One Thing with Dr. Adam Rinde – Détails, épisodes et analyse

In this Episode I welcome on Sami Inkinen CEO of Virta Health to discuss Virta Health's approach to Type 2 Diabetes reversal'

Virta Health utilizes a continuous remote care intervention (CCI) that incorporates individualized carbohydrate restriction, health coaching, and telemedicine to manage and reverse Type 2 Diabetes

We cover topics such as:

Impact of individualized carbohydrate restriction:

The role of the patient-provider relationship:

Addressing quality of food

The Virta change model:

GLP-1 Receptor agonists as a bridge:

Sustainable solutions require addressing nutrition:

Research Findings of Virta's approach.

Long-Term Effects of CCI: A 2-year non-randomized clinical trial published in Frontiers in Endocrinology showed significant and sustained improvements in multiple clinical markers of diabetes and cardiometabolic health in the CCI group compared to the UC (usual care) group . These included reductions in HbA1c, fasting glucose and insulin, weight, blood pressure, triglycerides, and liver alanine transaminase . The CCI group also saw higher rates of diabetes reversal and remission .

GLP-1 Deprescription: A recent study published in Diabetes Therapy explored the impact of discontinuing GLP-1 agonists in patients who had successfully integrated Carb-Restriction Nutrient Therapy (CRNT) supported by Virta's telemedicine model . The study found that patients did not experience weight regain after stopping GLP-1 medications, and while HbA1c levels increased slightly, they generally remained below the diagnostic threshold for diabetes

About Sami:

Join NowSami InkinenFounder, Chief Executive Officer

Sami Inkinen is the Chief Executive Officer and Co-Founder of Virta Health, the leader in diabetes reversal and sustainable weight loss. With a combination of proven nutrition, expert support, and advanced technology, Virta empowers members with the tools and knowledge to sustain changes for a longer, healthier life.

A data-driven technology entrepreneur, Sami's personal experience with diabetes and passion to advance global health was the motivation behind Virta. Working with over 500 large employers, health plans, and government organizations across the country, Virta has helped over 100,000 members reverse their diabetes and obesity.

Previously, Sami was co-founder of leading online real estate marketplace Trulia, serving as its COO, president, and board member until its IPO and eventual sale to Zillow Group, and held roles at Microsoft and McKinsey & Company. He also founded Fat Chance Row to raise awareness of the dangers of sugar and its connection to diabetes, rowing from California to Hawaii — 2,750 miles — with his wife, completely unsupported. 

He holds a MS in engineering physics from the Helsinki University of Technology and a MBA from Stanford University, and is also a triathlon age group world champion and 8 hour 24 minute Ironman finisher, having completed seven Hawaii Ironmans. He lives in Colorado with his wife and two daughters, enjoying the outdoors and the delight of their small barn of egg-laying chickens.

Socials

Website: https://www.virtahealth.com/Instagram: https://www.instagram.com/virtahealth/?hl=enFacebook: https://www.facebook.com/virtahealth/Linkedin: https://www.linkedin.com/company/virta-healthYouTube: https://www.youtube.com/virtahealthX: https://x.com/virtahealth

In this episode of The One Thing Podcast, hosted by Dr. Adam Rinde, the focus is on integrative and naturopathic medicine, specifically addressing complex chronic illnesses and cancer care. Dr. Rinde introduces the guest, Dr. Paul Anderson, a leading voice in the field with over 30 years of clinical experience. The episode aims to explore the topic of coagulopathy in chronic disease, discussing its mechanisms, implications, and potential treatments.

