In this podcast, Akram Nader SalahEldeen Mustafa discusses the recently published review, ‘Guardians at the Interface: Microbiota, Intestinal Barriers, and the Gut–Liver Axis in Liver Health and Disease’. The article examines the gut-liver axis as a dynamic, bidirectional system in which alterations in the gut microbiota can impair intestinal barrier function, increase microbial translocation, and expose the liver to inflammatory signals that contribute to liver disease. The authors summarize current evidence linking gut dysbiosis, increased intestinal permeability, and microbial products to liver injury, while highlighting that many of the underlying mechanisms remain incompletely understood.
Guardians at the Interface: Microbiota, Intestinal Barriers, and the Gut–Liver Axis in Liver Health and Disease
Reda M. Mansour, Sherif S. Abdel Mageed, Akram N. Salah, Gharieb S. El-Sayyad, Wesam A. Abduljabbar, Walaa A. El-Dakroury, Ahmed E. Elesawy, Nourhan H. Elshami, Nehal I. Rizk, Osama A. Mohammed, Marwa Yousry A. Mohamed, Ahmed S. Doghish
Comprehensive Physiology 2026 16:5, e70262
https://doi.org/10.1002/cph4.70262