Welcome to Weekly Pep Talk — where GLP-1s, peptides, and longevity get real and judgment-free. Hosted by Prime Longevity Protocol, each episode covers semaglutide, tirzepatide, peptide therapy, biohacking, weight loss, metabolic health, and wellness optimization. Real talk for Warriors who refuse to settle for average. No shame. No gatekeeping. Just real people chasing real results. New episodes every week. Come optimize with us. 🧬
Nothing discussed is medical advice. Always consult your healthcare provider.
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Données mises à jour le 22/10/2026
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Hair Transplant Day 10 Results + Hair Growth Peptides & FLGR-242 | Mike Sheffer & Max Plasencia
Épisode 29
lundi 19 octobre 2026 • Durée 44:01
Mike Sheffer shares his early hair transplant recovery and what he experienced during the first 10 days after the procedure.
In Episode 29 of Weekly Pep-Talk, Mike and Max Plasencia discuss hair loss, DHT, minoxidil, finasteride, GHK-Cu, BPC-157, TB-500, nutrition, inflammation, and the peptides and topicals Mike personally used during recovery.
The conversation then shifts to an early FLGR-242 case discussion, where they review changes in body weight and lean mass before breaking down myostatin inhibition, muscle-building limits, training, nutrition, and why younger lifters should be cautious with performance-enhancing compounds.
MOTS-c Human vs Mouse, PNC-27 & Next-Gen Peptides | Mike Sheffer & Max Plasencia | Ep.28
Épisode 28
lundi 5 octobre 2026 • Durée 36:47
What is the difference between human and mouse-sequence MOTS-c, and could the sequence you're using affect how you respond?
In Episode 28 of Weekly Pep-Talk, Mike Sheffer and Max Plasencia dive deep into MOTS-c, mitochondrial function, peptide reactions, next-generation amylin compounds, PNC-27/PNC-28, and growth hormone peptide combinations.
The conversation starts with MOTS-c and why the hosts believe it has become such an interesting compound for mitochondrial health, AMPK activation, energy production, glucose utilization and exercise-related performance. They then explain the distinction they discuss between the mouse sequence and human reference sequence, including the difference at position 14. Pasted text
Mike and Max also discuss why some people report reactions to MOTS-c, their experiences with histamine reactions, and the potential relationship they speculate about between quercetin and peptide reactions. They emphasize that their observations are not based on a controlled study. Pasted text
The episode then moves into Eli Lilly's amylin-focused compounds, including the discussion around cagrilintide and a newer amylin receptor agonist. They compare mechanisms, discuss gastric side effects, dose-response concepts from clinical trials, and why the hosts believe amylin-based approaches could become an important part of future weight-management strategies. Pasted text
Mike and Max also revisit PNC-27 and PNC-28, including their discussion of p53, MDM2/HDM2 and early laboratory and animal research. Importantly, they acknowledge that this is a highly experimental area and repeatedly frame these compounds as research-only rather than established cancer treatments. Pasted text
Finally, they answer a viewer question about combining Tesamorelin, Ipamorelin and CJC-1295, explaining how they view the different pathways, CJC variations and potential approaches to cycling these compounds.
RETA Update: FDA battle continues, New Reta addition, MK677, PCOS & Q&A
Épisode 27
lundi 28 septembre 2026 • Durée 53:56
MK-677, Retatrutide, growth hormone, peptide sourcing, testing, PE-22-28 and PCOS — this episode of Weekly Pep-Talk covers a wide-ranging Q&A on some of the most talked-about compounds and developments in the peptide and performance space.
Mike Sheffer and Max Plasencia break down what they know about MK-677, including why it isn't technically a peptide, how it relates to ghrelin and growth hormone release, and why interest in it has expanded beyond traditional bodybuilding circles.
The conversation also dives into the latest Eli Lilly and retatrutide discussion, including the potential implications of how retatrutide could be classified, pharmaceutical exclusivity, compounding, market access and the broader peptide industry.
They also discuss what could come next for GLP-1 and amylin-based therapies, including the potential role of amylin receptor agonists for people who have reached plateaus or are considering transitioning away from GLP-based compounds.
Another major topic is growth hormone availability and peptide sourcing, including concerns around overseas HGH, certificates of analysis (COAs), batch testing, chain of custody and the difference between testing a representative sample versus relying on third-party documentation.
Mike and Max also discuss PE-22-28, neuroplasticity, cognitive effects, Semax, Selank and Dihexa, followed by a discussion around PCOS, insulin resistance, inflammation and mitochondrial health.
🔬 Topics Covered
* MK-677 / Ibutamoren
* MK-677 and growth hormone
* Ghrelin receptor agonists
* Growth hormone and aging
* Retatrutide
* Eli Lilly and retatrutide
* GLP-1 and weight-loss compounds
* Amylin receptor agonists
How to Stay Shredded Year-Round: Peptides, Fat Loss, Muscle & Recovery
Épisode 26
lundi 21 septembre 2026 • Durée 56:31
What if you didn't have to wait until summer to get lean, shredded, and beach ready?
In this episode of Weekly Pep-Talk, Mike Sheffer and Max Plasencia take the conversation to the beach in South Florida and break down their approach to staying lean year-round — from tanning and appetite control to fat loss, muscle preservation, growth hormone, recovery, and maintaining results long-term.
The episode begins with a deep dive into Melanotan 1 vs. Melanotan 2, including how the two compounds differ in receptor activity and why Melanotan 2 is associated with additional effects such as increased libido and appetite suppression.
Mike and Max then discuss PT-141, its relationship to Melanotan 2, and why it has become an interesting topic for both men's and women's sexual health.
The conversation shifts to the most important part of getting shredded: losing fat without sacrificing muscle. They discuss GLP-1-based compounds including retatrutide and tirzepatide, newer amylin-receptor approaches, sustainable weight loss, appetite management, and why trying to lose weight too aggressively can make muscle preservation more difficult.
Mike and Max also break down the role of cardio and resistance training, including how they approach training when someone has significant weight to lose and why maintaining muscle should remain part of the plan during a cut.
The episode then moves into Tesamorelin, Ipamorelin, CJC-1295 and growth hormone, comparing different approaches and discussing their experiences with sleep, recovery, IGF-1, body composition, and training.
The final section features a wide-ranging Q&A from the community, covering FLGR-242, coming off Tesamorelin, sleep peptides, low red blood cell counts, methylene blue, traveling with peptides, alternative weight-loss compounds, daily tadalafil, PE-22-28, endurance compounds, receptor tolerance, broken sleep, and transitioning to maintenance after reaching a weight-loss goal.
The Future of Weight Loss Peptides + ARA-290 for Nerve Recovery | Mike Sheffer & Max Plasencia | Ep. 25
Épisode 25
lundi 14 septembre 2026 • Durée 52:20
What happens when peptide recovery protocols meet the next generation of weight-loss compounds?
In this episode, Mike Sheffer and Max Plasencia dive into some of the biggest conversations happening across the peptide, fitness, recovery, and longevity space.
The discussion begins with Mike's recent experience dealing with neck and nerve pain following years of injuries and intense training. Mike explains the recovery protocol he has been experimenting with, including BPC-157, TB4, KPV, and ARA-290, while Max breaks down the distinction between nerve damage and a mechanically pinched nerve.
They also discuss the role of recovery strategies beyond peptides, including traction, mobility work, tissue work, stretching, and nerve flossing, and why peptides should be viewed as one potential tool rather than a replacement for addressing the underlying cause of an injury.
The conversation then shifts to the rapidly evolving weight-loss peptide landscape, including compounds that target the amylin receptor and how they differ from GLP-1, GIP, and glucagon-based approaches. Mike and Max discuss why having different receptor pathways may give people additional options when they experience side effects, plateaus, or difficulty tolerating certain compounds.
They also answer questions about transitioning from retatrutide, tirzepatide, and other weight-loss compounds, the importance of avoiding unnecessarily aggressive dosing, and why individual protocols need to take a person's goals and response into account.
🔬 Topics Discussed
-ARA-290 and nerve recovery
-BPC-157
New Retatrutide Is Coming? Peptide Reactions & HGH vs. IGF-1 | Mike Sheffer & Max Plasencia
Épisode 24
lundi 7 septembre 2026 • Durée 56:06
The peptide landscape is changing fast and retatrutide is at the center of the conversation.
In this episode, Mike Sheffer and Max Plasencia discuss the latest developments surrounding a new long-acting retatrutide-related product, including the reported challenges around naming, regulation, pharmaceutical competition, and where the product could potentially fit into the future peptide market.
