Eight Drugs a Week Podcast – Détails, épisodes et analyse

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Eight Drugs a Week Podcast

Jana Stojanova & Florian Lemaitre

Forme & Santé

Fréquence : 1 épisode/69j. Total Éps: 21

Welcome to Eight Drugs a Week, a podcast about the latest in clinical pharmacology. Your hosts are Florian Lemaitre (France) and Jana Stojanova (Australia), a pair of pharmacology nerds and Beatles fans. Join us on this journey as we catch up with colleagues around the world and discuss new developments. We'll delve right into how drug exposure relates to effects and how we can optimize drug concentrations to personalize treatment. Eight Drugs a Week is supported by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT). The personal views of the hosts and guests do not necessarily reflect the position of the Association.

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Données mises à jour le 25/08/2026

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Eight Drugs a Week Episode 19 – I Want to Hold Your Hand: Guiding Clinicians Through Antifungal TDM

vendredi 10 juillet 2026 • Durée 35:31

Fungal infections remain a stubborn clinical problem: treatment options are limited, and the margin between an ineffective dose and a toxic one is often narrow. Getting antifungal exposure right for each patient is not a formality; it can be the difference between clearing an infection and losing ground to it. Therapeutic drug monitoring (TDM) offers clinicians a way to walk that line with more confidence, protecting efficacy on one side and guarding against adverse effects on the other.

In this episode, Isabel Spriet and João Telles, both deeply immersed in antifungal TDM in their respective hospitals, walk us through what it takes to guide a patient safely through azole therapy: choosing the first dose without perfect information, watching for the factors that push exposure up or down, negotiating for hospital resources to make TDM possible, and untangling drug interactions that still defy easy explanation.

In this episode we'll hear about:

How azole TDM (especially for voriconazole) is embedded into daily practice in Leuven and São Paulo, and where turnaround times still get in the way of timely dose decisions
The negotiation it takes to win hospital buy-in for a dedicated TDM team, built on clinical outcomes, value-based healthcare, and cost-effectiveness arguments
Why azole monitoring means tracking liver function, inflammation, genetic polymorphisms, and ECMO-related drug sequestration alongside plasma concentrations
Isabel's research into the flucloxacillin-voriconazole interaction, an abrupt CYP450-driven concentration drop that breaks the usual rules of enzyme induction
Where TDM should go next: echinocandin monitoring, filter adsorption during continuous renal replacement therapy, and unexplained treatment failures with micafungin

About our guests:

Isabel Spriet is Head of the Clinical Pharmacy Department at University Hospitals Leuven and Professor at KU Leuven.
João Telles is an infectious disease physician at the AC Camargo Cancer Centre in São Paulo, where he leads a dedicated antimicrobial TDM team.

Eight Drugs a Week is supported by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT). The personal views of the hosts and guests do not necessarily reflect the position of the Association.

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Eight Drugs a Week Episode 18 – Rennes 2026: Day Tripper… Moving from Legend to Reality 🙌

samedi 16 mai 2026 • Durée 20:17

What do Arthurian legend, a medieval convent, and the future of precision medicine have in common? They all converge in Rennes, France this September - and if this episode is anything to go by, the IATDMCT-SFPT Joint Congress 2026 is shaping up to be one of the most ambitious meetings our community has ever produced. In a first for France, the IATDMCT and the French Society of Pharmacology and Therapeutics (SFPT) are joining forces under one roof, bringing together TDM specialists, clinical toxicologists, pharmacovigilance experts, and clinical pharmacologists to ask a deceptively simple question: are we finally ready to turn the promise of precision medicine into everyday clinical reality?

In a special role reversal, our usual host Florian Lemaitre steps out from behind the microphone and into the hot seat, joined by his congress co-chair Marie-Clémence Verdier. Together, they take us on a tour of the scientific programme, the spirit behind the congress theme, and a few tantalising hints about what awaits delegates - including several secret surprises.

In this episode we'll hear about:

• Why two major pharmacology societies are joining forces for the first time on French soil, and what the IATDMCT community stands to gain from meeting its French counterparts

• How Brittany's own history of myth and reinvention inspired a vision for translating TDM tools into everyday clinical practice

• The sessions not to miss, including deep-dives into antipsychotic TDM, antiretroviral therapy and a cross-disciplinary bench-to-bedside exploration of drugs and the liver

• How the young scientists programme is tackling large language models in translational science, covering education, research practice, and ethics

• What to expect beyond the science: a Breton welcome reception, a congress dinner, and our very own 'Day Tripper' post-congress excursion to Mont Saint-Michel

Fixing a Hole: Using TDM to Address Medication Non-Adherence

lundi 2 mars 2026 • Durée 26:42

Adherence to medication is the very basic level we wish to reach in patient care. Yet for many patients taking drugs every day (sometimes several times a day, over long periods of time, this is far from straightforward. Treatment failure and adverse drug reactions can result not from the wrong medicine, but simply from inconsistent intake. Non-adherence is rarely intentional; it is a complex, multifaceted problem shaped by practical barriers, patient perceptions, and the realities of daily life. Therapeutic drug monitoring offers a powerful objective tool for fixing this hole — identifying who is and isn't taking their medication, enabling clinicians to have targeted, constructive conversations and intervene in ways that can make an effective difference.

In this episode we'll hear about:

What adherence really means, and why it matters clinically and for society
The importance of objective measures and the role of drug measurement
What patients really think about the 'vigilance' associated with adherence monitoring and having constructive conversations
Innovations on the horizon for adherence monitoring, including dried blood spot sampling, point-of-care testing, and what these tools could mean for primary care and resource-limited settings

About our guests:

Jorie Versmissen is an internist and clinical pharmacologist at Erasmus Medical Centre in Rotterdam, the Netherlands, with a research interest in adherence to antihypertensive medication. Jorie is also a familiar voice to regular listeners as our recent co-host, today joining us on the other side of the microphone.

Lene Halvorsen is a nephrologist at Oslo University Hospital, Ullevål, in Norway. She also has a special interest in hypertension, both in the clinic and in research, and is an elected council member in the European Society of Hypertension. Lene recently completed her PhD on the topic of adherence to antihypertensive medication, where Jorie was one of her opponents.

Tuberculosis drugs TDM: The long and winding road

mardi 6 janvier 2026 • Durée 34:57

Tuberculosis remains one of the world's most persistent infectious diseases, and despite decades of available treatments, achieving cure remains a long and winding road. The challenge isn't just the disease itself – there is also a notable difference in how patients respond to TB drugs. Where pharmacokinetic variability can range 20-50 fold and the complex multidrug regimens, therapeutic drug monitoring represents a crucial but underutilised tool. From the early bactericidal activity in the first two weeks to managing drug-resistant strains, TDM offers a path to optimising treatment while minimising toxicity. Yet significant barriers remain, particularly in the low- and middle-income countries where TB burden is highest.

In this episode, we'll hear about:

The role of TDM in first-line TB therapy: why pharmacokinetic variability matters and when to perform monitoring for optimal outcomes
Practical approaches to TB drug monitoring, from limited sampling strategies to population pharmacokinetic models, and how to interpret results in clinical context
The heightened importance of TDM for second-line drugs in multidrug-resistant TB, where narrower therapeutic ranges make the difference between cure and toxicity
Innovative solutions for resource-limited settings, including saliva-based point-of-care testing and alternative matrices that could democratise access to TDM in high-burden countries
The challenge of implementation: bridging the gap between sophisticated laboratory methods and community-level care where they're needed most

About our guests:

Thi Nguyen is a PhD candidate at Sydney University School of Pharmacy. Originally from Vietnam, a high-TB-burden country, she focuses on developing saliva-based therapeutic drug monitoring to make personalised TB treatment accessible in resource-limited settings.

Marieke Sturkenboom is the recently appointed Laboratory Head at the Clinical Pharmacy and Pharmacology department at the University of Groningen Medical Centre in the Netherlands, with special expertise in TDM and model-informed precision dosing of anti-TB drugs.

