This Week in Virology – Détails, épisodes et analyse

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This Week in Virology

Vincent Racaniello

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Fréquence : 1 épisode/5j. Total Éps: 1380

TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.

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TWiV 1165: What doesn't kill us primes our macrophages

Épisode 116

dimanche 10 novembre 2024 • Durée 01:44:58

TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

MicrobeTV Discord Server
MicrobeTV Fundraiser
Diane Griffin passes (Johns Hopkins)
Diane Griffin on TWiV 453
First H5N1 influenza virus in US pigs (CIDRAP)
IFITM3 controls interspecies influenza virus infection (Nat Comm)
Trained innate immunity by alveolar macrophages (Immunity)
Timestamps by Jolene. Thanks!

Weekly Picks

Angela – See a giant 'ghost particle' detector and more — October's best science images
Brianne – October 27 APoD: Bat nebula
Dickson – Nikon Small World Contest 2024 winners
Kathy – AAAS 150th anniversary video, celebrating scientists and Pew's 2024 annual Trust in Science survey findings
Rich – Cats Basically Are a Liquid After All, Study Confirms
Alan – HHMI's Beautiful Biology site
Vincent – EcoHealth Alliance Fights Back

Listener Picks

Hunter – Don't stop me now: Queen's Brian May on saving badgers — and the scientific method
Anne – Reasons to be cheerful

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

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TWiV 1166: Clinical update with Dr. Daniel Griffin

Épisode 1166

samedi 16 novembre 2024 • Durée 46:04

In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax's combination influenza and COVID vaccine, where to find PEMGARDA, how Paxlovid SAVES you money, when to use steroids to treat COVID-19 and how trace amounts of cytokines elicted during SARS-CoV-2 infection negatively impact cardiac function.

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Links for this episode

Bird flu flew into British Columbia Canada (Global News Canada)
H5N1 in British Columbia (CIDRAP)
Highly Pathogenic Avian Influenza flies commercial and domestic (USDA)
Countdown till the end of Marburg outbreak (WHO Rwanda)
First kid's death due to flu (CIDRAP)

TWiV 1167: Virus cloak and entry

Épisode 1167

dimanche 17 novembre 2024 • Durée 01:43:26

TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Links for this episode

MicrobeTV Discord Server
MicrobeTV Fundraiser
Novel H5N1 in Cambodia (medRxiv)
More cVDVP2 circulation (polioeradication.org)
Infectious parvovirus B19 with proteases (Nat Comm)
B cell receptor enhancement of dengue disease (PLoS Path)
Timestamps by Jolene. Thanks!

Weekly Picks

– based on – – – '

Listener Picks

TWiV 1168: Clinical update with Dr. Daniel Griffin

Épisode 1168

samedi 23 novembre 2024 • Durée 01:02:33

In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald's before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV's own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and translational science being conducted to understand long COVID including ongoing clinical trials, development of animal models and how sex may affect outcomes.

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Links for this episode

Micky D's onions linked to E. coli outbreak….another reason to not eat fast food (CDC)
RFK Jr. series…..does he get anything right? (FactCheck.org)
Salk polio vaccine : a calculated risk? (BMJ)

TWiV 1169: Can anyone hook me up with a duck?

Épisode 1169

dimanche 24 novembre 2024 • Durée 54:21

TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research.

Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel

Guests: Stephanie Gras and Jenna Guthmiller

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Links for this episode

Goldilocks zone of influenza immunity (J Inf Dis)
Broadly neutralizing HA antibodies (Nature)
T cell epitopes needed for influenza vaccines (Clin Transl Immunol)
T cell epitopes conserved in emerging H5N1 viruses (Clin Transl Immunol)
Timestamps by Jolene. Thanks!

TWiV 1170: Clinical update with Dr. Daniel Griffin

Épisode 1170

samedi 30 novembre 2024 • Durée 53:31

In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is "adapting" for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the 'seat belt' of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving!

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Links for this episode

Influenza weekly surveillance report: cliff notes (CDC FluView)
US respiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
In case you missed, US virus activity (CDC Respiratory Illnesses)

TWiV 1171: The born immunity

Épisode 1171

dimanche 1 décembre 2024 • Durée 01:40:41

TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member's ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Links for this episode

Why RFK Jr is not suitable for HHS (YouTube)
Write your Senators to oppose RFK Jr
Support MicrobeTV
ASV 2025
Susceptibility to infections in asylum seekers (NEJM)
RSV hospitalization in adults (JAMA Net Open)
Ethics failings at French university (Science)

Weekly Picks Listener Pick

TWiV 1172: Clinical update with Dr. Daniel Griffin

Épisode 1172

samedi 7 décembre 2024 • Durée 38:04

In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center's long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood.

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Links for this episode

Influenza weekly surveillance report: cliff notes (CDC FluView)
US respiratory virus activity (CDC Respiratory Illnesses)
Influenza vaccines protect against in households (JAMA Network)

TWiV 1173: Holy Cow! Convergent evolution!

Épisode 1173

dimanche 8 décembre 2024 • Durée 01:59:32

TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey

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Links for this episode

Bhattacharya nominated to head NIH (Science)
Makary nominated to head FDA (Science)
Weldon nominated to head CDC (Chief Healthcare Exec)
Cervical cancer declining following vaccination (JAMA Net)
in Texas (Texas HHS)

Weekly Picks

TWiV 1176: Clinical update with Dr. Daniel Griffin

Épisode 1176

samedi 21 décembre 2024 • Durée 48:10

In his weekly clinical update, Dr. Griffin continues his discussion of whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses how routine childhood immunizations especially that against poliovirus are threatened by Robert F Kennedy Jr and Aaron Siri, the origin of the SAR-CoV-2 virus and retraction of Didier Raoult's research, then returns to discussing the first case of severe disease following H5N1 infection in humans and the state of California's "bird flu emergency", the benefit of the measles vaccine, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how vaccination reduced hospitalization of children between 5-17 years, the ACIP recommendation for the immunocompromised, where to find PEMGARDA, information for Columbia Unversity Irving Medical Center's long COVID treatment center, long COVID in cancer patients and the physical malaises of long COVID.

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Links for this episode