Back

Explore every episode of the podcast Bloody Minded

Dive into the complete episode list for Bloody Minded. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.

Rows per page:

1–50 of 106

TitlePub. DateDuration
Episode 104 - Immunology 102 | Lymphocyte Maturation & The Lymph Node15 Sep 202600:29:34

For the first time, Cale, Nick and Bashar have managed to maintain a contiguous thought across two different episodes and are returning to school - for the basics of immunology. But they’re not going back as teachers, no, the boys are going undercover as a naïve B-cell and following the journey to the lymph node. Will they be shunned to the uncool table like they were in high school? Can they avoid the murderous hunger games of the dark zone. Will they switch classes or somatically hypermutate? Find out on the next episode of 21 Ju… Lymph Node Street.

TIMESTAMPS

 0:53 - Disguise 101
 5:10 - Naive B cells journey
 7:56 - Lymph node anatomy refresher
 13:31 - Activation of naive B cells
 18:50 - Class switching
 21:38 - Into the dark zone
 24:45 - Diseases at the various stages of maturation
 27:18 - Take Home Messages 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 103 - On The Wards: Breaking Bad . . . Cells | Tumour Lysis Syndrome01 Sep 202600:42:35

Have you been asked to review “TLS” bloods?? Are you concerned the nursing staff are pranking you with haematology bloods that don’t include a FBC or coags? Why could you possibly want to look at something that isn’t a cell count? What crazy person decided after hours bloods needed to be collected on ICE? And WHY ?!?! Join us for an On The Wards approach to dealing with those TDS TLS SOS calls.

TIMESTAMPS:

0:56 - The team breaking stuff
3:40 - Episode overview
5:07 - Setting the scene
6:33 - The history of TLS
7:28 - (nailed it)
8:00 - Pathophysiology of TLS
10:41 - Mechanisms of renal injury in TLS
11:39 - Clinical consequences of TLS
12:46 - Diagnostic criteria in TLS
15:10 - Clinical TLS vs lab TLS
15:35 - Grading TLS
16:55 - Other clues of TLS
18:09 - Who is at risk of TLS?
23:15 - Prevention of TLS
24:27 - Allopurinol
26:58 - Rasburicase
33:03 - Fluids fluids fluids
33:44 - Deciding who gets prophylaxis
35:50 - What ARE TLS bloods?
36:31 - What to do with a TLS on the ward
40:05 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 102 - Reign in Blood | Heavy Metals in Haematology18 Aug 202600:31:36

It’s the heaviest matter of haematology as we look at the role of heavy metals in our favourite metalloenzymes. What - you don’t have a favourite metalloenzyme?  But nothing else matters?! Anyway, this is no esoteric surgical content, join us as Nick, Cale and Bashar get comfy with the weirder parts of the periodic table and how they apply to less common deficiencies or toxicities in haematology. Look we’ll be honest with you - this is pretty low yield listening but it was fun, and really isn’t that point at the end of the day. 

TIMESTAMPS

0:55 - Wacken Open Air or Bloody Minded?
3:58 - Molybdenum ft. Black Eyed Peas
11:07 - Copper ft. Calf Livers
14:41 - Zinc ft. Dentures
18:35 - Cobalt - ft. Goblins and Beer
22:40 - Lead ft. Basophilic Stippling
26:13 - Aluminium ft. Pronunciation Issues
28:29 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 101 - Let’s get K-rakin | All about Vitamin K 11 Aug 202600:42:06

Is it a giant Cthulu-esque sea monster? Is it an excellent Australian parody breakfast show? No - it’s everyone’s favourite (well everyone who counts) coagulation related Vitamin - Vitamin K! Where does it come from? Why is it so hard to find on the eMR when you want to prescribe it and what is it doing under phytomenadione? Can we test for it? After listening to Nick, Cale and Bashar wax lyrical about carboxylation for half an hour you’ll be ready to vitamin K-nock yourself out.

TIMESTAMPS

0:53 - Birdsong
3:54 - The history of Vitamin K
10:02 - Types of Vit K
12:02 - K1 + K2
13:16 - K3 + K4
14:18 - K1-4 without the possession
15:46 - What does Vit K actually do?
19:37 - Dietary sources of Vit K
23:20 - Vit K Absorption Pathway
28:00 - Vit K + Gamma glutamyl carboxylase
33:20 - Practical aspects of Vit K replacement
38:48 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 100 - 100 Not Out | A Bloody History of Haematology04 Aug 202600:37:30

Four humours in balance, the ancients decreed -
so open a vein, let the bad blood be freed.
From Galen to Harvey, from humours to genes, 
From black bile and phlegm to the things on our screens.
From PML::RARA to blood counts okay 
Let’s celebrate our specialty - we’ve come a damn long way

Join us as we travel from the first man to see a red cell, to the first to give people arsenic on purpose who was actually well-intentioned! Pour one out for Galen who was confidently incorrect for fifteen centuries but everyone just went with it anyway because it seemed pretty good at the time. We interrupt your scheduled haematinic programming for a historical grab bag and some chat about the podcast as we celebrate 100 episodes and still going strong. 


TIMESTAMPS

1:49 - Sappy Stuff
7:15 - In the Beginning
9:52 - Leeches
12:57 - Harvey
14:43 - Microscopes
16:08 - Leukaemia
18:11 - Transfusion
20:30 - Anticoagulants
22:55 - Molecular
27:23 - Chemo
29:34 - Transplant
31:07 - Coags
33:07 - CAR-T
35:11 - Wrapup

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 99 - It’s the B’s Knees | In The Lab : B12 and B9 (Folate) Testing28 Jul 202600:25:02

Two vitamins survived the great B-numbering cull to become the tests we order most and trust least. Meet the 80% of your B12 result your cells can't touch, and the antibody that sabotages the very test built to catch it. Join the Bloody Minded Crew as we come to the lab for a second time this season to learn how B12 and folate assays are performed. 

TIMESTAMPS

0:55 - The boys check out a new lab
 2:25 - Episode overview
 3:43 - Sample requirements
 4:12 - B12 refresher
 6:03 - Total B12 assays
 9:36 - Caveats in interpretation
 14:00 - Active B12
 15:59 - MMA and Homocysteine
 18:13 - Folate testing
 22:18 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 98 - Liver Storage World | Approach to Hyperferritinaemia21 Jul 202600:27:59

‘This bad boy can fit so much iron in it’ he said slapping the roof of a badly photoshopped molecule of apoferritin superimposed on a car. Is too much ferritin bad for you? Of course it is - too much is precisely the quantity that is in excess. But most of the time hyperferritinaemia has nothing to do with iron overload. Strap in to your 1992 Honda Civic as the Bloody Minded Crew learn all about ferritin, and why most of the time too much of it has nothing to do with your iron levels at all. Also join Cale specifically as he continues his vendetta against hepatology and their referrals. 