Guest Highlights • Dr. Paul Anderson: o Leading voice in integrative and naturopathic medicine. o Specializes in complex chronic illness and cancer care. o Over 30 years of clinical experience. o Led the interventional arm of a US NIH-funded human research trial on IV and integrative therapies for cancer patients. o Founder of Advanced Medical Therapies in Seattle, Washington. o Collaborates with clinics and hospitals worldwide. o Academic contributions include serving as a professor of pharmacology and clinical medicine and as the chief of IV Services for Baer's Oncology Research Center. o Published works include "Outside the Box Cancer Therapies" and "Cancer, the Journey for Diagnosis to Empowerment." o Notable work on intravenous nutrient therapy featured in a scientific reference textbook. Main Topics Covered 1. Mechanisms of Coagulation: o Discussion on the intrinsic and extrinsic pathways of coagulation. o Role of immune chemicals in triggering clotting. o Impact of chronic illnesses and infections like COVID-19 on coagulation. 2. Coagulopathy in Chronic Disease: o Excessive coagulation in chronic disease states. o Specific conditions discussed include COVID-19, fibromyalgia, chronic fatigue syndrome, and POTS (postural orthostatic tachycardia syndrome). o How coagulopathies may hinder patient recovery and the importance of assessing and addressing these issues. 3. Genetic and Environmental Factors: o Influence of genetics on susceptibility to hypercoagulability. o Role of diet, hydration, and lifestyle in managing coagulation issues. o Importance of testing and early detection for prevention and treatment. 4. Treatment Approaches: o Use of supplements like vitamin E, omega oils, and fibrinolytic enzymes (e.g., nattokinase, lumbrokinase). o Potential use of baby aspirin for managing clotting issues. o Importance of a stepwise approach to treatment, starting with lifestyle modifications and progressing to more intensive interventions if necessary. 5. Biofilm and Chronic Infections: o Connection between biofilm formation and chronic infections. o How pathogens use fibrin to form protective biofilms, complicating treatment. o Strategies for breaking down biofilms to improve patient outcomes. 6. Hope and Recovery: o Emphasis on the possibility of recovery from chronic illnesses and coagulopathies. o Importance of finding a supportive healthcare team and utilizing available resources for treatment and management

Related Links 1. Dr. Paul Anderson's Books: o "Outside the Box Cancer Therapies" by Dr. Paul Anderson and Dr. Mark Stengler o "Cancer, the Journey from Diagnosis to Empowerment" by Dr. Paul Anderson 2. Research on Coagulation and COVID-19: o Studies on interleukin-6 and its role in COVID-19 o Research on microclots in COVID-19 patients 3. Supplements Mentioned: o Nattokinase o Lumbrokinase o Baby aspirin o Vitamin E o Omega oils 4. Organizations and Labs: o Fry Laboratories (historical reference) 5. Conditions Discussed: o COVID-19 and Long COVID

Socials Mentioned:

• Social Media Handles: o Twitter: @DrAConsult o LinkedIn: Dr. Paul Anderson • Website: ConsultDrAnderson.com

The guest in this episode is Dr. Andrea McBeth, the CEO of Thaena , who talks about postbiotics and their role in addressing health imbalances. The podcast emphasizes the importance of consulting with a healthcare provider before making any changes to one's health routine. Dr. McBeth has dedicated this episode to Lesbians Who Tech https://lesbianswhotech.org/about/ and if we reach 300 plays in the first 30 days of launch a donation will be made in honor of Dr. McBeth to Lesbians Who tech. http://www.lesbianswhotech.org In this episode we discuss: - 💡 The concept of postbiotics, which are small molecules and metabolites produced by bacteria, is an emerging field of study in the microbiome space. - 💡 Thaena a postbiotic supplement developed by Dr. Andrea McBeth's company, takes a unique approach by using sterilized stool as a source to create a complex mixture of postbiotics. - 💡 Donor selection for postbiotic supplements is crucial, and Thaena has strict criteria in place to ensure the health and safety of their donors. - 💡 Postbiotics have shown potential in addressing various health imbalances, including gut health, brain health, and immune function. - 💡 Thaena is focused on gathering data and feedback from users to better understand the effects and potential applications of postbiotics. - 💡 Individualized approaches to healthcare are important, as the microbiome and its response to interventions can vary greatly between individuals. - 💡 The study of postbiotics and their impact on health is still in its early stages, but the potential for their use in supporting overall health and wellness is promising. Time stamps: 00:00 Welcome to the One Thing Podcast 00:43 Introducing Dr. Andrea Macbeth: A Deep Dive into Postbiotics 01:09 The Revolutionary World of Thaena Biotic 01:30 Exploring the Science and Impact of Postbiotics 04:35 The Journey from Scientist to Naturopathic Doctor 07:32 The Unique Approach of Thaena to Postbiotics 12:42 Understanding the Microbiome and Postbiotics 16:36 Personalizing Gut Health: Prebiotics, Probiotics, and Postbiotics 28:35 Finding and Qualifying Donors for Thaena 45:35 Final Thoughts and How to Access Thaena Products About Dr. McBeth Andrea McBeth, ND, is a naturopathic doctor, entrepreneur and activist dedicated to building products that reduce suffering while also challenging healthcare systems to reimagine what it means to heal. The CEO and co-founder of Thaena®, Andrea views wellness through the lens of the microbiota, emphasizing the relationship between gut health and overall health. Thaena®, pronounced | thay-nah |, is a female-founded, Pacific Northwest-based company and the proud creators of ThaenaBiotic®, the world's first stool-derived postbiotic supplement. Our mission is simple: To use science, radical innovation, and the microbiome to help people feel better. We believe in using the innate wisdom of the human body to shift the paradigms of medicine by expanding access to microbiome supports and putting postbiotics on the map. Special Links Mentioned In the Episode https://thaena.com/Rinde

 Bone health is one of the most important topics in medicine. Why? Because bone fractures are one of the leading causes of mortality in older adults.  In this episode we speak with Dr. John Neustadt; one of the leading integrative medicine clinicians in the area of bone health and osteoporosis. He has really brought to the forefront researched based nutrients such as Vitamin K2 (MK4), Calcium, Vitamin D , and other diet and lifestyle interventions that are geared toward reducing fracture risk. We discuss bone density testing and the context of the T-score on the Dexa Scan as well as what really matters when it comes to choice of therapies.  We speak about risk factors leading toward bone density issues and what we can all do to strive for healthy bones. Bone physiology is a fascinating topic as is a unique coordination of bone production orchestrated by osteoblasts and bone remodeling and re-absorption orchestrated by osteoclasts and for good bone to be made the body needs a coordination between these components.  It also has many factors such as hormone, immune, and inflammatory elements.  Bone density improvement does not necessarily mean better bones.  We go into this and more on this episode.

 About Dr. Neustadt

John Neustadt, ND was Founder and Medical Director of Montana Integrative Medicine and Founder and President of the dietary supplement Nutritional Biochemistry, Inc. (NBI) and NBI Pharmaceuticals. He’s a Medical Expert for TAP Integrative, a nonprofit educating doctors about integrative medicine. He’s published more than 100 research reviews and was recognized by Elsevier as a Top Ten Cited Author for his work. Dr. Neustadt’s books include, A Revolution in Health through Nutritional Biochemistry and the textbook, Foundations and Applications of Medical Biochemistry in Clinical Practice. Dr. Neustadt is an editor of the textbook, Laboratory Evaluations for Integrative and Functional Medicine (2nd Edition). He was the first naturopathic doctor ever voted Best Doctor among all physicians in his area. Dr. Neustadt received 15 Orphan Drug Designation by the US FDA for the use of natural products for the potential treatment of rare diseases. 

Dr. Neustadt is an expert in clinical approaches to improving sleep. He’s lectured at medical conferences, educating physicians about how they can more effectively help patients with insomnia and other sleep disorders. Based on his research he created the dietary supplement Sleep Relief. Sleep Relief’s bi-phasic, time-release technology delivers NBI’s proprietary formula with clinically validated nutrients in two stages—a quick-release first stage and a slow-release second stage to help you gently fall asleep, stay asleep and wake refreshed and ready for your day.

Autophagy is  a term that refers to cellular self-digestion.  We have heard the term self-attack-self in situations like autoimmunity; Well this a different type of process that is a normal every day process in the cell of cellular self-digestion. Technically autophagy is a catabolic metabolic program/process that is activated when intracellular nutrient uptake or availability is diminished.  It was coined in the 1960’s by the late Christian de Nuve. It has resurfaced quite predominately since  Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Medicine for his discoveries of mechanisms for autophagy – a study into how cells detoxify and repair themselves.  Autophagy has a number of pathways that are studied that are associated with it such as the Mammalian Target of Rapamycin (MTOR) and  Nuclear factor erythroid 2-related factor 2 (NRF2). This is relavant because we know inflammation causes disease and many protective pathways of inflammation are regulated by NRF2 . Likewise we know that protein aggregating in cells is one of the key findings in disease.  Autophagy is one of the pathways that clears up protein debris from harming cells.   So understanding inflammation and autophagy is kind of important.  Inflammation can knock down autophagy so these topics must be studied together. Our guest Dr. Jeffrey Novack understand these pathways quite well and most interesting to us is that he understands how nutrition and chemicals from plants can influence these pathways.   More about our guest. 

Dr. Jeff Novack earned his Ph.D. in pharmacology from the University of Washington School of Medicine (Department of Pharmacology) in signal transduction (lab of Dr. Joe Beavo). He did post-doctoral research in immunology and tyrosine kinase signaling at the Fred Hutchinson Cancer Center (lab of Dr. John Cooper). He taught pharmacology, immunology, infectious disease, and pathology at the medical school level for 13 years. He most recently was a tenured faculty at Bellevue College, where he taught anatomy and physiology, microbiology, cell biology, and nutrition. Dr. Novack joined the faculty at PNWU in September of 2012 and has taught immunology, portions of pathology, and pharmacology. He has done research on the effects of PSK on immune function in mice and humans and is interested in the effect of natural products on the innate and adaptive immunity and on inflammation. He likes to hike (has climbed all of the volcanoes in Washington state), bike, fish, cook and do polar bear swims in the winter.

Articles mentioned in the episode

Novack. Jeffrey. 2017, Autophagy and Proteostasis: A Unifying Theory of Neurodegenerative  Disease. Journal of Restorative Medicine.Vol 6 No 1. Pg 3-18

Autophagy Resources

DR.Yoshinuri Oshimi, Autophagy Nobel Peace Prize 2016

SIIM Land, Metabolic Autophagy 

Lara Briden, ND speaks on Endometriosis. A chronic inflammatory disorder presenting affecting primarily the pelvis but also other regions of the body. Lara Briden is a naturopathic doctor and the period revolutionary—leading the change to better periods. Informed by a strong science background and more than twenty years with patients, Lara is a passionate communicator about women's health and alternatives to hormonal birth control.  Her book Period Repair Manual is a manifesto of natural treatment for better hormones and better periods and provides practical solutions using nutrition, supplements, and natural hormones.  Now in its second edition, the book has been an underground sensation and has worked to quietly change the lives of tens of thousands of women.  Papers mentioned in the episode: paper about macrophages. https://www.ncbi.nlm.nih.gov/pubmed/30843336 blog post about endo and immune dysfunction. https://www.larabriden.com/endometriosis-treat-the-immune-system/ Period Repair Manual: https://www.amazon.com/gp/product/0648352404/ref=dbs_a_def_rwt_hsch_vapi_taft_p1_i0 Lara Briden website https://www.larabriden.com/ Instagram page https://www.instagram.com/larabriden/ One thing Podcast on Instagram: https://www.instagram.com/onethingpodcast/ One thing Podcast on Facebook  https://www.facebook.com/onethingpod

 In this episode we speak with Mitch Marder,DDS a well-known Biological Dentist. We speak about such important topics like mercury amalgams, root canals, and how oral health is actually related to the entire field of health and medicine.  For years, the field of dentistry has been seen as a distinct aspect of health focused on this “box” we call the mouth, yet we know how oral health is linked to brain health, gut health, and cardiovascular health.  Conditions like gingivitis are associated with disease process elsewhere in the body and Dr. Marder opens our minds about holistic approaches to cavities and root canals.

