In what may be one of the most niche topics for a podcast, Operations Utopia is a podcast about the desperate need to streamline Life Sciences Operations to get treatments to patients faster and explores how life sciences organizations should operate—by examining why they usually don’t.
Disclaimer: The podcast content represents the opinion of the speakers, guests & host and does not reflect those of their organizations, system vendors, or service providers.
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02 | Validation Reimagined: From Paper Binders to Agentic AI, with Bryan Ennis
Épisode 2
vendredi 15 mai 2026 • Durée 47:05
Executive Summary
Computer system validation in life sciences is at the most significant inflection point of the last 25 years. In this conversation, Matt Neal sits down with Bryan Ennis — co-founder of Sware and a 27-year veteran of regulated systems work at Genzyme and Veeva — to trace how validation evolved from rooms full of IBM testers writing scripts against floppy-disk installs, through the cloud era's shift of responsibility to vendors, and into today's reality of agentic AI and vibe coding.
Key Topics
Why validation exists in the first place Validation's purpose is common sense — proving that a manufacturing line stamping 100,000 pills an hour, a heart-rate-monitoring device, or a clinical trial data pipeline actually works the way it was designed. Patient safety, product quality, data integrity, and signature legitimacy are the real targets; everything else is overhead.
The on-prem era (late 1990s–2000s) Bryan recalls 35 IBM testers in a room writing scripts for a Siemens e-clinical system. Companies built their own machines (this predates ordering a Dell or Gateway through the mail), installed software from 25-disk floppy sets, and rewrote their own GxP applications. Validation made sense because everything was bespoke and error-prone — but it meant nobody changed software for three to five years.
Risk-based validation, pre-CSA Bryan was doing risk-based validation at Genzyme starting in 2005, guided by ISPE's GAMP framework. The principles were already there; the industry just wasn't following them.
The cloud transition and the Veeva era Cloud vendors began delivering validation evidence with the platform — but also pushed three to four releases per year. Installation got easier; maintenance got harder. Companies went from validating once every three to five years to validating thousands of releases annually.
FDA's CSA guidance — rebrand or revolution? The Computer Software Assurance guidance flips CSV's document-heavy default into a critical-thinking, risk-based exercise. For practitioners who'd been advocating this for a decade, it felt like rebranding — but it's a clear signal from the agency to redesign the process around patient safety, product quality, and data integrity rather than testing every field.
Why the change has been slow Many sponsors externalized validation to billable-hour consultancies whose business model rewards more testing, not less. Internal common-sense streamlining is the only way to break the pattern, but companies often default to "if it ain't broke, don't fix it" until they swap a vendor entirely.
Vendor responsibility is now table stakes You cannot sell GxP software in life sciences today without ISO and SOC certifications, a validation package, and ongoing maintenance services. Veeva helped normalize this; the entire vendor ecosystem has caught up.
The AI inflection — vibe coding hits regulated software "You can't fund a software company right now unless AI is core to your narrative." Vendors are using Claude Code and similar tools internally. Sware itself runs Claude Code agents end-to-end. Requirements are no longer drafted up front — they emerge from the system, which interestingly mirrors the old waterfall model from the on-prem era.
The "SaaS-pocalypse" and analysis paralysis Foundations are shifting under buyers in real time. This may be the slowest growth year ever for SaaS in the space as customers reevaluate roadmaps and vendors reinvent themselves on AI-native architectures.
Agentic validation and the MCP connect layer Nearly every software company Bryan has spoken to in recent months has a Model Context Protocol connect layer on its roadmap. AI agents inside one platform can talk to agents like Salesforce Agentforce, crawl audit trails and configuration logs, and signal a validation platform to auto-generate requirements, draft test scripts, and execute them. This is what cracks the "final mile" problem that brittle automated testing scripts could never solve.
Real-time, continuous validation The future state: every release re-validates the entire system. Paper records become end-state artifacts that emerge from the data, not the foundation of the effort. Quarterly release cadences and 18-to-24-month migrations give way to something closer to real time.
The trust question Customers have already trusted vendors with disaster recovery, the cloud, and their data. The next layer of trust is validation itself — and the rumblings around Salesforce reportedly monetizing customer data are a cautionary signal that this trust isn't unconditional.
