to push through.

If you’ve been searching for answers about Epsom salt bath side effects, feeling dizzy after a hot bath, or the possible connection between histamine intolerance and Epsom salts, this episode offers a starting point for understanding your reaction and discussing it with your practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed?

In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms.

Discover:

• The connection between sulfur intolerance and the gut microbiome.
• Why hydrogen sulfide production and clearance both matter.
• The uses and limitations of stool and breath testing.
• Joanne’s clinical approach to low sulfur diets, oregano, molybdenum and digestive support.

Joanne also discusses where the evidence remains limited and why symptoms alone cannot confirm the cause.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Struggling with constipation on the low-FODMAP diet? If your bloating has improved but your bowel movements have slowed down, what should you consider next?

In this short Q&A episode of The Histamine Well Podcast, naturopath Joanne Kennedy shares how she approaches constipation in patients following a low-FODMAP diet. She discusses fibre intake, hydration, digestive support, and the role of the nervous system in bowel regularity.

If you’re navigating constipation, SIBO, bloating or histamine intolerance, this episode offers practical topics to discuss with your treating practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can an imbalanced gut microbiome contribute to anxiety and depression?

We often think of mental health conditions as beginning solely in the brain. However, growing research suggests that the gut microbiome may also influence mood through the gut–brain axis.

In this episode of The Histamine Well, Joanne explores what gut dysbiosis is and how the gut communicates with the brain through the vagus nerve, immune signalling, inflammation, stress hormones, short-chain fatty acids and neurotransmitter precursors.

Joanne also examines what the research actually says about probiotics, intestinal permeability, depression and anxiety—without overstating the evidence or promising a simple cure.

In this episode, you’ll learn:

• What gut dysbiosis means and what can disrupt the gut microbiome
• How the vagus nerve connects the gut and brain
• Why short-chain fatty acids are important for inflammation and brain health
• How gut bacteria may influence the stress response and serotonin production
• What studies have found about the microbiome and depressive symptoms
• Why the evidence for depression is currently stronger than the evidence for anxiety
• What “psychobiotics” are and why probiotic benefits are strain-specific
• Why gut health interventions should complement—not replace—appropriate mental health treatment
• Practical ways to support microbial diversity and the gut–brain axis
• Why fermented foods and some prebiotic fibres may not suit everyone with histamine intolerance or SIBO

The science supports a genuine connection between gut health and mental health, but the relationship is complex. There is no single probiotic, diet or supplement proven to resolve anxiety or depression on its own.

Supporting the gut through a diverse, fibre-rich diet, appropriate prebiotic or fermented foods, regular movement, sufficient sleep and stress management may form one valuable part of a broader approach to mental wellbeing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could sluggish bile be affecting your digestion, gut health and histamine symptoms?

In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption.

Joanne breaks down four popular bile-support supplements—ox bile, TUDCA, taurine and phosphatidylcholine—including how each works, when it may be considered and why they are not interchangeable.

In This Episode, You’ll Learn:

• Common symptoms of sluggish or inadequate bile flow
• What happens to digestion after gallbladder removal
• How poor bile flow may contribute to SIBO and histamine intolerance
• The connection between fat malabsorption and oxalates
• How ox bile supports fat digestion
• How TUDCA supports liver health and bile flow
• Why taurine is needed to produce functional bile salts
• How phosphatidylcholine supports bile quality and methylation
• Important supplement precautions involving gallstones and bile duct obstruction

Listen now to understand how bile affects digestion—and how targeted support may benefit your liver, gallbladder and gut health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions.

You’ll learn how the HPA axis responds to stress, why cortisol is helpful in the short term, and what can happen when the body becomes less responsive to cortisol’s anti-inflammatory effects. Joanne also discusses how reduced vagal tone may affect inflammation, mast cell reactivity, and the body’s ability to return to a calm, regulated state.

In this episode, you’ll discover:

• How stress activates the HPA axis and sympathetic nervous system
• The connection between cortisol, mast cells, and histamine
• Why chronic stress may worsen histamine intolerance and MCAS symptoms
• How stress-signalling molecules can trigger histamine release
• What glucocorticoid resistance is and how it may affect inflammation
• The role of the vagus nerve in immune and nervous-system regulation
• Why antihistamines may not address the upstream cause
• Practical ways to improve vagal tone and support nervous-system regulation

Joanne also shares simple strategies to help the body shift from fight-or-flight into rest-and-repair mode, including breathwork, humming, singing, gentle neck massage, and other vagus nerve exercises.

If your histamine symptoms seem to flare during periods of stress, this episode will help you understand why—and what you can do to begin breaking the stress–histamine cycle.

Resources mentioned:

• The Secret Language of the Body
• The Workout Witch nervous-system programs

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving?

In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation.

Oxalates are naturally occurring compounds found in many foods—including some commonly considered healthy. For sensitive individuals, a high oxalate load may contribute to pain, digestive problems, urinary symptoms, fatigue, and increased reactions to foods and supplements.

In this episode, Joanne and Melanie discuss:

• What oxalates are and how they can affect the body
• The connection between oxalates, histamine, and inflammation
• Common high-oxalate foods that may be contributing to symptoms
• Signs and symptoms associated with oxalate overload
• How gut health may influence oxalate absorption
• The impact of oxalates on minerals, sulfur, and important detoxification pathways
• Why some people develop multiple food and supplement intolerances
• The role of methylation and transsulfuration pathways
• Why nervous system regulation is an important part of recovery
• Why oxalates should be reduced carefully rather than eliminated too quickly

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

What is histamine, and why does it cause so many frustrating symptoms? 

In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, anxiety, insomnia, hives, eczema, reflux, bloating, and more. 

Discover why a low-histamine diet alone isn't enough and why identifying the root cause is the key to lasting relief. 

Whether you're new to histamine intolerance or revisiting this episode, this is the perfect place to start your healing journey.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

One of our most downloaded episodes is back.

If you've been diagnosed with histamine intolerance, MCAS, or unexplained food sensitivities, this replay is one you won't want to miss.

In this listener-favorite episode, Joanne Kennedy explains why histamine intolerance is not a diagnosis—it's a symptom of deeper underlying health issues. While many people rely on a low histamine diet to manage symptoms, lasting improvement comes from identifying and treating the root causes driving excess histamine production.

Drawing on years of clinical experience, Joanne walks through the most common contributors to histamine intolerance, including SIBO, gut dysbiosis, leaky gut, digestive enzyme insufficiency, mold illness, oxalates, methylation issues, hormonal imbalances, and chronic inflammation.

Whether you're a practitioner, student, or someone struggling with chronic histamine symptoms, this episode will help you better understand why histamine intolerance develops—and where to start looking for answers.

Listen, Learn & Share

If this episode helps you better understand your histamine symptoms, please follow The Histamine Well Podcast, leave a review, and share it with someone searching for answers.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment.

In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap, and why some people continue to react despite following a low histamine diet. Drawing on her clinical experience, Joanne explores how histamine is processed in the body, the role of DAO and HNMT enzymes, common triggers for mast cell activation, and why addressing the root cause is essential for long-term recovery.

She also discusses the connection between mould mycotoxins, gut dysfunction, SIBO, oxalates, nervous system dysregulation, and histamine-related illness, while sharing practical insights into how she approaches assessment and treatment in clinical practice.

In this episode, you'll learn:

• The difference between histamine intolerance and Mast Cell Activation Syndrome (MCAS)
• Why these conditions share many of the same symptoms but require different treatment approaches
• How DAO and HNMT enzymes help regulate histamine in the body
• Common causes of histamine intolerance, including gut dysfunction, SIBO, mould exposure, oxalates, and hormone imbalances
• Why MCAS symptoms are often more severe, unpredictable, and triggered by non-food factors
• The connection between mould mycotoxins, chronic inflammation, and mast cell activation
• Which laboratory tests may be helpful—and why some commonly recommended tests have limited clinical value
• Joanne's clinical approach to identifying and treating the root causes of histamine-related symptoms

Whether you're navigating histamine intolerance, suspect MCAS, or you're a healthcare practitioner wanting a deeper understanding of these complex conditions, this episode provides practical, evidence-informed insights to help you take the next step towards better health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause.

In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioidentical oestrogen and progesterone. She discusses the signs of low oestrogen and progesterone, the limitations of standard hormone testing, and how bioidentical hormone therapy may support women during this transition.

You'll learn:

• The difference between perimenopause and menopause
• Common symptoms of low oestrogen and low progesterone
• How hormonal changes can influence histamine intolerance and mast cell activation
• Why hormone blood tests don't always tell the full story
• The potential benefits and challenges of bioidentical oestrogen and progesterone
• The connection between hormones, anxiety, sleep, mood, energy, libido, and weight
• Why hormone therapy should be individualised rather than one-size-fits-all

Whether you're navigating perimenopause yourself or supporting women through this stage of life, this episode offers practical insights to help you better understand the relationship between hormones, histamine, and healthy ageing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity.

But what if more methylation isn't always better?

In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supplementation. Joanne explains the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why many people experience worsening anxiety, insomnia, irritability, and other adverse effects when taking methylated supplements.

Whether you're a practitioner, student, or someone navigating histamine intolerance, hormone imbalances, or chronic health concerns, this episode provides a balanced, evidence-informed perspective on one of today's most talked-about health trends.

In this episode, you'll learn:

• What methylation is and why it's essential for health
• How methylation affects neurotransmitters, hormones, detoxification, and gene expression
• The difference between undermethylation and overmethylation
• The role of MTHFR, COMT, folate, and vitamin B12 in methylation pathways
• Common symptoms of excess methyl groups
• Why genetic testing alone doesn't tell the whole story
• The potential risks of methylated supplements
• A more personalised approach to methylation support

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)?

In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle?

Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase.

You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines. Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement.

In This Episode You'll Learn:

• What PMDD is and how it differs from PMS
• The relationship between histamine and women's hormones
• How estrogen can increase histamine levels
• The role of progesterone in histamine regulation
• Mast cell activation and hormone-related symptoms
• Why histamine may worsen anxiety, irritability, and mood swings
• The science behind H1 and H2 blockers
• Potential risks of long-term antihistamine use
• Histamine's effects on neurotransmitters including serotonin and dopamine
• The connection between PMDD, MCAS, and histamine intolerance
• Why methylation may play a role in PMDD symptoms
• Common root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunction
• Natural strategies for addressing histamine-related hormone symptoms

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve.

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified.

You'll learn how three key factors often work together to impair cellular energy production:

• Mycotoxins and their direct toxic effects on mitochondria
• Sulfur depletion and reduced glutathione production
• Oxalate accumulation and mitochondrial stress

Joanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation.

This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness.

Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery.

In this episode, you'll discover:

• How mould toxins damage mitochondrial function
• Why fatigue often persists despite rest and sleep
• The critical role of sulfur in energy production and detoxification
• How oxalates can contribute to mitochondrial dysfunction
• Common signs of mould-related mitochondrial impairment
• Why addressing mould exposure alone may not be enough for recovery

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction.

If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction.

Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed.

In this episode, you’ll learn:

• Why mould illness and SIBO commonly occur together
• How poor vagal tone affects digestion and bacterial overgrowth
• The connection between mould, histamine intolerance, and mast cell activation
• Why low stomach acid and sluggish bile flow can worsen gut symptoms
• How chronic inflammation disrupts gut motility and digestive function
• Why antibiotics and herbal antimicrobials may not fully resolve SIBO
• The importance of mould testing in chronic gut health conditions

#SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation.

Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms.

In this episode, Joanne explains:

• How poor bile flow contributes to histamine intolerance
• Why mold toxicity and mycotoxins affect the liver and gallbladder
• The vicious cycle between SIBO and bile dysfunction
• How estrogen dominance impacts bile flow and histamine
• Why oxalates can worsen inflammation and histamine symptoms
• The role of methylation and phosphatidylcholine in healthy bile production
• How vagus nerve dysfunction affects digestion and bile release
• Common signs and symptoms of poor bile flow

This episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms.

🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine.

#HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients.

High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12.

Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements.

In this episode, you’ll learn:

 • What high homocysteine means and why it matters
 • The connection between homocysteine and methylation
 • Why methylated B vitamins can trigger symptoms
 • Histamine intolerance and supplement sensitivity
 • The role of MTHFR, COMT, and methylation pathways
 • Overmethylation vs undermethylation explained
 • Practical clinical insights for improving tolerance to methyl nutrients

Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing.

Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms.

Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing.

This episode also covers:

•  The role of estrogen during menopause and HRT 
•  Why over-detoxifying estrogen may worsen symptoms 
•  The connection between beta-glucuronidase, the estrobolome, and gut microbiome health 
•  Histamine intolerance, hormone imbalance, and menopause symptoms 
•  Natural considerations for estrogen metabolism and hormone support 
•  Why gut health may be more important than estrogen detox supplements 

If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight. 

Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms.

This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms.

You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected.

In this episode, Joanne discusses:

• The link between SIBO, histamine intolerance, and hormonal imbalance
• Why bloating, PMS, headaches, and acne may stem from gut dysfunction
• The difference between hydrogen and methane SIBO
• How nutrient deficiencies affect hormones, mood, and energy
• Why is bowel motility essential for successful SIBO treatment
• The role of biofilms in persistent gut symptoms
• Functional medicine strategies for improving gut and hormone health

Whether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation?

In this Q&A episode of The Histamine Well Podcast, Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate)—and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities.

You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity.

🎧 In this episode, you’ll learn:

•  What Epsom salt (magnesium sulfate) actually is 
•  How transdermal absorption supports magnesium levels 
•  The role of sulfate in liver detoxification (sulfation pathway)
•  Why sulfate is essential for gut lining, skin, and connective tissue health
•  How Epsom salt baths support the nervous system and stress response
•  Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues
•  How to safely start Epsom salt baths (especially if sensitive) 

Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system.

This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms.

If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance.

Tune in to learn how to use this simple therapy effectively and safely.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better?

In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction.

If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fatigue, this episode will help you understand what may really be going on beneath the surface.

🎧 In this episode, you’ll learn:

• What “sulfur intolerance” actually is (and why that term is misleading)
• The difference between sulfide, sulfite, and sulfate
• How disrupted sulfur metabolism impacts your gut, energy, skin, and brain
• The connection between hydrogen sulfide gas and mitochondrial dysfunction
• Why sulfur issues can trigger or worsen histamine intolerance
• Hidden sources of sulfur in foods, supplements, and water
• The role of methylation, molybdenum, and gut bacteria
• Key symptoms of sulfur imbalance (including bloating, fatigue, headaches, and food sensitivities)

Many people are told to simply eliminate more and more foods—but what if the real issue isn’t the food itself?

This episode offers a functional medicine perspective to help you understand the deeper biochemical pathways behind your symptoms and why your body may be reacting the way it is.

Understanding sulfur metabolism can completely shift how you approach healing—and may explain why nothing else has worked.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts?

In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups—and why this is often more than just a psychological issue.

This episode explains the physiological root causes of anxiety at night, including the critical role of blood sugar regulation, liver glycogen stores, and stress hormones like cortisol and adrenaline. When blood sugar drops overnight, your body triggers a stress response—leading to symptoms that can feel like panic attacks. 

You’ll learn:

•  Why anxiety often spikes between 2AM–4AM
•  The connection between low blood sugar and night-time panic
•  How cortisol and adrenaline disrupt sleep 
•  Common triggers like skipping meals, low protein intake, and caffeine use
•  Why this pattern is especially common in perimenopause
•  Simple strategies to stabilize blood sugar and improve sleep quality

Joanne also shares practical tips, including how a protein-based evening snack may help prevent early morning wake-ups and reduce overnight anxiety.

If you’ve been struggling with disrupted sleep, anxious thoughts at night, or waking at 3AM feeling wired, this episode offers a new perspective—and actionable steps to support your body.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results?

In this episode of The Histamine Well Podcast, Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability.

Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders. Joanne breaks down why this often goes undiagnosed, even when glucose, insulin, and HbA1c levels appear normal.

This episode explores the connection between blood sugar, hormones, histamine, gut health, and neurotransmitter production—and why women are particularly vulnerable, especially during high stress or perimenopause.

You’ll also discover real-life patterns seen in clinical practice, including:

•  High-achieving women relying on coffee and insufficient protein intake, contributing to blood sugar instability 
• Busy mothers under-eating and overwhelmed
• Women using intermittent fasting in ways that disrupt hormones
• Hidden links between histamine intolerance and blood sugar imbalance

If you’ve ever felt like your anxiety “doesn’t make sense,” this episode will help you understand what’s really happening in your body—and what to do about it.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

If your blood tests are “normal”… why do you still feel inflamed?

