Explore every episode of the podcast Double-stranded

If you’ve ever analyzed sequencing data, chances are you’ve used tools developed by Phil Ewels—whether you knew it or not. He’s the creator of MultiQC, a key developer behind Nextflow and nf-core, and a major advocate for making bioinformatics workflows scalable, reproducible, and user-friendly.

In this episode, we dive into:
🔬 How MultiQC became the standard for bioinformatics quality control
⚙️ The philosophy behind nf-core and the trade-offs of workflow standardization
🤖 The role of AI in bioinformatics—will machines build pipelines for us?
🌍 The future of open-source collaboration and making workflows more accessible

If you’ve ever struggled with workflow management, questioned reproducibility, or wondered where bioinformatics is heading, this is the episode for you.

🎧 Tune in now to hear my conversation with Phil Ewels.

🤝 Connect with Phil here: https://phil.ewels.co.uk/

🐦 Tell me what you think of the episode on X: https://x.com/Mike__Kazemi

Welcome to today's episode. I'm excited to introduce our guest, Dr. Senjuti Saha, the Deputy Executive Director of the Child Health Research Foundation in Bangladesh. Dr. Saha is a trailblazer in genomic research and a passionate advocate for equitable science education. From her discovery of the chikungunya virus as a cause of pediatric meningitis to her leadership roles with the WHO and her program 'Building Scientists for Bangladesh,' Dr. Saha’s work bridges the gap between cutting-edge research and real-world impact in low- and middle-income countries. Today, we’ll dive into her journey, the challenges and opportunities in global health research, and her vision for the future. Stay tuned for an enlightening conversation.

Professor Joly is an internationally acclaimed figure in health law, intellectual property, and bioethics, leaving an enduring impact on the ethical landscape of modern medicine. With pivotal roles in the International Cancer Genome Consortium (ICGC) and the International Human Epigenome Consortium (IHEC), he has spearheaded the development and implementation of controlled access mechanisms in genomics research since 2009, influencing emerging models worldwide. With over 120 peer-reviewed publications, influential book chapters, and recognition such as the "Innovation Merit" award from the Quebec Bar, his influence extends to legal, ethical, and scientific domains. Testifying before esteemed bodies like the Council of Europe and the Canadian Senate, his expertise shapes genetic discrimination discourse. Inducted into the Canadian Academy of Health Sciences (CAHS), his current research navigates the intricate interplay of scientific knowledge, health law, and bioethics at the forefront of biotechnology and emerging health technologies.

Check out Dr. Joly's latest research here: https://tinyurl.com/25ff2u5n Connect with me here: https://twitter.com/Mike__Kazemi

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In this episode, we delve into the intricate world of the human pangenome with Cristian Groza, a Ph.D. student specializing in bioinformatics from Bourque lab at McGill University.

A Draft Human Pangenome Reference paper Connect with Cristian here Connect with me here

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Dr. Sarah Gagliano Taliun is a researcher affiliated with the Montréal Heart Institute and the Université de Montréal. She specializes in neurogenetics, complex traits, and genomics. Her research focuses on understanding genetic factors and tackling questions surrounding human health from a mechanistic and biological perspective. She employs state-of-the-art computational and bioinformatics approaches, including machine learning techniques, to study these genetic factors. Dr. Gagliano Taliun's work involves the development of predictive models that are specific to an individual's sex, contributing to personalized medicine. Using statistical and computational methods, she aims to uncover the underlying mechanisms and genetic components related to various health conditions. Her research has the potential to enhance our understanding of complex traits and advance the field of genomics.

• Her lab: https://sgagliano.github.io/
• The paper discussed on the show: https://pubmed.ncbi.nlm.nih.gov/36119674/

Connect with me on Twitter: https://twitter.com/Mike__Kazemi

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Dr. John A. Morris is a Postdoctoral Scientist at the New York Genome Center, supported by a NHGRI K99 Fellowship. His work aims to understand common human genetic variation through genome editing. connect with him on Twitter or LinkedIn.

See STING-seq preprint here Check out these great Twitter threads on STING-seq here and here

connect with me on Twitter

https://linktr.ee/double_stranded

Dr. Daniel Taliun is a Human Genetics Assistant Professor at McGill University. His research interests are in developing computational algorithms and software tools for analyzing genetic data combined with molecular, behavioural, imaging and environmental data.

His scope of research includes genomic and clinical data integration, web-based analytical tools and interactive visualizations, secure data sharing, distributed computational algorithms for in-house and cloud computing computational platforms, analysis of rare genetic variations across diverse populations, and gene-disease associations.

Connect with me on Twitter: https://twitter.com/Mike__Kazemi This podcast is produced in collaboration with CKUT radio: https://ckut.ca/

Dr. Raquel Cuella Martin joined the Department of Human Genetics and the Canada Excellence Research Chair in Genomic Medicine as an assistant professor in August 2022.

Dr. Martin's current research employs large-scale precision genome editing to investigate the DNA damage response and its connection to human disorders. Her lab aims to integrate DNA repair and checkpoint control activities to prevent tumorigenesis and preserve cellular homeostasis. The lab also explores how precision genome editing can help understand disease-associated genetic variation and advance intelligent drug design.

Connect with her on Twitter: https://twitter.com/raquel_cuella

Connect with me on Twitter: https://twitter.com/Mike__Kazemi

This podcast is produced in collaboration with CKUT radio: https://ckut.ca/