What doesn't change "AI self-validation is only going to go so far." There's still a human component — domain expertise, judgment, and the responsibility for patient safety — that doesn't go away just because agents are doing the grunt work.
Notable Quotes
"Paper validation is just dead in that model. There's no way it scales to an AI company that's going to do 3,000, 5,000, 10,000, 20,000 releases a year."
"I used to have stacks of paper in my office. They were so tall I created a maze so that nobody could see me at my desk."
"We're in a very similar position with AI as we were at the cloud right now."
"There's no CIO at any pharma of any size who's going to say, 'Yeah, we're not going to do AI because the validation team told me they don't want to.'"
"By this time next year, I think we're in a completely different spot."
Operations Utopia - Where Regops, Innovation, Technology, and Execution Meet.
Disclaimer: This podcast reflects only the opinion of the podcaster and guests and does not reflect those of their organizations, system vendors, or service provider
Original show theme "Little Sammy" by Matt Neal
01 | Why Biopharma Operating Models Collapse Under Scale
Épisode 1
vendredi 24 avril 2026 • Durée 25:13
Why Biopharma Operating Models Collapse Under Scale
What regulatory operations and R&D platforms reveal about how organizations actually function
Most life sciences organizations don’t struggle because of regulation—they struggle because of how they interpret it.
From the vantage point of Global Regulatory and R&D information systems, this episode examines why modern platforms like Veeva promise leverage but often deliver friction. The issue isn’t technology—it’s how operating models distribute ownership across IT, Quality, and the business, and how risk is interpreted at scale.
This conversation explores how over-validation, misaligned incentives, and legacy thinking slow execution, fragment systems of record, and ultimately increase risk.
This is not a technology discussion.
It is a systems-level diagnosis.
This episode is based on a fireside chat with Fritz Stolp at an industry session hosted by Implement Consulting Group, exploring real-world experiences with Veeva Systems platforms in regulatory and R&D environments.
Key Themes
1. The Expectation Gap
Organizations expect a connected operating system but configure fragmented tools.
Platforms designed to unify data and workflows become siloed and underutilized.
2. Misaligned Ownership Across Functions
IT optimizes for requirements and infrastructure
Quality applies legacy validation models
The business often lacks visibility into what’s possible
Result: No single group owns the outcome.
3. Over-Validation as Risk Creation
Validation is necessary—but often misapplied.
When simple changes take weeks or months:
05 | Trust Architecture: Rethinking Validation for a Probabilistic World — with Nuno Valério
Épisode 5
vendredi 19 juin 2026 • Durée 57:46
Executive Summary
For most of life sciences history, validation has been a snapshot — freeze the configuration, prove it behaves as designed, trust the system until you change it. Nuno Valério has spent his career inside that paradigm, and he's now one of the clearest public voices on what has to change for it to survive the AI era. As Head of Innovation, R&D Quality at Merck, Nuno is building AI governance frameworks for pharma R&D in real time — and he joins Matt Neal for a wide-ranging conversation about validating probabilistic systems, the trap of blanket "human-in-the-loop" thinking, and what genuine trust looks like when the model itself keeps changing.
Key Topics
AI as a liberator — when you stay the driver. Nuno's framing: AI is an enabler and a modulator, but the moment you let it produce your voice instead of you being behind the voice, it becomes hollow. The F1 analogy: what was great about watching Senna and Prost wasn't the cars, it was the art of the driver — the late brake that was almost too late, but not quite. AI is a powerful car. The driver still matters.
Set the model to challenge you. A practical antidote to the validation-loop trained into LLMs: prompt the model to push back, ask clarifying questions, and always offer a different angle. Sometimes the angle is irrelevant; sometimes it reshapes the whole question. It's how you keep the tool from collapsing into agreeable blandness.
The expertise paradox. AI is hugely powerful when you know your subject deeply — you can dig with a backhoe instead of a shovel. When you don't, it sounds great and can be completely wrong, and you won't know to push back. Matt's framing: when you really know something, you notice how not great it is on first blush.
AI as the first alien intelligence. Not alien in the extraterrestrial sense — alien in the sense of an intelligence that originated outside the patterns of natural selection that produced us. We've never met one before. The implication: we shouldn't assume it will behave like the only kind of intelligence we already know.
