Explore every episode of the podcast Épigénétique et mémoire cellulaire - Edith Heard
| Title | Pub. Date | Duration | |
|---|---|---|---|
| Conférence - Stephen Quake : Medical Innovations from the Genome Revolution: Liquid Biopsies | 22 sept. 2025 | 00:43:23 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Conférence - Stephen Quake : Medical Innovations from the Genome Revolution: Liquid Biopsies Stephen Quake Head of Science at the Chan Zuckerberg Initiative and Lee Otterson Professor at Stanford University Stephen Quake est invité par l'assemblée du Collège de France sur proposition de la Pr Edith Heard. Résumé One of the most important medical innovations to arise from the genome revolution is the development of liquid biopsies: simple blood tests which replace the need for invasive sampling in fields as diverse as pregnancy, transplant medicine, infectious disease, and cancer. Virtually all of these liquid biopsies are based on a physiological phenomenon discovered in Strasbourg in 1948: circulating cell free nucleic acids. Despite more than a half century of research, this phenomenon did not have a clinical use until it was paired with high throughput sequencing and knowledge of the human genome sequence. I will describe how our lab developed a variety of diagnostic tests which have replaced invasive biopsies and are now used by millions of patients each year. Stephen Quake Stephen Quake is Head of Science at the Chan Zuckerberg Initiative, where he oversees CZI's science grant programs, technology development, and the CZ Biohub Network. He has received numerous awards for his contributions to science and is one of only two dozen scientists elected to all three National Academies. Steve also holds a faculty position at Stanford University, where he is the Lee Otterson Professor of Bioengineering and Applied Physics. Previously he was the founding co-president of the Chan Zuckerberg Biohub (2016-2022), investigator of the Howard Hughes Medical Institute (2006-2016), and professor at the California Institute of Technology (1996-2005). | |||
| Conférence - Stephen Quake : Understanding the Mysteries of the Cell: Our Immune Repertoire Viewed Through the Darwin's Eyes | 08 sept. 2025 | 00:46:13 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Conférence - Stephen Quake : Understanding the Mysteries of the Cell: Our Immune Repertoire Viewed Through the Darwin's Eyes Stephen Quake Head of Science at the Chan Zuckerberg Initiative and Lee Otterson Professor at Stanford University Stephen Quake est invité par l'assemblée du Collège de France sur proposition de la Pr Edith Heard. Résumé The nature of the immune system's antibody repertoire has been a subject of fascination for more than a century. This repertoire is highly plastic and can be directed to create antibodies with broad chemical diversity and high selectivity. There is now a good understanding of the potential diversity available and the mechanistic aspects of how this diversity is generated. Antibodies are formed by a mixture of recombination among gene segments, sequence diversification at the junctions of these segments, and point mutations throughout the gene. However, certain very elementary questions have remained open more than a half-century after being posed: It is still unclear what fraction of the potential repertoire is expressed in an individual at any point in time and how similar repertoires are between individuals who have lived in similar environments. Moreover, because each individual's immune system is an independent experiment in evolution by natural selection, experiments about repertoire similarity also inform our understanding of evolutionary diversity and convergence. I will discuss how we have used high throughput sequencing to sequence immune repertoires in both humans and model organisms to address these questions. Stephen Quake Stephen Quake is Head of Science at the Chan Zuckerberg Initiative, where he oversees CZI's science grant programs, technology development, and the CZ Biohub Network. He has received numerous awards for his contributions to science and is one of only two dozen scientists elected to all three National Academies. Steve also holds a faculty position at Stanford University, where he is the Lee Otterson Professor of Bioengineering and Applied Physics. Previously he was the founding co-president of the Chan Zuckerberg Biohub (2016-2022), investigator of the Howard Hughes Medical Institute (2006-2016), and professor at the California Institute of Technology (1996-2005). | |||
| Colloque - L'inactivation du chromosome X : Closing words | 11 juin 2025 | 00:04:35 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Closing words Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Edith Heard Professeur du Collège de France | |||
| Colloque - L'inactivation du chromosome X : XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells | 11 juin 2025 | 00:18:10 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Simão José Teixeira da Rocha IBB, Lisbonne, Portugal | |||
| Colloque - L'inactivation du chromosome X : Modulation of X chromosome inactivity and phenotypic consequences | 11 juin 2025 | 00:16:03 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Modulation of X chromosome inactivity and phenotypic consequences Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Céline Morey Université Paris Cité, France | |||
