We're not getting any younger... yet. – Détails, épisodes et analyse

In this episode, Eric Verdin, CEO of the Buck Institute, and Stanford University’s Dr. Tony Wyss-Coray discuss the groundbreaking science of brain rejuvenation through heterochronic parabiosis, a process where young blood factors are shown to restore cognitive function and potentially extend lifespan. Moving from the lab to the clinic, they explore the next frontier: Proteomic Clocks. By measuring thousands of proteins, scientists can now determine the biological age of individual organs, allowing for the detection of Alzheimer’s and other neurodegenerative diseases up to 15 years before symptoms appear. This shift toward high-precision organ tracking marks a new era in preventative geroscience and personalized longevity.

Tony Wyss-Coray is a Professor of Neurology and Neurological Sciences and the Director of the Phil and Penny Knight Initiative for Brain Resilience at Stanford University. His lab studies brain aging and neurodegeneration with a focus on age-related cognitive decline and Alzheimer’s disease. The Wyss-Coray research team discovered that circulatory blood factors can modulate brain structure and function and factors from young organisms can rejuvenate old brains. Current studies focus on the molecular basis of the systemic communication with the brain by employing a combination of genetic, cell biology, and –omics approaches in killifish, mice, and humans. Wyss-Coray has presented his ideas at Global TED, the Tencent WE Summit, and the World Economic Forum. He co-founded Alkahest Inc. and several other companies targeting Alzheimer’s and neurodegeneration and has been the recipient of an NIH Director’s Pioneer Award, a Zenith Award from the Alzheimer’s Association, and a NOMIS Foundation Award.

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What if aging is less a fate and more an engineering challenge? We sit down with George Church to unpack a future where gene therapy, cellular reprogramming, and AI-driven delivery systems converge to extend healthspan—and possibly lifespan—without sacrificing identity or safety. From bowhead whales and cancer risk to ethics, trial rigor, and how to deliver rejuvenation to the brain, this is a deep dive into what’s coming next and what it will take to get there.

George Church is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT). He is Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science. He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute and election to the National Academy of Sciences and Engineering.

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What is the goal of living longer? It’s not simply to celebrate a number, but to do something meaningful with that time. Renowned Stanford psychologist Laura Carstensen speaks with Gordon about the experience of aging, in the past and in the future, and why changes in culture must accompany changes in healthspan so we can flourish as a society.

Laura L. Carstensen is Professor of Psychology at Stanford University where she is the Fairleigh S. Dickinson Jr. Professor in Public Policy and founding director of the Stanford Center on Longevity. Her research on the theoretical and empirical study of motivational, cognitive, and emotional aspects of aging has been funded by the National Institute on Aging without interruption for more than 30 years. Carstensen is an elected member of the National Academy of Medicine and the American Academy of Arts and Sciences. She served on the MacArthur Foundation’s Research Network on an Aging Society and was a commissioner on the Global Roadmap for Healthy Longevity.  Carstensen’s awards include a Guggenheim Fellowship, the Kleemeier Award, The Richard Kalish Award for Innovative Research and distinguished mentor awards from both the Gerontological Society of America and the American Psychological Association. She is the author of A Long Bright Future: Happiness, Health, and Financial Security in an Age of Increased Longevity. Carstensen received her B.S. from the University of Rochester and her Ph.D. in Clinical Psychology from West Virginia University. She holds an honorary doctorate from the Katholieke Universiteit Leuven, Belgium.

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We're back! In season one, we investigated the biology of aging in many different organisms to learn why and how we age. This season we'll take a close look at potential interventions that modify mechanisms of aging biology and may dramatically change the way we age in our lifetimes.

Get ready for season two of the Buck's podcast We're not getting any younger... yet. with scientist Gordon Lithgow. Subscribe today!

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Gordon and Stella revisit key concepts from the conversation with Arne Akbar, such as using sestrins to modulate T-cells and telomeres. Looking back over the course of season one, Stella and Gordon discuss the need to think about aging as an organizing principle, and how to deal with all the things we don't yet know.

Stay tuned for season two!

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What role does the immune system play in aging? How do senescent cells evade it and promote inflammation? And what does it reveal about developing effective interventions? Immunologist Arne Akbar joins Gordon to break down the array of actors and pathways involved, including sestrins, immune memory, the gut microbiome, and more. Along the way, Arne highlights the need to connect across research areas, and shares why courage is the most important quality for a scientist to cultivate.

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After the conversation with Monica Driscoll, Gordon and show editor Stella connect to discuss the link between cell death and aging, what we can learn from sending worms to space, and the need for personalized medicine in aging interventions. Finally, they look forward to the next episode with immunologist Arne Akbar.

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How do different cells in our bodies age differently? What exactly happens when a neuron takes out its trash? In this episode, neuroscientist Monica Driscoll takes Gordon on a tour through her serendipitous career. Topics include sloppy developmental biology, enigmatic exophers, worms in space, and the importance of studying things no one else is thinking about.

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After a wide-ranging conversation with Nir Barzilai, Gordon and show editor Stella discuss efforts to turn research on geroprotective mechanisms into effective interventions, and look forward to the next episode with neuroscientist Monica Driscoll.

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Is aging truly inevitable? Can we study the genetics of long-lived people to learn how to delay or reverse aging? In this episode, Gordon talks with Dr. Nir Barzilai about his research on centenarians, insulin signaling pathways, and moving aging interventions out of the lab and into the clinic. 

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