Lungcast – Details, episodes & analysis

For a probing discussion detailing the American Lung Association’s recent 2024 “State of Lung Cancer” report, we are joined by esteemed thoracic medical oncologist Dr. Jacob Sands of Dana-Farber Cancer Institute and Harvard Medical School. Offering insight into actionable targeted mutations, Dr. Sands addresses how precision oncology is fundamentally changing lung cancer diagnosis and treatment.

The novel immunotherapy drugs, though proven to be safe and effective with significant improvements in response and survival rates, have challenges as well—this episode covers the gamut.

Episode Highlights

0:00 Start

1:00 Topic of discussion

2:42 Introducing Jacob Sands, MD

3:39 NCCN guidelines for lung cancer

6:51 Recently-approved drugs for lung cancer

13:46 Patient responses to targeted mutations

17:58 Off-target side effects with drugs

21:34 State of Lung Cancer report

23:04 Estimated number of candidates for targeted therapies

26:13 Insurance coverage for biomarker testing

28:12 Other issues with ordering biomarkers

31:20 Closing comments

32:36 Outro

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

In this episode, multiple points of view are presented regarding Asthma Exacerbated Respiratory Disease (AERD). Lungcast host Albert Rizzo, MD, was joined by allergist and immunologist Mitchell Grayson, MD, of Nationwide Children’s Hospital, as well as patient advocate Rhonda Nelson and her husband Wayne Nelson of The Little River Band. This discussion delves into the trials and tribulations of diagnosing—and living with—AERD, from disease misconceptions to daily management.

Join the discussion as these guests focus specifically on the role of AI in chest imaging and uncover how these advancements are improving the future of patient care.

Episode Highlights
0:00 Start
1:00 Focus of each guest
2:55 Sampter’s triad and AERD
6:30 Patient experiences with AERD
10:18 Delayed diagnosis and recent changes
11:35 Therapy for AERD
16:32 Resources for patients with asthma
19:01 Day-to-day AERD management
24:14 Importance of keeping a medical journal
27:42 Outro

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

0:16 Intro
2:28 Recent modifications to the lung allocation score
5:11 Monitoring chronic graft rejection
9:23 The rising use of ex vivo lung perfusion 
16:17 The presence of post-COVID patients on the lung transplant waitlist
21:01 Impact of long Covid on transplant rehabilitation
22:51 Double lung transplant in bilateral lung cancer—what’s the future?
26:52 Effect of LAS on lung transplant survival racial disparity
31:05 What lies ahead in the practice of lung transplantation
35:00 Outro

Cleveland Clinic’s Maryam Valapour, MD, MPP, rejoins the broadcast, along with her colleague Kenneth McCurry, MD to discuss optimization of the lung allocation system to continue reducing waitlist times and patient mortality. 

It includes commentary on how recent changes to scoring protocols are expected to impact ongoing disparities related to race and socioeconomic status. They additionally talk about the role of transplantation in patients who have severely damaged lungs resulting from COVID-19 infection, an update since our April 2021 conversation.

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights
0:15 Intro
3:09 Low-dose CT screening uptake in Canada
4:45 Evolution of adjuvant, neoadjuvant therapies
7:10 Reviewing CheckMate 816
10:56 Reviewing KEYNOTE-671
12:58 The impact of neoadjuvants on operability
16:15 Treatment-specific biomarkers for lung cancer
21:13 The short-term future of lung cancer therapy
24:31 Outro

Precision medicine–delivering the right drug at the right time to the right patient–is the direction in which lung cancer treatment is heading. In this episode, we talk about an exciting, emerging drug class with one of the most prominent investigators involved with its development, Dr. Jonathan Spicer at McGill University’s Thoracic Oncology Network. 

It provides a deep dive into neoadjuvant therapy for patients who have operable lung cancer, offering insight into what is currently known about response and failure rates.

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights

0:15 Intro
1:48 Remembering the 1964 Surgeon General Report
3:01 The impact of the report on cardiology
6:47 The strategies and impact of anti-smoking campaigns
10:33 The modern vaping challenge
17:38 Outro

In recognition of 60 years since the 1964 Surgeon General Report—a historic contribution to our understanding of the negative health impacts of cigarette smoking—host Albert Rizzo, MD, meets with preventive cardiology expert Viet Le, DMSc, PA-C to reflect on the myriad of cascading effects delivered by this landmark report.

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights
0:15 Introducing Sue Padernacht, EDd, PCC
1:16 The definition of burnout
3:53 The history of burnout
7:45 Differences between stress and burnout
14:34 Physical and behavioral signs of burnout
20:55 Steps the health care industry can take against burnout

We are beginning 2024 with a matter that extends beyond the confines of pulmonary medicine and really has become something of a crisis in the U.S. healthcare system over the last decades. Organizational psychology expert Dr. Sue Padernacht joins Lungcast to provide an in-depth look into physician burnout—what are its drivers, what factors are exacerbating it, and how the collective medical community can work toward curbing its effect among caregivers.

