What the HEK is Immunotherapy?

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https://laraantebi.bandcamp.com/
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https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-amtagvi-til-therapy-melanoma
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https://www.nejm.org/doi/full/10.1056/NEJMoa2308917
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06: What the HEK are viruses?

Épisode 6

mardi 13 août 2024 • Durée 27:41

Some cool and emerging immunotherapies use viruses to kill cancer cells. But what the HEK are viruses and how do they work?

In this week’s episode we chat with Trinity Tooley, a graduate student studying viruses at Queen’s University. Trinity helps us break down exactly what viruses are and how they function. So sit back and unlock the wonderful world of viruses with Grace and Trinity!

Interested in learning more about immunotherapy? Check out our other episodes and give us a follow on instagram @wthisimmunotherapy and twitter @WTHisImmunoT! And check out our new website wthisimmunotherapy.com. Or feel free to reach out to us at wthisimmunotherapt@gmail.com if you have any questions or any ideas for episodes!

Access Transcript here.

Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

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05: What the HEK are you studying? (About TILs)

Épisode 5

mercredi 3 juillet 2024 • Durée 36:23

Last episode we learnt all about tumour infiltrating lymphocyte or TIL therapy through interviewing Dr. Simon Turcotte. We touched on his research, but what other research is going on within the TIL space in Canada? Well, in this episode we chatted with two students, Meghan Kates & Allyson Banville, all about their cool research on TILs!

Want to learn more about cool immunotherapy research? Check out our other episodes and give us a follow on instagram @wthisimmunotherapy and twitter @WTHisImmunoT! Or feel free to reach out to us at wthisimmunotherapt@gmail.com if you have any questions or any ideas for episodes!

Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

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04: What the HEK is TIL therapy?

Épisode 4

mercredi 5 juin 2024 • Durée 39:46

This month Gillian and Pauline learn all about Tumor infiltrating Lymphocyte (aka TIL) therapy with Dr. Simon Turcotte! Dr. Turcotte is a surgical oncologist at the CHUM Research Centre in Montreal, Quebec, who has a keen interest in TIL therapy. Listen in as we discuss things such as what TIL therapy is, what types of cancer it's been approved for, the TIL therapy scene within Canada, and what Dr. Turcotte researches and how he hopes to bring TIL therapy to Canada through a clinical trial!

Below are some useful links if you want to learn more:

Lifileucel approval

Melinda's story

TIL clinical trial in Canada led by Dr. Turcotte

Transcript

Don't forget to give us a follow on instagram @wthisimmunotherapy or feel free to reach out with questions at wthisimmunotherapy@gmail.com

Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

03: What the HEK are you studying? (about CAR T cells)

Épisode 3

jeudi 9 mai 2024 • Durée 33:49

So we learnt all about CAR T cell therapy on episode 2 with Dr. Scott McComb, but what exactly is the current landscape of CAR T cell therapy research like? To answer some students we chatted with 4 PhD students to learn a bit about their research and what they are excited for in the future.

Big thank you to our guests: Alex Shepherd, Bigitha Bennychen, Lorenzo Lindo, and Katie Flight

Also, don’t forget to give us a follow on instagram @wthisimmunotherapy! Or feel free to reach out to us at wthisimmunotherapt@gmail.com

Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

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BONUS: What the HEK is the patient experience with immunotherapy?

mercredi 17 avril 2024 • Durée 17:18

This week we are doing something a bit different - Grace and I sit down with Danielle Eldridge to chat about her experience receiving immunotherapy.

About Danielle:

Danielle recently graduated in May 2023 with a degree in Industrial Engineering from Texas A&M University. She grew up in Houston, Texas , works in technical marketing at Siemens, and is a Leukemia survivor. Danielle was diagnosed in June 2023 with Acute Lymphoblastic Leukemia but is happy to report that as of September 2023 she is in complete remission and is currently undergoing maintenance chemotherapy. Danielle completed 2 rounds of the hyper-CVAD frontline chemotherapy regime and 4 rounds of blinatumomab accompanied by periodic infusions of Rituximab and Inotuzumab. Danielle is currently competing for Visionary of the Year, a 10-week fundraising competition benefiting the Leukemia and Lymphoma Society. She is the youngest candidate this year and 1 of only 3 cancer survivors in her regional division. Danielle would very much appreciate any possible donations to her fundraising page. DONATE HERE:https://pages.lls.org/voy/txg/houston24/deldridge

Also, don’t forget to give us a follow on instagram @wthisimmunotherapy! Or feel free to reach out to us at wthisimmunotherapt@gmail.com

Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

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02: What the HEK is CAR T cell therapy?

Épisode 2

jeudi 11 avril 2024 • Durée 46:38

On this month’s episode we are joined by Dr. Scott McComb, a researcher at the National Research Council of Canada, to talk about Chimeric Antigen Receptor aka CAR T cells! Listen in as we discuss topics such as what exactly is a CAR T cell, how it is currently being used, some current challenges with this therapy, what Dr. McComb brings to the field, and what we are excited to see in the future with CAR T cell therapy!

Below are some useful links of things mentioned in the episode:

About BioCanRx: https://biocanrx.com/about/about-biocanrx

CLIC-01 Trial: https://doi.org/10.3389/fimmu.2022.1074740

Paper mentioned on CAR T cells for autoimmune diseases: https://doi.org/10.1056/NEJMoa2308917

CD22 CAR Paper from Dr. McComb's lab: https://doi.org/10.1016/j.omton.2024.200775

Episode Script: https://drive.google.com/file/d/1h0jUDBnVgdZcZk6aPCJ6IwaCIAt9uRml/view?usp=sharing

Don’t forget to give us a follow on instagram @wthisimmunotherapy! Or feel free to reach out to us at wthisimmunotherapt@gmail.com

Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

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What the HEK is immunotherapy? Trailer

jeudi 7 mars 2024 • Durée 01:23

What the HEK is immunotherapy? With this podcast we are trying to answer that question! Through interviews with professors, students, patients, and other experts in the field we hope to introduce different types of immunotherapy and the research that is ongoing, specifically within the Canadian field. Join us as we try to make immunotherapy more digestible!

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01: What the HEK is immunology?

Épisode 1

jeudi 7 mars 2024 • Durée 22:11

Before we dive into the different types of immunotherapy we wanted to take a step back to actually give a primer on what the HEK is immunotherapy? In this month's episode, hosts Gillian and Grace, along with co-creator Dr. Pauline Loos, describe the different components of the immune system, including the innate immune cells, adaptive immune cells such as T and B cells, and how these cells contribute to vaccine and cancer responses. We hope this immunology primer serves to get everyone up to speed on the major players in immunology that are utilized to fight cancer, or other diseases, in immunotherapy treatments.

Transcript link: https://docs.google.com/document/d/15QCCKCMprWAFkLX-drdXBvgxaKBW6TkaB-hFHYJjUiQ/edit?usp=sharing

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07: What the HEK are oncolytic viruses?

Épisode 7

jeudi 5 septembre 2024 • Durée 33:11

Wait, viruses as cancer therapy?? That's right! Oncolytic viruses or OVs are a newer and promising type of therapy that uses viruses to take down cancer in a safe manner. But how the HEK do they work?

This month we sit down with Dr. Lee-Hwa Tai from the University of Sherbrooke, Quebec to discuss all about OVs. Join us as we dive into how OVs kill cancer, their current status in the clinic, how safety is managed, exciting research in the field, and more!

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Interested in learning more about immunotherapy? Check out our other episodes and give us a follow on instagram @wthisimmunotherapy and twitter @WTHisImmunoT! And check out our new website wthisimmunotherapy.com. Or feel free to reach out to us at wthisimmunotherapy@gmail.com if you have any questions or any ideas for episodes!

Access Transcript here.

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Creators & Producers: Gillian Savage, Grace Bernard, and Dr. Pauline Loos

Podcast Logo is designed by Mia Portelance

Music is by Lara Antebi (https://laraantebi.bandcamp.com/)

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09: What the HEK is new in immunotherapy? (2024 recap)

Épisode 9

lundi 30 décembre 2024 • Durée 25:36

To end off the year Grace and Gillian dive into some of the scientific findings and news they found most interesting in the immunotherapy field for 2024! We hope this gets you excited about the progress of immunotherapy and the many breakthroughs to come!

For more information on the immunotherapies discussed here check out the links below:

Lifileucel, the first FDA-approved TIL product: https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-amtagvi-til-therapy-melanoma

CAR T cell therapy for autoimmune disease: https://www.nejm.org/doi/full/10.1056/NEJMoa2308917 and https://www.science.org/content/article/breakthrough-cancer-immunotherapy-now-taking-aim-autoimmune-disease

7th approved CAR T cell product (AUCATZYL): https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-obecabtagene-autoleucel-adults-relapsed-or-refractory-b-cell-precursor-acute

First FDA-approved CAR T cell product for CLL: https://www.lls.org/news/fda-approves-first-car-t-cell-therapy-chronic-lymphocytic-leukemia#:~:text=Rye%20Brook%2C%20N.Y.%2C%20March%2019,not%20responded%20to%20previous%20treatments.

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