The Metabolic Link – Détails, épisodes et analyse

Join Dr. Norwitz for a Live Q&A on September 10th at 12pm PT/3pm ET on The Metabolic Initiative platform! Visit this link to register, and also watch his presentation Cookies & Cholesterol Controversy inside the platform (first 7-days are free): https://membership.metabolicinitiative.com/norwitz

In this episode, Dr. Nick Norwitz returns to The Metabolic Link podcast to explore the future of personalized medicine and the evolution of metabolic health research with host, Dr. Dominic D’Agostino. Join us as they dive into the landscape of traditional randomized control trials, the rise and evolution of individualized health protocols, and the exciting potential of multiomics and continuous glucose monitoring in shaping a new era of healthcare.

Dr. Norwitz, a passionate advocate for science communication and education, shares his insights on how emerging technologies and personalized approaches can revolutionize medicine, empowering individuals to take control of their metabolic health. Dr. Norwitz also shares his unique career journey and aspirations, providing valuable insights and advice for pre-med and medical students. Whether you're a medical professional, student, or health enthusiast, this episode offers a thought-provoking glimpse into the next frontier of medicine.

About Dr. Norwitz
Dr. Nick Norwitz is a researcher-educator whose mantra is “Stay Curious” and whose mission is to “Make Metabolic Health Mainstream.” He graduated Valedictorian from Dartmouth College in 2018, majoring in Cell Biology and Biochemistry. He then completed his PhD in Metabolism at the University of Oxford in 2021, before attending Harvard Medical School to complete his MD. Dr. Norwitz enthusiasm for the field of Metabolism derives from a personal struggle with severe Inflammatory Bowel Disease that left him physically emaciated, mentally depleted, and emotionally fragmented. In desperation, he found that a ketogenic diet put his disease into remission where conventional approaches had failed. Fast forward: Nick is now completing the last months of his dual doctorate, with a distinctive determination to upset the intellectual and social environment with respect to metabolic health. Learn more about Nick on his website or watch this video about his story titled "Metabolic Health Saved My Life: Here's Why It Should Matter To You"

Special Thanks to our Episode Sponsors
* Genova Connect, powered by Genova Diagnostics - Receive 15% off any of their tests with code METABOLICLINK here
* Fatty 15 - Get 15% off their 90-day subscription Starter Kit with the code M

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access a robust bank of cutting edge metabolic health content, private ad-free podcast episodes, and earn CMEs here!

More than a billion people around the world suffer from mental and neurological disorders, and the numbers are escalating rapidly. Current treatments often fail to provide relief, resulting in many patients struggling with persistent symptoms and resistance to available therapies.

In this episode, we’re sharing a full presentation by world-renowned Harvard Psychiatrist, Dr. Christopher Palmer, filmed at Metabolic Health Summit 2024. Dr. Palmer presents a novel perspective that examines the potential link between metabolic dysfunction and mental illness. His theory, Brain Energy, proposes that metabolic dysfunction may serve as a unifying mechanism underlying various mental health conditions.

Key highlights from this episode include: 

• A dive into the surge in prevalence of mental disorders such as autism, ADHD, and depression
• Current limitations and challenges within traditional treatment options
• Emerging evidence suggesting metabolic dysfunction as a potential root cause of mental illnesses
• The role of the ketogenic diet and other innovative treatment

Join us for an insightful exploration with Dr. Palmer as we examine how metabolism could reshape our understanding and treatment of mental health conditions.

About Dr. Chris Palmer
Dr. Christopher M. Palmer is a Harvard psychiatrist and researcher working at the interface of metabolism and mental health. He is the Founder and Director of the Metabolic and Mental Health Program and the Director of the Department of Postgraduate and Continuing Education at McLean Hospital and an Assistant Professor of Psychiatry at Harvard Medical School. For almost 30 years, he has held administrative, educational, research, and clinical roles in psychiatry at McLean and Harvard. He has been pioneering the use of the medical ketogenic diet in the treatment of psychiatric disorders—conducting research in this area, treating patients, writing, and speaking around the world on this topic. Most recently, he has proposed that mental disorders can be understood as metabolic disorders affecting the brain, which has received widespread recognition in both national and international media outlets.