Dr. Marder has been working in biomedical dentistry for over 30 years. His philosophy is that each person who entrusts their care to him deserves his best. Dr. Marder is a member of the American Academy of Craniofacial Pain, International Academy of Oral Medicine and Toxicology, Environmental Dental Association, Holistic Dental Association, American Orthodontic Society, American Academy for Functional Orthodontics, and Academy of Dental Sleep Medicine. His special interests are in Craniofacial Development (assisting the growing skull and cranium), Treating Sleep Disorders – being aware of the airway (apnea, snoring), Facial Pain – treating TMJ and headache issues, Dental Implants (introducing non-metal implants), and holistic care.  He earned his Doctorate in Dental Surgery (D.D.S) from the University of Illinois in 1981 and his Bachelors in Art in Biology  from Northwestern University in 1977.

Polycystic Ovarian Syndrome (PCOS) effects 1 out of 10 women and is one of the most common causes of infertility. PCOS at its core is a metabolic and reproductive hormone problem. Anyone who has dealt with it can tell you that it feels like the metabolism has a mind of its own and common approaches to helping bring hormone balance or blood sugar balance often aren't enough. I brought in Dr. Shannon Hirst a Naturopathic Physician who specializes in women’s hormone health to discuss PCOS. Dr. Hirst is licensed Naturopathic Physician in Woodinville, Washington and received a Doctorate in Naturopathic Medicine and Family Medicine Residency from Bastyr University in Kenmore , Washington. She also holds a bachelors in science in Cellular and Molecular Biology from Western Washington University. You can find her at www.drshannonhirst.com and on twitter @drhirst. In this episode we discuss the underlying hormone and metabolic imbalance in PCOS and what’s important to know. Also, we go the issues that people with PCOS face. With many people silently struggling with this condition; I am appreciative of the integrative and holistic approach Dr. Hirst takes. Our podcast focuses on the integrative health arena with a special emphasis on gut, metabolism, inflammation, and emotional health; this episode approaches and discusses many of these areas. Enjoy and share with friends, loved ones, and colleagues.

If you are alive, it is safe to say you know someone diagnosed with a mental health disorder.  You also likely know how important it is to receive an accurate diagnosis and limit the stigma attached to a mental health diagnosis.  In this episode Dr. Teray Garchitorena Kunishi an experienced expert in mental health and a Naturopathic Physician in San Francisco speaks about mental health and the concept of neurodiversity ; where mental health issues are seen as a variant of what is considered as a norm rather than as as firmly abnormal.  This has become a particularly important concept in Autism Spectrum Disorders,  Bipolar Disease, and Schizophrenia.  It is not without controversy and we look at both aspects of neurodiversity approaches in this episode.  We also speak about societies where conditions like Schizophrenia are treated like a gift and people who deal with this gift are supported and nurtured rather then ostracized.   This is a very deep and meaningful episode and one that I am sure will be thought provoking. Please follow Dr. Teray on her website where you also find her course on the Art, Science, and practice of Happiness. It was an honor to interview Dr. Teray and I hope you enjoy  the episode as much as I did. Subscribe to our episode in your favorite podcast player including itunes and stitcher

 Debbie Miller, ND earned her doctorate in naturopathic medicine from Bastyr University, and her undergraduate degree from Brandeis University.  She practices at Sound Mind Medicine in Seattle, WA During her naturopathic education, she received additional training and clinical experience in biofeedback, counseling, and mind-body medicine. It was then she became fascinated by the connections between our thinking minds and physical symptoms, and the impact that chronic stress has on our bodies, relationships, and daily activities. She has since become board certified through the Biofeedback Certification International Alliance.  In addition to her practice, she currently serves as adjunct faculty at Bastyr University.  In this episode we speak about how to regulate vagal nerve tone through training heart rate variability with biofeedback techniques. This is a useful approach for anxiety, digestive disorders, sleep problems, hypertension, and many other conditions. Show notes at our page.