| Colloque - L'inactivation du chromosome X : Xist RNA and XCI maintenance mechanisms in female B cells | 11 juin 2025 | 00:22:50 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Xist RNA and XCI maintenance mechanisms in female B cells Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Monserrat Anguera Université de Pennsylvanie, États-Unis | |||
| Colloque - L'inactivation du chromosome X : Inactive X chromosome erosion in TNT reprogrammed hiSPC | 10 juin 2025 | 00:18:56 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : How is X-chromosome inactivation restricted to females? Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Marnie Blewitt WEHI, Australie | |||
| Colloque - L'inactivation du chromosome X : How is X-chromosome inactivation restricted to females? | 10 juin 2025 | 00:18:01 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : How is X-chromosome inactivation restricted to females? Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Edda Schultz Max Planck, Allemagne | |||
| Colloque - L'inactivation du chromosome X : Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function | 10 juin 2025 | 00:29:55 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Elphège Nora UCSF, États-Unis | |||
| Colloque - L'inactivation du chromosome X : Exploring X-inactivation's raison-d'être | 10 juin 2025 | 00:15:40 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Exploring X-inactivation's raison-d'être Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Rafael Galupa CBI, France | |||
| Colloque - L'inactivation du chromosome X : Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation | 10 juin 2025 | 00:17:36 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Vincent Pasque KU Leuven, Belgique | |||
| Colloque - L'inactivation du chromosome X : Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development | 10 juin 2025 | 00:13:17 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Charbel Alfeghaly Université Paris Cité, France | |||
| Colloque - L'inactivation du chromosome X : Using marsupials to understand the evolution of mammalian X inactivation | 10 juin 2025 | 00:31:10 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Using marsupials to understand the evolution of mammalian X inactivation Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) James Turner Crick Institute, Royaume-Uni | |||
| Colloque - L'inactivation du chromosome X : L'inactivation du chromosome X | 10 juin 2025 | 00:16:14 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : L'inactivation du chromosome X Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Dounia Djeghloul Université Paris Cité, France | |||
| Colloque - L'inactivation du chromosome X : Mechanisms of sexual dimorphism in liver physiology and cancer | 10 juin 2025 | 00:14:00 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Mechanisms of sexual dimorphism in liver physiology and cancer Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) James Cleland EMBL, Allemagne | |||
| Colloque - L'inactivation du chromosome X : HCFC1, a novel activator of XCI | 10 juin 2025 | 00:16:01 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : HCFC1, a novel activator of XCI Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Hegias Mira Bontenbal Erasmus, Pays-Bas | |||
| Colloque - L'inactivation du chromosome X : The impact of sex chromosomes on the mouse preimplantation embryo | 10 juin 2025 | 00:17:02 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : The impact of sex chromosomes on the mouse preimplantation embryo Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Daniel Snell Crick Institute, Royaume-Uni | |||
| Colloque - L'inactivation du chromosome X : L'inactivation du chromosome X | 10 juin 2025 | 00:14:33 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : L'inactivation du chromosome X Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Osamu Masui Riken, Japon | |||
| Colloque - L'inactivation du chromosome X : Escape from X-inactivation is directly modulated by Xist RNA levels | 10 juin 2025 | 00:12:49 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque - L'inactivation du chromosome X : Escape from X-inactivation is directly modulated by Xist RNA levels Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Agnese Loda EMBL, Allemagne | |||
| Colloque - L'inactivation du chromosome X : Introduction | 10 juin 2025 | 00:02:15 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Colloque : L'inactivation du chromosome X Organisation : Pre Edith Heard (Collège de France, chaire Épigénétique et mémoire cellulaire) et Pre Claire Rougeulle (Institut Curie) Edith Heard Professeur du Collège de France Claire Rougeulle Institut Curie | |||
| 04 - Implications de l'inactivation du chromosome X pour la biologie féminine | 02 juin 2025 | 02:09:23 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2024-2025 Nouvelles connaissances sur les mécanismes épigénétiques : l'inactivation du chromosome X et d'autres exemples d'expression monoallélique 04 - Implications de l'inactivation du chromosome X pour la biologie féminine | |||
| Conférence - Stephen Quake : Understanding the Mysteries of the Cell: How Do Mutations Arise in Our Bodies? | 26 mai 2025 | 00:45:14 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Conférence - Stephen Quake : Understanding the Mysteries of the Cell: How Do Mutations Arise in Our Bodies? Stephen Quake Head of Science at the Chan Zuckerberg Initiative and Lee Otterson Professor at Stanford University Stephen Quake est invité par l'assemblée du Collège de France sur proposition de la Pr Edith Heard. Résumé The question of how heritable mutations arise is one of long-standing interest in biology. In the case of bacteria, there was a debate about whether mutations arise as a consequence of adaptation to selective pressure from the environment, or whether they are pre-existing in populations even in the absence of such selective pressure. This was famously resolved as the latter by Luria and Delbruck. Genomic technologies now allow us to ask similar questions in humans. How is genetic diversity generated and what are the consequences? How do mutations acquired during the course of our life sometimes lead to cancer, and can we understand the evolutionary history of a tumor? My lecture will discuss these issues and illustrate how we have used single cell genomics to provide answers to some of these questions. Stephen Quake Stephen Quake is Head of Science at the Chan Zuckerberg Initiative, where he oversees CZI's science grant programs, technology development, and the CZ Biohub Network. He has received numerous awards for his contributions to science and is one of only two dozen scientists elected to all three National Academies. Steve also holds a faculty position at Stanford University, where he is the Lee Otterson Professor of Bioengineering and Applied Physics. Previously he was the founding co-president of the Chan Zuckerberg Biohub (2016-2022), investigator of the Howard Hughes Medical Institute (2006-2016), and professor at the California Institute of Technology (1996-2005). | |||
| 03 - Évolution de l'inactivation du chromosome X et dynamique développementale | 26 mai 2025 | 02:01:28 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2024-2025 Nouvelles connaissances sur les mécanismes épigénétiques : l'inactivation du chromosome X et d'autres exemples d'expression monoallélique 03 - Évolution de l'inactivation du chromosome X et dynamique développementale | |||
| 02 - La génétique et l'épigénétique de l'inactivation du chromosome X et d'autres exemples d'expression monoallélique | 19 mai 2025 | 02:07:47 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2024-2025 Nouvelles connaissances sur les mécanismes épigénétiques : l'inactivation du chromosome X et d'autres exemples d'expression monoallélique 02 - La génétique et l'épigénétique de l'inactivation du chromosome X et d'autres exemples d'expression monoallélique | |||
| Conférence - Stephen Quake : Understanding the Mysteries of the Cell: How Do Many Cell Types Arise From One Genome? | 12 mai 2025 | 00:57:04 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Conférence - Stephen Quake : Understanding the Mysteries of the Cell: How Do Many Cell Types Arise From One Genome? Stephen Quake Head of Science at the Chan Zuckerberg Initiative and Lee Otterson Professor at Stanford University Stephen Quake est invité par l'assemblée du Collège de France sur proposition de la Pr Edith Heard. Résumé Although the genome is often called the blueprint of an organism, it is perhaps more accurate to describe it as a parts list composed of the various genes that may or may not be used in the different cell types of a multicellular organism. Although nearly every cell in the body has essentially the same genome, each cell type makes different use of that genome and expresses a subset of all possible genes. This has motivated efforts to characterize the molecular composition of various cell types within humans and multiple model organisms, both by transcriptional and proteomic approaches. We used single cell transcriptomics to create a human reference atlas comprising more than one million cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression, and provides an experimental basis to understand the cell type diversity which can be generated from a single genome. Stephen Quake Stephen Quake is Head of Science at the Chan Zuckerberg Initiative, where he oversees CZI's science grant programs, technology development, and the CZ Biohub Network. He has received numerous awards for his contributions to science and is one of only two dozen scientists elected to all three National Academies. Steve also holds a faculty position at Stanford University, where he is the Lee Otterson Professor of Bioengineering and Applied Physics. Previously he was the founding co-president of the Chan Zuckerberg Biohub (2016-2022), investigator of the Howard Hughes Medical Institute (2006-2016), and professor at the California Institute of Technology (1996-2005). | |||
| 01 - Découverte de l'inactivation du chromosome X (lyonisation) | 12 mai 2025 | 02:02:36 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2024-2025 Nouvelles connaissances sur les mécanismes épigénétiques : l'inactivation du chromosome X et d'autres exemples d'expression monoallélique 01 - Découverte de l'inactivation du chromosome X (lyonisation) | |||
| Conférence - Virginijus Šikšnys : From CRISPR-Cas Immunity to Targeted Genome Editing and Beyond | 21 mars 2025 | 01:10:37 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2024-2025 Conférence - Virginijus Šikšnys : From CRISPR-Cas Immunity to Targeted Genome Editing and Beyond Virginijus Šikšnys Professeur, Vilnius University, Vilnius Virginijus Šikšnys est invité par l'assemblée du Collège de France sur proposition de la Pr Edith Heard. Résumé Bacteriophages (viruses that infect bacteria) pose a lethal threat to bacteria. In response, bacteria evolved multiple defense barriers that comprise a primitive immune system of bacteria. CRISPR-Cas system functions as an adaptive immune system that provides resistance against invading viruses. CRISPR-Cas immunity is enabled by programmable nucleases that act as DNA scissors that recognize and destroy invading nucleic acids. Easy programmability of CRISPR-Cas nucleases paved the way for the development of versatile tools for targeted genome engineering. Currently, Cas9 and Cas12 CRISPR-Cas nucleases are rapidly advancing into the clinics for the treatment of different diseases. Despite this exciting progress, significant challenges remain and need to be overcome, including precise delivery to target tissues, safety related to off-target effects and immune interactions and low efficiency of gene insertions. Therefore, in order to optimize therapeutic potential of genome editing technologies, novel tools that are more compact, more precise and safer are highly desirable. Recently, very compact RNA-directed transposon-related TnpB nucleases have been identified enabling the development of a new class of DNA-scissors. Further exploration and systematic discovery of novel antiviral defense systems is likely to decode novel enzymatic functions that could be repurposed for technological applications. | |||
| Conférence - Harold E. Varmus : How Can Science and Its Benefits Be Shared Globally? How Medical Science Can Be Used in Developing Countries | 25 mars 2024 | 01:01:21 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2023-2024 Conférence - Harold E. Varmus : How Can Science and Its Benefits Be Shared Globally? How Medical Science Can Be Used in Developing Countries Harold E. Varmus Prix Nobel de physiologie ou médecine Résumé In the final lecture, I will talk about the ways in which parts of the scientific enterprise are trying to create a world in which the opportunities to be a scientist and to share the benefits of science are available everywhere. I will talk about several initiatives, supported by governments or philanthropies, that either promote science as a global activity or improve access to advances in health care made possible by science. The initiatives will include examples funded by the US government, French-American collaborations, the World Health Organization, and others, to reduce the toll taken by malaria, cancers, and other diseases. | |||
| 04 - L'épigénétique à l'interface organisme-environnement : Exemples d'impacts environnementaux sur le règne végétal | 25 mars 2024 | 02:14:44 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2023-2024 04 - L'épigénétique à l'interface organisme-environnement : Exemples d'impacts environnementaux sur le règne végétal | |||
| Conférence - Harold E. Varmus : How Do Scientists Inform Others about Their Work? Why Evolving Publication Practices Are Contentious | 18 mars 2024 | 01:11:24 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Année 2023-2024 Conférence - Harold E. Varmus : How Do Scientists Inform Others about Their Work? Why Evolving Publication Practices Are Contentious Harold E. Varmus Prix Nobel de physiologie ou médecine Résumé I will talk about how scientists inform others about their results, with emphasis on the rise of scientific journals and the often excessive importance conferred upon work that appears in a few especially prestigious venues. A central element of this lecture will concern the use of the internet to make scientific information more accessible through public digital libraries, "open access" publication practices, preprint servers, and posts in social media. Problems associated with publication practices and peer review – including non-reproducibility, misconduct, and misuse of artificial intelligence – will also be discussed. | |||
| 03 - L'épigénétique à l'interface organisme-environnement : Exemples d'impacts environnementaux sur le règne animal | 18 mars 2024 | 01:42:28 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2023-2024 03 - L'épigénétique à l'interface organisme-environnement : Exemples d'impacts environnementaux sur le règne animal | |||
| Conférence - Harold E. Varmus : How Do Scientific Discoveries Affect the Way We Live? How Studies of a Chicken Virus Changed Cancer Therapy | 11 mars 2024 | 01:02:17 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2023-2024 Conférence - Harold E. Varmus : How Do Scientific Discoveries Affect the Way We Live? How Studies of a Chicken Virus Changed Cancer Therapy Harold E. Varmus Prix Nobel de physiologie ou médecine Résumé The main theme of the second lecture concerns the way in which fundamental biological research (as an example, my own work to identify and characterize the genes that produce cancers in animals) can produce important benefits for society (e.g., by leading to better treatments of common lethal human diseases, like cancer). I will also comment on the societal elements (commercial, regulatory, etc) required to change medical practice after scientific discoveries are made. | |||
| 02 - L'épigénétique à l'interface organisme-environnement : Comment l'environnement influence-t-il les phénotypes ? | 11 mars 2024 | 02:11:12 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2023-2024 02 - L'épigénétique à l'interface organisme-environnement : Comment l'environnement influence-t-il les phénotypes ? | |||
| Conférence - Harold E. Varmus : Who Becomes a Professional Scientist and Why? My Path from Literature and Medicine to Basic Biology | 04 mars 2024 | 01:06:33 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2023-2024 Conférence : Reflections on the Scientific Enterprise Who Becomes a Professional Scientist and Why? My Path from Literature and Medicine to Basic Biology Harold E. Varmus Prix Nobel de physiologie ou médecine Résumé I will begin by talking about the nature of scientific thought, contrasted with the experience of working in a complex "enterprise." Then I will note some of the reasons (personal, cultural, economic, political or other) that explain why people chose a career in science. I will describe in detail my own unusual route, influenced by literature, medicine, the Vietnam War, and finally the appeal of laboratory work. I will also recount how choice of a scientific career was displayed in a famous old movie and summarize my concerns about the unequal representation in the demography of science. | |||
| 01 - L'épigénétique à l'interface organisme-environnement : Introduction | 04 mars 2024 | 02:13:11 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2023-2024 01 - L'épigénétique à l'interface organisme-environnement : Introduction | |||
| 04 - Biais liés au sexe dans la susceptibilité aux maladies : L'importance de la régulation du dosage des gènes sur le chromosome X dans la susceptibilité à certaines maladies | 27 mars 2023 | 02:21:21 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2022-2023 Biais liés au sexe dans la susceptibilité aux maladies : causes génétiques et épigénétiques L'importance de la régulation du dosage des gènes sur le chromosome X dans la susceptibilité à certaines maladies | |||
| 03 - Biais liés au sexe dans la susceptibilité aux maladies : L'impact de l'expression des gènes liés aux chromosomes X inactif et Y sur les différences entre les sexes | 20 mars 2023 | 02:10:38 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2022-2023 Biais liés au sexe dans la susceptibilité aux maladies : causes génétiques et épigénétiques L'impact de l'expression des gènes liés aux chromosomes X inactif et Y sur les différences entre les sexes | |||
| 02 - Biais liés au sexe dans la susceptibilité aux maladies : causes génétiques et épigénétiques : Biais liés au sexe : comment distinguer les effets dus aux chromosomes sexuels, hormones ou mode de vie ? | 13 mars 2023 | 02:07:27 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2022-2023 Biais liés au sexe dans la susceptibilité aux maladies : causes génétiques et épigénétiques Biais liés au sexe : comment distinguer les effets dus aux chromosomes sexuels, hormones ou mode de vie ? | |||
| 01 - Biais liés au sexe dans la susceptibilité aux maladies : causes génétiques et épigénétiques : Introduction : les maladies ont-elles un sexe ? | 06 mars 2023 | 02:04:57 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2022-2023 Biais liés au sexe dans la susceptibilité aux maladies : causes génétiques et épigénétiques Introduction : les maladies ont-elles un sexe ? | |||
| 05 - Mémoire cellulaire au cours de la vie | 29 mars 2021 | 02:02:34 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2020 - 2021 Mémoire cellulaire au cours de la vie | |||
| 04 - Mémoire cellulaire au cours de la vie | 22 mars 2021 | 02:03:11 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2020 - 2021 Mémoire cellulaire au cours de la vie | |||
| 03 - Mémoire cellulaire au cours de la vie | 15 mars 2021 | 01:56:06 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2020 - 2021 Mémoire cellulaire au cours de la vie | |||
| 02 - Mémoire cellulaire au cours de la vie | 08 mars 2021 | 02:01:41 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2020 - 2021 Mémoire cellulaire au cours de la vie | |||
| 01 - Mémoire cellulaire au cours de la vie | 01 mars 2021 | 02:02:03 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2020 - 2021 Mémoire cellulaire au cours de la vie | |||
| 01 - Le génome en quatre dimensions | 09 mars 2020 | 01:58:25 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2019-2020 Le génome en quatre dimensions | |||
| 05 - Épigénétique, Environnement et Biodiversité | 15 avr. 2019 | 01:10:37 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2018-2019 Épigénétique, Environnement et Biodiversité | |||
| 04 - Épigénétique, Environnement et Biodiversité | 11 déc. 2018 | 01:37:29 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2018-2019 Épigénétique, Environnement et Biodiversité | |||
| 03 - Épigénétique, Environnement et Biodiversité | 04 déc. 2018 | 01:52:24 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2018-2019 Épigénétique, Environnement et Biodiversité | |||
| 02 - Épigénétique, Environnement et Biodiversité | 13 nov. 2018 | 01:50:50 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2018-2019 Épigénétique, Environnement et Biodiversité | |||
| 01 - Épigénétique, Environnement et Biodiversité | 06 nov. 2018 | 01:59:06 | |
Edith Heard Collège de France Epigénétique et mémoire cellulaire Cours 2018-2019 Épigénétique, Environnement et Biodiversité | |||