Dr Aengus Tran is the CEO of Harrison.ai — an Australian radiology AI startup who have raised $160M.

Harrison.ai just released their radiology foundation model, Harrison.rad.1. And it's really good.

0:00 Intro

2:25 I'm glad I didn't found my startup in the US

4:21 Partnering with a clinical operator is key

7:28 Scrappy stories from the early days

11:17 Where human radiologists outperform AI (zero-shot learning)

17:23 Big bets on the future of radiology

21:18 What happens when GPT-8 arrives?

25:29 How can AI reach suprahuman radiology performance?

28:58 What boss moves did you make?

Links

Harrison.ai: ⁠https://harrison.ai⁠

Dr Mustafa Sultan: ⁠https://www.musty.io⁠

Michael Meucci (CEO) transformed Arcadia — formerly a mid-sized consultancy into a healthcare platform with $100M of Annual Recurring Revenue. How?

Lots of smart moves, including becoming really good at enterprise healthcare selling. Here's how he did it.

Links

Arcadia: https://arcadia.io/

Dr Mustafa Sultan: https://www.musty.io/

Dr Jared Dashevsky writes Healthcare Huddle (acquired by Workweek). He's scaled to over 30,000 subscribers. And it was pretty simple.

Here are 12 frameworks that work for healthcare content creation (and mistakes to avoid).

0:00 Intro

1:14 Consistency is king; systematise it

7:40 McKinsey reverse pyramid principle for writing

9:10 You need to have a unique/controversial take

11:41 Content for network building

15:51 Lean startup thinking does not work for content

20:35 Nobody cares about errors

25:52 Injecting personality is a competitive advantage

29:32 Boring content will make you rich

34:13 Don't make a useless audience; acquire data

41:19 Lessons from Jerry Springer

45:18 Hyperoptimisation paradox

48:49 Do things that don't scale

Links

Healthcare Huddle: https://workweek.com/brand/healthcare-huddle/ Dr Jared Dashevsky: https://twitter.com/jareddashevsky Dr Mustafa Sultan: https://www.musty.io/

What's the difference between UK and US medical training?

Dr Ikram Haq trained at Imperial College Medical School, interning at McKinsey before starting training at the Mayo Clinic in the US — considered one of the best hospitals in the world.

We talk about the difference between US and UK medical training, how Ikram got to where he is — covering both the high level philosophies and granular details — as well as how he deals with failure.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Can you automate therapy?

Ross Harper studied both Neuroscience (Cambridge) and Mathematical Modelling (UCL) — combining the two into his lovechild: Limbic — an AI therapy assistant.

We talk about the challenges of working in mental health, different business models in the area and how Ross sold his face to pay off his uni debt.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you make good decisions in health leadership?

Professor Sam Shah is founder of the Faculty of Digital Health, Chief Medical Strategy Officer at Numan and former Director of Digital Development at NHS X.

He has extensive experience in consulting, health policy and healthtech. We talk about good decision making in health leadership roles, how to make clinicians digitally proficient, and some of his failures along the way. I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How can you extend life?

Professor Tom Kirkwood is Emeritus Professor at Newcastle University where he headed the Institute for Ageing and Health. He delivered the famous Reith Lectures and was awarded a CBE in 2009.

Perhaps most famously he put forward the ‘Disposable Soma Hypothesis’ — which postulates that the body has a limited budget of resources and energy. It must therefore make a compromise between living longer (longevity) and activities which will help it reproduce.

Interestingly, he also invented the INR in the 80s, which is a blood test used everyday by doctors to measure the clotting of a patient’s blood.

We talk about the disposable soma theory, how calorie restriction may extend lifespan, anti-ageing interventions which Prof Kirkwood finds interesting and how you would design a trial to show the efficacy of an anti ageing drug.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What are the pros and cons of VC funding as a doctorpreneur?

Dr Fiona Pathiraja was a Consultant Radiologist at UCLH and is now Founder and Managing Director of Crista Galli Ventures — a pan-European healthtech fund. She also holds an MBA and an MPH.

We dive into her story, Venture Capital and she gives loads of valuable advice for doctorpreneurs. 

I hope you enjoy.

Crista Galli Ventures: https://www.cristagalli.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

So it's your first day as Health Secretary — what do you do!?

Richard Sloggett was former Special Advisor to the Health Secretary (Matt Hancock) during which he worked across public health, the NHS and social care. He’s also Senior Fellow at the think tank Policy Exchange and has been named one of the 100 most influential people in healthcare policy by the Health Service Journal.

Richard has also recently founded a global healthcare policy research centre: Future Health. The Centre is researching health and economic opportunities in building more resilient and preventative healthcare systems enabled by new technologies: https://www.futurehealth-research.com

We talk about whether healthcare is as unique as medics like to think, Richard’s learnings from his time as special advisor and his specific recommendations for getting clued up on health policy.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How can we use models to diagnose patients with rare diseases earlier?

Rudy Benfredj is Co-founder and CEO of Mendelian; who are helping doctors find and diagnose rare disease patients earlier.

Rare diseases are individually rare, but collectively quite common — they affect 1 in 17 people. With 8000+ rare diseases and some only affecting a handful of people across the globe — rare diseases take an average of 7 years to diagnose — which is dubbed the diagnostic odyssey.

Rudy is super interesting and I pick his brain about how artificial intelligence can be used help reduce the diagnostic odyssey in rare diseases. I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Professor Karl Friston is the most frequently cited neuroscientist in the world. Some of his most fascinating ideas centre around brain imaging, and of course, his infamous free energy principle — a grand unifying principle for cognitive science and biology.

Professor Friston is incredibly insightful and patient with my questions — which at times feel like a 5 year old playing with a grand chess master. We speak about consciousness, brain computer interfaces as well as Professor Friston’s story and advice for young academics. I try to deconstruct some of what his enabled him to put forward so many novel, impactful ideas.

I hope you enjoy.

I recommend listening to Lex Fridman’s interview of Professor Friston. Lex asks much more intelligent questions: https://lexfridman.com/karl-friston/

Secondly there’s a wonderful Wired article written by Shaun Raviv which you won’t be able to put down: https://www.wired.com/story/karl-friston-free-energy-principle-artificial-intelligence/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What can you learn from studying the brains of London cabbies?

Hugo Spiers is Professor of Cognitive Neuroscience at UCL. He studies how we remember, navigate and imagine space.

Some of his most interesting work has examined the brains of London cabbies who are required to learn the roads of London in painstaking detail. Now he leads the SeaHeroQuest project, in which his team are studying dementia using a mobile game.

We talk about his research — which in my opinion is fascinating but I delve a bit deeper — asking how ordinary people can themselves do fascinating research and not get stuck on mind numbingly boring projects. We speak about how he manages his time, how he sees work, mentorship and how he communicates and publicises his research so effectively.

I hope you enjoy.

Professor Spier's fiction book recommendation: Book of the New Sun by Gene Wolfe.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Do you need to be a d**k to be a good leader? Here's what Dr Nadine said...

Dr Nadine Hachach-Haram BEM is a plastic surgeon and CEO of Proximie — an augmented reality platform for virtual surgical collaboration. Rather than telemedicine it’s about telepresence. It means that a surgeon in the UK could open up their web browser, and see what another surgeon across the world is doing in real time and collaborate.

Proximie has had incredible impact: it’s helped people in need across the world access surgical care, it’s been used by NHS surgeons who are self-isolating due to coronavirus and it’s also being used by the RAF.

Dr Nadine received the British Empire Medal in the 2018 Queen’s Birthday Honours for her innovation in surgery.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Despite $billions of investment into the sector — there are still no AI discovered drugs on the market. Why? Recursion Pharmaceuticals (NASDAQ: RXRX) is one of the hottest AI drug discovery companies on the market. Especially after NVIDIA's $50M investment into them. Dr Imran Haque (SVP of AI and Digital Sciences) explains why AI drug discovery is so tricky — and when it's arriving. 0:00 Intro 0:42 Decoding biology (the big idea) 2:18 Why is AI drug discovery harder than it looks? 4:48 Simulating the Sims (game) vs AI drug discovery 6:58 Building data for AI drug discovery 14:47 Recursion's successes and failures 24:22 The barriers to AI drug discovery 26:45 How optimistic should we be about AI drug discovery 35:26 Being aggressively generalist for success People Dr Imran Haque: https://www.recursion.com/team-members/imran-haque Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Mustafa Sultan: https://www.musty.io/

Do you need to be a d**k to be a good leader? Here's what Dr Eric Topol said...

Dr Eric Topol is in the top 10 most cited doctors in the history of Medicine. He is a cardiologist, geneticist and digital medicine expert — and was commissioned by the UK’s Health Secretary to write a report to prepare the NHS for the digital future: The Topol Review.