Notable Quotes
References, People & Resources
04 | From Alexa to Agents: Two Decades of Change in RegOps — with Scott Cleve
Épisode 4
vendredi 12 juin 2026 • Durée 48:43
Host: Matt Neal Guest:Scott Cleve, Vice President, Regulatory Operations, Information and Compliance, Daiichi Sankyo
Executive Summary
Few people have lived through more change cycles in regulatory operations than Scott Cleve. Across 20+ years at Accenture, AbbVie, Astellas, Boehringer Ingelheim, bluebird bio, and now Daiichi Sankyo, Scott has built and led global Reg Ops organizations through wave after wave of new technology — and figured out a few things about how change actually sticks.
Matt and Scott trace the arc from a 2017 Alexa pilot at Boehringer Ingelheim (RIP — voice capture for affiliate correspondence) to today's reality of AI agents working alongside humans as teammates. Along the way: the three obstacles that quietly slow every change initiative, why "training" a workforce two weeks before go-live with a PowerPoint is the corporate equivalent of asking a kid to play in the World Cup, and the backhanded compliment that defines a great Reg Ops team — you guys do your job so well, I don't even think about it.
About the Guest
Scott Cleve is Vice President of Regulatory Operations, Information and Compliance at Daiichi Sankyo. His 20+ year career spans consulting at Accenture and Reg Ops leadership at AbbVie, , (where he led the company's global Reg Ops org from Germany), and — giving him a rare view across big pharma, family-owned multinationals, and cell & gene therapy.
Key Topics
Notable Quotes
Who This Episode Is For
References, People & Resources
03 | Rethinking the Fence: Data, Standards, and the New Energy in Regulatory — with Crystal Allard
Épisode 3
vendredi 29 mai 2026 • Durée 53:44
About the Guest
Crystal Allard is Senior Director of Government Strategy at Veeva Systems, where she works with regulators and industry to shape the future of the submissions ecosystem and increase speed to market.
Crystal spent roughly 15 years at the FDA across innovation and technology roles — including time working for the agency's Chief Data Officer and at the Center for Tobacco Products, plus stints as an FDA consultant. She also worked in regulatory operations before joining the agency, giving her a rare full-circle view of how submissions are built, reviewed, and inspected. She recently co-authored published commentary on the joint FDA–EMA Guiding Principles of Good AI Practice in Drug Development (January 2026) and is a speaker at the Veeva R&D and Quality Summit.
Key Topics
A new wave of energy. After years of stasis, health authorities are increasingly open to modern, data-driven technology. Crystal's read: it feels inevitable now in a way it simply didn't two years ago.
Standards bodies in flux. Standards like CDISC have been in place for essentially Crystal's whole career — but new leadership at CDISC, HL7, and its Vulcan FHIR Accelerator is creating real willingness to revisit old assumptions. HL7 groups already use AI to draft standards, data models, APIs, and implementation guides, compressing timelines with far fewer resources. The new bottleneck: the testing, voting, and adoption infrastructure, still geared to a three-years-ago cadence.
Notable Quotes
Who This Episode Is For
References, People & Resources
Work moves into spreadsheets and email
Systems of record are bypassed
Traceability decreases
Risk doesn’t go away. It moves.
4. Decision Latency at Scale
Governance structures intended to reduce risk often increase it by slowing execution and diffusing accountability.
Simple configuration changes become prolonged processes, creating friction across the organization.
5. SaaS Reality vs Legacy Thinking
Modern platforms evolve continuously.
Organizations that resist change fall behind the very capabilities designed to improve them.
In no other industry do customers ask technology providers to stop innovating.
6. The User Adaptability Myth
A major interface change introduced no disruption in practice.
Users adapt quickly.
Organizations assume they won’t.
This gap reinforces unnecessary controls and slows adoption.
Summaries and show notes created from transcript using ChatGPT w/ some light editing - let me know if you find anything crazy that needs to change.
Operations Utopia - Where Regops, Innovation, Technology, and Execution Meet.
Disclaimer: This podcast reflects only the opinion of the podcaster and guests and does not reflect those of their organizations, system vendors, or service provider
Original show theme "Little Sammy" by Matt Neal
Trust architecture — validating the workflow, not the model. The old validation paradigm — take a snapshot of a deterministic system, freeze the configuration, trust it holds — doesn't survive probabilistic models whose outputs change with each input. Nuno's framework validates the whole ecosystem around the model: the tool, the human reviewing the output, the infrastructure, the guardrails, and the drift monitoring that flags when the model wanders. The goal isn't perfection — it's predictability you can sign under.
The human-in-the-loop trap. Putting a human everywhere isn't governance — it's burnout. Picture the reviewer at 5pm with 300 outputs to validate and a partner waiting at home. The first 257 were perfect, so he clicks through 258, 259, 260. "Human-in-the-loop" needs to mean human-on-the-loop where it matters — triggered by drift, risk thresholds, or signals the model is operating outside its trusted envelope.
Risk-based proportionality. A model that summarizes a meeting doesn't carry the same risk as one producing a safety report for a submission. The validation effort should reflect the consequence of failure. Quality has been doing risk-based work for decades — sampling, focusing where it counts, accepting you can't be everywhere. AI doesn't change that principle; it raises the stakes for applying it well.
The customization trap. Nuno's pushback on Matt's optimism about Veeva and Salesforce implementations: pharma companies routinely insist they're special, customize the standard configuration to match how they already work, and then can't absorb new features. AI capabilities increasingly only work — or only work well — on standard configurations. The cost of "specialness" is now showing up in the roadmap. And requirements gathered from people doing it the old way produce new systems that look exactly like the old systems.
Data quality, compounded over decades. Pharma's data is messy because there was never an incentive to fix it. Decades of operations stack up. Synergies across silos and regions matter only if the underlying data can be connected — which is exactly why frontier AI labs see life sciences as so much opportunity. Nuno's advice: don't try to fix 50 years; cut a reasonable line and move forward from useful data.
The GIP provocation. Matt's controversial proposal: the industry is missing a standard. GMP and GCP cover their domains. The little "x" in GxP gets stretched until everything is high-risk — and the result is fear-based bottlenecks. He proposes Good Information Practice — a discipline grounded in modern systems that trace every click, every change, every reason. If a spreadsheet column took three months to add, the real risk isn't governance; it's the columns you stopped adding. Nuno's response: he's wary of more letters, but agrees the binary GxP / non-GxP switch is broken, and proportionality has to be applied inside GxP too.
Sandboxes and pre-competitive collaboration. Nuno's call for shared, experimental spaces where industry, regulators, and vendors define what "good" looks like together — modeled on aviation safety. Pre-competitive information isn't IP. We can all get better at what everyone has to do, without giving up what makes anyone different. He sees the beginnings of that maturity in the sector, and signs from regulators that make him hopeful.
The dawn of AI maturity. Quality is a culture used to knowing what it's talking about — built from decades of guidelines, mistakes, and corpus. AI shifts every professional out of that seat. The only honest path forward, in Nuno's framing, is to think out loud, share the work, and accept that nobody has it all figured out yet.
"If you use AI just to produce your voice instead of you being behind that voice, it becomes hollow."
"What I was seeing was not the cars. What I was seeing was the art of the person at the wheel."
"AI might be the first alien intelligence — not in the sense of being from outside Earth, but in the sense of being originated outside of our patterns."
"Trust, to me, is predictability that you can sign under."
"He actually was very thorough. He checked everything. This one is certainly fine as well. Click, click, click."
"Every pharma company thinks they are very special. And then they pay the price of that specialty."
"The age of AI shifts everyone — every professional — from their seat."
Good Information Practice (GIP) — Matt's proposed framing
Pre-competitive collaboration and regulatory sandboxes
Everyone relaxes when you say "human in the loop." Nobody pictures the reviewer at 5pm, 257 clean outputs deep, clicking approve on the 258th because the first 257 were fine. The loop isn't a safeguard; it's an architecture problem. Validation used to prove a system does what you specified; with probabilistic systems the spec can't save you, so the real question stops being *does it work* and becomes *under what conditions can I sign under it.* That's the shift I care about. That's what I mean by trust architecture; not a new framework I'm selling, more a way of framing what our industry already half-know.
Operations Utopia - Where Regops, Innovation, Technology, and Execution Meet.
Disclaimer: This podcast reflects only the opinion of the podcaster and guests and does not reflect those of their organizations, system vendors, or service provider
Scott is a regular voice in the Reg Ops community — keynoting the Veeva R&D and Quality Summit, appearing on industry podcasts, and serving on conference panels (he and Matt have shared the stage at DIA RSIDM on "Regulatory 3.0 — A Data-Driven Approach"). His focus throughout: pulling organizations forward through change without breaking the people inside them.
Building a global Reg Ops org. Scott's first big leadership challenge was inheriting Boehringer Ingelheim's global Reg Ops function — a US leader living in Germany, navigating a family-owned multinational with a different time horizon and culture, and footprints across Japan, China, Europe, and the US. The playbook he refined: gather requirements, honestly assess where you're strong and where you need to grow, align investments with the company's priorities, and use outsourced centers of excellence for what fits.
The 2017 Alexa pilot. Long before Copilot and ChatGPT, Scott's team ran a pilot using Amazon Alexa to capture correspondence from global affiliates — voice in, PDF out, archived directly into document management. The catch: "Alexa has a really short attention span." It didn't roll out, but it opened doors to voice capture, voice-to-text archiving, and the broader question of how to embed new tech in real workflows.
Finding the tinkerers. Every Reg Ops team has early adopters who want to do their job easier — the people who actually read Word and Excel release notes. Scott's pattern: identify the advocate, give them a single use case on a single deliverable, demonstrate visible progress, and let the knock-on effect pull the rest of the group along.
The three obstacles to fast change. Data first — is it structured, clean, complete enough to feed into modern tools? Organizational readiness second — disrupting processes people have run for years creates real anxiety, not just resistance. Compliance and validation overhead third — the documentation and testing burden that makes iteration slow, even when the technology itself isn't the bottleneck.
The training paradox. Scott's analogy: a pro athlete gets coached and feedback from age seven onward. The corporate version is to roll out a new document management system, hand people a PowerPoint two weeks before go-live, and call it "hyper care" when it goes sideways. "We're asking people to fundamentally change the way they've worked for years with a minimal amount of support" — and Matt's revelation from a recent summit: why are you making me train people on your software?
Change as a constant. Five or ten years ago the industry talked about change fatigue. Today, between iPhone updates, Outlook updates, and the Veeva release cadence, change is just the default — and the leadership job is reframing it as continuous improvement and sharing the vision: "I've been to the beach, I know it's there. You're still on the other side of the mountain."
The Reg Ops symphony. As teams have grown, the publisher-does-everything model has bifurcated — into publishing, submission management, and an emerging data-steward track for IDMP, PQ/CMC, and future data submissions. The question Scott hasn't fully solved: how do you keep these specialists working in symphony without losing the cross-functional reach that made the old generalist Reg Ops role so valuable?
Bots as team members. RPA was the warm-up. The new mental model: think of an agent the same way you'd think of a new hire. "Bot one, you're going to do all the document formatting checks — here's how much work I expect from bot one in a typical day. Bob is overseeing bot one." Humans become managers of humans and bots, with the human-in-the-loop critical for change control, error handling, and upskilling the agents over time.
The self-driving tipping point. Matt's analogy: when self-driving is genuinely better than humans in every condition, it becomes irresponsible to drive. The same logic is coming for Reg Ops work — and the open question is the time scale. Scott's read: a lot will change in the next five years, technology is pushing the field along, and AI is going to start "eating from the bottom" of the task list.
The career arc for publishers. As automation absorbs the click-work, the people who built that expertise become the most valuable teachers in the building — data stewards, submission managers, and trainers of the next wave of both humans and bots. Retaining that knowledge in the organization is the leadership challenge of the decade.
The hidden magic of Reg Ops. When the team does its job perfectly 99.9% of the time, nobody notices — they only see the 0.1%. Submissions go out two days earlier after a Veeva upgrade, and no one outside the team knows why. Scott calls the resulting feedback "the most backhanded compliment": you guys do your job so well, I don't even think about it. The trusted-partner relationship with regulatory strategists is real and valuable — and chronically under-recognized.
"Everyone's favorite system is the one you just stopped using."
"You guys do your job so well, I don't even think about it. It's the most backhanded compliment."
Regulatory operations and regulatory affairs leaders managing change at scale; Reg Ops professionals navigating new tools, validation overhead, and shifting role definitions; R&D IT, RIM, and digital transformation leaders in life sciences; and anyone interested in what AI and automation actually look like inside a high-performing operations team.
