Explore every episode of the podcast Decera Clinical Education Infectious Disease Podcast
Dive into the complete episode list for Decera Clinical Education Infectious Disease Podcast. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.
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Title
Pub. Date
Duration
Persisting in HIV Care: Considerations for People With Substance Use Disorders
13 Sep 2024
00:15:47
In this episode, Alexander Wong, MD, FRCPC, discusses how to optimize treatment and engagement in care for individuals with HIV and substance use disorder, including:
Barriers to care for persons with substance use disorder
Colocating HIV and other services (eg, addiction care medicine, social services)
Leveraging a multidisciplinary approach to care
Integrating a low-barrier model to foster an environment of open discussion
Best practices for opioid agonist therapy implementation
Considerations for cultural dynamics to provide personalized treatment plans
Importance of supporting his team members
Presenter
Alexander Wong, MD, FRCPC Associate Professor Division of Infectious Diseases Department of Medicine University of Saskatchewan Regina, Saskatchewan, Canada
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Integrating New Data From AIDS 2024: Pharmacist Perspectives
30 Aug 2024
00:18:22
In this episode, Jennifer Cocohoba, PharmD, AAHIVP, and David Koren, PharmD, MPH, AAHIVP, FIDSA, cover the most impactful LA ART and LA PrEP clinical studies presented at AIDS 2024, including:
The PURPOSE 1 study of twice-yearly lenacapavir injections vs daily oral tenofovir as PrEP in cisgender women
An open-label extension of HPTN 084 evaluating LA CAB safety during pregnancy
48-week data from the IMPAACT 2017/MOCHA study of LA CAB + RPV in adolescents with HIV
A substudy of FLAIR evaluating the efficacy, safety, and tolerability of SC self-administration of LA CAB + RPV
Presenters:
Jennifer Cocohoba, PharmD, AAHIVP Professor of Clinical Pharmacy Department of Clinical Pharmacy University of California San Francisco School of Pharmacy San Francisco, California
David Koren, PharmD, MPH, AAHIVP, FIDSA Adjunct Clinical Professor Temple University School of Pharmacy Clinical Pharmacist Specialist Temple University Health System Philadelphia, Pennsylvania
To access all of our new podcast episodes, subscribe to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.
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Optimizing PBC Pruritus Care in the Clinic
29 Jul 2024
00:21:06
In this episode, Stuart C. Gordon, MD, FACP, FACG, AGAF, FAASLD; Marlyn J. Mayo, MD; and Brenda Remo discuss strategies for optimizing PBC pruritus care in the clinic setting.
Listen to their conversation on how important it is to ask patients about their pruritus, validate their symptoms and feelings, and offer treatment options framed with realistic expectations.
Presenters:
Stuart C. Gordon, MD, FACP, FACG, AGAF, FAASLD Professor of Medicine Wayne State University School of Medicine Director, Division of Hepatology Henry Ford Health Detroit, Michigan
Marlyn J. Mayo, MD Professor of Internal Medicine Division of Digestive & Liver Diseases University of Texas Southwestern Dallas, Texas
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Q&A on HIV PrEP: Episode 1 on Transgender Individuals and Racial and Ethnic Minority Men Who Have Sex With Men
08 Sep 2023
00:35:33
In this episode, Raphael J. Landovitz, MD, MSc, and Hyman Scott, MD, MPH, discuss key considerations for PrEP uptake in transgender individuals and racial and ethnic minority men who have sex with men, including:
Misconceptions about PrEP eligibility
Strategies to improve lab monitoring on PrEP
Leveraging patient navigators and clinic staff to expand PrEP access
Data on PrEP efficacy in key populations (eg, transgender men, people who inject drugs)
Considerations for prescribing on-demand and same-day PrEP
Addressing healthcare professional hesitancy to prescribe PrEP
US Preventive Services Task Force PrEP guideline updates
Bundling sexually transmitted infection services with PrEP
Faculty
Raphael J. Landovitz, MD, MSc Professor of Medicine Division of Infectious Diseases David Geffen School of Medicine University of California, Los Angeles Director, UCLA Center for Clinical AIDS Co-Director, Center for HIV Identification, Prevention, and Treatment Services Los Angeles, California
Hyman Scott, MD Assistant Clinical Professor Department of Medicine University of California, San Francisco Clinical Research Medical Director Bridge HIV San Francisco Department of Public Health San Francisco, California
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RSV Recommendations From ACIP: How to Apply Them in Your Older Adults
08 Sep 2023
00:11:55
In this episode, Angela Branche, MD, discusses the Advisory Committee on Immunization Practices recommendations for RSV vaccines in older adults, including:
Use of shared clinical decision-making
How to approach the conversation about the RSV vaccine with patients
Key populations who may benefit the most, such as those at risk for severe RSV disease (eg, increasing age and persons who are frail or have cardiopulmonary comorbidities)
Faculty:
Angela Branche, MD
Associate Professor of Medicine Division of Infectious Diseases Department of Medicine University of Rochester Rochester, New York
Link to full program: https://bit.ly/3nb25xe
Link to downloadable slides: https://bit.ly/3nb25xe
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Challenging Scenarios: Managing Virologic Failure in a Heavily Treatment–Experienced Patient
22 Aug 2023
00:19:32
In this episode, Renslow Sherer, MD, discusses managing virologic failure in a person living with HIV who is heavily treatment experienced, including:
Guideline recommendations for selecting a new ART regimen
Options for patients with multidrug-resistant HIV from existing drug classes and novel mechanisms of action with no cross-resistance
Data from TMB-301 and TMB-311 for ibalizumab, BRIGHTE for fostemsavir, and CAPELLA for lenacapavir on the use of these agents for people living with HIV who are heavily treatment experienced with multidrug-resistant HIV
Presenter:
Renslow Sherer, MD Director International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Health Department of Medicine University of Chicago Chicago, Illinois
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PrEP Talks: Uptake in Cisgender Women
08 Aug 2023
00:17:13
In this episode, Oni Blackstock, MD, MHS, and Brittany Williams, PhD,discuss key considerations to pre-exposure prophylaxis (PrEP) uptake in cisgender women, including:
The misconception by patients and healthcare professionals (HCP) that cisgender women are at low risk for HIV
Reframing HIV prevention from “risks” to “reasons” such as promoting self-care and taking control of one’s own sexual health
CDC PrEP guidance recommendations
Increasing PrEP awareness by sharing PrEP experiences with others in the community
The importance of community representation in PrEP marketing and campaigns
Challenges with finding HCPs who prescribe PrEP for cisgender women
Promoting self-advocacy when seeking care, including HIV prevention
Strategies for patients to engage with their HCPs to learn about and obtain PrEP
Available resources for PrEP coverage
Faculty:
Oni Blackstock, MD, MHS Founder & Executive Director
Health Justice
New York, New York