Mike and Max then answer viewer questions about GLP-1 weight-loss compounds, peptide tolerance, receptor sensitivity, weight-loss plateaus, and the importance of using the minimum effective approach rather than aggressively increasing doses. They also discuss concerns around muscle loss during rapid weight loss and why maintaining muscle is important when pursuing long-term body-composition goals.
Another major part of the conversation focuses on histamine and allergic-type reactions to peptides. Max shares his personal experimentation with different injection locations and reconstitution concentrations after experiencing reactions to tesamorelin. Mike adds his own experiences with compounds including MOTS-c and discusses possible factors such as injection site, concentration, mast-cell activity, and individual sensitivity.
The episode also covers an important community question about alternating retatrutide and tirzepatide, including the differences between their receptor activity and why the hosts discuss alternative approaches such as amylin-based compounds.
Later, Mike and Max compare nasal vs. injectable administration of C-MAX and Selank, discussing convenience and the different effects they associate with each route.
Finally, they break down HGH vs. IGF-1, including their different mechanisms, potential benefits and risks, blood glucose considerations, muscle growth, recovery, and why monitoring IGF-1 levels can be useful when discussing growth-hormone-related compounds.
Peptides vs. Bioregulators: What's the Difference & Which Is Better?
Épisode 23
lundi 31 août 2026 • Durée 55:25
What is the difference between peptides and bioregulators, and could bioregulators represent the next evolution of peptide therapy?
In Episode 23, Max Plasencia and Mike Sheffer dive deep into bioregulators, peptide signaling, gene expression, recovery, cognitive health, muscle growth, mitochondrial function, and the future of health optimization.
The conversation begins with the fundamental differences between traditional peptides and shorter bioregulators. Mike and Max discuss their view that longer-chain peptides primarily act as signaling molecules, while shorter bioregulators may interact more directly at the cellular and gene-expression level.
They explore examples including Ovagen, Testagen, Bronchogen, Livagen, Cardilax, Cortagen and Vessagen, as well as the research associated with Dr. Cavinson and the Cavinson Institute. The discussion also explores potential applications involving aging, tissue health and eyesight.
Mike shares his personal experience with declining eyesight and previous laser eye procedures, leading into a discussion about potential bioregulator combinations for eye health.
The conversation then moves into Cortagen + ARA-290, the relationship between bioregulators and signaling peptides, and why Mike and Max believe a bioregulator could potentially become the foundation of a broader peptide protocol.
Mike and Max also discuss Semax vs. Adamax, PE-22-28, Selank, chronic stress, cortisol, inflammation and mitochondrial health, including Mike's personal experience experimenting with different compounds.
Finally, they introduce FLGR-242, a newer myostatin-inhibition approach designed around muscle growth, albumin binding and longer-lasting activity, and discuss its potential implications for bodybuilding and muscle development.
The Future of Peptides: Retatrutide, Muscle Growth, HGH & Longevity | Mike Sheffer & Max Plasencia
Épisode 22
mardi 25 août 2026 • Durée 55:01
Welcome back to another episode of Weekly Pep-Talk with Mike Sheffer and Max Plasencia.
In this episode, Mike and Max break down the rapidly changing peptide landscape, starting with the latest developments surrounding retatrutide and Eli Lilly, the future availability of peptide products, and what increasing pharmaceutical regulation could mean for the research peptide market.
The conversation then moves into the next generation of peptide technology, including albumin-bound peptides, longer-acting compounds, Follistatin/FLGR, muscle growth, HGH, testosterone, and the potential future of targeted muscle-building therapies.
Mike and Max also compare AOD-9604 and HGH Frag 176-191, discussing their similarities, differences, solubility issues, and why they believe HGH Frag may be an interesting alternative for people frustrated with AOD's reconstitution and stability challenges.
The episode finishes with a discussion around fibromyalgia, mitochondrial function, inflammation, insulin resistance, SS-31, MOTS-C, ARA-290, KPV, VIP, and the importance of taking a holistic approach to health rather than relying on peptides alone.