Timestamps

0:59 - Bashar visits the salon
2:03 - Hyperferritinaemia overview
3:13 - Ferritin vs Iron Overload
6:08 - Signs and Symptoms associated with Hyperferritinaemia
10:50 - Causes of Hyperferritinaemia w/o Iron Overload
16:59 - Hyperferritinaemia w/ Iron Overload
21:30 - Chelation
22:43 - Erythoferrone
24:16 - Summary

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

BONUS - BloodyMinded x THANZ go to ISTH202620 Jul 202600:28:03

It's a BONUS episode today as the Bloody Minded Crew are delighted to partner with the Thrombosis and Haemostasis Society of Australia and New Zealand (THANZ). After (correctly) exiling Nick to another country after he suggested yet more coagulation themed episodes, he's returned like Gandalf stronger and more powerful than ever. We cornered THANZ members at the International Society for Thrombosis and Haemostasis 2026 meeting to chat about what was keeping them interested.

Special thanks to Dr Danny Hsu, Dr Sara Ng, Dr George Mason, Dr Angela Huang, Dr Ibrahim Tohini-Esfahani, Dr Emily Powley, Dr Catherine Neal, Dr Marc Ellis, Dr Charithani Keragala, Hadley Bortz and Danielle Boyle for their contributions.

Check out the THANZ website (www.thanz.org.au) and consider signing up if you're an Australian based scientist, clinician, nurse or allied health professional with an interest in Thrombosis and Haemostasis.

There will be no show notes for this episode and our regular programming will continue as usual. 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 97 - There's a Hole in My Bucket | Iron, B12 and Folate Deficiency in Clinic14 Jul 202600:39:38

Nick wanted to talk about buckets all episode. I’ve convinced him to at least let us get angry at iron polymaltose, hypophosphatemia and nangs all over again. You don’t think you need this episode but you’d be amazed how many consults come through to Haem thinking we’re the gatekeepers of iron in the building. Ironic, really.

TIMESTAMPS

0:56 - 1960s pop culture reference
3:20 - Episode overview
4:40 - Iron deficiency
6:28 - Pica chat
7:53 - Presentations of iron deficiency
8:36 - Causes of iron deficiency
11:10 - Taking a menstrual history
12:53 - Non-menstrual causes of iron deficiency
14:40 - Oral iron replacement
18:19 - IV iron replacement
25:01 - Folate deficiency
27:18 - Folate replacement
29:18 - B12 deficiency
31:19 - Causes of B12 deficiency
32:00 - Diagnosis of B12 deficiency
32:55 - B12 replacement
34:58 - Dealing with concurrent deficiencies
36:20 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 96 - On the Ning Nang Nongs | B12 and Folate Metabolism07 Jul 202600:34:47

On the Ning Nang Nongs where the youths smoke bongs and the marrow all screams HELP! Join the Bloody Minded crew as they go through the round window, follow B12 and folate around the body in a Nang induced haze, presumably just like the writers on Play School once were. 

Mandatory viewing: https://www.youtube.com/watch?v=3SUU1f3Mgpc&list=RD3SUU1f3Mgpc&start_radio=1

TIMESTAMPS

0:53 - A Bloody Minded After School Special
1:50 - Megaloblastic Anaemias
2:59 - An Intro to B12
7:49 - B12 Absorption
12:55 - Role of B12
15:07 - MMA + Homocysteine
16:40 - Causes of B12 Deficiency
20:04 - Nangs - Again
23:18 - Intro to Folate
25:32 - Folate Absorption
27:03 - Folate Deficiency
30:00 - Concurrent B12 + Folate Deficiency
32:18 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 95 - Feeling Rusty? | In The Lab: Iron Studies 30 Jun 202600:26:52

Heal with steel? Absolutely not - There’s no alloys or for that matter surgeons allowed in the safe space of the laboratory. Join us on another wonderful lab adventure as Bashar, Cale and Nick head down to the biochemistry lab to work out exactly how our iron studies are performed in the lab before you throw the serum iron in the bin.

TIMESTAMPS

0:53 - An early etymological diversion
2:53 - Serum iron
9:43 - UIBC
11:22 - TIBC
13:34 - Transferrin
15:45 - Transferrin saturation
17:25 - Ferritin
20:42 - Example of how the numbers work
23:31 - The iron stain
25:02 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 94 - It should be a Fe-lony | Interpeting Iron Studies23 Jun 202600:25:08

Taunted by transferrin? Befuddled by ferritin? Scratching your head at why we throw the serum iron results directly into the confidential waste bin, which is a more dignified burial than it deserves? Come along as the boys discuss the interpretation of iron studies in a definitely tight, definitely 20ish minute episode.

Timestamps

00:54 - Just Iron Studies with No Nonsense
02:21 - Overview of Iron Stuides
03:42 - Serum Iron
05:35 - Transferrin
07:32 - TIBC
08:35 - UIBC
10:47 - Transferrin Saturation (TSat)
12:38 - Ferritin
14:34 - Soluble Transferrin Receptor (sTfR)
15:45 - Invasive Iron Studies
16:52 - Rapid Fire Case Studies ft. Geraldine
22:25 - Summary & Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 93 - The Silmaril-IRON | Iron Metabolism16 Jun 202600:44:03

One molecule to rule them all, one molecule to find them. One molecule to bring them all, and in the liver bind them. Hepcidin is the key to understanding iron metabolism and we examine how iron gets into, around and out of the body. We promise not to be too Celebrimbor-ing as you join Nick, Cale and Bashar  for this discussion of the basic science of iron handling in preparation for our journey into the building blocks of blood. Welcome to Lord of the Haematinics. 