Special Thanks to our Episode Sponsors: 

• Genova Connect, powered by Genova Diagnostics: Receive 15% off any of their tests with code METABOLICLINK here.
• AirDoctor: Receive up to $300 off select air purifiers with code METABOLICLINK here.
• Timeline:

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.

The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.

The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.

They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.

Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.

This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.

Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at https://gdx.net/themetaboliclink

As mentioned in the introduction, you can watch the free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health here.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.

The discussion then progresses to the groundbreaking future of human performance, including the use of digital twins for simulating and optimizing individual health outcomes, and the exploration of advanced technologies such as in-mouth sensors, full-body MRI, shoe sole force plates, and markerless motion capture.

Case studies are presented to illustrate the successful application of these innovative approaches, showcasing the potential for precision and customization in coaching for optimal health and performance.

This talk is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.

Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at gdx.net/themetaboliclink

As mentioned in the introduction, you can watch this free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Jeff Volek, a professor at The Ohio State University. With a PhD in Kinesiology specializing in exercise and nutrition science from Penn State University, Dr. Volek has performed cutting edge research on how humans adapt to diets restricted in carbohydrates with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 300 peer-reviewed scientific manuscripts and five books, including a New York Times Best Seller.

In this wide-ranging interview, we cover:

💡 Unexpected normalization of muscle glycogen on ketogenic diets

💡 Muscle production of beta-hydroxybutyrate as an alternative fuel and cellular NAD+ source

💡 The emerging science on improved function of a heart muscle fueled by ketones

💡 Revisiting the FASTER study: Fitness, Aging, Stress & TBI Exposure Repository

💡 Ketogenic diets to enhance military resilience under high-stress conditions

💡 Targeting diabetic complications - studies that show hard outcomes are needed to change policy

💡 Educating physicians on therapeutic nutrition - the value of credible science-based platforms

💡 Helping address the epidemics of obesity, diabetes, and metabolic disease through lifestyle change

Watch the  video version on our Metabolic Health Summit YouTube channel. If you enjoy The Metabolic Link, make sure you sign-up for The Metabolic Link: Private Feed for access to exclusive Q&As, presentations, and interviews from world-renowned metabolic health experts. You gain access a member of The Metabolic Initiative and can listen in from your favorite podcast player. Claim your 7-day trial here.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week's episode of The Metabolic Link features a full presentation from Metabolic Health Summit 2024. Dr. Ben Bikman, professor at Brigham Young University, dives deep into the intricacies of fat and its relationship to metabolic health.

This is the full presentation he delivered at Metabolic Health Summit 2024 in Clearwater Beach, Florida. In it he shares his expertise on the link between body fat, insulin resistance, and chronic diseases such as obesity and diabetes. Throughout this talk, he covers:

💡 The role of insulin in regulating obesity and diabetes, and its direct correlation with maintaining fat mass.
💡 Understanding the concept of the personal fat threshold and how it differs among individuals, leading to insulin resistance when exceeded.
💡 Why studying weight gain provides crucial insights into the mechanisms of obesity, rather than merely focusing on weight loss.
💡 The paradox of hyperplasia and its unexpected role in improving insulin sensitivity.
💡 How exercise influences fat cell behavior through hormonal signals, particularly insulin.

If you enjoy this episode, it is just one of 30 fascinating presentations captured at Metabolic Health Summit 2024. You can still get on-demand access and watch all the action just like you were there in-person. But the doors close on February 29th! Go to metabolichealthsummit.com to get your virtual pass now.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Georgia Ede, a Harvard-trained psychiatrist specializing in nutrition science and brain metabolism. With over 25 years of clinical experience, including 12 years as a college psychiatrist and nutrition consultant at Smith College and Harvard University Health Services, Dr. Ede was the first to offer students nutrition-based approaches as an alternative to psychiatric medications. She speaks internationally about using dietary therapies for psychiatric disorders, co-authored the first inpatient study of the ketogenic diet for treatment-resistant mental illness, and developed the first accredited course on ketogenic diets for mental health practitioners. Her new book Change Your Diet, Change Your Mind was published in January 2024.

In this wide-ranging interview, we cover:

• Implementing a therapeutic ketogenic diet in Dr. Ede’s clinical practice and the mental health benefits observed
• The critical role of ketones in alleviating cerebral glucose hypometabolism
• Why metabolic health forms the foundation for optimal mental health
• The lack of practical nutrition education in medical training and why it matters
• Alzheimer’s disease as a metabolic disorder
• The importance of insulin levels, not just glucose, for gauging metabolic health

Watch the full episode on our Metabolic Health Summit YouTube channel and be sure to catch Dr. Ede on The Metabolic Psychiatry Panel featuring Dr. Chris Palmer, Dr. Iain Campbell, and Matt Baszucki. On-Demand access closes on Friday, February 16th so don't wait! Get your virtual pass at metabolichealthsummit.com.

Also be sure to catch Dr. Ede on March 6th where she'll be joining us for a live Q&A on The Metabolic Initiative. We’ll be exploring ketogenic therapy for mental health. Register to join us here.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

In this episode of The Metabolic Link, Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field recap Metabolic Health Summit 2024, the world’s leading medical and scientific conference on metabolic health. Listen to this episode to get an inside look at the top scientific highlights and surprising moments from the perspective of the hosts who made it happen.

Want to learn about all the cutting-edge research and scientific insights on metabolic health and therapy that you won’t find anywhere else? We recorded the entirety of Metabolic Health Summit 2024 and you can still watch the replay, but the window is closing very soon! Click here to secure your access before time runs out.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

We’ve just launched an extra and exciting episode of The Metabolic Link podcast! It features an eye-opening conversation between our host Dominic D’Agostino PhD, and guests Dave Feldman and Dr. Nick Norwitz, two researchers and MHS 2024 speakers spearheading investigations into the lean mass hyperresponder (LMHR) phenotype.

Dave Feldman is a software engineer who became deeply interested in lipidology after seeing his cholesterol spike on a low-carb, high-fat diet. He has since performed self-experiments and published several papers on the possible mechanisms behind LMHR. He is currently conducting a clinical study out of UCLA through his newly formed public charity, the Citizen Science Foundation.

Nicholas Norwitz completed his PhD at the University of Oxford and his thesis focused on ketone metabolism and neurodegenerative diseases. He is currently a medical student at Harvard Medical School.

In this episode Dave, Dr. Norwitz, and Dr. D'Agostino dive into…

• The debate around whether saturated fat drives increased LDL levels, especially in the LMHR phenotype.
• The "Lipid Energy Model" hypothesizing a metabolic/physiological process underlying LMHR phenotype.
•  Concerns about erroneously grouping lean mass hyperresponders with familial hypercholesterolemia patients.
•  The importance of separating discussions of underlying mechanism from clinical recommendations.
• Their vision for the future direction of LMHR research and public education on this topic.

Be sure to secure your spot at MHS 2024 in Clearwater Beach, Florida, where Dave and Nick will be presenting their latest research! Both virtual and in-person seats are still available at metabolichealthsummit.com.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dominic D’Agostino and Dr. Jonathan Jun, a pulmonary critical care and sleep medicine physician at Johns Hopkins.

He is an expert in the diagnosis and treatment of sleep-disordered breathing, and in the care of critically ill patients in the Medical ICU. He is a member of the Sleep Fellowship Program Evaluation and Clinical Competency Committee and provides teaching to medical students and residents at Johns Hopkins.

In this episode, we cover:

💡 Defining obesity hypoventilation syndrome (OHS) and its overlap with sleep apnea
💡 Assessing CO2 retention and implementing non-invasive ventilation
💡 The role of dramatic weight loss in treating OHS
💡 Using ketogenic diets to lower CO2 levels and improve sleep apnea
💡 Developing pharmacological options for OHS and sleep disordered breathing
💡 Studying the impacts of exogenous ketones ingestion prior to sleep

Be sure to secure your spot at MHS 2024 in Clearwater Beach, Florida as Dr. Jun will be joining us to present more of his research! CMEs and CPEUs available. Virtual registration is also an option for those who can’t join us in person! Go to metabolichealthsummit.com to learn more.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.