Revolution 9: How the microbiome is evolving our understanding of drug disposition

vendredi 31 octobre 2025 • Durée 26:11

The human microbiome, a complex community of bacteria, fungi, protozoa, and viruses, doesn't just passively coexist with the drugs we take; it actively participates in a bidirectional relationship that can impact drug efficacy and toxicity. From immunosuppressants in transplant patients to medicines in other fields of medicine, it is becoming apparent that the microbiome has been a missing piece in our understanding of drug variability, and that it can uniquely impact drug interactions. As this field rapidly evolves, it promises new strategies for personalising medicine through microbiome biomarkers and targeted manipulation of our microbial communities.

In this episode, we'll hear about:

The bidirectional nature of drug-microbiome interactions: how drugs alter microbial composition and how microbes chemically modify drugs or influence their disposition
Mycophenolate and tacrolimus as case studies that demonstrate how the microbiota influences drug disposition in transplant patients
The clinical consequences of microbiome-drug interactions, from gastrointestinal toxicity to unexpected variability in dose requirements
The challenges and limitations researchers face, and why regulatory frameworks need to evolve to incorporate microbiome considerations in drug development.

About our guests:

Laure Elens is a Professor of Pharmacokinetics at UCLouvain's Faculty of Pharmacy and Biomedical Sciences, and leads the PMGK research lab.

Roland Lawson is an Associate Professor of Pharmacology at the University of Limoges and leads the microbiome group of the INSERM research unit, Pharmacology & Transplantation.

IATDMCT annual meeting in Singapore. I've got a meeting (I've got a feeling)

mercredi 16 juillet 2025 • Durée 27:52

We gather the two chairs of the upcoming IATDMCT annual meeting in Singapore, Sophie Stocker and Jana Stojanova, plus Cindy Lau, who contribute to the organization of the young scientists' part of the event to discuss the content, urbi et orbi, of our annual meeting.

In this episode we'll hear about:

The journey from an inspiration to the building of a real conference dedicated to creating innovative solutions in therapeutic drug monitoring and clinical toxicology.
The keynote lectures, main topics and hosts selected highlights of a scientific program going from biosensors applications in TDM and CT to pharmacogenomics integrated approaches and the strong choices made by the local organizing committee.
The networking initiatives conceived by the local organizing committee to foster collaboration within IATDMCT members and build a solid sense of belonging to the TDM and CT community.
Not to mention, the social activities, culinary art and secret events and places cooked by the team to help you discover Singapore and have fun during the meeting.

Eight Drugs a Week is supported by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT). The personal views of the hosts and guests do not necessarily reflect the position of the Association.

To join IATDMCT, visit: https://iatdmct.org/join-us/

Subscribe to Eight Drugs a Week on your preferred podcast platform.

About our guests:

Sophie is an associate professor of Pharmacology at the Sydney Pharmacy School in Sydney, Australia, the actual Chair of the IATDMCT Anti-infective scientific committee and the co-Chair of the 2025 annual IATDMCT meeting in Singapore.

Jana is a senior scientist at St Vincent's Hospital in Sydney, Australia, the founder and main host of the IATDMCT podcast "Eight Drugs A Week" and the co-Chair of the 2025 annual IATDMCT meeting in Singapore.

IATDMCT annual meeting in Singapore. I've got a meeting (I've got a feeling)

mercredi 16 juillet 2025 • Durée 27:52

In this episode we'll hear about:

The journey from an inspiration to the building of a real conference dedicated to creating innovative solutions in therapeutic drug monitoring and clinical toxicology.
The keynote lectures, main topics and hosts selected highlights of a scientific program going from biosensors applications in TDM and CT to pharmacogenomics integrated approaches and the strong choices made by the local organizing committee.
The networking initiatives conceived by the local organizing committee to foster collaboration within IATDMCT members and build a solid sense of belonging to the TDM and CT community.
Not to mention, the social activities, culinary art and secret events and places cooked by the team to help you discover Singapore and have fun during the meeting.

To join IATDMCT, visit: https://iatdmct.org/join-us/

Subscribe to Eight Drugs a Week on your preferred podcast platform.

About our guests:

Pharmacogenetics: Here, There and Everywhere

jeudi 7 novembre 2024 • Durée 21:10

Pharmacogenetics now surrounds us and is an efficient tool to prevent disease or to guide drug therapy. By studying polymorphisms in the genes coding for metabolism enzymes and drug transporters, we can have clues to help choose the right drug or adjust drug dosage. Not to mention that pharmacogenetics is the ideal companion for therapeutic drug monitoring for a comprehensive treatment optimization. Treatment failure and adverse drug reactions may, at least partly, be explained with pharmacogenetics and we have never been so close to large-scale implementation of this strategy.