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal.

Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fog, skin issues, gut dysfunction, and hormonal imbalances. This episode explains why that disconnect happens and what may actually be driving your symptoms.

CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) are commonly used markers for inflammation—but they primarily detect acute, systemic inflammation, not the chronic low-grade inflammation seen in many complex health conditions. 

In this episode, you’ll learn:

•  Why CRP and ESR can be normal despite ongoing symptoms 
•  The difference between acute vs chronic low-grade inflammation 
•  Common drivers of hidden inflammation (gut issues, histamine, mold, blood sugar imbalance, stress) 
•  How inflammation can show up as skin, neurological, hormonal, and digestive symptoms 
•  Why patients are often dismissed despite real underlying issues 

If you’ve ever been told “your labs are normal” but still don’t feel well, this episode will give you the clarity and validation you’ve been looking for.

This is essential listening for anyone dealing with:

•  Histamine intolerance 
•  Chronic inflammation 
•  Gut health issues (SIBO, candida, dysbiosis) 
•  Hormonal imbalances 
•  Unexplained symptoms despite normal blood tests 

🎧 Subscribe to The Histamine Well Podcast for more expert insights on root-cause healing, inflammation, and complex chronic conditions.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface.

Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery.

If you’ve tried supplements, improved your diet, and still experience symptoms like PMS, PMDD, anxiety, insomnia, migraines, or hormonal acne, this episode provides a deeper framework for understanding why.

What You’ll Learn

• Why hormones may not improve despite treatment
• How inflammation disrupts ovulation and lowers progesterone
• The connection between histamine intolerance and estrogen dominance
• Why symptoms worsen around ovulation and before your period
• The role of methylation in estrogen detoxification
• Differences between overmethylation and undermethylation
• Why some supplements may worsen symptoms
• Key drivers behind PMS, anxiety, sleep issues, and hormonal imbalance

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Are bioidentical hormones truly “natural”—or is that just clever marketing?

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioidentical hormones actually are, where they come from, and how they differ from both synthetic hormones and herbal remedies.

Many women exploring hormone replacement therapy (HRT) feel uncertain about what they’re putting into their bodies—especially when terms like “natural,” “plant-based,” and “bioidentical” are used interchangeably. In this episode, we clarify the science in a simple, grounded way so you can make informed decisions about your health.

You’ll learn:

• What “bioidentical hormones” really means
• How hormones derived from wild yam and soy are processed
• The difference between plant compounds and human-identical hormones
• Why bioidentical doesn’t mean “straight from nature”
• How these hormones interact with your body
• Common misconceptions about HRT and hormone therapy

If you’ve ever struggled with hormone imbalance, menopause symptoms, or felt worse on hormone therapy, this episode will help you understand what’s actually happening beneath the surface.

This is essential listening for women navigating perimenopause, menopause, or anyone questioning whether hormone therapy is right for them.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women.

Joanne Kennedy shares a clinical case study showing how histamine overload and gut dysfunction can worsen HRT side effects like brain fog, fatigue, mood swings, and skin reactions.

Learn how the estrogen-histamine connection, gut health, and inflammation impact hormone tolerance—and why addressing SIBO and histamine intolerance may help restore balance.

Perfect for women experiencing menopause symptoms, HRT intolerance, or ongoing hormone imbalances.

🌿 In This Episode, You’ll Learn:

• Why histamine intolerance can worsen HRT side effects
• The connection between estrogen and histamine (and why it matters)
• How gut issues like SIBO drive inflammation and hormone imbalance
• Common symptoms: brain fog, fatigue, low mood, skin reactions
• Why fixing the gut can improve hormone tolerance
• A real clinical approach to restoring balance naturally

💡 Who This Episode Is For:

• Women struggling with HRT side effects
• Those experiencing menopause symptoms like fatigue, brain fog, and low mood
• Anyone with histamine intolerance or food sensitivities
• Practitioners looking to understand the gut-hormone connection

For worldwide online consultations via Zoom, visit: www.joannekennedynaturopathy.com

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this Q&A Clarity Session of The Histamine Well Podcast, naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway, often referred to as the body’s “master switch” for protection and repair.