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights

0:16 Intro
1:44 How to approach stage IV lung cancer, with Dr. David Tom Cooke
4:13 The ALA Lung Health Cohort Research Study, with Dr. Ravi Kalhan
8:42 What is the atopic march, with Dr. Payel Gupta
10:53 Weight loss for asthma care, with Dr. Anne Dixon
15:11 Air Quality Index 101, with Dr. Al Rizzo
18:47 Lung Cancer Age Equity, with Dr. Carolyn Presley
21:45 The emerging treatments for long Covid, with Dr. Julia Moore Vogel
24:28 The future of pulmonary embolism care, with Dr. Parth Rali
28:08 The modern fight against RSV, with Dr. Barbara Taylor
33:26 Detecting unhealthy air exposure, with Dr. Mark Hernandez
36:12 Living while fighting lung cancer, with Christy Fischer
38:51 Outro

Though some subjects are clear favorites, it is nearly impossible to select a single answer to the question, “What was the biggest story in pulmonology this year?” 

Since the American Lung Association (ALA) and HCPLive launched Lungcast in the summer of 2020, the field of respiratory health has evolved in unprecedented fashion. One doesn’t have to look further than the show’s episode library to appreciate the great shifts in the field—brought on by a global pandemic, numerous public health phenomena, and practice-changing innovations in screening, diagnostics, prevention and therapy. From vaccination to late-stage lung cancer care, the world of respiratory health is irrevocably changed from just a short span of 4 years.

To reflect on this year’s spectacular headlines in the field, HCPLive presents the annual recap episode in conjunction with This Year In Medicine, where the Lungcast team reflects on their favorite interview segments of 2023.

Subscribe to Lungcast on YouTube: https://www.youtube.com/@Lungcast

Want more content? Visit us at https://www.hcplive.com/podcasts/lungcast and https://www.lung.org/professional-education/lungcast.

For this episode fully focused on indoor air pollution, we are joined by Professor Mark Hernandez who serves as director of the Aerobiology and Disinfection Lab at the University of Colorado. Listen in to learn about the harmful impact of pollutants such as mold, toxic chemicals and asbestos on respiratory health, particularly in a school setting. Equally important, what can be done to help alleviate these effects?

Episode highlights

0:16 Intro
0:50 Introducing Mark Hernandez, PhD, PE
2:15 The most pressing issues of school air quality
4:12 Advice for school administrators
6:25 The link to pediatric asthma
12:23 Trends in national monitoring
14:16 How COVID-19 changed ventilation priorities
16:29 An equitable, affordable solution
18:34 Signs of unhealthy air exposure
20:53 How clinicians and guardians can get involved
23:47 Outro

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Christy Fischer, a miraculous 17-year stage IV lung cancer survivor, connects with us to discuss stress, stigma and significant changes in the treatment landscape. Hear how Christy transformed a daunting diagnosis into hope for others.

This educational and inspirational episode touches upon the raw emotions of what it is like to live (and thrive!) with advanced cancer.

Episode Highlights
0:17 Intro
1:55 Christy's first diagnosis
3:53 Reacting to Stage IV lung cancer
5:28 Initiating treatment
7:18 The lung cancer stigma
9:51 Finding the right doctor
11:16 How lung cancer care changed over 17 years
14:20 Clinical trial participation
16:51 Becoming an advocate
20:33 Advice for physicians diagnosing lung cancer
22:18 How to keep living after diagnosis

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

With cases of Respiratory Syncytial Virus (RSV) on the rise this fall, Dr. Barbara Taylor, professor of infectious diseases at UT Health San Antonio, joins us for this timely episode all about RSV. Importantly, she covers the unprecedented events of the 2022-2023 season that was marred by a ‘tripledemic’ of respiratory diseases.  How do the lessons learned change the preventive approach to better protect against the deadly infection?  

Episode Highlights

0:16 Intro
0:48 The burden of RSV today
2:11 Transmission, presentation and diagnosis of RSV
4:33 Likelihood of an RSV, COVID-19, flu “triple-demic”
7:35 The history of RSV vaccine development
12:09 Risk of RSV mutation and variants
14:19 The new RSV vaccines
20:09 Spacing the RSV vaccine with other seasonal shots
22:14 Age and comorbidities as vaccine criteria
24:30 In vitro immunization
27:39 Nirsevimab and monoclonal antibodies for RSV
29:31 Using the full toolset against RSV
31:50 Yearly COVID-19 vaccine updates?
33:24 A universal flu vaccine?
37:20 Outro

Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast