This week, Avi follows up Episodes 112 and 114 with the question: How does a bacterial species called Deinococcus radiodurans withstand extreme levels of radiation?

You can read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

This week, Dr. Mike Todorovic returns as a special guest to tell us about his book with Dr. Matt Barton, The Body A-Z!

Join us as Dr. Mike gives us a sneak preview of the interesting questions and fascinating insights within. You can order the book here, and show notes for this episode are here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

This week, Tony shares another "fresh case" physiology question: Why don't we all get spontaneous HIT? 

You can read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student (soon to be resident) Giancarlo Buonomo is our producer.

The Curious Clinicians explore why chronic laxative use can cause melanosis coli.

Check out the episode's show notes here.

Click here to obtain AMA PRA Category 1 Credits™ (1.00 hours), Non-Physician Attendance (1.00 hours), or ABIM MOC Part 2 (1.00 hours).

Audio edited by Clair Morgan of nodderly.com

This week, The Curious Clinicians investigate the curious laterality of catamenial pneumothoraces. Why do they almost always arise on the right side of the chest?

Check out the episode's show notes here.

Don't forget to claim your CME/MOC credits, courtesy of VCU Health!

Audio editing by Clair Morgan of Nodderly.com. 

The Curious Clinicians head all the way back to June, 2020 and reboot episode 3, exploring why trimethoprim/sulfamethoxazole can cause an isolated rise in creatinine. 

Check out the show notes here. 

Claim your CE/MOC credits here. 

The Curious Clinicians examine why advanced systolic heart failure can induce the Cheyne-Stokes respiratory pattern.

Check out the episode's show notes here.

Don't forget to claim your CME/MOC credits, courtesy of VCU Health!

Audio editing by Clair Morgan of Nodderly.com. 

In this episode, The Curious Clinicians examine why the drug Carbidopa-Levodopa has the brand name Sinemet. They also discuss the origin stories of the names of several other commonly prescribed medications.

Check out the episode's show notes here.

Audio edited by Clair Morgan of nodderly.com

*CME/MOC credits are not available for this episode.

On this episode the Curious Clinicians investigate why corticosteroids often cause blood eosinophil counts to drop so quickly and dramatically. 

Check out the show notes on our website. 

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly. 

The Curious Clinicians, led by Tony, investigate why nephrotic syndrome causes edema.

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly.

In this episode The Curious Clinicians investigate why some people absolutely love cilantro while others taste soap if they try to eat it.

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly.

In this episode The Curious Clinicians investigate why too much oxygen (aka hyperoxia) can be harmful.

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly.

For the final episode in our Intern Questions series, The Curious Clinicians examine why urinary tract infections cause burning with urination.

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly. 

This week, Avi shares new insights on the topic of episode 61: alpha-gal! We tackle the question: How could alpha-gal be used to treat cancer?

You can read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student (soon to be resident) Giancarlo Buonomo is our producer.

This week The Curious Clinicians examine why albuterol (and other beta agonists) can cause lactic acidosis.

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCUHealth!

Sound editing by Nodderly. 

Tony, Hannah and Avi are back at it with another cardiology-nephrology episode, this time examining why calcium "stabilizes" the cardiac membrane in hyperkalemia. For that matter, what does it even mean to stabilize a membrane?

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly.

In this episode The Curious Clinicians investigate why furosemide can improve dyspnea in acute heart failure almost immediately, long before any diuresis occurs. 

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Sound editing by Nodderly. 

On this episode Tony explores the benefits of fevers, including why even trees and bees mount fevers in response to infection. 

Check out the show notes on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

This episode is another installment in our Intern Question series, where Hannah examines why some patients feel short of breath specifically when bending over aka "bendopnea". 

You can read the show notes for this episode on our wbesite. 

Don't forget to pick up CME/MOC credits, courtesy of VCU Health!

The Curious Clinicians explore a theory about the prevalence of CFTR gene mutations and why cystic fibrosis carriers may have a selective advantage.

You can read the show notes for this episode on our website.

