EP Edge – Details, episodes & analysis

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EP Edge

Niraj Sharma MD FACC FHRS

Science

Health & Fitness

Frequency: 1 episode/12d. Total Eps: 11

EP-EDGE brings you the latest in cardiac electrophysiology — from breakthrough research and clinical insights to future-shaping innovations. Hosted by Dr. Niraj Sharma, an electrophysiologist with over 15 years of experience, each episode delivers clear, evidence-based updates designed to inform, inspire, and elevate your practice.

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🇺🇸 USA - lifeSciences
25/07/2026
#75
🇺🇸 USA - lifeSciences
16/07/2026
#76
🇺🇸 USA - lifeSciences
15/07/2026
#96
🇺🇸 USA - lifeSciences
08/07/2026
#94

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Score global : 69%

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Targeting the Intrinsic Pathway: Is Factor XI Inhibition Poised to Redefine Stroke Prevention in AF: EP Edge August 2025 Issue 4A

Episode 4

Tuesday, October 28, 2025 • Duration 10:22

What if stroke prevention in atrial fibrillation no longer meant trading protection for bleeding risk?

Factor XI inhibition—led by trials like AZALEA–TIMI 71, LILAC–TIMI 76, and LIBREXIA–AF—is poised to rewrite the anticoagulation playbook. By targeting the intrinsic pathway, these agents may decouple thromboembolic protection from major bleeding, potentially reshaping the role of left atrial appendage occlusion (LAAO) in stroke prevention strategies.

In this episode of EP Edge, Dr. Niraj Sharma breaks down the evolving data, drug classes, mechanistic rationale, and implications for future guidelines—while also looking at where structural interventions may still fit in this shifting landscape.

For: Source data/infographics see EPEDGE Newsletter on LinkedIn
For feedback, collaborations, or questions, email Dr. Niraj Sharma at epedgecast@gmail.com or connect on LinkedIn

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First-Line VT Ablation: Trials, Tools & Timing: EP Edge Newsletter June 2025

Episode 2

Tuesday, October 28, 2025 • Duration 08:05

The paradigm is shifting. Ventricular tachycardia (VT) ablation is stepping out of the shadows—from rescue therapy to first-line strategy, driven by landmark trials like VANISH2, PAUSE-SCD, and PARTITA. Meanwhile, pulse field ablation (PFA) continues its rapid evolution—crossing over from atrial to ventricular applications—but questions about durability and embolic safety persist.

In this episode of EP Edge, Dr. Niraj Sharma takes you through the key data shaping modern electrophysiology, from trial outcomes to emerging technology, including injectable light-activated pacemakers and telomere-targeting strategies that may redefine longevity and prevention.

Whether you’re an EP, a general cardiologist, or in allied research, this episode offers evidence-based insights and forward-looking perspectives on where rhythm science is heading.
For: Source data/infographics see EPEDGE Newsletter on LinkedIn
For feedback, collaborations, or questions, email Dr. Niraj Sharma at epedgecast@gmail.com

or connect on LinkedIn

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Left Atrial Appendage Occlusion (LAAO): Where We Stand in 2025: EP Edge Newsletter 4B August 2025

Episode 5

Tuesday, October 28, 2025 • Duration 09:14

Left atrial appendage occlusion (LAAO) has evolved from a niche option for oral anticoagulation–intolerant patients to a frontline procedural strategy for stroke prevention in atrial fibrillation. Landmark trials like OPTION, SWISS‑APERO, and COMBINATION are redefining how and when we use these devices.

In this episode of EP Edge, Dr. Niraj Sharma walks through the historical arc of LAAO, key evidence shaping contemporary practice, procedural complications often under-recognized (like silent cerebral lesions), and where the field is headed with AI, new device designs, and competition from Factor XI inhibitors.

This is essential listening for electrophysiologists, interventional cardiologists, and rhythm specialists navigating the next era of stroke prevention.

For: Source data/infographics see EPEDGE Newsletter on LinkedIn
For feedback, collaborations, or questions, email Dr. Niraj Sharma at epedgecast@gmail.com or connect on LinkedIn

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Pulse Field Ablation: Promise, Peril, and the AI Revolution in EP: EP Edge Newsletter May 2025

Episode 1

Tuesday, October 28, 2025 • Duration 09:22

Pulse field ablation (PFA) has been hailed as the next frontier in atrial fibrillation therapy—nonthermal, ultra-selective, and lightning fast. But as new data emerges, important questions are rising about its systemic effects, cerebral safety, and vascular complications.

In this episode of EP Edge, Dr. Niraj Sharma unpacks the latest findings from the NEMESIS-PFA registry, explores silent cerebral lesion data, reviews a rare case of catastrophic coronary spasm, and introduces how AI—through models like DeePRISM—is changing how we think about ablation strategy.

Whether you’re in the lab, in clinic, or leading research, this episode offers a critical look at where the field is heading next.
For: Source data/infographics see EPEDGE Newsletter on LinkedIn
For feedback, collaborations, or questions, email Dr. Niraj Sharma at epedgecast@gmail.com

or connect on LinkedIn

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Lifestyle Modification and Atrial Fibrillation: Redefining the role of the Electrophysiologist: EP Edge Newsletter July 2025

Episode 3

Tuesday, October 28, 2025 • Duration 14:59

Ablation is powerful—but lifestyle is transformative. As atrial fibrillation (AF) continues to rise globally, emerging evidence makes it clear: lifestyle modification is not just complementary care, it’s frontline therapy.

In this episode of EP Edge, Dr. Niraj Sharma explores how structured lifestyle interventions—targeting weight, alcohol use, sleep apnea, blood pressure, diabetes, and physical activity—can rival or even surpass the outcomes of ablation alone.

We’ll discuss key data from landmark trials, gender differences in response, and how the modern electrophysiologist’s role is evolving—beyond the lab and into lifestyle medicine.
For: Source data/infographics see EPEDGE Newsletter on LinkedIn
For feedback, collaborations, or questions, email Dr. Niraj Sharma at epedgecast@gmail.com

or connect on LinkedIn

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Beyond CRT: LBBAP and the New Era of Physiological Pacing — Promise and Pitfalls: EP Edge Newsletter October 2025 Issue 5

Episode 6

Monday, October 27, 2025 • Duration 10:31

In this episode of EP Edge Podcast, Dr. Niraj Sharma dives deep into the clinical promise and procedural realities of LBBAP:

Clinical advantages: improved LVEF, narrower QRS, lower VT/VF and AF incidence.
RV protection: reduced risk of pacing-induced cardiomyopathy.
Sex-specific outcomes: women with NICM + LBBB derive greater benefit.
Complications: lead fracture, TR progression, microperforations, and capture failure.
Future directions: integrating imaging, refining technique, and advancing lead technology

This is where physiology meets precision—and where CRT is being redefined.

For: Source data/infographics see EPEDGE Newsletter on LinkedIn
For feedback, collaborations, or questions, email Dr. Niraj Sharma at epedgecast@gmail.com or connect on LinkedIn

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EP Edge Newsletter Part I: Pulsed Field Ablation (PFA) — Electroporation, Biophysics, Engineering, Tissue Selectivity, and Lesion Formation

Episode 9

Wednesday, February 11, 2026 • Duration 20:03

In this foundational episode of the EP Edge Newsletter Podcast, we examine the scientific and engineering principles underlying pulsed field ablation (PFA), a transformative advance in catheter ablation for atrial fibrillation. Unlike radiofrequency or cryoablation, which rely on thermal injury, pulsed field ablation produces myocardial lesions through irreversible electroporation, a non-thermal mechanism that disrupts the cell membrane by applying precisely controlled electric fields. This represents a fundamental shift in ablation biology, where lesion formation is governed not by heat, but by transmembrane voltage thresholds, membrane destabilization, and controlled cellular injury.

This episode traces the history of electroporation, from its origins in physics and industrial biotechnology to its adoption in oncology as a non-thermal tumor ablation modality and eventual translation into cardiac electrophysiology. We then explore the Engineering Trinity of pulsed field ablation—the waveform, catheter, and pulse generator—and how these components interact to determine lesion size, safety profile, tissue selectivity, and procedural effectiveness. Understanding this integrated engineering system is essential to interpreting differences between pulsed field ablation platforms and explains why voltage alone does not define lesion durability or procedural success.

We also examine the cellular and molecular mechanisms of PFA lesion formation, including nanopore creation within the lipid bilayer, calcium influx, ATP depletion, mitochondrial dysfunction, and regulated cell death pathways. These membrane-driven injury mechanisms produce lesions that differ fundamentally from thermal ablation, preserving extracellular architecture while eliminating cardiomyocytes. This unique biology underlies one of the most important advantages of pulsed field ablation—tissue selectivity, where myocardial cells demonstrate greater susceptibility to irreversible electroporation compared with surrounding structures such as the esophagus, nerves, and vasculature, enabling effective ablation with reduced collateral injury risk.

Finally, we review the , including sharply demarcated injury zones, preserved tissue scaffolding, and progressive fibrocellular remodeling over time. These distinctive lesion characteristics explain both the safety profile and long-term behavior of pulsed field ablation and provide critical insight into how electrophysiologists should interpret acute procedural endpoints and long-term durability.

Cannabis and the Heart: Atrial Fibrillation, Arrhythmias, Stroke, Myocardial Infarction and Sudden Cardiac Risk Explained

Episode 8

Monday, December 22, 2025 • Duration 24:06

In this EP-EDGE podcast episode, Dr. Niraj Sharma, cardiac electrophysiologist, breaks down the latest evidence linking modern high-THC cannabis to cardiovascular and electrophysiologic risk. Drawing from large real-world datasets, mechanistic studies, and global meta-analyses, this episode explains how today’s cannabis products—vapes, edibles, dabs, and synthetic cannabinoids—are very different from the low-potency marijuana of the past.

We explore the science behind CB1 receptor activation, autonomic imbalance, endothelial dysfunction, platelet activation, and how these mechanisms translate into real-world clinical outcomes—including:

Atrial fibrillation and supraventricular tachycardia
Premature atrial and ventricular beats
Ventricular tachycardia and ventricular fibrillation
Myocardial infarction and stroke in young adults
Endothelial dysfunction as an early vascular warning sign
Why high-potency THC and route of use (vaping, edibles, dabs) matter

This episode reviews landmark studies from JACC Advances, Heart, JAMA Cardiology, European Heart Journal, and Heart Rhythm, including massive EHR-based cohorts involving millions of patients. We also address common misconceptions, including why some older studies show neutral risk—and why those findings do not apply to modern high-potency cannabis use.

Whether you are a cardiologist, electrophysiologist, primary care clinician, or an informed patient, this episode provides a clear, evidence-based framework to understand why modern cannabis is not cardiovascularly benign and how it should be discussed in clinical practice—especially in patients with atrial fibrillation, ventricular arrhythmias, or unexplained cardiac events.

References, infographics, and detailed study breakdowns are available in the EP-EDGE LinkedIn Newsletter (December 2025 issue).

When Atrial Fibrillation Ablation Fails: Have We Reached the Limit or Just the Wrong Target?

Episode 7

Sunday, November 23, 2025 • Duration 11:55

In this issue, we trace the fascinating evolution of atrial fibrillation (AF) therapy — from the Cox Maze procedure to Haïssaguerre’s discovery of pulmonary vein ectopy, through Pappone’s wide antral isolation, and onward to the era of pulse field ablation (PFA).

We explore how ablation technologies have transformed — radiofrequency, cryo, and PFA — yet the success rates remain stubbornly static. Why do some ablations fail? Are we reaching the limits of substrate modification, or simply targeting the wrong mechanisms?

Join Dr. Sharma as he dissects the mechanistic layers of ablation failure — from pulmonary vein reconnection and atrial substrate remodeling to inflammation, fibrosis, and autonomic imbalance. The discussion looks ahead to next-generation strategies that may redefine success in AF therapy.

If you enjoy this episode, subscribe and share the podcast to help grow the EPH community.
For questions, suggestions, or collaboration ideas, reach out at EPEdgeCast@gmail.com

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EP Edge Newsletter Part III: Pulsed Field Ablation Complications — Hemolysis, Coronary Spasm, Silent Stroke, Phrenic Nerve Injury, and CIED Interaction

Episode 10

Wednesday, February 25, 2026 • Duration 30:04

Pulsed field ablation (PFA) has rapidly transformed atrial fibrillation ablation, offering a non-thermal mechanism of myocardial injury through irreversible electroporation. While early clinical trials emphasized its favorable safety profile compared with radiofrequency and cryoablation, expanding real-world experience has revealed a distinct complication spectrum driven by high-voltage electric field interactions with myocardium, coronary arteries, blood, nerves, and cardiac implantable electronic devices. Unlike thermal injury, these complications are mediated by electrical, autonomic, and vascular effects, including delayed coronary vasospasm, malignant ventricular arrhythmias, and transient electrical instability. Understanding these mechanisms is critical as pulsed field ablation becomes more widely adopted in electrophysiology practice.

This episode explores key complications including intravascular hemolysis and associated acute kidney injury, coronary artery spasm and ischemia, silent cerebral ischemic lesions, phrenic nerve injury, esophageal temperature elevation, and neuromuscular stimulation such as laryngospasm. These risks are strongly influenced by catheter design, lesion burden, waveform characteristics, and proximity to vulnerable structures. We also examine the interaction between pulsed field ablation and pacemakers and implantable cardioverter-defibrillators (ICDs), including transient pacing inhibition, electromagnetic interference, and rare cases of permanent device malfunction. As pulsed field ablation expands into more complex lesion sets and broader patient populations, recognizing these platform-specific risks is essential for procedural planning, patient selection, and post-procedural monitoring.

Full references, detailed analysis, graphs, and visual summaries are available on the EP Edge Newsletter on LinkedIn, and the complete long-form article is also available on Substack at epedge.substack.com. If you have any questions, suggestions, or feedback, please contact epedgecast@gmail.com.

EP Edge – Details, episodes & analysis

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EP Edge – Details, episodes & analysis

Podcast details

Recent rankings

Apple Podcasts

Shared links between episodes and podcasts

RSS feed quality and score

Publication history

Latest published episodes

Similar podcasts and content

Related Shows Based on Content Similarities

Related Shows Based on Content Similarities

Apple Podcasts

Spotify