Industry veterans, degenerate gamblers & besties Chamath Palihapitiya, Jason Calacanis, David Sacks & David Friedberg cover all things economic, tech, political, social & poker.
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WHOOP CEO, Will Ahmed: 50B Hours of Health Data, a 4 Million Member Data Moat, & the FDA Fight
Thursday, October 29, 2026 • Duration 55:39
(0:00) Welcome Will Ahmed, CEO of WHOOP
(0:59) WHOOP's $500 Hardware Problem & the Subscription Pivot
(6:59) Inside 50 Billion Hours of 24/7 Health Data
(19:31) WHOOP's AI Coach, Journal Insights & GLP-1 Tracking
(34:57) WHOOP vs. the FDA & Competitor Wearables
(44:33) Lightning Round & LeBron James becomes a WHOOP Ambassador
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As wealth grows, complexity compounds. Between investments, tax strategy and estate planning, coordinating it all can feel like a full-time job. Creative Planning can help with the heavy lifting. Learn more at https://CreativePlanning.com/AllIn
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AI Cyber Panic, Ken Griffin's Bubble Warning, The Fall of France?
Friday, October 23, 2026 • Duration 01:43:23
(0:00) Bestie intros!
(0:11) Ken Griffin's AI bubble warning
(8:19) Palo Alto Networks CEO Nikesh Arora joins
(14:24) AI Cyber panic: PHP exploits and the tumultuous year ahead
(44:17) France on the brink: Riots, immigration referendum, debt crisis
(1:31:49) Trump's second half strategy, Press Secretary J-Cal?
Arvind Krishna & Nikesh Arora: Quantum Threat, Open vs Frontier AI, AI Cyber Warfare & SaaS Collapse
Wednesday, October 21, 2026 • Duration 40:00
(0:00) Arvind Krishna & Nikesh Arora talk about Quantum Computing's Threat to Encryption
(9:07) Open Weight vs. Frontier AI Models
(18:07) AI and Cyber Warfare
(21:14) AI Regulation and the Global AI Arms Race
(30:32) Vertical Integration and Software Consolidation
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Dylan Field: Is AI Replacing Designers?, Design is the New Code & Democratizing Creativity
Monday, October 19, 2026 • Duration 40:33
(0:00) Dylan Field joins the show: Figma's origin story and mission
(3:16) Adobe's $20B deal blocked: inside the antitrust fight
(12:29) Is AI killing SaaS? Frontier Companies vs. Figma, the "SaaS apocalypse"
(18:52) Creativity in the AI era: why taste and boldness win
(36:02) Human agency, AI's promise, and what comes next
Thanks to our partners for making this possible!
As wealth grows, complexity compounds. Between investments, tax strategy and estate planning, coordinating it all can feel like a full-time job. Creative Planning can help with the heavy lifting. Learn more at: https://CreativePlanning.com/AllIn
With over nine million acres protected across all fifty states, The Conservation Fund secures the irreplaceable lands we love. Learn more at http://conservationfund.org
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CoreWeave Crash, AI Trade Cracks, Anthropic IPO Red Flags, Bill Gates Doomer
Saturday, October 17, 2026 • Duration 01:34:06
(0:00) Ben Horowitz fills in for Friedberg!
(2:18) CoreWeave's debt selloff: did the AI bubble just pop?
Elizabeth Holmes' Husband Billy Evans: The Trial, Prison & Nathan Fielder's Documentary
Thursday, October 15, 2026 • Duration 41:55
(0:00) Billy Evans joins Friedberg
(3:38) How they met, Elizabeth the person vs the headlines, indictment
(11:02) Life on trial, having a child, where she went wrong in fundraising
(19:28) Understanding the verdict, sentencing, and the mistake of staying silent
(26:09) Elizabeth calls from prison, her life in jail
(31:34) Why they did the documentary with Nathan Fielder
(35:47) The road home, restitution math, why his new company is not Theranos 2.0
Thanks to our partners for making this possible!
IREN is a vertically integrated AI Cloud platform, delivering data centers, compute and software for AI training and inference. https://iren.com/
Oracle connects the data, applications, and infrastructure that turn AI into business outcomes—with the flexibility, choice, and control to optimize as AI evolves. http://oracle.com/ai
EY helps tech innovators scale from startup to exit to megacap. You build the future. We'll handle the rest. http://www.ey.com
Meta believes the future is for everyone. We're focused on giving every person the tools to reach their full potential and making sure the benefits of technology are distributed to all. http://www.meta.com
Keel Infrastructure owns the power, land, and connectivity that HPC and AI run on - backed by secured energy assets and established grid interconnections across North America. https://keelinfra.com/
Airwallex - Agentic Global Business Accounts. Open local accounts in 70+ countries to accept payments, earn yield, pay globally, and manage spend.
Martin Shkreli: Big Pharma's Blind Spot, Betting Against Quantum & What Prison Taught Him
Monday, October 12, 2026 • Duration 25:17
(0:00) Martin Shkreli joins the Besties!
(0:55) Why quantum computing is a one-trick business and why he's betting against it
(7:42) The drugs big pharma sells too cheap and his journey from hedge fund trader to pharma
(11:37) AI, drug discovery, and who actually wins
(21:32) Brilliance and rule-breaking, the gifted-kid trap & what prison taught him
Thanks to our partners for making this possible!
IREN is a vertically integrated AI Cloud platform, delivering data centers, compute and software for AI training and inference. https://iren.com/
Oracle connects the data, applications, and infrastructure that turn AI into business outcomes—with the flexibility, choice, and control to optimize as AI evolves. http://oracle.com/ai
EY helps tech innovators scale from startup to exit to megacap. You build the future. We'll handle the rest. http://www.ey.com
Meta believes the future is for everyone. We're focused on giving every person the tools to reach their full potential and making sure the benefits of technology are distributed to all. http://www.meta.com
Keel Infrastructure owns the power, land, and connectivity that HPC and AI run on - backed by secured energy assets and established grid interconnections across North America. https://keelinfra.com/
Is Claude Conscious? Pope Rejects, Model Welfare Movement, OpenAI's Math Backlash, France Riots
Saturday, October 10, 2026 • Duration 01:33:15
(0:00) Bestie intros!
(2:53) Anthropic believes Claude might be conscious: a new religion? Lobbying the Pope, alignment risks, model welfare
(38:28) OpenAI's math breakthroughs and community backlash
(1:02:03) Riots in France, Friedberg's socialism metric, bond market
(1:21:41) Grok Bot goes headless, OpenAI launches Dots, is IP worthless?
PayPal has been revolutionizing commerce globally for more than 25 years. Creating innovative experiences that make moving money, selling, and shopping simple, personalized, and secure, PayPal empowers consumers and businesses in approximately 200 markets to join and thrive in the global economy. For more information, visit https://www.paypal.com
Google for Startups connects founders with the right people, products, and best practices to help startups build faster and go further. https://startup.google.com/
Airwallex - Agentic Global Business Accounts. Open local accounts in 70+ countries to accept payments, earn yield, pay globally, and manage spend. http://airwallex.com
PayPal has been revolutionizing commerce globally for more than 25 years. Creating innovative experiences that make moving money, selling, and shopping simple, personalized, and secure, PayPal empowers consumers and businesses in approximately 200 markets to join and thrive in the global economy. For more information, visit https://www.paypal.com
Google for Startups connects founders with the right people, products, and best practices to help startups build faster and go further. https://startup.google.com/
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