In this episode, the Chair and Vice-Chair of the IATDMCT pharmacogenetic scientific committee will give us an overview of everything you need to know on pharmacogenetics.

In this episode, we'll hear about:
• How pharmacogenetics can be used to secure drug use in the field of oncology
• Some other applications where gene polymorphisms are of particular interest: for example, to manage the antiplatelet effect of clopidogrel or to ensure an appropriate use of voriconazole
• The interest of pharmacogenetic panels for primary care and the key study raising the level of evidence for the approach
• The gap that still needs to be closed from a multiplexed approach with a few studied genes to the thousands required to fully explain drug variability
• The win-win combination of pharmacogenetics with TDM (like a good Len-Mac song) for patient care

To join IATDMCT, visit: https://iatdmct.org/join-us/
Subscribe to Eight Drugs a Week on your preferred podcast platform.

About our guests:
Erika is director of the Experimental and Clinical Pharmacology Unit of the Aviano Oncology Referral Centre, and contract professor at the School of Clinical Pharmacology and Toxicology, University of Trieste, Italy.

TDM for beta-lactams in critical care: You know my name (Look up the number)

mardi 13 août 2024 • Durée 37:26

Given we traditionally only monitored particular antibiotics to spare toxicity, and that beta lactams were widely considered such safe drugs, it was once difficult to imagine this drug class would become important TDM candidates. A bit more than a decade ago we started to see the first reports about augmented renal clearance in critically ill patients, often in situations in which antibiotic treatment was crucial, such as sepsis. TDM of beta lactams in the critical care is now recognised as a valuable tool to ensure adequate drug exposure and optimise therapeutic outcomes for these vulnerable patients. But the space is full of nuances and unanswered questions remain.

We are joined today by two big names in this space, Professors Birgit Koch and Jason Roberts, who we are fortunate to have help us navigate this complex therapeutic domain.

In this episode we'll hear about:

• TDM for beta-lactams in intensive care is growing, but are we doing it well?

• The long (and winding) road to practice change.

• Exposure targets: our experts' approach and some helpful advice.

• How much of a barrier do compatibility issues pose for continuous infusions?

• Jason's Venn diagram to consider patient outcomes

• Augmented renal clearance - not just in ICU patients: other settings where it ought to be considered.

• Spot the difference: our experts describe their services.

To join IATDMCT, visit: https://iatdmct.org/join-us/

Exploring new frontiers in TDM and toxicology (IATDMCT Banff 2024): Not a second time!

mercredi 19 juin 2024 • Durée 25:04

This time, it's the right time - not a second time, but a unique time - to take the road to Banff, Canada, for the 22nd edition of the IATDMCT annual congress.

This time, following a very successful virtual edition in 2020, we are very glad to be meeting in person. And what a place to meet! - surrounded by Banff's mountainous splendour. We are so grateful the congress organizing committee accepted the mission to make the show happen again, and we acknowledge the incredible work they've put behind two wonderful congresses.

We hope attendees will be inspired by the location, and we are certain it will be a very special IATDMCT meeting this year.

Joining us for the episode are organising committee heroes, congress chairs David Kinniburgh and Penny Colbourne, and Pamela Lyons, who apart from being an event organising extraordinaire, is also IATDMCT member manager, and runs our head office!

In this episode we'll hear ab-oo-t (pun intended!):

• How the congress theme ties in with Banff's history of exploration and beautiful mountain scenery.

• How the scientific program balances traditional topics with new frontiers in TDM and CT: wastewater testing for drug use, pioneering genetic testing and AI applications, developments in keeping abreast of novel psychoactive substances.

• The pre-congress workshop on emerging topics in clinical toxicology, including novel drug checking services and lessons learned following marijuana legalization.

• The social program that ensures guests will be fully immersed in the Canadian Rockies experience, including hiking opportunities, a western-themed dinner, and wildlife spotting

• Why inspiration, creative insight and joyful collaboration are essentially guaranteed at this meeting!

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