BEaTS Research Radio's Podcast – Details, episodes & analysis

Nicole Chu from the University of Ottawa speaks with Dr. Javed Butler. Dr. Javed Butler, MD, MPH, MBA, is the President of the Baylor Scott and White Research Institute, and Senior Vice President and Maxwell A. and Gayle H. Clampitt Endowed Chair at the Baylor Scott and White Health in Dallas, Texas. He is also the Distinguished Professor of Medicine at the University of Mississippi in Jackson, Mississippi. In this episode, Dr. Butler shares with us the major findings from the recent EMPACT-MI clinical trial and his perspective on the future of heart failure therapies. The EMPACT-MI trial investigated whether a medicine called empagliflozin, a SGLT2 inhibitor, helps to lower the risk of heart failure and death in people had experienced a heart attack (myocardial infarction). 

Learn more about the EMPACT-MI clinical trial https://www.nejm.org/doi/full/10.1056/NEJMoa2206286 

Nicole Chu from the University of Ottawa speaks with Dr. Rosalin Miles. Dr. Miles is an active community member of the Lytton First Nation and a Research Associate in the Indigenous Health and Physical Activity program at The University of British Columbia School of Kinesiology. Her research focuses on the promotion of Indigenous health and wellness and understanding the value of traditional, cultural, and historical knowledge using a strength-based approach. Dr. Miles founded the Indigenous Physical Activity and Cultural Circle (IPACC), a national non-profit for First Nations, Métis and Inuit people who are involved in Traditional Activities, Fitness, Recreation, and Sports.

Tune in to this episode to learn more about how the IPACC creates a community to promote physical activity as a way to health and wellness.

Register for the upcoming National Indigenous Physical Activity & Wellness Conference Date: May 15th & 16th, 2024

www.iactive.ca/conference/
 
Learn more: www.iactive.ca

This episode of Beats Radio, hosted by Danyaal Ansari, written by Shay Patel, produced by Hasssan Taleb, and edited by Anas Khoja, features an in-depth discussion with immunology expert Dr. Michele Ardolino from the University of Ottawa and the Ottawa Hospital Research Institute. The conversation centers around the fascinating interplay between the immune system and cancer, with a particular focus on the process of trogocytosis and its role in immune evasion by cancer cells. Dr. Ardolino elaborates on his groundbreaking research into how cancer cells transfer PD-1 to Natural Killer (NK) cells via trogocytosis, effectively inhibiting these critical components of the immune response. This detailed exploration sheds light on the sophisticated mechanisms cancer cells employ to evade immune detection and opens up discussions about potential therapeutic strategies targeting these interactions.


https://www.ohri.ca/profile/mardolino/cancer-immunology-lab

0:00 - Introduction
0:57 - Trogocytosis Explained
2:51 - Choosing Trogocytosis for PD-1 Transfer Study
5:00 - NK Cells' Functional Variability
8:10 - Immune System's Complexity & Beauty
10:50 - Rapid Fire Q&A
14:27 - Closing Remarks

Podcast by Danyaal Ansari (Host), Shay Patel (Writer), Hasssan Taleb (Producer), Anas Khoja (Editor)

Music by "Podcast Background Music"  https://www.youtube.com/watch?v=cdFqvdekuvI 

Alzheimer's is a disease unique in the lack of treatment dand diagnostic techniques aimed at mitigating it's effects.  To address these issues, researchers at Dr. Clifford Cassidy’s neuroscience lab are investigating the use of novel imaging techniques that have great potential to improve both our understanding of molecular mechanisms underlying Alzheimer’s and improve our ability to predict the development of it’s symptoms. At the heart of these new techniques is a brain structure called the locus coeruleus (LC), which is the primary site of release of a chemical called norepinephrine. It has already been established that gradual degeneration of the LC is an important feature of alzheimer’s disease. However, the contribution of this degeneration to development of disease symptoms remains poorly understood due to limitations in existing imaging techniques. To solve this issue, Dr. Casidy’s lab is investigating the use of Neuromelanin, a pigment found abundantly in the LC to more accurately detect this structure’s degeneration and its relation to Alzheimer’s and its symptoms.

Learn more: https://www.cliffordcassidy.com/

00:00 I Podcast Introduction
02:32 I Overview of the Cassidy Lab
4:24 I What is NM-MRI?
6:40 I Overview of the Paper about NM-MRI
9:40 I What is the role of neuroadronergic system in psychotic symptom progression?
12:20 I What is the broader role of NM-MRI
14:30 I Outro

Podcast by Patrick Chary(Host), Abdul Karim Halal (Producer), Elijah Van Dinther (Script), Nicholas Lafreniere (Editor).