In This Episode:
-Eli Lilly and the future of retatrutide
-Retatrutide availability and regulation
-The changing research peptide market
-Pharmaceutical industry influence
-Next-generation peptide technology
-Albumin-bound peptides
-Long-acting peptide development
-Follistatin and FLGR
Sign in Inside the Peptide Industry: Testing, Quality, Safety & What Comes Next
Épisode 22
vendredi 21 août 2026 • Durée 01:45:40
What really happens behind the scenes in the peptide industry?In this episode, Trevor Kruder sits down with Michael Sheffer and Max Plasencia for a deep discussion about peptides, fitness, bodybuilding, manufacturing, quality control, third-party testing, regulation, and the future of peptide technology.Michael Sheffer brings more than 14 years of experience in health coaching and performance, along with his background as a WBFF Pro, IFBB Professional Men’s Physique athlete, 2019 Mr. Canada champion, clinical consultant, and peptide expert. His engineering background also brings a technical perspective to the conversation around testing, quality, and peptide development.Max Plasencia brings more than 20 years of experience across fitness, nutrition, performance, lifestyle optimization, and transformation. As an entrepreneur, coach, media personality, founder of Prime Longevity Protocol, and Lifestyle Editor at Digital Muscle, Max has spent years working at the intersection of health, physique, performance, and longevity.Together with Trevor, they explore what is actually happening behind the rapidly growing peptide industry.In This Conversation:-How Mike and Max discovered peptides-Their backgrounds in fitness and bodybuilding-Why peptides are becoming increasingly popular-Looking beyond the most commonly discussed peptides-Follistatin and the evolution of peptide research-Peptide stability and degradation-New approaches to peptide development-The potential future of oral peptides-Why third-party testing matters-Quality control and peptide manufacturing-Inside an ISO 5 manufacturing environment-The future of the research peptide market-Peptide safety claims and misinformation online-Conspiracy theories surrounding peptides-Trevor's own introduction to peptides-Building a business within the peptide industry-Where peptide technology could be heading next🎙️* Featuring*Trevor KruderHost / EntrepreneurMichael ShefferPeptide Expert • Clinical Consultant • WBFF Pro • IFBB Professional Men's Physique Athlete • 2019 Mr. Canada ChampionMax PlasenciaLifestyle Optimization Expert • Entrepreneur • Coach • Media Personality • Founder, Prime Longevity Protocol
Buy Peptides online at Prime Longevity Peptides: Enter code:welcome20 for 20% off your first order:
The Health Problems Hiding in Your Body: Parasites, Liver Detox, Water & Peptides | Ariel Jarvis
Épisode 21
lundi 17 août 2026 • Durée 01:30:33
Welcome back to another episode of Weekly Pep-Talk
This week, Mike sits down with Ariel Jarvis, a natural health practitioner, herbalist, nutritionist, Traditional Chinese Medicine practitioner, blood scientist, entrepreneur, and CEO of Vitality Wellness World.
This is one of the deepest conversations yet about the relationship between physical health, emotional health, the nervous system, nutrition, hydration, detoxification, parasites, inflammation, and peptides.
Ariel explains why someone can have seemingly "perfect" blood work while still feeling terrible, and why she believes that looking beyond conventional lab markers can reveal a much bigger picture.
In This Episode:
-Why people can feel sick despite normal blood work
-The nervous system and chronic stress
-Emotional patterns and their relationship to health
About Weekly Pep-Talk: Weekly Pep-Talk is a podcast covering peptides, longevity, GLP-1s, fat loss, bodybuilding, performance enhancement, recovery, biohacking, and health optimization.
About Weekly Pep-Talk: Weekly Pep-Talk is a podcast covering peptides, longevity, GLP-1s, fat loss, bodybuilding, performance enhancement, recovery, biohacking, and health optimization.
About Weekly Pep-Talk: Weekly Pep-Talk is a podcast covering peptides, longevity, GLP-1s, fat loss, bodybuilding, performance enhancement, recovery, biohacking, and health optimization.
-Why peptides should be part of a holistic approach
-Nutrition, exercise and sustainable health
🎙️ Hosts
Mike Sheffer, Max Plasencia
About Weekly Pep-Talk: Weekly Pep-Talk is a podcast covering peptides, longevity, GLP-1s, fat loss, bodybuilding, performance enhancement, recovery, biohacking, and health optimization.
About Weekly Pep-Talk: Weekly Pep-Talk is a podcast covering peptides, longevity, GLP-1s, fat loss, bodybuilding, performance enhancement, recovery, biohacking, and health optimization.
New episodes every week.
Buy Peptides online at Prime Longevity Peptides: Enter code:welcome20 for 20% off your first order:https://primelongevitypeptides.com