Guest & Career
Scott Cleve on LinkedIn — VP, Regulatory Operations, Information and Compliance, Daiichi Sankyo
Operations Utopia - Where Regops, Innovation, Technology, and Execution Meet.
Disclaimer: This podcast reflects only the opinion of the podcaster and guests and does not reflect those of their organizations, system vendors, or service provider
Original show theme "Little Sammy" by Matt Neal
The lasting lesson of COVID. Rolling reviews proved faster review is possible — but regulators did it the hard way, because data wasn't in the format they needed. The insight: standardization doesn't always equal usability, or even validity. Data needs to be accessible and analyzable. The goal now is to keep the speed but build the "easy button."
Global convergence — and its limits. At DIA Europe, multiple health authorities discussed reliance and the "inevitability" of a shared submission process, while staying cagey on technology. Standards organizations are quietly driving convergence — ICH guidelines like M4Q(R2) now publish in a common format across many countries. Missed opportunities remain, notably the lack of shared data-security requirements and a separate ICH Module 1 per country.
Rethinking the submission "fence." Today's model is over-the-fence: build a package, toss it across. Crystal floats a reframe — what if the space between sponsor and regulator isn't just a transfer point but a shared storage and viewing space? APIs and direct connections could enable continuous, "live" review. It's a different paradigm than eCTD and even eCTD v4.0, which Crystal frames as both a globalization attempt and a missed opportunity at better exchange technology.
Security, IP, and who owns the data. Centralization cuts both ways — a single shared space is either a bigger target or a better-defended fortress. In the US, submission data is owned by the sponsor; FDA only stewards it — so sponsors can do more with their own data, and their own FDA letters, than they realize. Meanwhile FDA wants earlier access to sponsor data but can't share its review memos across authorities — a catch-22 that may take legislation to resolve.
The RIM blind spot — and the special-format mistake. Many at health authorities have never built a submission, so they underestimate the data management, QC, and validation work behind one — and were often unaware of regulatory information management (RIM) systems at all. Crystal shares a candid "learning experience" from her Center for Tobacco Products days: special submission formats (a PDF-backbone structure, and later eSTAR and other e-submitter formats) were designed to be easier — but modern AI tooling is now so good at standard formats like eCTD that the special ones cost more time and money.
The reviewer disconnect. Many format rules exist not because a reviewer wants to read a document, but because review software needs specific data sets for automated analyses. Yet reviewers are rarely in the room when those tools or the guidance are built — "a massive disconnect." See the endless bookmark-and-hyperlink debate, and an industry that fears a technical rejection that, inside FDA, is barely a blip.
The future of Reg Ops and review. Both roles are converging on a hybrid: regulatory or scientific expertise, plus the ability to move data, separate signal from noise, and prompt effectively. Less document-and-business-process, more data-and-structure.
A shared vision, freely given. As a public benefit corporation, Veeva balances commercial interest with contributing to the wider ecosystem — and Crystal argues data standards, and possibly exchange platforms, must be freely available for true interoperability. The bigger gap: ICH-style groups have reviewers, health authorities, and industry, but are missing the "third leg of the stool" — technologists.
"EMA is writing it down. FDA is saying it out loud." — on regulators and APIs
"Standardization doesn't always equate to use and usability, or even validity."
"[They] want to keep doing it, but maybe make it the easy button." — on COVID-era rolling reviews
"It takes more effort and time and money to create these special sources that we thought were easier."
"What if we just rethink the fence?"
"You can leave the FDA, but you never leave the public health mission behind."
Regulatory operations and regulatory affairs leaders; data standards and submissions professionals (CDISC, HL7, ICH); clinical operations and R&D IT teams; health authority and policy professionals tracking modernization; and anyone interested in how AI and data standards are reshaping regulatory review.
Guest & Company
Crystal Allard — Senior Director, Government Strategy, Veeva Systems
Regulatory reliance; "live review"; RIM systems; Meaningful Use (cited as a legislation-driven data-sharing precedent)
Operations Utopia - Where Regops, Innovation, Technology, and Execution Meet.
Disclaimer: This podcast reflects only the opinion of the podcaster and guests and does not reflect those of their organizations, system vendors, or service provider
Original show theme "Little Sammy" by Matt Neal
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