Rather than acting as a simple antioxidant, sulforaphane works at a deeper level—helping to switch on a network of protective genes responsible for detoxification, antioxidant production, inflammation control, and immune regulation 

This episode breaks down complex science into simple, practical insights—perfect for both practitioners and those navigating chronic health issues.

In This Episode, we discussed:

•  What sulforaphane is and how it works in the body 
•  The role of the NRF2 pathway in detoxification and inflammation 
•  How sulforaphane supports antioxidant production and immune health 
•  Why gene expression (not just supplements) matters in healing 
•  How this applies to histamine intolerance, chronic inflammation, and gut health 

Who This Episode Is For:

•  Those interested in functional medicine and natural health 
•  People dealing with inflammation, histamine intolerance, or detox issues 
•  Practitioners wanting to understand sulforaphane and NRF2 
•  Anyone looking to support their body’s natural detox and repair systems 

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the gut lining and activating protective genes.

Learn how sulforaphane, NRF2 activation, and targeted microbiome support can help improve gut inflammation, histamine intolerance, food sensitivities, and chronic illness.

In this episode, you’ll learn:

• What the GEMM Protocol is and how it works
• How sulforaphane activates the NRF2 pathway and protective genes
• Why traditional antimicrobial gut protocols can worsen dysbiosis
• How gut inflammation contributes to histamine intolerance and food sensitivities
• The role of heat-killed probiotics and immune signaling in gut repair
• Why restoring the gut lining can improve conditions throughout the body
• How diet and prebiotics support microbiome recovery
•  Why some patients with chronic illness react to many supplements

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO?

The truth is—it depends.

In this episode, Joanne breaks down the two distinct patient scenarios she commonly sees in clinical practice. She explains when antibiotics may be a practical and supportive option, especially for those with lifestyle limitations, and when a deeper, more comprehensive approach may be necessary to address the root causes of SIBO.

You’ll learn:

When antibiotics can be helpful—and when they may not be enough
Why SIBO often keeps coming back
The role of underlying drivers like gut motility, bile flow, and nervous system health
What a natural, layered approach to healing looks like
How to determine the best path forward for your unique situation
This episode offers a balanced, practical perspective—helping you move beyond one-size-fits-all solutions and toward a more personalized approach to gut healing.

If you’re struggling with recurring SIBO or unsure which direction to take, this conversation will give you clarity and guidance.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction?

In this episode of The Histamine Well Podcast, Joanne explains why SIBO rarely develops in isolation and why antibiotics or herbal antimicrobials alone often fail to prevent relapse.

If you’ve been stuck in the cycle of treating SIBO repeatedly without lasting improvement, this episode explores the underlying mechanisms that may be driving bacterial overgrowth in the first place.

Joanne unpacks how impaired gut motility, nervous system dysregulation, low stomach acid, sluggish bile flow, estrogen dominance, mold toxicity, thyroid dysfunction, and histamine intolerance all contribute to creating the perfect environment for SIBO to thrive.

Rather than focusing solely on eliminating bacteria, this episode highlights a terrain-based, root-cause approach to restoring long-term digestive health.

In This Episode, We Discuss:

• What SIBO (Small Intestinal Bacterial Overgrowth) actually is
• Why SIBO often returns after antibiotics
• The migrating motor complex (MMC) and gut motility
• The vagus nerve and nervous system regulation
• Bile flow and its antimicrobial role
• Estrogen dominance and SIBO
• Mold toxicity and mitochondrial dysfunction
• The connection between SIBO and histamine intolerance
• Why relapse happens — and how to prevent it

If you found this episode helpful, please subscribe, leave a review, and share it with someone navigating SIBO or chronic gut issues.

For worldwide online consultations via Zoom, visit: www.joannekennedynaturopathy.com

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance, histamine clearance, and stress resilience — and why low folate, vitamin B12, B6, and B2 can contribute to symptoms such as anxiety, depression, brain fog, fatigue, insomnia, and “wired but tired” patterns.

We also discuss slow COMT activity, the link between estrogen and histamine, and how imbalances can drive mood swings, palpitations, and poor stress tolerance. Discover how real-time methylation testing (Mood Sense saliva swab) can provide personalised insights, plus how to book a Zoom consultation for deeper support.

If you're struggling with histamine intolerance, hormone imbalance, anxiety, or low mood, this episode connects the biochemical dots.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.