Check out Avi's tweetorial on this topic as well.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Hannah, Avi and Tony examine why we feel cold while febrile (shouldn't we feel hot?) and can develop shaking chills/rigors. The answer has implications for why rigors may be a more timely predictor of active bacteremia than fevers. 

You can read the show notes for this episode on our website. 

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health!

Avi, Hannah, and Tony investigate why myocardial infarctions lead to ST elevations (and/or ST depressions) on EKG. The answers they found are mind-bending. 

You can read the show notes for this episode on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health! 

This episode is another installment in our "Questions from Intern Year" series. Hannah explores whether disseminated intravascular coagulation (DIC) can itself be a source of shock.

You can read the show notes for this episode on our website.

Don't forget to pick up your CME/MOC credits, courtesy of VCU Health! 

In this episode of The Curious Clinicians, Tony, Hannah and Avi learn about the mechanisms of thirst, why drinking liquids immediately quenches thirst, and why patients with primary polydipsia drink excessively. 

Remember to get your CME/MOC credit for listening to the episode.

Check out the show notes for the episode at our website as well as Tony's original tweetorial. 

You can support the podcast and pick up sweet swag from our online store!

This week, Hannah dives into a question inspired by nature: Why do humans have such a keen smell for the scent of the rain?

You can read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student (soon to be resident) Giancarlo Buonomo is our producer.

This is the second episode in a two-part series called "The Eyes Have It", where The Curious Clinicians explore questions related to the eye. In this episode Hannah, Avi, and Tony learn about why bilirubin deposits in the eye, as well as why the term "scleral icterus" is anatomically incorrect. 

Remember to pick CME/MOC credit just for listening to the episode! 

Check out the show notes for this episode.

You can support the podcast and pick up sweet swag from our online store!

This is the first episode of a two-part series called "The Eyes Have It", where The Curious Clinicians explore questions related to the eye. In this episode Tony, Hannah, and Avi explore why Wilson disease can present with Kayser-Fleischer corneal rings. 

Remember to pick up CME/MOC credit just for listening to the episode! 

Check out the show notes for this episode and read Avi's tweetorial on this topic. 

You can support the podcast and pick up sweet swag from our online store!

Tony appeared as a guest on the Bedside Rounds podcast with Adam Rodman. Tony and Adam delve into race, racism, and the social determinants of health through three historic plagues in the United States — yellow fever in New Orleans, poliomyelitis, and the early days of HIV/AIDS — and explore what lessons we can learn for the current COVID-19 pandemic.

This episode was recorded live at the annual meeting of the Massachusetts American College of Physicians.

Check out the original Bedside Rounds post.

Read Tony's tweetorial on Original Antigenic Sin as exemplified by dengue. 

Learn about why cryptococcal meningitis can cause such severe elevations in intracranial pressure, while often causing only minimal inflammation. 

Don't forget, you can get CE/MOC credit just for listening!

Check out the show notes for this episode and read Avi's tweetorial on this topic.

You can support the podcast and pick up some sweet swag from our online store.

This is the next installment of our series on questions from intern year, with a question that came up on rounds. Hannah examines theories as to why septic pulmonary emboli often present in the periphery and bases of the lungs, while "bland" pulmonary do not. 

Don't forget to pick up your CE/MOC credits, courtesy of VCU Health!

You can read the show notes for this episode and subscribe to our mailing list on our website.

Support the podcast and pick up some sweet swag from our online store.

The Curious Clinicians plug-in to learn about why uremia interferes with platelet function and increases bleeding propensity. 

Don't forget, you can get CE/MOC credit just for listening!

Check out the show notes for this episode here.

And you can also read Tony's tweetorial on this topic here.

The Curious Clinicians are back at it, exploring why magnesium so effectively treats the arrythmia torsades de pointes. Hint: it's the same mechanism as magnesium's effects on bronchospasm in severe asthma and seizures in eclampsia!

As always, you can get CE/MOC credits just for listening!

To learn more, check out the show notes for this episode on our website.

You can also read Avi's original tweetorial on torsades and magnesium here. 

This is the first in a series where Hannah explores clinical questions that have arisen during her intern year. In this episode, The Curious Clinicians learn why acetaminophen toxicity can lead to an anion gap metabolic acidosis. 

