Explore every episode of the podcast GasGasGas - Anaesthetic Science for Anaesthesia!

This episode explores how volatile anaesthetics behave and affect patients.

Shownotes @: https://gasgasgas.uk/gasgasgas-compartmentalised-volatiles-and-a-brief-jaunt-with-sevoflurane/

Chiefly thinking about how the compartments in a breathing circuit and patient interplay to achieve depth / maintain anaesthetic depth and emerge from anesthesia.

Absolutely worth a listen to get your head around compartments and also starting thinking about blood gas and oil gas partition coefficients

VOLATILE AGENTS, SEVOFLURANE, ANAESTHETIC GASES, SATURATED VAPOUR PRESSURE, BOILING POINT, BLOOD GAS PARTITION CO-EFFICIENT.

This primary FRCA podcast episode introduces clearance and then descends into bedlam trying to think about how the liver really clears drugs on a kinetics level.

Shownotes @: https://gasgasgas.uk/gasgasgas-hepatic-clearance/

I am not making you run for the hills by talking phase 1 and 2 metabolism ,CYP and all that jazz, that's for later.

Clearance, First order, Zero order, Kinetics, FRCA, Primary, Anaesthetics, Fun

We're talking pKa and all the delightful brain strain associated (or disassociated!) from it

pKa is a concept which is critical to how drugs cross membranes to their respective active sites.

Shownotes @: https://gasgasgas.uk/gasgasgas-pka/

pKa, Association and disassociation coefficient, pharmacokinetics, 

This Primary FRCA Podcast episode talks up Volume of distribution,

A pharmacological concept used as an introduction to compartmentalising humans into a variety of volumes in order to think about how drugs (or chemicals, or really anything even water....) distributes around a human.

Show Notes @: https://gasgasgas.uk/gasgasgas-volume-of-distribution/

VOD volume of distribution, pharmacokinetics, FRCA, Primary, Anaesthetics

FRCA Primary Podcast

Were talking the core fentanyl waffle, a jump into the opiate GPCRs Receptors

And closing up with some talk on using fentanyl in day to day practice and a brief introduction to pKa

Show Notes @: https://gasgasgas.uk/fentanyl-frca-primary-exam/

FRCA Primary Anaesthetics, Fentanyl, PKA, VOD, CYP2EI, norfentanyl

FRCA Primary Podcast - 

Were talking the core propofol waffle, what PKa is and how to think of it, and a bit about how to apply propofol to day to day work.

Show Notes @: https://gasgasgas.uk/gasgasgas-propofol/

Propofol FRCA Primary Anaesthetics PKa 2,6 di-isopropylphenol

FRCA Primary podcast covering the pharmacodynamics and pharmacokinetics of rocuronium

An introduction and full breakdown of rocuronium.

https://gasgasgas.uk/gasgasgas-rocuronium/

Talking Thiopentone, the bits needed for the exam and the practical bits of when it might get used (rarely, unless the boss happens to be from the 1940's) or you're doing obstetrics.

Shownotes @: https://gasgasgas.uk/gasgasgas-thiopentone/

THIOPENTONE, BARBITUATES, TAUTOMERISM, TAUTOMER, PKA, HALFLIFE, PORPHYRIA

Frca Primary Podcast looking at the properties of Atracurium, further introduction to the action of neuromuscular blocking agents and that all important exam structure!

Shownotes @ : https://gasgasgas.uk/gasgasgas-atracurium-frca/

ATRACURIUM, LAUDANOSINE, HOFFMAN ELIMINATION, FRCA, FRCA PRIMARY, CIS-ATRACURIUM, BENZYLISOQUINOLINIUM

The whirlwind that is enzyme kinetics in the human body for the FRCA primary exam, Enjoy!

Show Notes @: https://gasgasgas.uk/gasgasgas-michaelis-menten-mass-action-enzyme-kineticsgasgasgas/

MICHAELIS MENTEN – MASS ACTION – ENZYME KINETICS - FIRST ORDER - ZERO ORDER - ALLOSTERIC - VMAX - KM

Today were covering more volatiles, thinking a bit more about the defining characteristics of volatiles and exploring MAC, Minimum alveolar concentration.

Show Notes @ : https://gasgasgas.uk/gasgasgas-mac-and-the-partition-co-efficients/

MAC, Minimum Alveolar Concentration, Ed50, Blood gas partition coefficient, Oil:gas partition coefficient, Partial Pressure, Mac-AWAKE, Mac-BAR

This episode focuses on drawing comparisons between the different volatile anaesthetic agents 

Shownotes @ : https://gasgasgas.uk/gasgasgas-comparing-volatiles/

Specifically : Comparisons between the blood gas partition coefficient their oil gas partition coefficient the boiling points and saturated vapour pressure differences and we’re going to define those two points a little bit and then also thinking about their global warming potential as well as the differences that a patient may experience.

A Brief intro as to why I am doing this podcast, and introducing the viva-cast subseries coming soon!

https://gasgasgas.uk/gasgasgas-why/

This FRCA primary exam podcast explores the kinetics and dynamics of Ketamine, describes the NMDA receptor in detail and discusses the clinical uses of ketamine in UK anaesthetic practice.

Shownotes @ : https://gasgasgas.uk/ketamine-for-the-frca-primary/

FRCA Primary, Anaesthetics, GasGasgas, frca, Viva, OSCE, SBA

Ketamine, NMDA Receptor, NMDA Receptor Antagonist, Non-Competitive, Ketamine Dose, 

This FRCA Primary Exam Podcast analyses Morphine and the opiate receptors, the mechanisms, pharmacokinetics, pharmacodynamics and puts its use into context.

Shownotes @ : https://gasgasgas.uk/Morphine for the FRCA Primary Exam/

Welcome to the first episode the straight up emulates the viva (bar the drawing). This crack at interview style podcast covers sterilisation and cleaning of medical equipment, one of the many viva curveballs!

Show Notes @: https://gasgasgas.uk/cleaning-and-sterilisation-for-the-frca-primary-exam/⁠

This FRCA Primary Exam Podcast discusses Suxamethonium, its action, uses and pharmacology as well as an intro to neuromuscular blockade monitoring and cholinesterase deficiency.

Shownotes @ : https://gasgasgas.uk/suxamethonium-for-the-frca-primary-exam/

Willing Victim Tom wields his knowledge Vs Dr Gas

ShowNotes on GasGasGas.uk

1. How Carbon dioxide is transferred from tissue to atmosphere
2. The influences Carbon Dioxide, Oxygen, Mechanical and Drug factors have on intra-cranial pressure
3. Closing out with how the neonatal gasp and umbilical cord clamp triggers a number of cardio-vascular events in the ex-utero world.

Willing Victim Tom wields his knowledge Vs Dr Gas

⁠ShowNotes on GasGasGas.uk ⁠

1. How Carbon dioxide is transferred from tissue to atmosphere
2. The influences Carbon Dioxide, Oxygen, Mechanical and Drug factors have on intra-cranial pressure
3. Closing out with how the neonatal gasp and umbilical cord clamp triggers a number of cardio-vascular events in the ex-utero world.

Finsihing with a debrief on avoiding self laid traps - categorisation, and definitions