H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrupt digestive signaling — creating the perfect environment for small intestinal bacterial overgrowth (SIBO) and rising histamine levels. The result can be a “histamine storm” of inflammation and systemic symptoms.

Common signs may include:

• Food reactions
• Bloating and gas
• Hives or eczema
• Anxiety and insomnia
• Headaches
• PMS, estrogen dominance, and perimenopause flares

Joanne also discusses the pros and cons of triple therapy (antibiotics plus proton pump inhibitors), post-treatment gut repair, and natural strategies such as sulforaphane and gut-healing support.

If your histamine symptoms persist despite dietary changes, this episode explores a deeper gut–histamine–hormone connection that may be driving the root cause.

What You’ll Learn:

• How H. pylori disrupts stomach acid and digestion
• The link between low stomach acid, SIBO, and histamine intolerance
• Why mast cell activation increases systemic symptoms
• How histamine impacts estrogen and perimenopause
• Treatment considerations and natural support options

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive. 

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms.

She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break histamine down.

You’ll learn why antifungals alone often fail, how gut “terrain” factors like low stomach acid, poor bile flow, digestive enzyme insufficiency, microbiome imbalance, mold exposure, and chronic stress allow fungal overgrowth to persist, and how SIBO and SIFO are connected through small intestinal pH imbalance.

If you struggle with histamine intolerance, sugar cravings, brain fog after carbs, bloating, or recurrent candida, this episode explains the deeper root causes — and why nervous system regulation is essential for long-term healing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system. 

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure.

After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel shares how targeted support using sulforaphane, digestive enzymes, and Epsom salt baths helped stabilize her system and gradually restore tolerance to food.

Joanne explains the biochemical drivers behind mold-related illness, including sulfur metabolism, detoxification pathways, and nervous system load, and why aggressive protocols, heavy supplementation, and herbal overuse can often worsen symptoms in sensitive individuals.

This conversation highlights the importance of gentle, well-timed interventions, practitioner guidance, and understanding the body’s capacity before pushing detoxification.

Topics covered include:

• Severe food reactions and histamine intolerance
• Mold exposure and chronic illness
• Sulforaphane and detoxification support
• Sulfur metabolism and nervous system balance
• Why “less is more” in complex healing cases

Show Notes: 

🌐 Official Program Links

1. The Gupta Program – Brain Retraining

This is the main site for the limbic retraining and neuroplasticity program designed to help calm the nervous system and support recovery from chronic and sensitivity-related conditions.

2. Irene Lyon – Somatic & Nervous System Work

This is the official site for Irene Lyon, a nervous system expert who provides somatic-based exercises and education to help regulate the nervous system body-mind connection.

3. Cell‑Logic – G.E.M.M. Protocol for Patients

This page explains the G.E.M.M. Protocol (Gut Ecology & Metabolic Modulation) — an approach focused on restoring cellular health and gut-immune balance.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what actually supports healthy histamine balance, gut health, and energy. Perfect for anyone navigating MTHFR, chronic fatigue, or food sensitivities. 

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms.

Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protective biofilms. She explores the connection between MARCoNS and symptoms such as fatigue, brain fog, migraines, anxiety, poor detoxification, and heightened inflammatory responses, especially in individuals who don’t improve despite targeted gut or histamine protocols.

This episode walks listeners through how MARCoNS are identified, with a focus on nasal swab testing, and outlines evidence-informed treatment strategies, including biofilm disruptors, targeted herbal antimicrobials, and supportive therapies designed to reduce bacterial load and calm immune activation.

Whether you’re a health practitioner working with complex chronic cases or an individual struggling with ongoing symptoms that don’t fully resolve, this episode provides practical insight into MARCoNS as a hidden driver of inflammation and histamine dysregulation.

In This Episode, You’ll Learn:

• What MARCoNS are and how they impact the immune system
• Why MARCoNS are linked to chronic inflammation and histamine-related symptoms
• Common signs and symptoms associated with MARCoNS colonization
• How nasal swab testing is used to identify MARCoNS
• Treatment approaches including biofilm disruptors and targeted antimicrobials

Joanne discusses laboratories that provide MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci) nasal swab testing, commonly used in clinical practice to identify bacterial colonisation linked to chronic inflammation, histamine-related symptoms, and mould-associated illness.

• Nutripath (Australia): https://nutripath.com.au/
• Microbiology Dx (USA): https://www.microbiologydx.com/

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health.

Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is often overlooked, how genetic variations can impact B12 utilization, and why choosing the correct form of B12 supplementation is essential for optimal outcomes.

Joanne and James also examine the different forms of Vitamin B12—including methylcobalamin, hydroxocobalamin, adenosylcobalamin, and cyanocobalamin—discussing how each functions in the body and when one may be more appropriate than another.

 The conversation highlights common signs and symptoms of B12 deficiency, from fatigue and brain fog to neurological and mood-related concerns, and offers practical, evidence-informed strategies for assessing and supporting B12 status.

This episode is especially valuable for health practitioners, functional medicine clinicians, and individuals seeking a deeper understanding of how Vitamin B12, genetics, and methylation intersect to influence long-term health.

In This Episode, You’ll Learn:

• Why Vitamin B12 is essential for methylation, detoxification, and neurological health
• The different forms of Vitamin B12 and how they work in the body
• Common and often-missed symptoms of Vitamin B12 deficiency
• How B12 supports homocysteine regulation and cardiovascular health
• How to choose the right B12 supplementation based on individual needs
• The connection between genetics, methylation pathways, and B12 metabolism

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation.

This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react badly to methylated B vitamins, and how over-methylation can drive symptoms such as anxiety, irritability, insomnia, nervous system overload, and chronic inflammation.

Joanne also introduces the Mood Sense test as a real-time tool for assessing methylation status, helping practitioners and individuals move away from guesswork and toward personalized, symptom-aware support. With insights inspired by James Bradshaw, this episode is essential listening for anyone navigating estrogen-related symptoms, mood instability, or complex supplement reactions.

What you’ll learn in this episode:

• Why over-methylation is becoming more common, especially in women
• How COMT enzyme activity influences mood, stress tolerance, and neurotransmitter
• The connection between estrogen dominance and over-methylation
• Common emotional and inflammatory symptoms linked to over-methylation
• Why methylated supplements can worsen symptoms for some people
• How the Mood Sense test can help assess methylation status in real time
• Key considerations for supporting estrogen balance and calming the nervous system

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Are your hormones out of balance? In this episode of The Histamine Well Podcast, Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine, to demystify perimenopause and the role of Hormone Replacement Therapy (HRT) in supporting women’s health.

They explore what actually happens during hormone fluctuations in perimenopause, how to recognize estrogen dominance, and the benefits and risks of estrogen, progesterone, and testosterone therapy. Rachel shares practical insights on how personalized care, detailed hormone testing, and integrative medicine can help women navigate this transitional stage with confidence.

You’ll learn how early intervention with the right HRT protocol can improve energy, mood, sleep, and long-term wellbeing—plus how to avoid common pitfalls with synthetic hormones, patches, and oral estrogen.

Whether you’re just entering perimenopause or already considering HRT, this episode offers a clear, empowering look at how to restore hormonal harmony and thrive through midlife.

Learn more about Rachel’s integrative approach to hormone health and women’s wellbeing:

• Website: https://www.ginkgointegrativemedicine.com/ 
• Instagram: @ginkgointegrative

🧪 Rachel’s Recommended Annual Serum Lab Panel (Age 40+)

Done fasting, ideally once per year. Tracks hormonal shifts & key biomarkers:
CBC w/ diff · Ferritin, TIBC, Iron sat · CMP · GGT · SHBG · DHEA-S · Free & Total Testosterone · Estradiol LC/MS (Cycle Day 2–3) · FSH (Day 2–3) · LH · Progesterone LC/MS (Day 20–21) · Homocysteine · MMA · HSCRP · Insulin · HbA1c · ApoB · Lp(a) · TSH · Free T4 · Free T3 · rT3 · TPO antibodies · ANA · Vitamin D

Additional testing based on the case: DUTCH · Tiny Health GI Pro · Mira · 3x4 Genetics · Total Tox Burden · DEXA · OATS · Mood Sense

💡 At-Home Hormone Tracking — Listener Discount

Rachel checked in with Mira, a home-based hormone urine testing device, to offer a special 20% off discount for listeners of The Histamine Well Podcast.

🔸 Public Discount Code: 2GINGKO20
🔸 Mira Website: www.miracare.com

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!