Dr Topol has three best selling books on the future of Medicine: the Creative Destruction of Medicine, The Patient Will See you Now and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. 

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Look around and you’ll be surrounded by let’s face it... d**ks. Not just in politics and business — but also in Medicine.

We’re taught lots about the multidisciplinary team and how important each member is — but that’s not always the experience in the real world. What I really want to know is: Do you need to be a d**k to be a good leader?

And not just the knee jerk response of: "of course not". I want to know the ins and outs, and maybe — if sometimes it’s useful to be a bit brash or abrasive — and not always be everyone’s best friend

So I’m on a mission to ask this question to all the people I admire in Medicine. Whether that’s clinicians, academics, policymakers or people in business. People of all backgrounds, races, genders etc. It should be really interesting.

I hope you enjoy the series — and as always reviews on iTunes are worth their weight in gold.

Inspired by Max Joseph's excellent short film: https://www.youtube.com/watch?v=gRRvjZ_XNog

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Why switch from Investment Banking to Medicine?

Dr Yusef Smith is a doctor, competitive gymnast and powerlifter. In a previous life, he was an investment banker before packing it in and training in Medicine. Whilst at Medical School he started Propane Fitness — the passive income from which has now overtaken his salary as a doctor.

Yusef is a friend and one of the most contemplative people I know. We talk about passive income, physical and mental health, tools for productivity and why Yusef went on a 10 day silent meditation retreat.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Stephen Bourke is the co-founder of Echo; the online pharmacy. If you haven’t heard of Echo, it’s a bit like Deliveroo for your medication. It delivers repeat prescriptions to your door, free of charge and hassle-free. It was acquired by McKesson, the group who own Lloyds Pharmacy in 2019.

This is a really valuable conversation and Stephen is hilarious, honest and gives a tasty inside scoop into the world of online pharmacy. We talk about how to improve patient adherence, how Echo rose to the top despite not being the first company of its kind by a long shot, Stephen’s experience of making something cool but also accessible and how sometimes — you need to listen to all your friend’s advice, nod your head — and then ignore it all to take a big leap.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Sir Bruce Keogh was National Medical Director for over a decade — leading clinical policy and strategy as well as being responsible for clinical leadership, quality and innovation. Sir Bruce was a celebrated cardiac surgeon prior to this, and during his tenure as Medical Director — he was most notably responsible for making clinical outcomes the currency of the NHS.

He has been declared the most influential clinician in the NHS by the Health Service Journal for three years and was appointed Knight Commander of the Order of the British Empire in 2003.

Honestly, I was nervous about speaking to someone of Sir Bruce’s stature. Fortunately, he is one of the kindest people I’ve interviewed — and I’m really happy to have captured his leadership philosophy, how he made decisions and decided what was important as Medical Director, and his life advice for medics with similar aspirations.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How does a doctor start working for DeepMind/Google? 🤖 

Joe Ledsam is a Clinician Scientist at Google Japan after formerly working at DeepMind. He started his career off as a doctor, before migrating to research and eventually coming to his current position.

He’s worked on some of the most influential medical deep learning papers to date — published in the likes of Nature. For many nerds in Medicine — he’s living the dream. He was recommended to me by Pearse Keane who I spoke to on episode #10, who described him as simply exceptional.

We talk about how Joe started working for DeepMind and then Google, how he actively seeks out fields he’s uncomfortable with, how the Simpsons influenced his life philosophy, why he wakes up at 2am and what he believes — are the dark horses in this field.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Simon Eccles is the Chief Clinical Information Officer for Health and Care and Deputy CEO of NHS X. Amongst many responsibilities, he’s accountable for delivery of the Personal Health and Care 2020 programme, and the central expenditure for the NHS’s IT.

Whilst doing all of this, he also practices one day a week as a Consultant in Emergency Medicine.

He’s funny, he’s opinionated, he has a strong vision and he gives wonderful insight into what it’s like as a doctor policymaker. He talks about what he’s learned along the way, electronic health records, his views on blockchain and what he took away from his time at Saïd Business School at the University of Oxford.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Why should doctors learn how to code?

Josh is really cool. He’s an Australian doctor on a big mission — to empower medics with code.

Josh recently released Code Blue: An Introduction to Programming for Doctors. I highly, highly recommend picking this up for a 0–100 guide on coding for medics: https://gum.co/NMtSD 

We talk about why you should learn how to code as a medic — but then I push back and challenge Josh — I ask him why you should bother learning how to code when a) no doctor I’ve spoken to in MedTech actually codes much themselves and b) when today, there are so many good no-code solutions out there

Finally Josh explains how to start coding for two very different types of medics:

Firstly, the hustler, the entrepreneur, the person who doesn’t care about the tools or computers — they just want to build their next startup.

Secondly, he explains the path for the academic, who wants to understand the nuts and bolts, build their own models, publish papers and work with companies like DeepMind/Google Health.

I hope you enjoy.

Find Josh

Twitter: @_JoshCase https://twitter.com/_JoshCase

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Where are the dark horses in medical AI? 🐴 

Professor Geraint Rees is the Dean of the Faculty of Life Sciences at UCL, Pro-Vice-Provost of AI and is also the director of UCL Business — its technology transfer arm. His research is primarily in cognitive neuroscience and he has been cited over 35,000 times with a h index of 93.

He sits at the intersection of academia, technology and business — so he has a really rich, birds eye perspective on MedTech.

I asked him which areas of AI in Medicine don’t get enough attention, the role of private companies in research and whether you need to work disproportionately hard to reach the upper echelons of a field.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Do we want a Silicon Valley for healthcare?

Professor Tony Young is the National Clinical Director for Innovation at NHS England, co-founder of the UK’s £500M MedTech Campus, founder of the NHS Clinical Entrepreneur Programme and a consultant urological surgeon. Tony was awarded an OBE for services to clinical leadership in the 2019 New Year Honours List.

Tony has recently opened applications for the NHS Clinical Entrepreneur programme. Apply here: https://www.england.nhs.uk/aac/what-we-do/how-can-the-aac-help-me/clinical-entrepreneur-training-programme/

This is a really fun conversation — we cover Tony’s story, how and if the UK can make a Silicon Valley for healthcare and how to be charismatic.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 NVIDIA's $50M investment into Recursion Pharmaceuticals 2:28 NVIDIA is becoming a seed investor 3:45 Bull case for Recursion Pharmaceuticals 9:20 Recursion's two big acquisitions 13:05 How are Recursion going to make money? 14:15 Recursion is overhyped 19:45 Recursion is unprofitable 22:21 Kim Kardashian's full body MRI scan 26:03 Longevity doctor's advice to Kim K 31:49 Speculating on Kim K's longevity regime (what she takes) 35:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

A paper published in the Lancet Digital Health found that less than 1% of clinical AI studies reviewed were of sufficient quality to have confidence in their results. This is a huge problem.

Dr Xiao Liu and Professor Alastair Denniston are part of the team who published that study — and to tackle this this problem — they have today published the first international standards for the reporting of clinical AI trials. These are called SPIRIT-AI and CONSORT-AI and have today been published in Nature Medicine, the Lancet Digital Health and the BMJ.

The goal of these guidelines is to improve the quality of clinical AI studies and increase their transparency.

We talk about the general quality problem in clinical AI research, we talk about their guidelines and some of the recommendations within them — and also about what the future of clinical AI validation looks like.

Papers

Nature Medicine

CONSORT-AI: https://doi.org/10.1038/s41591-020-1034-x

SPIRIT-AI: https://doi.org/10.1038/s41591-020-1037-7

The Lancet Digital Health

CONSORT-AI: http://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30218-1/fulltext

SPIRIT-AI: http://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30219-3/fulltext

BMJ

CONSORT-AI: https://www.bmj.com/content/370/bmj.m3164

SPIRIT-AI: https://www.bmj.com/content/370/bmj.m3210

What's it like running a company which has raised $90M?

Dr Ben Maruthappu is the co-founder and CEO of Cera Care — a technology enabled home care company.

I could speak about Ben’s achievements and accolades for hours, but to give you a whistle stop tour — he is a successful doctorpreneur, has published some very influential papers, and has worked in health policy — perhaps most notably — he was an advisor to Simon Stevens (CEO of NHS England).

Ben was awarded an MBE for services to Health and Care technology in the 2020 Queen’s New Year Honours List.

We talk about how Ben got to where he is along with what he learned at every step. We also dive quite deep into what it’s actually like to be CEO of such a large company. This is one of my favourite interviews — because Ben is incredibly candid and gives lots of useful advice. I hope you enjoy.

Find Ben

LinkedIn: https://www.linkedin.com/in/mahibenmaruthappu/

Cera Care: https://ceracare.co.uk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Do you need to be a silverback gorilla to be a good leader? 🦍 

Professor David Lomas is the Vice Provost (Health) at University College London and Head of UCL Medical School. He is also a hugely accomplished academic with his most notable work focusing on alpha-1 antitrypsin deficiency. He has a h-index of 95.

We talk about lots of things — like the future of medical education,  what makes a good leader and how to make good decisions.

Find Prof David Lomas

UCL: https://iris.ucl.ac.uk/iris/browse/profile?upi=DALOM96

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Do you want the granular step-by-step on how to launch your own MedTech startup?

Dr Krishan Ramdoo was an ENT Surgeon before co-founding TympaHealth; the world’s first all in one hearing health assessment system.

It’s essentially a digital otoscope (a scope that helps visualise inside the ear). Traditionally this was an analogue device, so no one else could see what you saw when you examined the ear — but with the Tympahealth system, you can see what the scope is looking at on your phone screen and then save that video to the patient’s records.

Unlike other similar devices, you can also use it to remove ear wax. It was the winner of the global UX design award and it’s seriously beautiful. You can go to tympahealth.com to see what it looks like.

TympaHealth have been very active in the battle against COVID, and the system has been trialled in the UCLH Trust in the country’s first tele-otology service.

This conversation is basically a deep dive into how Krishan has achieved what he has with TympaHealth. How he went from an idea in his head to his device being used by 1000s of patients as well as by Boots Hearing Care.

He’s a masterful storyteller — I hope you enjoy.

Find Krishan

TympaHealth: https://www.tympahealth.com

Krishan: https://www.linkedin.com/in/krishan-ramdoo-10086979/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What does the future radiologist look like? What does everyone get wrong when regulating their AI startup?

Dr Hugh Harvey trained as a consultant radiologist and is now the managing director of Hardian Health; a health-tech consultancy firm.

He has had an incredible career, sitting at the interface of Medicine and technology. He was headhunted by Dr Eric Topol to co-chair the Topol Review, he sits on the board of Nature Digital Medicine and was formerly head of regulatory affairs at Babylon Health.

He has twice been awarded science writer of the year by the Institute of Cancer Research in London and you can find him on Twitter @DrHughHarvey, where he candidly shares his thoughts on medical AI and clinical validation amongst other things. Seriously, I recommend following him.

Essentially he understands the worlds of AI, Medicine, business as well as regulation and validation. This is a really interesting conversation — hope you enjoy.

Find Hugh

Twitter: https://twitter.com/DrHughHarvey

Hardian Health: https://hardianhealth.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

You're an average medical student with no connections — how do you get published!?

*Congratulations to Azeem who was awarded the British Empire Medal for services to Medical Education during COVID-19*

Dr Azeem Alam completed his surgical AFP training in London and is the co-founder of BiteMedicine — the medical knowledge platform. He shares his step-by-step framework on getting published without a leg up.

Find Azeem

BiteMedicine: https://www.bitemedicine.com

LinkedIn: https://www.linkedin.com/in/azeemalam/

Music: https://www.youtube.com/watch?v=9Ngjub5Ntqk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How can a surgeon assist in an operation across the world — using their web browser?

Dr Nadine Hachach-Haram BEM is a plastic surgeon and CEO of Proximie — an augmented reality platform for virtual surgical collaboration. Rather than telemedicine it’s about telepresence. It means that a surgeon in the UK could open up their web browser, and see what another surgeon across the world is doing in real time and collaborate.

Proximie has had incredible impact: it’s helped people in need across the world access surgical care, it’s been used by NHS surgeons who are self-isolating due to coronavirus and it’s also being used by the RAF.

Dr Nadine received the British Empire Medal in the 2018 Queen’s Birthday Honours for her innovation in surgery

This is a really cool interview: we start off by talking about augmented reality in surgery before moving onto Dr Nadine’s transition from a plastic surgeon to a CEO, some business strategy and finally her advice for fledgling doctorpreneurs.

Find Dr Nadine:

Twitter: https://twitter.com/DrNadz

Proximie: https://www.proximie.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How could better understanding your internal state improve your mental health?

Dr David Plans is a lecturer in Organisational Neuroscience and CEO of BioBeats; a company on a mission to free people from mental suffering. He’s completing his second PhD in Experimental Psychology at the University of Oxford and has raised over $6M to turn his academic research into a bustling company.

This is a really interesting conversation in which I’m completely out of my depth. We start by discussing David’s story and his view of hustle culture and how enhancing peoples’ interoception (which is loosely defined as understanding the internal state of your body) could improve their mental health.

Thank you to Elise Plans for the music you hear.

Find Dr David Plans

BioBeats: https://biobeats.com

David's Personal Website: http://www.davidplans.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Professor Shafi Ahmed is the world’s most watched surgeon. 

He has live-streamed operations using Google Glass, the Snapchat Spectacles — and even virtual reality technology. He’s really at the cutting edge of surgical innovation so it was a real privilege to speak to him.

He is the co-founder of Medical Realities; a company which specialises in surgical VR and AR tech. He has spoken at Wired Health, TEDx — he leads charity work in his native Bangladesh, he’s setting up a hospital of the future in Bolivia.

He has consulted for Google, PwC, Roche — he has advised the NHS on the Long Term Plan and was awarded the Future NHS Award by members of Parliament in 2018.

Find Professor Shafi Ahmed

Website: https://surgeon.ai

Twitter: https://twitter.com/ShafiAhmed5

Wired Health Talk: https://www.youtube.com/watch?v=vftA-_c1hYc

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you enact systems-level change within the NHS?

Dr Owain Hughes was an ENT registrar before he decided to do something bold: fix NHS referrals. But systems-level solutions aren't as simple as just making an app... here's how Cinapsis did it.

Find Dr Owain Hughes:

Cinapsis: https://www.cinapsis.org

Twitter: https://www.linkedin.com/in/owainrhyshughes

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Ever waited months for a scan? Scan.com is making getting a scan as easy as booking an Uber. Behind the scenes of the disruptor changing medical imaging forever. 0:00 Race to the bottom? 1:34 AirBnB 11 star framework 9:57 Scan.com looks really easy to build — what's hard about it? 12:19 Lessons from working at Deliveroo 15:14 How do you make a lot of money? 19:41 Buying the domain name Scan.com 24:16 How to build a marketplace business 27:50 The perils of price transparency 30:36 What I would do to build a competitor 32:43 You need grit when building a health startup 35:46 Billion $ health ideas Podcast Links YouTube: https://www.youtube.com/channel/UCEzluDRmBTVby0WsO37V-xg Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Mustafa Sultan: https://www.musty.io/ Charlie Bullock: https://scan.com/

What would you be working on if you were a medical student today?

Dr Eric Topol is in the top 10 most cited doctors in the history of Medicine. He is a cardiologist, geneticist and digital medicine expert — and was commissioned by the UK’s Health Secretary to write a report to prepare the NHS for the digital future: The Topol Review.

Dr Topol has three best selling books on the future of Medicine: the Creative Destruction of Medicine, The Patient Will See you Now and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. This conversation was a lot of fun — hope you enjoy.

Find Dr Eric Topol:

Twitter: https://twitter.com/EricTopol

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you forge your own career path as a doctor?

Dr James Somauroo is a former anaesthetics/ICU doctor and the founder of the healthtech agency: somX. He writes for Forbes and is also the host of the Health-tech podcast — the biggest podcast in this space with listeners in over 100 countries.

Find Dr James Somauroo:

LinkedIn: https://www.linkedin.com/in/james-somauroo/

The Health-tech Podcast: https://podcasts.apple.com/gb/podcast/the-health-tech-podcast/id1438968893

somX: https://somx.co.uk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How did a Paediatrician become the Managing Director of NHS Services at Babylon Health? 

We talk about Umang's advice for medics entering the business world, how to keep your clinical job, Babylon's validation and some incredible advice on crafting your own story.

——————

Find Dr Umang Patel:

LinkedIn: https://www.linkedin.com/in/drumangpatel/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you achieve peak performance as a medical student, doctor or clinical academic?

Professor Neil Sebire works at the Great Ormond Street Hospital in London — the country's leading childrens' research hospital. He's published over 700 peer reviewed papers, has a h-index of 88 and 32,000+ citations. Here's everything he's learnt along the way.

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Find Professor Sebire:

LinkedIn: https://www.linkedin.com/in/neil-sebire-64780435/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Cellen is bringing medical cannabis to UK patients. I spoke to Dr Benjamin Viaris de Lesegno who is a French-trained NHS doctor as well as the co-founder and CMO of Cellen.

The first half of this conversation covers the landscape of medical cannabis in the UK and its clinical need. We then talk about Benjamin's advice for fellow doctorpreneurs — and why 45 might be the best age to found your startup.

Harvard Business Review article mentioned: https://hbr.org/2018/07/research-the-average-age-of-a-successful-startup-founder-is-45

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Find Benjamin:

Cellen: https://www.cellenhealth.com

LinkedIn: https://www.linkedin.com/in/benjamin-viaris-de-lesegno-52833161/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you run a successful startup and code academy — all whilst completing your final year at Imperial College Medical School?

Harvinder Power is the co-founder and CEO of Motics — a company which brings physiotherapy into the digital era. He was the winner at the Kickstart Global Incubator, the McKinsey Venture Academy, the UCL VC Fund amongst many other accolades.

In this conversation, I tease out the trials and tribulations of a medical student entrepreneur. We talk about how he started Motics, how you convince patients to do something they're not doing and what medics can learn from engineers and marketers.

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Find Harvinder:

LinkedIn: https://www.linkedin.com/in/harvinder-power-70800b124/

Motics: https://www.motics.co.uk

CodeMD: https://www.codemd.co.uk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Ali has reached medic nirvana. He has over 770,000 YouTube subscribers, a successful business (6med), one of my favourite podcasts (Not Overthinking It) and is an all round wise man. He's managed to diversify so that Medicine is not his livelihood — it's a hobby he can approach on his own terms.

His content started with advice for prospective and fledgling medical students — although he has now expanded into tech, productivity and entrepreneurship. You're going to love this episode if you're a wannabe creative, entrepreneur or want to get out of Medicine's rat race and play your own game.

I've been chasing Ali for a long time because I knew he would provide so much value. He doesn't disappoint.

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Find Ali

Website/Newsletter: https://aliabdaal.com

YouTube: https://www.youtube.com/user/Sepharoth64/videos

Not Overthinking It Podcast: https://www.notoverthinking.com

Instagram: @AliAbdaal // Twitter @AliAbdaal

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you convert an idea in medical school into a company that just raised $11M and has over 1 million users?

Sarim, Yusuf and Maroof were three medical students at Imperial College London. They wanted to help people quit smoking  by delivering gold-standard addiction therapy digitally.

Fast forward to today and they’ve expanded across the Atlantic and have over 1 million users, as well as becoming a multi addiction platform tackling smoking, alcohol and opioid addiction.

We talk about Sarim's story, how to bring an idea into fruition and his advice for entrepreneurial medics. 

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Find Sarim

LinkedIn: https://www.linkedin.com/in/sarim-siddiqui-64b4b8103/

QuitGenius: https://www.quitgenius.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What's management consulting really like (all expensed trips to Vegas)!? How do you get your digital health solution into the NHS? And why do so many world-class performers have a performance/executive coach? This week's episode was a lot of fun, and you're going to love it if you want to hear advice from a super accomplished doctorpreneur.

Dr Charlotte Lee is the UK director at Big Health, who generate $10M in revenue and are helping millions achieve good mental health — digitally. They have 12 RCTs under their belt, and are most famous for Sleepio, which digitally delivers CBT for insomnia. In a former life, Charlotte was a medical doctor, Darzi Fellow and management consultant at KPMG.

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Find Charlotte 

LinkedIn: https://www.linkedin.com/in/charlottelee/

Twitter: https://twitter.com/DrChar_Lee

Big Health: https://www.bighealth.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Isn't it strange when everyone is raving about something — but you just — don't get it? That's the position Dr David Watkins (@DrMurphy11) found himself in in 2017.

Babylon had launched in the UK and promised to provide the powers of AI and telemedicine to the NHS. Babylon lets you video consult with a doctor, often on the same day. This was slightly controversial, but not compared to its other head.

Babylon had developed a sophisticated chatbot AI. After a game of 20 questions, the chatbot would suggest a diagnosis — although crucially (from a regulatory point of view) it wouldn't diagnose you.

You would then be directed (triaged) to appropriate care. Mild headache and flu-like symptoms? No problem! Stay at home and take paracetamol. One-sided weakness and slurring your words? Call 999 🚑

Dr Watkins installed the app and began testing it. The details of this testing are disputed — Babylon who refer to him as a 'troll' claim that he ran 2400 tests, Dr Watkins claims just hundreds.

More insidiously, Dr Watkins began to notice mistakes the chatbot was making — mistakes that no doctor would ever make. In one test, a 59-year old male smoker presents with central chest pain and nausea. Cookie-cutter symptoms of a heart attack, and he is duly warned.

