DiabetesBio – Details, episodes & analysis

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DiabetesBio

American Diabetes Association

Science

Frequency: 1 episode/27d. Total Eps: 36

DiabetesBio co-hosts Darleen Sandoval (University of Colorado), Kirk Habegger (University of Alabama-Birmingham), and Kevin Williams (UT Southwestern) interview authors of editor-selected biomedical research articles published in the journal Diabetes, the American Diabetes Association's flagship research publication.

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https://diabetesjournals.org/diabetes
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https://diabetesjournals.org/journals/pages/podcasts
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https://diabetes.org/research/pathway
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https://www.linkedin.com/in/deepthi-mallela-md-mph
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https://www.linkedin.com/in/joseortiz8
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https://www.linkedin.com/in/magnusgroendahl/
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Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus "Sweet Talk" with Banting Medal recipient Jens Juul Holst

Season 1 · Episode 26

Friday, November 7, 2025 • Duration 01:06:37

Welcome to the November 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2025 issue of Diabetes.

6:00 In the first segment, our hosts are joined by Kaylia Reynolds, MS and Nora Franceschini, MD, MPH, FAHA, both of the Department of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina. Their paper, "Diabetes Genetic Clusters and Clinical Outcomes in American Indians," is available for free at doi.org/10.2337/db25-0322.

20:40 To discuss the latest Paper of the Month, our hosts are joined by first author Stephanie K. Holm, a postdoctoral student in the Clemmensen group, and Christoffer Clemmensen, Associate Professor in the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. Their paper, "Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice," is available for free at doi.org/10.2337/db24-1056.

38:15 In the latest edition of "Sweet Talk," Kevin and Kirk speak with Banting Medal recipient Jens Juul Holst, MD, DMSc, of the University of Copenhagen, whose work with incretin hormones laid the foundation for therapies now used around the world. His article, "Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture," is available for free at doi.org/10.2337/dbi21-0026.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!

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Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, "Sweet Talk" on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity

Season 1 · Episode 25

Wednesday, October 8, 2025 • Duration 01:07:35

Welcome to the October 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2025 issue of Diabetes.

5:50 In the first segment, our hosts are joined by Tessa M. Cacciottolo, PhD, a Chain Florey TTI Fellow in the MRC Laboratory of Medical Sciences at Imperial College London. She is the first author of the article "Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis," available for free at doi.org/10.2337/db25-0209.

22:15 In honor of last month being Childhood Obesity Month, in this month's edition of "Sweet Talk", our hosts speak with Kristen Nadeau, MD, MS, a professor of pediatrics at the University of Colorado Anschutz Medical Campus, and Bethany Cartwright, MD, PhD, an Assistant Instructor in the Department of Pediatrics at UT Southwestern Medical Center. They discuss the complications children with obesity can face, as well as the stigma and weight biases that accompany these diagnoses. Cartwright's article, "Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity," is available for free at doi.org/10.2337/dbi24-0044.

Francis C. Lynn on tracking insulin- and glucagon-expressing cells, David C. Wraith & Michael J. Price on antigen-specific immunotherapy for T1D, and Sweet Talk with Bret H. Goodpaster

Season 1 · Episode 16

Monday, February 10, 2025 • Duration 50:06

Welcome to the February 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2025 issue of Diabetes.

3:55 In the first interview segment, our hosts our joined by Francis C. Lynn, BSc PhD, Associate Professor in the Department of Surgery and School of Biomedical Engineering at the University of British Columbia in Vancouver. He is the corresponding author of the article "Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line." The article is available for free at doi.org/10.2337/db24-0756.

18:25 Darleen, Kevin, and Kirk speak with David C. Wraith, PhD, Emeritus Professor of Immunology, and Michael J. Price, PhD, a research fellow, both at the Institute of Immunology and Immunotherapy at the University of Birmingham in the UK. They discuss their article, "Pre-clinical development of a tolerogenic peptide from glutamate decarboxylase as a candidate for antigen-specific immunotherapy in type 1 diabetes," available at doi.org/10.2337/db23-0996.

35:50 In the latest edition of "Sweet Talk," our hosts welcome Bret H. Goodpaster, PhD, Scientific Director and Senior Investigator at the AdventHealth Translational Research Institute for Metabolism and Diabetes in Orlando, FL, and Professor of Medicine at Johns Hopkins University.

Philipp Scherer & Joel Elmquist on the interplay between the brain and adipose tissue and Jonathan Flak on the brain's role in glucose regulation, energy balance, and bodyweight control.

Season 1 · Episode 15

Thursday, January 9, 2025 • Duration 49:44

Welcome to the January 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2025 issue of Diabetes.

2:00 In a special format for the first episode of the new year, our hosts introduce a Sweet Talk double feature.

3:35 In part one of this special Sweet Talk segment, our hosts are joined by Philipp Scherer, PhD, Professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas, and Director of the Touchstone Diabetes Center, and Joel Elmquist, DVM, PhD, Professor of Internal Medicine at UT Southwestern Medical Center, and Director of its Center for Hypothalamic Research. Both are previous recipients of the ADA's Outstanding Scientific Achievement Award, and Scherer recently received the ADA's Banting Medal.

They share their perspectives on the evolution of diabetes, obesity research, the interplay between the brain and adipose tissue, and what the future holds for understanding and treating these complex diseases.

33:00 In part two, our hosts speak with Jonathan Flak, PhD, Assistant Professor of Pharmacology & Toxicology at the Indiana University School of Medicine, and former recipient of the ADA's Pathway to Stop Diabetes Award. He discusses his work on the brain's role in glucose regulation, energy balance, and bodyweight control.

His article, "Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes," can be found in the of

Stilgenbauer & Sadagurski on the link between airborne pollutants and metabolic disease, Petersen on the effect of weight loss on skeletal muscle bioactive lipids, and Page & Alves on the neurodevelopmental pathways to obesity and type 2 diabetes.

Season 1 · Episode 14

Thursday, December 5, 2024 • Duration 01:05:23

Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes.

0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include:

Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery doi.org/10.2337/db23-0445
Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans doi.org/10.2337/db24-0388
Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice doi.org/10.2337/db23-0172
Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop doi.org/10.2337/dbi24-0020
Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes doi.org/10.2337/db23-0827
Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia doi.org/10.2337/db24-0175

Maxwell and Grillo on the link between feeding behaviors and leptin activation of dorsal raphe neurons, Fruttiger on microvascular damage and neurodegeneration in early diabetic retinopathy, and Yeo on the genetics of metabolic health.

Season 1 · Episode 13

Wednesday, October 30, 2024 • Duration 01:14:18

Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes.

3:45 After a quick rundown of our hosts' Halloween plans, this month's episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code 'FALL24' at checkout. Act fast because this offer expires November 30, 2024!

5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and Claudia Grillo, a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article "Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior." This article is available for free at doi.org/10.2337/db24-0207.

27:05 Our hosts discuss the November issue's Paper of the Month, "Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy." They're joined by senior author, Dr. Marcus Fruttiger, Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at .

Grøndahl on glucagon clearance decrease in kidney disease despite preservation in liver cirrhosis, Barra and Russ on cryopreservation of stem cell–derived β-like cells, Sunilkumar and Dennis on targeting REDD1 to combat diabetes complications, & more!

Season 1 · Episode 12

Thursday, October 10, 2024 • Duration 51:16

Welcome to the October 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner.

4:05 This month's episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code 'FALL24' at checkout. Act fast because this offer expires November 30, 2024!

5:15 Darleen and Kirk speak with Dr. Magnus Grøndahl, faculty of Health and Medical Sciences and doctor of medicine at University of Copenhagen, about his paper, "Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis." This article is available for free at doi.org/10.2337/db24-0305.

19:05 Our hosts discuss a featured article entitled "Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function." They're joined by the study's lead author, Dr. Jessie Barra, and corresponding author—as well as Barra's mentor—Dr. Holger Russ. This study is available at doi.org/10.2337/db24-0346.

Jose Ortiz and Teresa Ku on trefoil factor 2 expression by pancreatic acinar cells, Adrian Vella on the effect of diabetes-associated variation in TCF7L2 on islet function, Matthew Webber on being a Pathway to Stop Diabetes awardee, and more!

Season 1 · Episode 11

Wednesday, September 4, 2024 • Duration 01:02:27

Welcome to the September 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner.

4:20: Darleen and Kirk are joined by Jose A. Ortiz and Hsun Teresa Ku, first and last authors of "Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0490.

25:07: Kirk and Darleen talk to Adrian Vella, last author of "The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans." This article is also an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db24-0192.

50:21: In this month's Sweet Talk segment, Kevin chats with Matthew J. Webber, a 2019 Pathway to Stop Diabetes Accelerator Award winner, about his research on materials that can sense and respond to changing glucose.

To learn more about Diabetes and , please visit . Thank you for listening, and don't forget to smash that "follow" button!

Scientific Sessions Reviewed by ADA Podcast Co-Hosts! In this special episode, the co-hosts of DiabetesBio, Diabetes Care "On Air," Diabetes Core Update, and Diabetes Day by Day discuss highlights from the ADA's 2024 Scientific Sessions

Season 1 · Episode 10

Friday, August 16, 2024 • Duration 54:39

Welcome to a very special episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care "On Air," acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care "On Air"; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care "On Air," DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer.

This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the "bench-to-bedside" spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.)

Correction:
•Dr. Carmella Evans-Molina is from the Indiana University School of Medicine
•Dr. Lou Philipson is from the University of Chicago

Inbal Caspi and Danwei Huangfu on glucose transporters in human glucostat, Deepthi Mallela discusses the genetics of bile acids and their association with diabetes, Bernard Thorens and David Hodson revisit a 1993 "Classic" on GLP-1, and more!

Season 1 · Episode 9

Tuesday, August 6, 2024 • Duration 01:11:58

Welcome to the August 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2024 issue of Diabetes.

2:39: Darleen and Kirk are joined by Dr. Inbal Caspi and Dr. Danwei Huangfu, lead author and corresponding author, respectively, of the August Paper of the Month, entitled "Glucose Transporters Are Key Components of the Human Glucostat." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0508.

27:30: Kirk and Darleen host Dr. Deepthi P. Mallela, co-lead author of "Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0676.

50:21: In this month's Sweet Talk segment, Kevin and Kirk engage in a scintillating discussion with Dr. Bernard Thorens and Dr. David J. Hodson, coauthors of a recent "Classics in Diabetes" feature, named "Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al." This article is an editor-selected feature article and is freely accessible at . The original "Classics" article is freely accessible at .

DiabetesBio – Details, episodes & analysis

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DiabetesBio – Details, episodes & analysis

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