Soundtrack by the Underground Drive, Song title: Nobody. All rights reserved.
Listen more: https://open.spotify.com/artist/4sCJG8TMQyTZ9FDd1JjJmR

Amy Stewart from the University of Ottawa speaks with Dr. Marta Cerruti, a professor in the Department of Mining and Materials Engineering at McGill University, a prominent figure in the research field of bio-synthetic materials, and the team leader of the Bio-Interface lab. As of today, Dr. Cerruti is the co-director of the McGill Institute for Advanced Materials and an associate member of the Faculty of Dentistry and the Department of Bioengineering. In the Bio Interface lab, her work centers around the incorporation of implants, tissues and drugs into the human body, as well as how minerals such as calcium and magnesium are formed in living organisms that help her address the questions of curing mineral-based diseases. Today, we'll be discussing her work centering around mineral deposits that lead to aortic valve stenosis.

Learn more: https://www.mcgill.ca/materials/marta-cerruti

0:15 l Introduction to BEaTS and Dr. Cerruti
1:25 l What is aortic valve calcification and what are the causes?
2:54 l Are there other minerals that develop in the heart?
3:45 l What are the methods used to view clacium deposits?
7:06 l Differences in calcification between men and women
12:01 l Future research
14:10 l Conclusion
14:45 l Credits

Podcast by Amy Stewart (Show Host), Shikshita Singh (Producer), Minh Tran (Writer Editor), Jade Gamelin Kao (Audio Master).

Soundtrack by Lexin_music featuring the song "sicence documentary". All rights reserved. Listen more: https://pixabay.com/music/build-up-scenes-science-documentary-169621/

Fiona Haugen of the University of Ottawa speaks with Dr. Smita Pakhale of the Ottawa Hospital Research Institute about the impact of health inequities on the development of obstructive lung diseases in urban poor populations. Dr. Pakhale is a Senior Scientist, staff respirologist at The Ottawa Hospital, and associate professor at the University of Ottawa who created The Bridge Engagement Center. The Bridge conducts research in partnership with and to improve the well-being of underserved populations in Ottawa, Ontario.

Learn more: https://bridgeengagement.ca/

00:05 | Introduction
01:10 | Overview of Dr. Pakhale's research
02:51 | The Bridge Engagement Center
03:44 | Tobacco and Ottawa's urban poor population
05:51 | Social determinants of health and lung disease
07:18 | Building trust with marginalized communities
09:15 | Unjustified exclusion of underserved communities in mainstream research 
11:22 | Addressing inequities in health and research
13:01 | How can we do our part?
14:12 | Conclusion and thanks

Podcast by Fiona Haugen (host and graphic design), Amandine Courtemanche (writer), Mairead Green (producer), Jade Poirier (audio-producer and writer)

Soundtrack by Grand_Project from Pixabay. All rights reserved. Listen more: 

https://pixabay.com/users/grand_project-19033897/?utm_source=link-attribution&utm_medium=referral&utm_campaign=music&utm_content=177572 

https://pixabay.com//?utm_source=link-attribution&utm_medium=referral&utm_campaign=music&utm_content=177572 

Nandini Biyani from the Translational and Molecular Medicine program at the University of Ottawa interviews Dr. Leila Mostaço-Guidolin, an assistant professor at Carleton University in the Department of Systems and Computer Engineering. With a focus in 3D-bioprinting, Dr. Mostaço-Guidolin leads a tissue engineering and bioimaging lab. In today's podcast, Dr. Mostaço-Guidolin dives into her research regarding the use of a microfluidic-based 3D bioprinting technology to synthesize new vasculature.            

Learn more: https://carleton.ca/mostacoguidolin/

0:28 | Topic Introduction 
0:36 | Guest introduction 
1:25 | Interest in the field of 3D bioprinting?
3:23 | Elaborating on the study 
4:51 | Specific choice of SV-ARBEC cells 
8:31 | What is microfluidic-based 3D bioprinting? 
9:56 | Limitations of the study 
12:56 | Future steps 
14:00 | Catch you later!   


This podcast was produced by Nandini Biyani (the show host), Esha Gahunia (the writer editor) & Gurrose Gahla (the audio master).                                        

Soundtrack by The Underground Drive. All rights reserved. Listen more:

https://music.apple.com/ca/artist/the-underground-drive/1571062779

https://open.spotify.com/artist/4sCJG8TMQyTZ9FDd1JjJmR

Siyona Kassel, a Translational and Molecular Medicine student at the University of Ottawa, interviews Dr. Juan Valerio Cauich-Rodriguez. Dr. Cauich-Rodriguez is a researcher at the Centro de Investigación Científica de Yucatán in Mexico, possessing a Bachelor of Science in Industrial Chemistry, a Masters in Polymer Science & Technology, and a PhD in Biomedical Materials. He is currently engaged in the development and assessment of new materials for their role in Regenerative Medicine, with a specific focus on the use of synthesized polymers. In this episode, Dr. Cauich-Rodriguez discusses his research using a unique and innovative polymer blend to advance the field of vascular grafts for medical application.

Learn more: https://www.cicy.mx/unidad-de-materiales/investigador/juan-valerio-cauich-rodriguez

0:21 I Introduction: Cardiovascular grafts
0:49 I  Intro to Dr. Juan Valerio Cauich-Rodriguez
1:29  I Dr. Cauich-Rodriguez's science background and current research
3:08  I  Polymers for biomedical applications in Mexico
4:21  I  What are polyurethanes?
6:39  I  Biomaterials as a treatment for cardiovascular disease 
8:40  I  Designing synthetic vascular grafts with polymer blends
10:40  I  Staying on top of the latest advancements in the field of regenerative materials
12:05  I  Personalized medicine and biomaterials 
13:29  I  Dr. Cauich-Rodriguez's future directions

Podcast by Siyona Kassel (Voice), Caleb Lakhani (Content Generation), Paul Nguyen (Producer and Post-Production) 

Credits for music: Soundtrack provided by the Underground Drive all rights reserved. 
Listen more: 

https://music.apple.com/ca/artist/the-underground-drive/1571062779

https://open.spotify.com/artist/4sCJG8TMQyTZ9FDd1JjJmR

Zachary Mitchell from the University of Ottawa speaks with Angelico Obille, a PhD candidate at the University of Toronto Institute of Biomedical Engineering in the Biological & Bioinspired Materials Laboratory. Tune in to learn more about their research on proteins involved in freshwater mussel adhesion and how this can be applied to develop new medical adhesive technology.

Learn more: https://www.sonelab.bme.utoronto.ca/

00:04 I Intro
01:05  I Why is it important to study freshwater mussel adhesion?
02:15  I What is a byssal proteome and what does it show us?
04:16  I What's special about the proteins of zebra mussels that allows them to stick so well to wet surfaces?
07:38  I Can you explain why you don't fully agree with considering these mussels as an invasive species?
11:52  I How have these mussels impacted our ecosystem?
13:24  I What do you think about biocontrol and do you think there is a way to live harmoniously with these animals?
14:15  I Outro

Podcast by Liliana Austin, Safa Ghaziasgar, Samarth Chauhan, and Zachary Mitchell

Soundtracks by the Underground Drive. All rights reserved. Listen more:

https://music.apple.com/ca/artist/the-underground-drive/1571062779  

https://open.spotify.com/artist/4sCJG8TMQyTZ9FDd1JjJmR   

Devin Brain from the University of Ottawa interviews Dr. May Griffith. Dr. May Griffith is a lead researcher at Université de Montreal and holds a Canada Research Chair in Biomaterials and Stem Cell Ophthalmology. She is one of the brilliant minds behind the development of LiQD Cornea, an injectable liquid that gels in the eye to help heal corneal perforations. In this episode, Dr. Griffith shares the story that inspired her to study eye conditions and shares her incredible research focused on developing a gel for corneal regeneration.


Learn more: https://www.griffithresearch.ca/may-griffith-2

0:07 | BEaTS and host introduction
0:37 | Statistical introduction to the cornea
1:01 | Introduction to Dr. May Griffith
1:40 | Dr. Griffith's story of inspiration
3:30 | What is a corneal perforation and how are they aquired?
4:25 | Addressing problems with current treatments for corneal perforations using LiQD Cornea
6:07 | LiQD Cornea administration route in relation to accessibility
8:00 | Future plans for LiQD Cornea treatment 
9:15 | What should patients expect from this treatment, short and long-term?
10:46 | Closing remarks and credits

Erica Anderson (script writing), Devin Brain (host), Rosalie Salati (audio editor), Tamara Synek (script writing).  All shared role of producer

Soundtrack by The Underground Drive. All rights reserved. Listen more:
https://music.apple.com/ca/artist/the-underground-drive/1571062779
https://open.spotify.com/artist/4sCJG8TMQyTZ9FDd1JjJmR