The exact same situation but this time, the patient is a woman—

She is warned of a panic attack.

This week's podcast is the story of Dr Watkin's battle against Babylon Health.*

*Views expressed are those of Dr Watkins'*

This week's episode presents a single side of the story. For context, Babylon have done a lot of good in the world. They've brought affordable healthcare to Rwanda, created a clinical AI fellowship for doctors and generally offer lucrative remote working opportunities. 

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You can find Dr Watkins on Twitter @DrMurphy11. The title of this podcast episode is adapted from Dr Watkins' talk at the Royal Society of Medicine: "Cowboys and unicorns in #DigitalHealth — why validation is more important than valuation".

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 David Sinclair's controversial claim 1:39 Bull v bear case 6:23 David Sinclair's history of exaggerating and profiteering 8:34 Adam Neuman's involvement 11:40 Raising from unsophisticated investors 16:30 Why aren't big pharma interested in longevity? 22:45 Cynics are right, optimists get rich 25:26 Will a longevity drug be the most valuable therapeutic ever made 28:52 Feedback and outro David Sinclair's Tweet: https://twitter.com/davidasinclair/status/1679178670743732249?s=20 David Sinclair's Research Paper: https://www.aging-us.com/article/204896/text Elon Musk Tweet: https://twitter.com/davidasinclair/status/1679504700285104129?s=20 Dr Charles Brenner's Critique of Sinclair: https://twitter.com/CharlesMBrenner/status/1679213673771057152?s=20 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

How do you get into MedTech and collaborate with DeepMind/Google Health to lead world-renowned Deep Learning research? All to help stop people from going blind? 

This is 30 minutes of pure gold — Dr Pearse Keane's advice on how to get into exciting Deep Learning projects, approaches that worked for him and books he recommends.

Dr Pearse Keane is a consultant ophthalmologist and NIHR Clinician Scientist at Moorfields Eye Hospital in London. Pearse was responsible for starting the collaboration between Moorfields and DeepMind. Some of his most famous research uses deep learning to identify retinal disease from OCT scans.

Clinically applicable deep learning for diagnosis and referral in retinal disease: https://www.nature.com/articles/s41591-018-0107-6)

Ever wondered if astronauts are honest with their doctors? Or what it feels like to look out of the window at Earth?

Helen Sharman was the first British astronaut. Project Juno, was a joint Soviet-British programme which took Helen to the Mir Space Station. Helen was working as a research technologist for Mars (the confectionery company) before hearing about the opportunity on the radio.

We talked about the selection and training, what it’s like being in Space and the peculiar doctor-astronaut relationship.

What’s AI? What’s machine learning? What’s deep learning? This week’s episode is a crash course on machine learning for medics.

Dr Chris Lovejoy is a doctor, data scientist and content creator. He runs some exceptional ‘machine learning for medics’ day courses in London which is where I met him — and he also puts out loads of great content on his YouTube channel and newsletter. He also recently published a systematic review in the BMJ titled: AI Versus Clinicians: a Systematic Review.

If you’re someone who has heard of concepts in AI and machine learning, but don’t necessarily understand them — Chris is the very best person I could think of to help explain them.

I sat down with Chris to go from zero -> hero in machine learning as it relates to healthcare. Hopefully you'll get a better idea of what some of the buzzwords and key ideas are, how you can interpret a medical machine learning paper — and where you can go to keep your finger on the pulse and to learn more.

Find Chris

Website: https://chrislovejoy.me

Newsletter: https://chrislovejoy.substack.com/p/artificial-intelligence-in-drug-discovery

YouTube: https://www.youtube.com/channel/UCDoIFHMTKsgIweO-OZt1ecw

Resources and Links Mentioned

Luke Oakden-Rayner's post explaining metrics used to measure machine learning algorithm performance: https://lukeoakdenrayner.wordpress.com/2017/12/06/do-machines-actually-beat-doctors-roc-curves-and-performance-metrics/

Eric Topol: Twitter and book

Chris's BMJ Paper: https://www.bmj.com/content/368/bmj.m689

Doctor Penguin Newsletter: http://doctorpenguin.com/about

Andrew Ng's Machine Learning Course: https://www.coursera.org/learn/machine-learning

AI for Medicine Coursera: https://www.coursera.org/specializations/ai-for-medicine

Find Me

www.bigpicturemedicine.co.uk

Twitter @MustafaSultan