Brittany Williams, PhD Assistant Professor of Higher Education and Student Affairs Administration
Department of Education
University of Vermont
Burlington, Vermont
Link to full program: https://bit.ly/3PZGYdR
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Long-Acting Lipoglycopeptides for Skin and Soft Tissue Infections : Implementation Into Practice
08 Aug 2023
00:18:53
In this episode, Kyle Molina, PharmD, BCIDP, discusses key considerations for successful implementation of long-acting lipoglycopeptides into clinical practice. Listen as he gives perspectives on:
Reasons to consider use of long-acting lipoglycopeptides (eg, poor adherence to oral antibiotics, PICC-related costs and complications)
Data supporting and challenging cost effectiveness of long-acting lipoglycopeptides
Identifying the target patient population
Selecting the right location to provide long-acting lipoglycopeptides
Strategies to maximize institutional impact with key stakeholders (eg, hospital avoidance, reduced ED and hospital length of stay)
Key characteristics of available long-acting lipoglycopeptides
Addressing logistical challenges, including navigating the reimbursement process
Faculty:
Kyle Molina, PharmD, BCIDP Infectious Diseases Clinical Pharmacist Scripps Green Hospital La Jolla, California
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People of Childbearing Potential and Their Infants: Overcoming HBV Barriers
03 Aug 2023
00:33:31
In this episode, Joseph Ahn, MD, MS, MBA; Christina Delacruz Leyson, MD; and Alice Chan, a person who experienced pregnancy as a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in people of childbearing potential and their infants, including:
HBV screening and vaccination in pregnancy
Management of pregnant people who are HBsAg positive
Infant care
Breastfeeding
Presenters:
Joseph Ahn, MD, MS, MBA Professor of Medicine, Section Chief Division of Gastroenterology and Hepatology Oregon Health & Science University Portland, Oregon
Christina Delacruz Leyson, MD Associate Professor Medical Director, Liver Transplant Program Program Director, Hepatology Fellowship University of Kentucky Lexington, Kentucky
Alice Chan, person living with chronic hepatitis B
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Managing ART Failure: Answering the Questions
03 Aug 2023
00:48:55
In this episode, Daniel R. Kuritzkes, MD, and Cristina Mussini, MD, discuss managing ART failure, including:
The definitions of virologic blips, low-level viremia, and virologic failure on ART
The infrequency of failure with resistance on first-line INSTI-based ART and the instances where this has occurred with BIC- and DTG-based ART in clinical trials and in the real world
The potential reasons for ART failure, including patient/adherence-related factors, HIV-related factors, and regimen-related factors
The impact of adherence on viral suppression with BIC- and DTG-based ART
Drug-drug interactions as a reason for failure of first-line INSTI-based ART
What to do if someone is experiencing virologic failure requiring an ART change
The use of proviral DNA testing in patients with viral suppression or low-level viremia with ART treatment experience
The impact of high HIV-1 RNA on ART effectiveness
The impact of NRTI resistance, including the M184V and K65R mutations, on the effectiveness of BIC- and DTG-based ART
Strategies to encourage and measure patient adherence to ART
Presenters
Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Infectious Diseases Brigham and Women’s Hospital Boston, Massachusetts
Cristina Mussini, MD Professor Department of Infectious Diseases University of Modena and Reggio Emilia Modena, Italy
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Challenging Scenarios: Managing a First ART Failure
26 Jul 2023
00:18:04
In this episode, Renslow Sherer, MD, discusses managing a first ART failure in the setting of COVID-19, including:
Guideline recommendations for resistance testing
Guideline recommendations for selecting a new ART regimen
Data on retained efficacy of NRTIs in second-line regimens in the EARNEST and NADIA studies
Consideration of drug‒drug interactions between ART and COVID-19 treatment
Presenter: Renslow Sherer, MD Director International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Health Department of Medicine University of Chicago Chicago, Illinois
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PrEP Talks: Uptake in Racial and Ethnic Minority Men Who Have Sex With Men and Transgender Individuals
19 Jul 2023
00:20:42
In this episode, Kenyon R. Farrow and Raphael J. Landovitz, MD, MSc, discuss key considerations to PrEP uptake in transgender individuals and racial and ethnic minority men who have sex with men, including:
Rates of HIV diagnoses in Black and Brown communities
Issues stalling success in HIV prevention (eg, stigma, healthcare coverage, and administration and operational barriers)
Considerations for healthcare professionals when discussing PrEP with patients
Importance of representation (eg, racial and ethnic minority people, transgender people) at clinic offices
Promoting cultural humility to build strong patient-provider relationships
Faculty:
Kenyon R. Farrow Vice President of Policy Point Source Youth Contributing Editor TheBody.com Cleveland, Ohio
Raphael J. Landovitz, MD, MSc Professor of Medicine Division of Infectious Diseases David Geffen School of Medicine University of California, Los Angeles Director, UCLA Center for Clinical AIDS Co-Director, Center for HIV Identification, Prevention, and Treatment Services Los Angeles, California
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PrEP Initiation: Answering the Questions
13 Jul 2023
00:51:29
In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD, and Meredith Clement, MD, discuss PrEP initiation, including:
The importance of taking a sexual history and getting to know your patient
Recommendations for who should be considered for PrEP
Practicalities of PrEP initiation including laboratory assessments, interview and physical exam, evaluating concomitant medications, counseling, and prescribing
Summary of PrEP eligibility by regimen
Review of the clinical trial and real-world data for each PrEP modality
The likelihood of cross-resistance between PrEP options and ART options if someone were to become infected with HIV while receiving PrEP
Time to effective concentrations of PrEP after initiation
Whether there are data for on-demand dosing of FTC/TAF
Recommendations for FTC/TDF on demand for heterosexual cisgender men
Individualizing PrEP for each person to increase the likelihood of adherence, persistence, and efficacy
Recommendations for the use of LA CAB for PrEP during pregnancy and in people of childbearing potential
STI and point-of-care testing for people receiving PrEP
The possibility of implantable PrEP in the future
Presenters:
Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD Professor and Director The Desmond Tutu HIV Centre University of Cape Town Cape Town, South Africa
Meredith Clement, MD Assistant Professor Section of Infectious Diseases Louisiana State University Health Sciences Center University Medical Center New Orleans, Louisiana
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The Patient Experience With Cholestatic Pruritus in PBC
29 Jul 2024
00:13:05
In this episode, Stuart C. Gordon, MD, FACP, FACG, AGAF, FAASLD; Marlyn J. Mayo, MD; and Brenda Remo discuss the patient experience with cholestatic pruritus in PBC.
Listen to their conversation on how people describe the experience of cholestatic pruritus, the extent to which pruritus negatively affects quality of life, and the importance of educating healthcare professionals on this important symptom of PBC.
Presenters:
Stuart C. Gordon, MD, FACP, FACG, AGAF, FAASLD Professor of Medicine Wayne State University School of Medicine Director, Division of Hepatology Henry Ford Health Detroit, Michigan
Marlyn J. Mayo, MD Professor of Internal Medicine Division of Digestive & Liver Diseases University of Texas Southwestern Dallas, Texas
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Treatment of Skin and Soft Tissue Infections
11 Jul 2023
00:27:38
In this episode, Kyle Molina, PharmD, BCIDP, provides an overview of treatment of skin and soft tissue infections (SSTIs) and challenges in practice. Listen as he gives perspectives on:
Guideline recommendations for treatment of purulent and nonpurulent SSTIs
Logistical challenges with IV and oral antibiotics
Pros and cons of various locations of care
Data supporting the safety and efficacy of long-acting lipoglycopeptides for treatment of SSTIs
Use of long-acting lipoglycopeptides in special populations of interest, including patients with obesity, diabetes, and injection drug use
Overall place in therapy of long-acting lipoglycopeptides for SSTIs
Faculty:
Kyle Molina, PharmD, BCIDP Infectious Diseases Clinical Pharmacist Scripps Green Hospital La Jolla, California
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Answering the Questions on Which HIV PrEP for Which Patient: Latesha Elopre and Jason Farley
03 Jul 2023
00:26:07
In this episode, Latesha Elopre, MD, MSPH, and Jason Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN, answer questions about HIV PrEP including:
How long someone can receive PrEP and the monitoring that is needed over time
Recommendations for monitoring bone health while receiving oral PrEP
Treatment as prevention and PrEP efficacy data and options for people who inject drugs
The role of circumcision in HIV prevention
The use of PrEP in pregnancy
Concern for ART resistance if someone seroconverts while receiving PrEP, especially when using nondaily PrEP options
The possibility of using FTC/TAF on demand
Inequities in adherence and persistence
Cost considerations with different PrEP modalities
Recommendations for hospitalized patients receiving PrEP
PrEP considerations for patients with renal dysfunction and higher BMIs
PrEP efficacy based on site of exposure
Presenters:
Latesha Elopre, MD, MSPH Associate Professor Division of Infectious Diseases Assistant Dean of Diversity and Inclusion General Medical Education University of Alabama at Birmingham Birmingham, Alabama
Jason Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN Professor School of Nursing Johns Hopkins University Nurse Practitioner Department of Infectious Diseases John G. Bartlett Specialty Practice Baltimore, Maryland
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Q&A on Barriers to HIV PrEP: Pharmacist Perspectives
27 Jun 2023
00:10:17
In this episode, Milena Murray, PharmD, MSc, BCIDP, AAHIVP, FCCP, and Kevin Astle, PharmD, BCPS, BCACP, AAHIVP, CDCES, discuss key considerations to barriers to PrEP uptake, including:
Limited data on “on-demand” PrEP in cisgender women
Strategies on improving communication with non‒English-speaking populations
Role of pharmacists with injectable PrEP
CDC PrEP guideline recommendations on routine HIV-1 RNA testing
Engaging with pregnant persons who might want access to PrEP in the pharmacy setting
Oral PrEP efficacy based on adherence in cisgender women, including recent data presented at CROI 2023 by Marrazzo and colleagues
Presenters:
Milena Murray, PharmD, MSc, BCIDP, AAHIVP, FCCP Associate Professor Department of Pharmacy Practice Midwestern University College of Pharmacy, Downers Grove Campus Downers Grove, Illinois System-Level HIV/ID Clinical Pharmacist Ambulatory Pharmacy Northwestern Medicine Wheaton, Illinois
Kevin Astle, PharmD, BCPS, BCACP, AAHIVP, CDCES Assistant Professor Department of Pharmacotherapy and Clinical Research University of South Florida Clinical Pharmacist Tampa General Medical Group Tampa, Florida
Content based on an online CME program supported by an independent educational grant from ViiV Healthcare.
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Older Adults: Overcoming HBV Barriers
23 Jun 2023
00:39:55
In this episode, Robert S. Brown, Jr., MD, MPH; Nancy Reau, MD; and Eric, a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in older adults, including:
Awareness of HBV and CHB in older adults
Updated HBV screening and vaccination recommendations
Monitoring of renal and bone disease
Adjustment of monitoring and treatment as a person with HBV ages
Presenters: Robert S. Brown, Jr., MD, MPH Vincent Astor Distinguished Professor of Medicine Chief, Division of Gastroenterology and Hepatology Weill Cornell Medicine New York, New York
Nancy Reau, MD Professor of Medicine Chief, Section of Hepatology Associate Director, Solid Organ Transplantation Richard B. Capps Chair of Hepatology Rush University Medical Center Chicago, Illinois
Eric, person living with chronic hepatitis B
Link to downloadable slides: please link to VM404 downloadable slides when ready
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Hepatitis Delta in Focus: Episode 4 of Answering the Questions on Screening, Diagnosis, and Treatment
22 Jun 2023
00:39:58
In this episode, Tarik Asselah, MD, PhD, and Ira Jacobson, MD, provide expert insight on HDV screening, diagnosis, and management, including:
Approach to screening
Barriers to screening (eg, test availability)
Disease progression and complications
Differentiating between coinfection and superinfection
Approach to treatment (eg, whom to treat and when, treatment options, considerations for combination therapy)
Management of patients with decompensated cirrhosis
Surrogate markers to measure treatment success
Role of correcting thrombocytopenia before initiating therapy
Faculty:
Tarik Asselah, MD, PhD Professor of Medicine Department of Hepatology Hôpital Beaujon Université de Paris Clichy, France
Ira Jacobson, MD Professor of Medicine NYU School of Medicine Director of Hepatology Division of Gastroenterology and Hepatology NYU Langone Health New York, New York
Link to full program: https://bit.ly/3yp1Lxf
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Preparing for the Fall: New RSV Vaccine Approvals
19 Jun 2023
00:12:51
In this episode, Helen Y. Chu, MD, MPH, shares updates on RSV vaccines, including:
An overview of vaccine candidates under investigation
Recently FDA-approved RSV vaccines for older adults
Considerations for the next respiratory viral season
Coadministration of RSV vaccines with other respiratory viral vaccines (eg, influenza, SARS-CoV-2)
Target populations for RSV vaccination
RSV prevention in infants with the maternal vaccine and monoclonal
Faculty:
Helen Y. Chu, MD, MPH Associate Professor of Medicine Division of Allergy & Infectious Diseases University of Washington School of Medicine Seattle, Washington
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Hepatitis Delta in Focus: Episode 3 of Answering the Questions on Screening, Diagnosis, and Treatment
19 Jun 2023
00:42:02
In this episode, Nancy Reau, MD, and Heiner Wedemeyer, MD, provide expert insight on HDV management, including:
Use of noninvasive imaging or biopsy for staging liver disease
Screening for hepatocellular carcinoma
HBV treatment
Role of comedications (eg, erythropoietin, eltrombopag)
Approach to complex cases, such as patients with:
Significant fibrosis and low HDV RNA levels
Hepatitis delta antibody positivity, but HDV RNA negativity
HIV coinfection
Decompensated or recently decompensated cirrhosis
Faculty:
Nancy Reau, MD Professor of Medicine Chief, Section of Hepatology Associate Director, Solid Organ Transplantation Richard B. Capps Chair of Hepatology Rush University Medical Center Chicago, Illinois
Heiner Wedemeyer, MD Professor and Chairman Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover, Germany
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Modifying ART in the Presence of Hyperlipidemia: Using HIV-ASSIST
09 Jun 2023
00:11:58
In this episode, Maunank Shah, MD, PhD, discusses using HIV-ASSIST to optimize treatment for both HIV and hyperlipidemia. Listen as he covers:
Hyperlipidemia and cardiovascular disease risk among people living with HIV
Recommendations for lipid screening for people living with HIV
Using HIV-ASSIST to support ART treatment decisions for people living with HIV with comorbidities
How HIV-ASSIST prioritizes certain ART agents in the setting of hyperlipidemia, including:
Deciding between bictegravir, doravirine, dolutegravir, raltegravir, and rilpivirine vs boosted protease inhibitors, including darunavir
Deciding between tenofovir disoproxil fumarate and tenofovir alafenamide or abacavir
How HIV-ASSIST incorporates drug‒drug interaction data from the University of Liverpool HIV Drug Interactions Checker and the DHHS guidelines when considering the use of statin therapy with ART
How HIV-ASSIST further incorporates drug resistance data from the Stanford HIV Drug Resistance Database
Maunank Shah, MD, PhD Associate Professor Infectious Diseases Johns Hopkins University Baltimore, Maryland
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The Burden of Skin and Soft Tissue Infections: Epidemiology, Clinical Presentation, and Diagnosis
08 Jun 2023
00:18:00
In this episode, Martin Krsak, MD, MSc, FASAM, provides background and context on skin and soft tissue infections. Listen as he gives perspectives on:
Epidemiology and clinical outcomes
Economic impact
Bacterial etiology
Importance of appropriate antimicrobial prescribing
Clinical presentation
Severity classification and distinction between purulent and nonpurulent infections
Role of incision and debridement vs antimicrobial management
Complications to be ruled out prior to treatment
Faculty: Martin Krsak, MD, MSc, FASAM Associate Professor of Medicine Division of Infectious Diseases University of Colorado School of Medicine Denver, Colorado
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How to Make Depression Care an Integral Part of HIV Care
24 Jul 2024
00:50:58
In this episode, Bradley N. Gaynes, MD, MPH, and Glenn J. Treisman, MD, PhD, discuss the importance of screening, diagnosing, and treating depression in people living with HIV. They illustrate their discussion through a patient case and provide strategies for accomplishing this, including creation of a virtual network and employment of measurement-based care.
Presenters:
Bradley N. Gaynes, MD, MPH Ray M. Hayworth, MD and Family Distinguished Professor Professor of Psychiatry and Epidemiology Director, Division of Global Mental Health Co-Director, Physician Scientist Training Program Department of Psychiatry University of North Carolina School of Medicine Chapel Hill, North Carolina
Glenn J. Treisman, MD, PhD Eugene Meyer III Professor of Psychiatry and Medicine Johns Hopkins University School of Medicine Baltimore, Maryland
To get access to all of our new infectious disease podcast episodes, subscribe to the CCO infectious disease podcast channel on Apple Podcasts, Google Podcasts, or Spotify.
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Choosing Between Initial ART Options: Answering the Questions
06 Jun 2023
00:46:49
In this episode, Marta Boffito, MD, PhD, FRCP, and Michelle Cespedes, MD, MS, discuss initial ART options, including:
Recommended first-line ART options for most PWH according to DHHS, IAS-USA, EACS, BHIVA, and WHO guidelines
Data for weight gain after ART initiation with different ARV classes and drugs
Weight gain disparities by race and gender after ART initiation
Data from the RESPOND study including risk factors for weight gain and CV event risk with INSTI vs non-INSTI–based ART
The impact of INSTIs on CV events in the Swiss HIV Cohort study
Recommendations for ART and contraception for PWH of childbearing potential
Drug–drug interactions between first-line ART and contraceptive options
Guideline-recommended first-line ART options in pregnancy with a discussion of how these regimens differ from those recommended for most PWH
Marta Boffito, MD, PhD, FRCP Consultant Physician Clinical Director, HIV, Sexual and Gender Health, Dermatology Chelsea and Westminster Hospital NHS Foundation Trust Imperial College London London, United Kingdom
Michelle Cespedes, MD, MS Professor of Medicine Division of Infectious Disease Department of Medicine Icahn School of Medicine at Mount Sinai New York, New York
Link to full program: bit.ly/3HPu4Lk
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Choosing ART for HIV With HBV and HCV Coinfections: Using HIV-ASSIST
30 May 2023
00:05:56
In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for PWH coinfected with HBV and HCV. Listen as she covers:
How HIV-ASSIST supports ART selection in primary care
Updates to viral hepatitis recommendations including:
CDC HBV screening and testing recommendations
AASLD simplified HCV treatment approach for PWH
HIV-ASSIST for managing HIV/HBV coinfections, including ensuring that NRTIs that are effective for both HIV and HBV are included in an ART regimen and alerting the user when an additional HBV treatment is needed
HIV-ASSIST for managing HIV/HCV coinfections, including showing how the HIV-ASSIST tool incorporates drug‒drug interaction considerations from the University of Liverpool HIV Drug Interaction Checker
Carolyn Chu, MD, MSc, FAAFP, AAHIVS Chief Clinical Officer National Clinician Consultation Center Professor Clinical Family Community Medicine University of California, San Francisco San Francisco, California
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Integrating New Data on LA ART From CROI 2023: Pharmacist Perspectives
22 May 2023
00:10:24
In this episode, Amanda Binkley, PharmD, BCIDP, AAHIVP, and Nimish Patel, PharmD, PhD, AAHIVP, discuss clinically relevant data on long-acting ART from CROI 2023, including:
LA CAB + RPV in San Francisco’s Ward 86 Safety Net Clinic Serving Publicly Insured PWH
SOLAR: Randomized Switch to LA CAB + RPV From BIC/FTC/TAF
Amanda Binkley, PharmD, BCIDP, AAHIVP Clinical Pharmacy Specialist Infectious Disease Department of Pharmacy Penn Presbyterian Medical Center Philadelphia, Pennsylvania
Nimish Patel, PharmD, PhD, AAHIVP Professor Department of Clinical Pharmacy Skaggs School of Pharmacy & Pharmaceutical Sciences University of California La Jolla, California
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Christine Katlama and Babafemi Taiwo: Answering the Questions on Optimizing Antiretroviral Therapy in Heavily Treatment–Experienced People With HIV
16 May 2023
00:41:52
In this episode, Christine Katlama, MD, and Babafemi Taiwo, MBBS, discuss optimizing ART for people with HIV who are treatment experienced or failing a current ART regimen, including:
Recycling agents from the NRTI, NNRTI, INSTI, and PI classes in salvage ART regimens
Maintaining NRTIs in second-line and salvage ART regimens, including the use of 3TC, TFV, and ABC
ART regimen simplification
When to perform genotypic resistance testing, including for PWH who have been off ART
When to perform DNA genotyping for archived resistance testing
Considering LA CAB + RPV with prior NNRTI exposure, ART resistance, or past adherence concerns with oral ART
Using boosted DRV + DTG in salvage regimens
Switching from boosted PIs to INSTIs in PWH receiving second-line therapy
Second-line regimens with LA CAB + RPV failure
Christine Katlama, MD Professor Sorbonne University APHP Paris Head, HIV/Hepatitis Clinical and Research Unit Department of Infectious Diseases Paris, France
Babafemi Taiwo, MBBS Gene Stollerman Professor of Medicine Chief, Division of Infectious Diseases Northwestern University Feinberg School of Medicine Chicago, Illinois
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Preconception ART Selection: Using HIV-ASSIST
11 May 2023
00:08:09
In this episode, Sonya Krishnan, MD, MHS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for a virologically suppressed PWH who is planning a pregnancy. Listen as she covers:
How to input patient specific factors into the HIV-ASSIST tool
Discussion of available education sheets to review the data and recommendations for her current ART regimen in pregnancy
An explanation of why some regimens are ranked lower because of adherence factors such as increased pill burden or dosing frequency
Guidelines informing the HIV-ASSIST output, including DHHS and IAS-USA, and the frequency with which updates are incorporated
How to use the HIV-ASSIST output to guide regimen selection in pregnancy
Use of the HIV-ASSIST tool in shared decision-making and patient counseling
Sonya Krishnan, MD, MHS Assistant Professor Division of Infectious Diseases Johns Hopkins University Baltimore, Maryland
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Long-Acting ART: Cabotegravir Plus Rilpivirine
10 May 2023
00:27:13
In this episode, Ian Frank, MD, discusses long-acting HIV treatment with cabotegravir plus rilpivirine for people with HIV, including:
Efficacy data with every-8-week dosing
Real-world use in people with viremia
Initiation and continuation strategies
Virologic failure data
Safety information
Presenter:
Ian Frank, MD
Associate Chief
Division of Infectious Diseases
Professor of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
To download the slides: https://bit.ly/3HX1GGn
To view the full online program: https://bit.ly/3ZjSFhg
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COVID-19 Update: Independent Conference Coverage of ECCMID 2023
05 May 2023
00:36:36
In this episode, Patrick W. G. Mallon, MB, BCh, PhD, FRACP, FRCPI, discusses new data on COVID-19 presented at ECCMID 2023, including:
Treatment in special populations
REDPINE: remdesivir in people with renal impairment hospitalized for COVID-19 pneumonia
Remdesivir and readmission for COVID-19 in immunocompromised patients
Molnupiravir vs nirmatrelvir plus ritonavir for COVID-19 with hematologic malignancy
Management of patients with severe disease
RECOVERY: higher-dose vs standard-dose corticosteroids for hospitalized patients with COVID-19
Real-world study of tocilizumab vs baricitinib for severe COVID-19
Novel antivirals
Ensitrelvir
Bemnifosbuvir
Novel vaccines
NB2155
AZD2816/AZD1222
qNIV/CoV2373
GRT-R910
NVX-CoV2373 in people with HIV
Faculty: Patrick W. G. Mallon, MB, BCh, PhD, FRACP, FRCPI Professor of Microbial Diseases Centre for Experimental Pathogen Host Research University College Dublin Dublin, Ireland
Content based on an online CME/CE program supported by independent educational grants from Gilead Sciences, Inc. and Novavax.
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2023 Audio Recap: Principles of Outpatient COVID-19 Management
03 May 2023
01:14:42
In this episode, Renslow Sherer, MD, and Trinh P. Vu, PharmD, BCIDP, discuss strategies for managing ambulatory patients with acute or previous COVID-19 infection, including:
Current COVID-19 landscape
Rapid antigen tests and PCR tests
Risk stratification of patients who have a positive SARS-CoV-2 test
Antiviral treatment (nirmatrelvir + ritonavir, remdesivir, and molnupiravir)
Long COVID
Presenters: Renslow Sherer, MD Director, International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Health Department of Medicine University of Chicago Chicago, Illinois
Trinh P. Vu, PharmD, BCIDP Clinical Pharmacy Specialist in Infectious Diseases Department of Pharmaceutical Services Emory University Hospital Midtown Atlanta, Georgia
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Complicated Clinical Infections: Clinical Impact of New Data From ECCMID 2023
03 May 2023
00:30:05
In this episode, David van Duin, MD, PhD, FIDSA, FAST, discusses new data on complicated clinical infections presented at ECCMID 2023, including:
Gram-negative resistance
Pharmacokinetic and clinical outcomes in patients receiving meropenem/vaborbactam for KPC-producing carbapenem-resistant Enterobacterales infections
Comparative study of cefiderocol- vs colistin-containing regimens for CRAB VAP with concomitant bacteremia
Real-world use of imipenem/cilastatin/relebactam for the treatment of infections caused by multidrug-resistant organisms
Antimicrobial stewardship
Safety and efficacy of antibiotic de-escalation from an antipseudomonal β-lactam in patients with Enterobacterales BSIs in SIMPLIFY
The SOAB study comparing clinical outcomes of switching to oral antibiotics after IV lead-in therapy vs continuing IV therapy in patients with Enterobacterales BSIs
Data from REGARD-VAP on outcomes of shortened antibiotic treatment for VAP guided by clinical criteria
Investigational agents
Open-label study following ATTACK of patients with colistin-resistant CRAB infections receiving sulbactam/durlobactam
Summary of findings from EAGLE-2 and EAGLE-3 of gepotidacin for uncomplicated UTI treatment
Post hoc DOOR analysis of SURE-2 of sulopenem for the treatment of complicated UTIs
Faculty: David van Duin, MD, PhD, FIDSA, FAST Professor of Medicine Director, Immunocompromised Host Infecious Diseases Program Division of Infectious Diseases University of North Carolina Chapel Hill, North Carolina
Content based on an online CME/CE program supported by an independent educational grant from Shionogi Inc.
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2023 Audio Recap: Practical Case Studies in Outpatient COVID-19 Management
02 May 2023
00:57:16
In this episode, Tracey Piparo, PA-C, and Renslow Sherer, MD, discuss cases of nonhospitalized patients with COVID-19, including:
Young, healthy patient with no risk factors
Young, healthy patient with risk factors
Older patient with immunocompromise
Older patient with renal dysfunction
Patient experiencing hypoxia
Presenters:
Tracey Piparo, PA-C Department of Palliative Medicine RJWBarnabas New Brunswick, New Jersey
Renslow Sherer, MD Director, International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Health Department of Medicine University of Chicago Chicago, Illinois
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Managing Weight Gain on ART
27 Jun 2024
00:24:00
In this episode, Cristina Mussini, MD,and William R. Short, MD, MPH, FIDSA,discuss the potential role of ART in weight change among people living with HIV.
Listen to their conversation on whether ART switch can lead to weight loss after weight gain and how to counsel people living with HIV on weight loss options, including lifestyle modifications and nonpharmacologic methods.
Presenters
Cristina Mussini, MD Director of Infectious Diseases Clinics Professor of Infectious Diseases University of Modena School of Medicine Modena, Italy
William R. Short, MD, MPH, FIDSA Associate Director of the HIV Clinical Trials Unit Associate Professor of Medicine Division of Infectious Diseases Perelman School of Medicine University of Pennsylvania Philadelphia, Pennsylvania
Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast channel on Apple Podcasts, Google Podcasts, or Spotify.
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Q&A: HDV Management Episode 2
26 Apr 2023
00:40:10
In this episode, Tatyana Kushner, MD, MSCE, and Stefan Zeuzem, MD, address key considerations when screening, diagnosing, and treating patients with HDV, such as:
Barriers to HDV screening, including limitations to AASLD guideline recommendations
Use of double reflex testing to improve HDV diagnosis
Considerations for repeat HDV testing in patients who are HBsAg positive who previously tested negative for HDV
Updated CDC recommendations for HBV screening for all adults using a triple panel test
Staging advanced liver disease in patients with HDV
Indications for HDV treatment, including patients with low ALT levels and advanced or progressive liver disease
Treatment landscape for HDV
Personal experiences with use of pegylated interferon for HDV treatment, including considerations for use in patients with compensated cirrhosis
Updates on novel HDV therapies, including:
Summary of efficacy data on bulevirtide from clinical trials
Interpretation of results from D-LIVR, a phase III trial assessing the safety and efficacy of lonafarnib
Link to full program: bit.ly/3yp1Lxf
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Overcoming HBV Barriers: Focus on Asian American People
25 Apr 2023
00:52:07
In this episode, Joseph Lim, MD; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and Jennifer Wild, MS, BSN, RN, OCN, discuss strategies for overcoming barriers to HBV care in Asian American people, including:
HBV-related stigma
Language barriers
Health insurance navigation
Presenters:
Joseph Lim, MD Professor of Medicine Director, Clinical Hepatology Vice-Chief, Section of Digestive Diseases Yale University School of Medicine New Haven, Connecticut
Mindie H. Nguyen, MD, MAS, AGAF, FAASLD Professor of Medicine (GI & Hepatology, Liver Transplant) Professor of Epidemiology & Population Health (By Courtesy) Director of Hepatology Fellowship Director of Hepatology Clerkship Stanford University Medical Center Palo Alto, California
Jennifer Wild, MS, BSN, RN, OCN Clinical Nurse UCSF Helen Diller Family Comprehensive Cancer Center GI Medical Oncology, Outpatient Hepatobiliary Program Oakland, California
Link to downloadable slides: please link to VM401 downloadable slides when ready
Link to program: please link to HEP 2023 HBV Key Communities VM (PRP5676) when ready
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African Immigrant People: Overcoming HBV Barriers
25 Apr 2023
00:58:49
In this episode, Essa Mohamed, PhD; Daouda Ndiaye; and Ponni Perumalswami, MD, MS, discuss strategies for overcoming barriers to HBV care in African immigrant people, including:
HBV awareness and misconceptions
HBV-related stigma
Language barriers
Health insurance navigation
Presenters: Essa Mohamed, PhD Clinical Researcher Division of Gastroenterology and Hepatology Mayo Clinic Rochester, Minnesota
Daouda Ndiaye Patient Navigator
Ponni Perumalswami, MD, MS Associate Professor of Internal Medicine Division of Gastroenterology and Hepatology University of Michigan Ann Arbor, Michigan
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Individualizing HIV ART: Considerations for Weight Gain
24 Apr 2023
00:05:36
In this episode, Daniel R. Kuritzkes, MD, discusses considerations for patients experiencing weight gain on antiretroviral therapy, including:
• Commonly implicated antiretroviral therapy regimens and patient populations
• Guideline recommendations for management of weight gain
Presenter:
Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Infectious Diseases Brigham and Women’s Hospital Boston, Massachusetts
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Rapid ART Initiation: Answering the Questions
21 Apr 2023
00:49:13
In this episode, Isolde Butler, MD, and Brenda E. Crabtree Ramírez, MD, discuss rapid ART initiation for people newly diagnosed with HIV, including:
The HIV care continuum in the United States and Latin America
Barriers to HIV diagnosis, including stigma, discriminatory laws and policies, social determinants of health, and lack of access to healthcare
Factors that predict delayed care linkage and inconsistent HIV care and treatment
Improved clinical outcomes that have been shown with rapid ART initiation, first in low- and middle-income countries and now worldwide
Recommendations for rapid ART—and regimen choices—from the DHHS, IAS-USA, CENSIDA, EACS, and WHO
Recommendations for transitioning from PrEP to ART when someone seroconverts while receiving either oral PrEP or LA CAB for PrEP
Barriers to rapid ART initiation in their individual care settings
The future of LA injectable ART for initial treatment and rapid initiation
Isolde Butler, MD Chief Medical Officer CrescentCare New Orleans, Louisiana
Brenda E. Crabtree Ramírez, MD Assistant Professor, HIV Program Department of Infectious Diseases Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán Mexico City, Mexico
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Individualizing HIV ART: Rapid Start
13 Apr 2023
00:04:28
In this episode, Daniel R. Kuritzkes, MD, discusses considerations for rapid initiation of antiretroviral therapy in patients who are newly diagnosed with HIV, including:
Recommended regimens
Management of patients previously receiving PrEP
Timing of laboratory testing
Presenter:
Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Infectious Diseases Brigham and Women’s Hospital Boston, Massachusetts
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Perspectives From Asia on Advances in HIV Treatment and Prevention
27 Mar 2023
00:21:38
In this episode, 2 HIV experts from the Asia-Pacific region share their thoughts on some of the most important new insights from HIV treatment and prevention research over the past year.
Specifically, the faculty discuss the role of newer innovations in HIV, including 2-drug oral antiretroviral therapy (ART) regimens, 2-drug long-acting injectable ART, and long-acting HIV pre-exposure prophylaxis in HIV care in the Asia-Pacific region, as well as the implications of weight gain with ART and important considerations related to the unique challenges associated with caring for the aging population of people with HIV in the region.
Presenters:
Anchalee Avihingsanon, MD, PhD HIV-NAT, Thai Red Cross AIDS Research Centre Pathumwan, Bangkok, Thailand Senior Clinical Trial Medicine Bangkok, Thailand
Reena Rajasuriar, BPharm, MPharm, PhD Associate Professor Department of Medicine University of Malaya Kuala Lumpur, Malaysia
Content based on an online program supported by an independent educational grant from Gilead Sciences, Inc. andViiV Healthcare.
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RSV in Adults: How It Presents
22 Mar 2023
00:12:24
In this episode, Angela Branche, MD, and Helen Y. Chu, MD, MPH, discuss the clinical presentation of respiratory syncytial virus (RSV) in adults and the importance of early detection, including:
Clinical symptoms and presentation
Complications, including exacerbations of cardiopulmonary diseases
Use of medical resources compared with other respiratory viruses
Diagnostic approaches and challenges
Treatment and management of RSV disease
Clinical impact of RSV awareness
Faculty:
Angela Branche, MD
Associate Professor of Medicine Division of Infectious Diseases Department of Medicine University of Rochester Rochester, New York
Helen Y. Chu, MD, MPH Associate Professor of Medicine Division of Allergy & Infectious Diseases University of Washington School of Medicine Seattle, Washington
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RSV in Adults: A Hidden Epidemic
22 Mar 2023
00:10:43
In this episode, Angela Branche, MD, and Helen Y. Chu, MD, MPH, discuss the impact of respiratory syncytial virus (RSV) and describe those at risk for severe RSV disease, including:
RSV prevalence and seasonality
RSV burden throughout life, including burden in older adults
Comorbidities that increase the risk of RSV complications
RSV transmission in the hospital and care home setting
Implications of risk factors for severe RSV on prevention and treatment
Faculty:
Angela Branche, MD Associate Professor of Medicine Division of Infectious Diseases Department of Medicine University of Rochester Rochester, New York
Helen Y. Chu, MD, MPH Associate Professor of Medicine Division of Allergy & Infectious Diseases University of Washington School of Medicine Seattle, Washington
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Answering the Questions on Optimizing Antiretroviral Therapy in Heavily Treatment–Experienced People With HIV: José R. Arribas and Melissa Badowski
21 Mar 2023
00:37:40
In this episode, José R. Arribas, MD, and Melissa Badowski, PharmD, MPH, FIDSA, FCCP, BCIDP, BCPS, AAHIVP, discuss optimizing antiretroviral therapy (ART) for people with HIV who are treatment experienced or failing a current ART regimen, including:
The use of proviral DNA genotyping for switching therapy
Maintaining nucleos(t)ide reverse-transcriptase inhibitors after a first failure
The role of zidovudine in salvage regimens
The use of twice-daily darunavir with protease inhibitor resistance and twice-daily dolutegravir with integrase strand transfer inhibitor resistance
Simplification of regimens and long-acting therapies for people with HIV who are highly treatment experienced
Drug‒drug interactions that may warrant dosing changes to avoid resistance development
When to consider antiretrovirals with novel mechanisms of action, such as fostemsavir, ibalizumab, and lenacapavir
The logistics of dosing, administration, and development of a complete ART regimen that includes novel mechanism antiretrovirals
Addressing psychosocial factors to increase the chance of success on a new ART regimen
Drug‒drug interactions with novel mechanism agents
How common ART resistance is for people with HIV in their own practices
The possibility of using long-acting cabotegravir plus rilpivirine in people with viremia in the future
Addressing low-level viremia
José R. Arribas, MD Professor of Medicine Department of Medicine Autónoma University School of Medicine Head, Infectious Diseases Unit Department of Internal Medicine Hospital La Paz Madrid, Spain
Melissa Badowski, PharmD, MPH, FIDSA, FCCP, BCIDP, BCPS, AAHIVP Clinical Associate Professor Section of Infectious Diseases Pharmacotherapy Department of Pharmacy Practice University of Illinois at Chicago, College of Pharmacy Chicago, Illinois
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A Triumphant Return: Welcoming People Back to HIV Care
17 Jun 2024
00:12:33
In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD, uses a case study to illustrate why patients living with HIV may disengage with their care and how best to reengage them once they present at the clinic, including discussion of:
The valid reasons patients have for disengaging with their HIV care
Why the return to care should be celebrated
How to support people living with HIV as they reengage in care
How to prevent future loss to follow-up
Presenter: Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD CEO, Desmond Tutu Health Foundation Director, Desmond Tutu HIV Centre Professor of Medicine Faculty of Health Sciences University of Cape Town Cape Town, South Africa
Content based on an online CME program supported by an educational grant from Gilead Sciences, Inc.
Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts or Spotify.
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Answering the Questions on HIV PrEP Persistence
16 Mar 2023
00:54:29
In this episode, Darrell H. S. Tan, MD, FRCPC, PhD, and Kenric Ware, PharmD, AAHIVP, discuss considerations for HIV pre-exposure prophylaxis (PrEP) persistence, including:
The PrEP continuum of care in the United States, including inequities in PrEP uptake and persistence by race
CDC PrEP guidance regarding PrEP indications
PrEP eligibility by regimen
Summary of renal, bone, and weight outcomes with different PrEP options
Data on HIV acquisition following PrEP discontinuation
Drug concentrations and recommendations for stopping long-acting cabotegravir for PrEP
Expanding PrEP options to facilitate adherence and persistence
Providing PrEP by telehealth
Presenters:
Darrell H. S. Tan, MD, FRCPC, PhD Associate Professor Division of Infectious Diseases University of Toronto Clinician-Scientist Division of Infectious Diseases St. Michael’s Hospital Toronto, Canada
Kenric Ware, PharmD, AAHIVP Associate Professor Department of Pharmacy Practice South University Savannah, Georgia Chairperson, Pharmacist Board of Directors Joseph H. Neal Health Collaborative Columbia, South Carolina
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Answering Questions on Which HIV PrEP for Which Patient: Carolyn Chu and Samantha Strong
15 Mar 2023
00:31:49
In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, and Samantha Strong, PharmD, BCACP, AAHIVP, CDCES, answer questions including:
Strategies to improve disparities in pre-exposure prophylaxis (PrEP) access in difficult-to-reach populations
Key remaining questions related to PrEP options for cisgender women and people who inject drugs
Concerns about resistance at seroconversion in patients with suboptimal PrEP compliance
Implementation of molecular screening for patients receiving PrEP
Expectations for weight gain and patient counseling points
Presenters:
Carolyn Chu, MD, MSc, FAAFP, AAHIVS Chief Medical Officer American Academy of HIV Medicine Chief Clinical Officer National Clinician Consultation Center
Samantha Strong, PharmD, BCACP, AAHIVP, CDCES Clinical Director of Pharmacy Nevada Health Centers Las Vegas, Nevada
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Hepatitis Delta in Focus: Episode 1 of Answering the Questions on Screening, Diagnosis, and Treatment
08 Mar 2023
00:22:43
In this episode, Maria Buti, MD, and Richard H. Davis, PA-C, address key considerations when screening, diagnosing, and treating patients with hepatitis delta virus (HDV), such as:
Barriers to screening
HDV screening based on patient risk factors
Universal screening for all patients with positive hepatitis B surface antigen (HBsAg)
Reflex testing
Availability of commercial testing
Monitoring suggestions in HBsAg positive and HDV antibody positive patients with negative HDV RNA
Limitations to evaluating advanced fibrosis in patients with HDV
Data on novel HDV therapies (eg, bulevirtide and lonafarnib)
Extending HDV therapy (eg, peginterferon) based on treatment response