TIMESTAMPS

0:56 - The next arc of the Bloody Minded Cinematic Universe
3:23 - Series overview
6:21 - Basic iron metabolism
7:54 - The three main player groups in iron metabolism
8:44 - Iron binding molecules: Heme
13:22 - Non-heme iron
14:05 - Iron binding molecules: Ferritin
17:12 - Iron binding molecules: Transferrin
20:44 - Iron transporters: DMT1
25:02 - Iron transporters: ferroportin
28:21 - Iron transporters: Hephaestin
29:28 - Iron flux
33:24 - Hepcidin: Master Regulator and The One Ring
39:04 - Non-hepcidin regulation of Ferroportin and IREs
41:32 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 92 - On The Wards: A Practical Guide To Anticoagulants | Part 3 (Fancy Anticoagulants) 02 Jun 202600:40:00

Has your ward team been hit with HITT? Is Jane the only Fonda you know? Is BAD an 80s hit and not a trio of anti-coagulation infusions (Bivalirudin, Argatroban and Danaparoid). Is Alison showing her age? Never fear; join Alison, Bashar, Nick and Cale as they aim to de-mystify less commonly used anticoagulation that may come up on the wards. 

TIMESTAMPS

0:56 - It's Fancypants Wednesday!
2:15 - Episode overview
4:37 - Fondaparinux
9:07 - When to use fonda
12:35 - Argatroban
17:25 - When to use argatroban
18:02 - Bivalirudin
19:11 - Mandatory historical diversion
22:50 - Back to bivali business
25:59 - Danaparoid
30:21 - When to use danaparoid
32:45 - Quick summary
34:13 - Dalteparin
38:02 - A bit of nonsense chitchat

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 91 - Have you tried turning it off and on again? | Allogeneic transplant in AML with Prof John Moore19 May 202600:57:06

Join us in our third straight week of incredibly nice and incredibly talented haematology gurus as Professor John Moore joins us as an expert guest to discuss stem cell transplant in the myeloid disease setting. 

TIMESTAMPS

 1:00 – HYTTIOAOA
 1:47 – Introducing Professor John Moore
 8:06 – Advice to RMOs on the Allo Term
 11:02 – The history of allogeneic transplantation
 18:26 – Modern morbidity/mortality from alloSCT for AML
 23:05 – Use of transplant scoring systems
 27:29 – The role of MRD in transplant decisions
 30:04 – MAC vs. RIC – Choice of Conditioning
 38:15 – The role of PTCy
 40:17 – Second allogeneic transplants
 42:02 – DLI
 43:08 – Biallelic TP53 – no good options
 45:29 – Free rein in the trials space
 49:11 – AlloSCT/CAR-T for autoimmune disease
 55:05 – Take Home Messages 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 90 - GENEsis | In the Lab: NGS in AML with Dr Michael Krigstein12 May 202600:54:44

This week we continue the pattern of guests who are really really ridiculously good at haematology and also really really ridiculously nice people as well. We are very excited to be joined by Dr Michael Krigstein who many of you would know as the a molecular haematology guru who has gotten countless patients through their diagnoses and countless haematology trainees through their exams.

Timestamps:

01:30 - Introducing Dr Michael Krigstein
04:23 - Getting into Lab Haem
08:30 - The Mechanics of NGS
16:57 - Learning to report - RCPA Modules
19:58 - After the NGS - Curation
24:14 - NGS - Not a panacea
28:45 - Why NGS is bad at ITDs
32:42 - Panel Design
36:37 - RNA vs DNA Panels
39:16 - The future of NGS in haematology
46:56 - A standout case
53:36 - Wrapup


Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 89 - What is this, disease for ants? | MRD in AML with Dr Jad Othman05 May 202600:59:11

What happens when you take someone who is really really ridiculously good at haematology and also a really really ridiculously nice person as well? You get Dr Jad Othman, consultant Haematologist and Haematopathologist at Royal North Shore Hospital in Sydney who will be joining us today to discuss the use of measurable residual disease in acute myeloid leukaemia.

Dr Othman is well suited to this topic, having written his doctoral thesis on molecular disease assessment in AML, sitting on the European LeukaemiaNet (ELN)-DAVID MRD Working Group as well as numerous ALLG AML and MDS working groups. We're delighted to have him field the Bloody Minded Crew's questions today. 

Timestamps

01:00 - The boys making outdated millenial references
02:50 - Getting to know Dr Jad Othman
09:50 - The concept of MRD
11:55 - Lab techniques for MRD
17:59 - Why doesn't everyone have an MRD marker?
20:51 - What makes a good MRD assay?
24:14 - Patients without a molecular MRD marker
26:21 - Clinical case
30:30 - What we do with MRD results
31:47 - The NPM1/FLT3 PB/BM situation
35:31 - Why MRD is actually helpful
39:40 - Why single agent treatment in AML is challenging
44:33 - The 2025 ELN DAVID update
48:44 - Does doing MRD improve OS?
52:21 - The INTERCEPT study
55:41 - Wrap up and summary

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 88 - 1-2-3-4-5-6 | Blastic Plasmacytoid Dendritic Cell Neoplasm28 Apr 202600:33:57

Here’s a question, what do CD123, CD4 and CD56 have in common? Other than pleasing The Count on Sesame Street. Sorry, another question perhaps - what happens if you cross a plasma cell and a dendritic cell? The answers to these questions can be found on a most enigmatic myeloid cell - the plasmacytoid dendritic cell. And what happens when these rare beasts become neoplastic - why BPDCN of course. Embark on a journey into this weird and not so wonderful (but highly examinable) neoplasm with the Bloody Minded Crew 

TIMESTAMPS

 0:57 – A glimpse into Cale's psyche
 2:39 – Intro to BPDCN
 6:56 – What IS a plasmacytoid dendritic cell?
 10:24 – Pathological PDCs in BPDCN
 11:42 – Clinical presentation – lots of rash talk
 15:23 – Morphology in BPDCN
 17:48 – Immunophenotype
 21:16 – Karyotypic and molecular features
 22:44 – Treatment of BPDCN
 24:00 – A bit on prognostic markers
 25:03 – Transplant
 25:28 – Tagraxofusp
 29:15 – Other treatment options
 31:33 – Take home messages 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 87 - Flitting About | In The Lab: FLT3 and NPM1 21 Apr 202600:52:25

“It’s pronounced nuc-ul-ophosmin” “Nucleophosmin”. “Noo-clee-o-phosmin”. FLT3-ITD got you In The Dumps? Have a Total Knowledge Deficit about TKD mutations? Struggling with the A-B-Cs of NPM1 mutations? Want to know how a cat sarcoma is somehow related to AML? Join the Bloody Minded Crew as they flit about the laboratory looking at the structure of FLT3 and NPM1, what these proteins usually do and how we test for mutations in the advanced myeloid episode.

== Edit 6/5/26 = We've been made aware that strictly speaking the current MANE approved transcript for NPM1.1 has only 11 exons and therefore the mutations are best to be considered in Exon 11 as opposed to exon 12 - in contrast to what we said. ==

Timestamps

0:52 - Bloody Minded issues a formal apology
2:40 - Introducing molecular chaperones
5:05 - What even NPM1?
9:30 - Functions of NPM1
10:55 - Molecular biology of NPM1 in disease
15:42 - Why the subtypes are important
19:53 - NPM1 prognosis
21:35 - MRD testing in NPM1
25:52 - NPM1 summary
27:13 - Intro to FLT3
28:30 - Mandatory FLT3 history
36:28 - FLT3 pathogenesis
37:37 - FLT3 structure, ITD vs TKD
41:16 - The juxtamembrane domain
42:53 - Prognostic features in FLT3
44:17 - TKD mutations
46:26 - FLT3 in the lab
50:30 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 86 - You Ugly | In The Lab: Bone Marrow Dysplasia14 Apr 202600:37:27

U-G-L-Y, you ain't got no alibi, you dysplastic yeah yeah you dysplastic. Apologies to all the ring sideroblasts out there, but this week the Bloody Minded crew is doing a Mean Girls and judging cells by their morphology. For now we’re deciding to ignore those that would argue that it’s what’s on the inside that counts (i.e. judging by NGS… that’ll come later).

TIMESTAMPS

2:28 - For some reason, an audio podcast on visual dysplasia 
5:05 - Normal erythroid morphology 
7:17 - Dysplastic erythroid morphology 
17:32 - Normal granulocyte morphology 
20:00 - Dysplastic granulocyte morphology 
28:33 - Monocyte morphology - dysplastic at baseline 
30:33 - Normal megakaryocyte morphology 
32:24 - Dysplastic megakaryocyte morphology 
35:02 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 85 - Wake Me Up! | Acute Promyelocytic Leukaemia (APML)07 Apr 202600:50:17

What do arsenic, acne tablets and Jodi Picoult have in common? Why, it must be a deep dive with Nick, Bashar and Cale on acute promyelocytic leukaemia. From buzzwords to brain bleeds, the sweetest of translocations to the cruellest of coagulopathies... The yield is almost as high as the survival rates.

TIMESTAMPS

00:57 - Bloody Minded Poetry Jam & Jodi Picoult
06:25 - APML Starts Here
08:02 - APML - Where does it fit in AML?
10:02 - Morphology & Flow
12:12 - PML::RARA - t(15;17) and rare variants
16:58 - Lab Summary
17:50 - Clinical Presentation
21:02 - APML Coagulopathy
26:46 - Treatment and Risk Stratification
33:53 - High Risk Aside
36:58 - Differentiation Syndrome

41:04 - Treatment SEs
44:18 - Microgranular Variant
47:00 - Summary and Takehomes

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 84 - Chemotherapeutic Boogaloo | AML Part 231 Mar 202600:58:14

After our initial intro to AML back in ep 79, we are back to dig deeper into AML this week, from pathophysiology through to treatment overview. The boys are joined by final year registrar Dr Georgina Calov who is here to cut through our nonsense and deliver some actual high yield content. And thank goodness for that, otherwise it'd be an hour of us making bad April Fool's day jokes.

Timestamps

2:09 - Introducing Dr Georgina Calov
3:34 - AML Refresher
7:12 - AML defined by recurrent genetic abnormalities
15:39 - AML defined by differentiation (aka whats with the M numbers)
18:14 - MN-pCT
19:03 - Prognostication - ELN Classification
21:58 - Diagnosing AML - Clinical
24:16 - Diagnosing AML - Lab
31:39 - New AML Workup
35:50 - Intro to Treatment - Induction in "Fit" patients
41:40 - Treatment - Consolidation & MRD
45:15 - Treatment - "Unfit"
48:02 - Treatment - Supportive
50:16 - Treatment - Relapse/Refractory
55:19 - Summary

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 83 - On The Wards: The NBM Transplant Patient24 Mar 202600:54:39

Cat got your tongue? Or in this case - mucositis? Does converting the acute allogeneic transplant patient who can no longer eat's medications to IV fill you with dread? In this practical for once episode join consultant haematologist Dr Alison Chandler as well as haematology pharmacists Andriana Colic & Ariana McCauley as they take us through the how to of this challenging, but very common, clinical scenario. 

Timestamps

0:58 - Nick's literal nightmare
2:18 - Today's outline
3:38 - Let's meet the A-team!
11:14 - What do you wish the haem doctors knew?
13:38 - Introducing the NBM transplant patient
15:18 - Tacrolimus
17:37 - Mycophenolate
19:51 - Ciclosporine (or cyclosporine or CsA or CyA, whatevs)
22:20 - Hot tip on TDM
23:47 - Antifungals
24:23 - Posaconazole
26:06 - Voriconazole
27:29 - Isavuconazole
28:45 - Echinocandins - mica/anidula
30:52 - Antivirals
33:27 - CMV treatment
37:41 - Antibacterials - PJP prophylaxis
39:22 - The NBM APML patient 
43:35 - Antiepileptics
46:24 - TLS prophylaxis
47:53 - Wrap up time!
50:18 - Episode summary

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 82 - MDS 102 | Much More on Myelodysplastic Syndrome17 Mar 202601:07:55

Was episode 79 too light on MDS for you? “Amateurs” you said, adjusting your sellotaped glasses. If so, you’re in the right place today as we prepare to look at classification, risk stratification and treatment of myelodysplastic syndrome. You also should seek out psychiatric attention, or perhaps just go outside. But in the meantime, enjoy this episode where we’ll dig deeper into the nitty gritty of MDS! We’ve got a lot to cover so we float about between intermediate and advanced for this episode.

TIMESTAMPS

1:11 - A Very Unhinged Intro  
3:34 - Actual Content Starts Here  
5:52 - Differentials for dysplasia  
7:54 - Presentations of MDS  
12:36 - MDS Subtypes  
14:23 - MDS with del(5q)  
18:29 - Lenalidomide in del(5q)  
25:03 - MDS with SF3B1  
29:05 - MDS with biallelic TP53 inactivation  
30:26 - Bonus cytogenetic abnormalities that pop up  
31:43 - Germline mutations that predispose to MDS and AML  
37:14 - MDS with low blasts  
38:08 - Ogata Score  
39:26 - Hypoplastic MDS  
44:03 - MDS with increased blasts  
44:58 - MDS with increased blasts and fibrosis  
46:22 - Breaking News - Blasts Should Now Be Counted By Flow  
48:30 - Prognostic models for MDS  
53:36 - Treatments for MDS  
1:04:39 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 81 - In the Beginning... | Myeloid Precursor Conditions (CHIP, ICUS, CCUS)10 Mar 202600:38:41

What if the prequel had a prequel? Join Bashar, Nick and Cale as they attempt to unpack the newfangled world of clonal haematopoeisis. Find out how CHIPs can kill and no, it’s not due to eating too many of them too fast. Though that might do it too. We’ve had one spectrum, but what about a second. We need to go deeper. 

TIMESTAMPS

0:56 - A classic chippy mixup  
2:56 - Episode overview  
3:54 - Where CHIP sits in haem  
5:15 - Clonal haematopoiesis  
11:21 - What genes acquire CH?  
13:42 - CHIP  
20:09 - Clinical implications of CHIP  
24:24 - Increased mortality in CHIP  
28:54 - ICUS  
32:40 - CCUS  
35:42 - Take home messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 80 - GATTTACA | In The Lab: Introduction to Molecular Haematology03 Mar 202601:12:11

 If we’re going to truly understand myeloid disease, we must dispense with the ward and journey to the dystopian heart that beats at the centre of each dysplastic cell. Learn what is valid and in-valid as we swim across an ocean of concepts - past the basic principles of DNA and RNA, Polymerase Chain Reaction and its many many variants, Fragment Analysis and Next Generation Sequencing. Just save a little something for the swim back to clinic next week.

PS The Extra T is for TYOTT 

Timestamps

0:55 - Back in the lab, baby!
2:08 - Today's outline
6:24 - What IS molecular testing?
8:13 - The central dogma of molecular biology
14:46 - Types of genetic mutations
20:05 - Nomenclature for gene variants (advanced)
23:52 - Samples for testing
27:42 - What comes after DNA extraction
30:11 - What is PCR and how did we discover it? 
38:45 - What we do post PCR
41:27 - Quantitative and RT-PCR 
46:54 - Asking the RIGHT question
48:55 - Digital droplet PCR
50:44 - Electrophoresis
52:35 - Fragment analysis and melt curve analysis
54:33 - NGS
1:00:02 - What is a VAF?
1:05:23 - Lab governance (for haem ATs)
1:09:32 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 79 - Ghosts in the Machine | Basics of MDS & A Brief Look at AML24 Feb 202600:54:16

Happy marrows are all alike; every unhappy marrow is unhappy in its own way.  When haematopoiesis behaves itself, it’s frankly quite boring. When it goes rogue, it can get very creative. Join Cale, Bash and Nick as they attempt to walk through how this process goes off the rails, how MDS and AML are best understood and how dysplasia, cytopenias, blasts and clones all fit together.

TIMESTAMPS

0:55 - Our serious introduction to counterbalance last week 
1:58 - Episode overview 
2:50 - Introducing MDS 
7:12 - Risk factors for MDS 
8:53 - MDS progression 
11:13 - Complications of MDS 
13:10 - Leukaemic transformation 
15:37 - MDS epidemiology 
16:27 - Diagnosing MDS 
21:19 - What is dysplasia? 
26:44 - What we test on marrow 
35:13 - Clonality assessment in MDS 
42:29 - Caveats in diagnosing MDS 
43:18 - MDS summary (finally) 
44:09 - MDS treatment in brief 
45:37 - Intro to AML 
51:32 - Episode summary 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 78 - All The Colours Of The Marrow | Overview of Myeloid Disorders17 Feb 202600:33:28

What’s a CHIP and why is it so delicious? Why do we still abbreviate myeodysplastic neoplasm to MDS? How did Bashar get his hands on the Necronomicon? These are questions that every budding haematologist asks themselves at some point and we will answer at least some of them here! Join us today for a birds-eye overview of the myeloid family of disorders before we dig into them more over the coming weeks. 

TIMESTAMPS

0:57 - Does anyone know a good priest?  
3:17 - Myeloid conditions in bucket form  
5:30 - Acute vs chronic in haematological diseases  
7:35 - Myeloid precursor lesions  
10:33 - Myeloproliferative neoplasms  
15:23 - Myelodysplastic syndromes  
18:50 - MDS/MPN Overlap Syndromes  
22:29 - Mastocytosis  
26:02 - Acute myeloid leukaemia  
28:23 - (Acute promyelocytic leukaemia)  
29:36 - Histiocytic/dendritic cell disorders  
31:14 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 77 - The Factory Must Grow | Myelopoiesis 10 Feb 202600:31:35

Hi-ho, Hi-ho, it's off the myeloid factory we go. Grab your fastest belt, a spare inserter and all the iron plates you can get your hands on as the Bloody Minded Crew embark on their nerdiest references yet and learn all about the basic science behind myelopoiesis. You’d better hop on a train, because the only main bus here goes straight from the marrow out to the periphery carrying all sorts of myeloid cells. And some blue circuits. 

0:52 - New year same us
2:44 - Season overview: myeloid time, baby!
5:15 - What is the myeloid compartment?
7:29 - Myelopoiesis
12:49 - Stem cell destiny... does free will exist?
14:28 - The myeloid progenitor
16:30 - Red cells and platelets
17:46 - White cell maturation
19:34 - Hormonal control of myelopoiesis
21:25 - Historical diversion into GCSF
23:19 - Clinical use of stimulating factors
26:39 - GCSF Bone Pain
28:15 - Emergency Myelopoiesis
30:08 - Wrap Up

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 76 - On the Wards: A Practical Guide to Anticoagulants | Part 2 (Oral Anticoagulants)27 Jan 202601:06:58

So you’ve been asked to start a DOAC? How is that different from a NOAC? Is there a difference? Which one should you start? Is warfarin a WOAC? How do I initiate these drugs? Why is the dose weird at the beginning? Do I need to check my dose is appropriate? 

If oral anticoagulation has you discombobulated you are in the right place!! In part II on the practical management of anticoagulation we are here to clarify all your questions on the most common types of oral anticoagulation you will come across as a junior doctor on the wards.

Timestamps
1:44 - Part I Recap and Part II Introduction
3:44 - History of Warfarin
8:37 - Mechanism of Warfarin
13:01 - Monitoring Warfarin
16:52 - Why Warfarin? and warfarin tips
21:40 - Warfarin reversal
31:05 - Warfarin Skin Necrosis & Drug Interactions
36:08 - Warfarin in Special Circumstances
40:25 - DOACs Intro
41:12 - Dabigatran
48:25 - Anti-Xa Agents (Rivaroxaban / Apixaban)
52:38 - Anti-Xa Monitoring (or not)
59:28 - DOACS - Special Circumstances
1:05:58 - Wrapup


Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 75 - On the Wards: A Practical Guide to Anticoagulants | Part 1 (Basic Injectables)20 Jan 202601:03:53

Does my blood look fat in this?

Does the idea of heparin being a fraction make you wish you listened harder in maths? What is unfractionated heparin? Why are haematologists so judgmental and prefer their anticoagulation low molecular weight? Why does haematology frown when you use the term “blood thinners” ?!?!

If injectable or parenteral anticoagulation feels confusing you have come to the right place! Today we look at unfractionated heparin and low molecular weight heparin,  practical things to think about and how to manage these drugs safely on the wards and beyond 

NB We’re going to leave the advanced injectables like Fonda/Danaparoid/Bivalirudin to a dedicated alternative, probably HITTS themed episode if you’re looking for these drugs



Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 74 - Christmas Disease | A Bonus Beginners Bonanza on Haemophilia B23 Dec 202500:39:53

Twas the night before Christmas, and all through the house, not a creature was stirring, particularly not a missing coagulation factor. Welcome to a very special present all wrapped and delivered by Santa and his Christmas elves and stuffed in your podcast queue in time to drive off for the holidays. Join Cale, a very dusty Bashar, Nick and Santa as we learn a little bit about Christmas Disease. We swear his jacket was that colour before we messed with his haemostatic pathways… CONTENT WARNING: Singing

TIMESTAMPS

00:55 - Pure unbridled musical talent 
03:34 - Intro to Christmas Disease/Haemophilia B
04:58 - History of Haemophilia B
14:01 - Presentation of Haemophilia B
18:25 - Haemophilia B Leyden
22:49 - Coagulation studies in Haemophilia B
26:20 - Treating Haemophilia B
28:12 - Where does factor replacement come from?
31:57 - Inhibitors
33:48 - Gene therapy
37:27 - Take home messages


Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 73 - What A Headache | CVST and Antithrombin Deficiency with Dr Caroline Dix16 Dec 202500:42:00

We’ve had one difficult coagulation topic yes, but what about second difficult coagulation topic? We are joined by the fantastic Dr Caroline Dix today to take us through not one but TWO challenging scenarios in thrombosis. First we’ll be revisiting Cerebral Venous Sinus Thrombosis but this time with someone who knows what they are doing. After that we’ll cover anticoagulating people when some very fundamental parts of the system are broken - the management of antithrombin deficiency. This episode wraps up our journey through clots… for now. 

Timestamps:

2:08 - Introducing Dr Caroline Dix
8:03 - CVST - Risks
11:15 - CVST - Clinical
18:08 - CVST - Duration
21:05 - Antithrombin Deficiency
25:12 - Antithrombin Deficiency - Diagnosis
29:43 - Antithrombin Deficiency - Management
37:34 - Wrapup

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 72 - How low can you go? | Thrombosis & Thrombocytopenia with Dr Sara Ng09 Dec 202500:41:45

Sometimes something comes along that puts a chill down the spine of every doctor. Any conversation that starts with "Oh hey do you remember that patient you saw...?". Mystery meat day in the cafeteria. Dealing with hospital executives. For these times in life you need a guide. Today we'll be covering one of those spine-chilling clinical scenarios with our very apt guide consultant haematologist Dr Sara Ng. Over forty minutes Sara will un-chill your spine with her practical approach to managing thrombosis when there just aren't that many platelets to go around, as well as talking about conditions where clots and thrombocytopenia are intimately linked.

Timestamps: 

2:11 - Introducing Dr Sara Ng
7:18 - Case 1: Acute PE and Thrombocytopenia
14:55 - Case 1.5: Subacute PE and Thrombocytopenia
18:20 - Case 2: Line Thrombus during Chemotherapy
22:09 - Thrombosis in ITP
26:15 - Oh no a STEMI
27:44 - Two sides of the same coin
31:58 - How 2 4T Score - HITS
35:15 - Other PF4 Antibodies
38:33 - Wrap up & Takehomes



Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 71 - Clotting For Good | In The Lab: Thrombophilia Testing II02 Dec 202500:30:53

Come one come all to see the thinnest extended reference in the universe. Draped over not one but TWO episodes, the Bloody Minded Crew continue to make vaguely topical references to popular recent films. Look - we go outside and experience the full gamut of popular culture. Oh and we finish up our discussion of thrombophilia testing in the lab - looking this week at activated protein C resistance testing, molecular Factor V Leiden assessment and Prothrombin gene mutations.

TIMESTAMPS

1:06 - Pay no attention to the man behind the curtain
3:10 - Activated Protein C resistance testing
10:27 - Testing in Australia for APCR
17:17 - FvL Testing
18:51 - PCR - Polymerase Chain Reactions
22:52 - Melt curve analysis
27:39 - Prothrombin G20210A Testing
28:44 - Take Home Messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 70 - The Wizard of Clots | In the Lab: Thrombophilia Testing I25 Nov 202500:37:31

Lions and tigers and… thrombosis? Oh my! Join the Bloody Minded Crew on the yellow brick road to visit the emerald laboratory and see the wonderful wizard of clots - your friendly laboratory coagulation scientist! Put on your blood red ruby slippers and join us for this bumper lab episode as we learn about how exactly we test for Protein C, S and antithrombin deficiencies as well as lupus anticoagulants. By the end of it you’ll have a brain for coags, a heart full of of love for thrombosis and the courage to peer behind the laboratory curtain 

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 69 - I Have No Brain And I Must Test | Thrombophilia Testing18 Nov 202500:40:45

“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WOULD NOT EQUAL ONE BILLIONTH OF THE HATE I FEEL FOR YOU ORDERING THROMBOPHILIA TESTING INAPPROPRIATELY.” Woah - Let’s calm down, that's a bit much. Cale and Bashar are exposed to Nick’s inner monologue as the Bloody Minded Crew learn about the what, when and when not of thrombophilia testing. 


TIMESTAMPS

0:52 - Nick gets stuck in an anger loop  
2:19 - Intro to thrombophilia testing  
4:25 - Inherited thrombophilias  
5:38 - Surprise historical diversion on antithrombin  
8:14 - Proteins C and S  
9:31 - Factor V Leiden  
10:56 - Prothrombin gene mutation  
11:52 - Risk profiles in inherited thrombophilia  
18:49 - Acquired thrombophilias  
18:56 - Antiphospholipid syndrome  
19:46 - PNH  
20:22 - JAK2  
21:08 - Mid-ep summary  
22:28 - The world's biggest soapbox: what not to do  
23:25 - Soapbox: no MTHFR pls  
25:19 - Soapbox: bad times to test  
26:46 - Soapbox: don't test the obvious provoked clots  
27:30 - Bonus soapbox: factor V levels vs Leiden  
28:54 - When SHOULD we test?  
30:41 - Benefits of testing  
32:33 - Clinical scenario: spoiler, no real answer  
33:26 - Scenarios where you might test  
37:49 - Take home messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 68 - The Gut Brain Axis | CVST, CRVO, Splanchnic Thrombosis and Other Rare Clots11 Nov 202500:50:35

We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, uterine and testicular thrombi it's clots as far as the eye can see (and those it can't like CRVO!)

Timestamps:

0:58 - ROADTRIP
4:07 - CVST
11:07 - CVST - Treatment
15:36 - Lemierre's
17:50 - CRVO
24:36 - Splanchnic Thrombi
34:45 - Renal Vein Thrombi
39:41 - Uterine Vein Thrombus
42:09 - Ovarian Vein
44:42 - Testicular Vein
46:35 - Takehomes

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 67 - Skin Deep | Superficial Thrombophlebitis04 Nov 202500:19:37

It's said that beauty is skin deep but you know what else lurks just under your epithelium - CLOTS! Nick, Cale and Bashar head very slightly under our outer layer to the peripheral vasculature in this increasing tortured metaphor as we learn on our shortest episode to date about what to do when those not so deep vessels fill with thrombus. 

Timestamps

2:12 - Where are superficial veins?
5:23 - What's the deal with thrombophlebitis
7:34 - MONDOOORS (To the tune of Trogdor)
9:11 - Risk Factors for SVT
10:56 - Investigations
11:53 - Treatment
17:54 - Summaries

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 66 - In The Lab: D-Lightful | The D-Dimer28 Oct 202500:37:04

D-ismayed by D-readful D-ressing D-owns by your D-emonstrably D-eplorable registrar? . Join de Bloody Minded Crew for a Tour D-Force of D-Dimer D-rama as we D-issect and D-iscuss this most D-ifficult of D-iagnostic tests!

Timestamps

2:14 - What is a D-Dimer and where does it come from?
6:57 - FXIII and D-Dimer
7:49 - Fibrinolysis and other degradation products
10:18 - D-Dimer Assays - LIA
14:22 - D-Dimer Units - Important!
15:39 - D-Dimer Assays - ELISA / ELFA
16:59 - D-Dimer Assays - POCT
18:13 Comparing Assays & Analytical Factors
22:12 - D-Dimer Interpretation - Clinical listeners start here!
30:16 - D-Dimer and Cancer
32:31 - D-Dimer and DIC
34:32 - Summary and Takehomes

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 65 - Take Your Breath Away | Pulmonary Embolism21 Oct 202500:46:22

“Give me a 2cc bolus of clot stat Emma. No wait - not there!” But it was too late, and Em-Bolused the 2cc of clot straight to the lungs”. Join the Bloody Minded Crew as they get to the heart… no get to the lungs of the topic of Pulmonary Embolism. VanQuish the V/Q and CriTically aPprAise the CTPA with these acronyms that are just as bad as a cardiology trial and half as useful. Sadly the Top Gun soundtrack is copyrighted but nothing will stop you playing Berlin over the background of the intro (and we’d strongly suggest it). 

Timestamps

4:55 - Types of PEs
7:14 - Risk Factors for PE
8:55 - Signs & Symptoms ft. ECGs
12:15 - Investigations
21:49 - Vibe Augmenting - Decision Scores
25:59 - Brief Recap
26:44 - Treatment
39:15 - Pregnancy
44:35 - Take Homes

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 64 - Never Skip Leg Day | Lower and Upper Limb Venous Thromboembolism14 Oct 202500:47:36

Calves, thighs, arms and more, 
Clots can form inside them all!


Join your hosts Cale, Bashar and Nick as they take a deep (hah) dive into the nitty-gritty things you should know about managing DVTs of the extremities

TIMESTAMPS

0:54 - Intro to Extremity Clots
3:49 - Veins of the Lower Limb
5:54 - History & Exam Lower Limb
10:54 - Phlegmasias
15:52 - Investigations
21:27 - Below Knee DVTs
26:41 - Proximal Lower Limb
29:40 - May-Thurner
33:04 - PTS
34:33 - Upper Limb
41:15 - How long to anticoagulate?
45:28 - Take Homes

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 63 - Virchow’s Revenge | Introduction to Venous Thromboembolism07 Oct 202500:41:03

Rudolf the red nosed physician
Wrote a very cool triad
And if you ever saw it
you would even say ‘Egad!’

All of the other physicians
used to laugh and call him dumb
They never let poor Rudolf 
join in the MDT fun

Then one foggy clinic day
a patient came to say
 “Rudolf with your triad so smart
won’t you describe to me the pathophysiology of clotting in a way that both makes sense and fits inside the metre of this children's song”

But he couldn’t, so welcome back to our next batch of episodes on the pod as we tackle the wonderful world of venous thromboembolism. How do I ask a patient about clots? Is a provoked thromboembolism when you call it names? Join Nick, Cale and Bashar jumping into the wild world of clots...

TIMESTAMPS

0:58 - Episode Intro
2:51 - Crafting a Clot Redux - Haemostasis
7:21 - Turbo Coag Cascade
8:34 - Thrombosis History
12:17 - Why we bother with history
16:39 - Risk factors for VTE
21:41 - Major vs Minor risk factors
23:54 - Thinking about risk factors
26:04 - The Thrombosis History
32:53 - Management Overview
37:40 - Summary and Takehomes

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 62 - The Man in the High (Lymph Node) Castle | Castleman Disease30 Sep 202500:39:51

Philip K. Dick once wrote, “Perhaps if you know you are insane then you are not insane. Or you are becoming sane, finally. Waking up.” Waking up, that is, not to the alternative history universe where the Axis won WWII but rather, to a new bonus episode on Castleman disease! Join Cale, Bashar and Nick as we explore one of Haem’s most zebra diagnoses, and do whatever we can to put off Nick’s clot season for just a bit longer.

TIMESTAMPS:

00:53 - Holiday to Bavaria
04:12 - Basics of Castleman Disease
07:41 - Histological Subtypes
10:57 - Clinical Subtypes - Unicentric
13:05 - Clinical Subtypes - Multicentric
16:08 - Brief Recap
18:00 - Pathophysiology of Castleman
21:38 - Historical Diversions
23:54 - Investigations
25:30 - Treatment - UCD
26:44 - Treatment - MCD
31:02 - Rarer than a Zebra (POEMS/TAFRO)
37:23 - Summary and Takehomes


Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 61 - On The Wards: BiTE Me and other T Cell Tasty Treats16 Sep 202500:53:12

Have you stumbled onto the haematology ward only to discover patients on bizarrely named BiTE & CART therapy? Why are we giving patients CARTs? Do they come with a horse?  Why does everyone freak out when these patients are febrile? Why is everyone so hung up about handwriting? What are these weird drugs? 

It's OK – we are here once more to demystify the acronyms – and help you know what we are giving, why we are giving it and how to manage complications of Bi-Specific and CAR-T therapy! 

TIMESTAMPS

3:48 - Intro to BiTEs  
5:26 - Intro to CAR-T  
8:27 - Examples of BiTEs  
16:36 - CAR-T Collection + Production  
18:44 - Examples of CAR-T Products  
19:35 - Similarities and Differences between BiTEs and CAR-T  
23:24 - Cytokine Release Syndrome (CRS)  
30:23 - Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS)  
39:29 - Treatments for CRS  
45:52 - Treatments for ICANS  
50:01 - Take Home Messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 60 - Twenty Pages About Basophils | Approach to Basophilia02 Sep 202500:26:15

Bamboozled by basophils bountiful booty of granules? Let’s begin brilliantly with a basophil based bonanza. Buckets and buckets of brazenly basophil related bonus banter. You beauty! But, beware the bawdy, boisterous boys babbling brobdignagian-ly about BASOPHILS. It sounds better if you read it in Hugo Weaving’s voice and it’s the 5th of November I swear. 

TIMESTAMPS

3:07 - What are basophils?  
6:54 - Snapping turtle trivia  
7:55 - Role of basophils  
9:42 - Basopenia  
10:41 - Cutoffs (arbitrary as usual)  
11:14 - Artefactual basophilia  
12:29 - Reactive basophilia  
14:27 - Haem Causes = MPNs Galore  
16:14 - CML (Again)  
19:17 - Zebras have hoofbeats too  
23:20 - Take Home Messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 59 - A Bad (eosino-)Feeling | Approach to Eosinophilia26 Aug 202500:31:26

The mighty eosinophil had triumphed. The last parasitic worm lay vanquished beneath his granule-studded pseudopodia. For years, he’d battled helminthic scourge, a hero in mucus armor. But now, with no foes left to smite, he grew restless. He turned his sharp gaze to pollen, peanuts, and pet dander. "Troublemakers," he muttered, unsheathing his cytotoxic arsenal. With righteous zeal, he charged into the sinuses and skin, sparking sneezes and wheals in his wake. “A threat is a threat,” he declared, as a baffled immunoregulatory system looked on. The worms were gone - but the war had only just begun. With more excerpts leaking from the Bloody Minded Cinematic Universe, it’s only a matter of time until our movie deal.

TIMESTAMPS

2:48 - What are eosinophils?  
4:44 - Cutoffs (arbitrary as usual)  
7:12 - The Problem with Eosinophilia  
8:32 - Infective causes  
9:32 - Medications  
10:36 - Other Secondary Causes  
12:32 - Haem Causes - CML and More  
18:08 - Quick Recap  
19:49 - Approach to eosinophilia  
24:31 - Treatment options  
25:52 - Case Study - Not Geraldine, I Promise  
28:52 - Take Home Messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 58 - Not even my final form | Approach to Monocytes19 Aug 202500:24:33

Put on your monocles and kimonos and hop on the monorail to our episode composed of monotonous monologues, monogamously dedicated to that most monolithic and sometimes monoclonal of mononucleated cells. We are monobviously talking about the monocyte. 

TIMESTAMPS

0:57 - Mono-Cyte!  
2:50 - What is a monocyte?  
4:20 - Monocyte subclasses  
6:00 - Role of monocytes  
8:10 - Causes of Monocytopenia  
9:43 - Hairy cell leukaemia  
12:42 - Reactive monocytosis  
15:10 - CMML - Not a Typo  
22:20 - Take Home Messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 57 - Running on Fumes | Approach to Pancytopenia12 Aug 202500:47:46

Behold the field in which I grow my cells and see that it is barren. It’s out of the frying pan and into the aplastic fire with not a cell in sight. Join Nick, Cale and Bashar without two neutrophils to rub together as we talk about an approach to that most concerning of FBC features - pancytopenia. 

TIMESTAMPS

2:22 - Definition of pancytopenia  
4:23 - Spurious pancytopenia  
6:04 - Cutoffs (arbitrary as usual)  
9:43 - Acquired aplastic anaemia  
15:30 - Inherited bone marrow failure syndromes  
18:52 - Environmental toxins  
19:47 - Medications  
20:52 - Haematinic deficiencies  
25:59 - MDS/Leukaemias  
30:54 - Marrow suppression  
33:32 - Infiltrative causes  
36:45 - Viral causes  
38:05 - Approach to pancytopenia  
39:06 - History  
40:12 - Examination  
41:13 - Investigations  
42:27 - Liver failure  
44:30 - Take Home Messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode 56 - Lymph and Let Die | Approach to Lymphocytosis05 Aug 202500:43:29

Once again the Bloody Minded Crew have ventured out of the lab to find and trap another haematology registrar from the wards and convince them to come back to the show and talk about cells. Join haematology registrar Dr Lise Kempler as she teaches the team about what to do when that lymphocyte number just creeps up and up and up. 

TIMESTAMPS

2:34 - Aspiring to be a lymphocyte  
5:44 - What are lymphocytes?  
9:52 - Cutoffs (arbitrary as usual)  
13:09 - Infective causes  
15:21 - Morphological clues  
17:23 - Investigations for infectious causes  
17:54 - Flow cytometry  
22:33 - Clues for Badness  
23:34 - Case Studies  
36:18 - T-LPDs  
38:10 - ALL Out of Nowhere  
40:54 - Take Home Messages  

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

© My Podcast Data · Independent project · Data from Apple & Spotify