Don't forget, you can obtain CE/MOC credits just for listening!

To learn more, check out the show notes for this episode on our website.

Avi, Tony, and Hannah are back at it, investigating why metronidazole treats both bacterial and parasitic infections, why it's only effective against anaerobic organisms, and how this relates to the supposed disulfiram-like reaction. 

The episode opens with an important message from Dr. Mark Shapiro (host of the Explore The Space podcast) about VoteHealth 2020.

Here are some links for obtaining CE/MOC credits just for listening to this episode and to read the show notes on our website.

You can also check out Avi's original tweetorial on metronidazole and all of The Curious Clinician Podcast's other episodes.

Hannah, Tony, and Avi dig into the origins and mechanism of that most wondrous of flavors: umami. 

Show notes: https://curiousclinicians.com/?p=722

CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

This week, Tony brings us a fresh case straight from morning report! Join  the Curious Clinicians as we learn: Why do patients with methemoglobinemia have an oxygen saturation fixed at 85%?

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

The Curious Clinicians examine why coronary ischemia can present with dyspnea.

Show notes: https://curiousclinicians.com/?p=888

CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

The Curious Clinicians dive into the history and physiologic effects of IV fluids and why saline is definitely not "normal".

Show notes: https://curiousclinicians.com/?p=824

CE/MOC: https://vcu.cloud-cme.com/course/search?p=4000&curriculum=Curious%20Clinicians

Avi, Hannah, and Tony investigate why the antibiotic azithromycin has anti-inflammatory properties. 

Show notes: https://curiousclinicians.com/?p=741

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

Tony, Avi, and Hannah examine the mechanisms of contraction alkalosis as a result of diuretic use, as well as the roles of chloride and a protein that none of them had previously heard of: pendrin.

Show notes: http://curiousclinicians.com/?p=788

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

Hannah, Tony, and Avi dive into the health and art of Vincent Van Gogh. Was he treated with digitalis? Was he "dig toxic" and did this influence his color palette? 

Show notes: https://curiousclinicians.com/?p=311

CE/MOC: https://vcu.cloud-cme.com/default.aspx?p=4000&curriculum=Curious%20Clinicians

On this episode of the The Curious Clinicians, Tony, Avi, and Hannah explore why trimethoprim/sulfamethoxazole can cause an isolated rise in creatinine. 

Show notes: http://curiousclinicians.com/?p=561

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

Hannah, Avi, and Tony break down why cancer leads to a hypercoagulable state, recalling the story of Armand Trousseau and exploring the roles of tissue factor and evading the immune system. 

Show notes: https://curiousclinicians.com/?p=304

CE/MOC: https://vcu.cloud-cme.com/default.aspx?P=0&EID=18166

Do you miss digging into the "why" behind what we do every day in medicine? Join Hannah, Tony, and Avi in The Curious Clinicians podcast as they delve into "why", starting with episode 1: Why does fingernail clubbing happen in so many different diseases?

Show notes: https://curiousclinicians.com/?p=481

CE/MOC: https://ce.vcuhealth.org/CuriousClinicians

In this preview of The Curious Clinicians, we provide an introduction to the podcast and a sneak peak at Episode 1! The full episode will be released June 3rd. 

We're on a gram negative run! Join the Curious Clinicians as we learn: Why does Pseudomonas smell like grapes?

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

Producer Giancarlo Buonomo is back! Join the Curious Clinicians as we learn: Why do we worry about Pseudomonas infection in diabetic patients?

Watch this episode on our new YouTube channel here, and read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Audio edited by Clair Morgan of Nodderly.com. Medical student Giancarlo Buonomo is our producer. 

Welcome back to the Curious Clinicians! In today's episode, Tony asks an important question: "Why don't we administer insulin orally?"

Read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

Happy Holidays from the Curious Clinicians! In today's episode, Avi shells us about a fascinating question: "Why do lobsters live so long?"

Read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).

In today's episode, Hannah asks the question: "Why do we 'automatically' form antibodies to ABO blood type antigens that are not our own?"

Read the show notes here!

Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours).