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TitreDateDurée
316: Food Addiction and the Gut Microbiome23 Aug 202400:56:23

TWiM describes experiments to explore gut microbiota signatures of vulnerability to food addiction in mice and humans, and how a phage tail-like protein suppresses competitors in populations of bacteria of plants.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

315: How Pseudomonas Became A Global Pathogen09 Aug 202400:58:00

TWiM explores evolution and host adaptation of Pseudomonas infections of plants, and the impact of COVID-19 on ESBL-producing E. coli on urinary tract and blood infections.

Hosts: Vincent Racaniello and Michael Schmidt.

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Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

306: Spirulina Smoothies15 Mar 202400:52:45

TWiM discusses the identification of natural products from reconstructed ancient bacterial genomes, and how plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin.

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216: It starts with a cough01 May 202001:03:35

The TWiM team discuses saliva as more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swab and how Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 

 

215: Cultural transformation and pathogen emergence17 Apr 202000:56:44

A ferret model for infection by SARS-CoV-2, and how Neolithization lead to emergence of a human bacterial pathogen.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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214: Masterful subversion03 Apr 202000:58:37

Vincent, Elio and Michael reveal the ASM COVID-19 summit, and how Salmonella injects a protein into the cell to drive suppression of the immune response.

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213: Fugitive emissions20 Mar 202001:01:17

Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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212: A coronavirus outbreak and IRF4 deficiency in Whipple's disease06 Feb 202000:55:26

The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple's disease. 

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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211: Bacteria, colon cancer and fire blight09 Jan 202001:18:11

The Fellowship of the TWiM reveal that colorectal cancer-associated microbiota are associated with higher numbers of methylated genes in colonic mucosa, and identification of metabolites needed by the fire blight disease bacterium for virulence in apples.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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210: The Waze of microbes05 Dec 201901:16:24

The Microbial Comrades present the oldest osteosynthesis in history, and how a small molecule produced by stressed bacteria is a warning signal that repels healthy populations to promote their survival.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

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209: Resuscitating persisters and flagellotrophic phage14 Nov 201900:58:18

The TWiM team reveals how ribosome modification resuscitates bacterial persister cells, and explain how a phage tail fiber protein exploits rotation of flagella to move towards the cell membrane.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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208: Georgia Tech microbial31 Oct 201901:22:50

Hosts: Vincent Racaniello, Michele Swanson and Michael Schmidt

Guests: Deanna Beatty, Mark Hay, Gina Lewin, Frank Stewart, and Marvin Whiteley

At Georgia Tech, members and trainees of the Center for Microbial Dynamics and Infection discuss the identification of pathogen essential genes during coinfections, and how coral management can improve coral defenses against pathogens.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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207: Partnerships to Advance Public Health17 Oct 201901:07:27

From ASM Microbe 2019 in San Francisco, Vincent speaks with Victoria McGovern, Carl Nathan, and Dan Portnoy about advancing human health through innovative collaborations.

Host: Vincent Racaniello

Guests: Victoria McGovern, Carl Nathan, and Dan Portnoy

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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305: The Marvel of MAC02 Mar 202400:49:51

TWiM reviews the ongoing cholera outbreak in Africa, and research showing that gut complement induced by the microbiota blocks pathogens and spares commensal bacteria.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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206: Bacteria send nucleotide signals03 Oct 201901:05:17

The TWiM holobionts pay tribute to Stuart Levy, and reveal the remarkably diverse array of cyclic nucleotides synthesized by bacteria that likely mediate interactions with animal and plant hosts.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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205: Asgards meet the Tardigrades20 Sep 201901:07:23

The tetracoccal TWiM team visits Tardigrades on the Moon, and the twelve year quest to isolate an archaeon that provides insights into the emergence of the first eukaryotic cell.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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204: Programmable bacteria for antitumor immunity06 Sep 201901:07:46

Host: Vincent Racaniello

Guests: Nicholas Arpaia and Tal Danino

Vincent meets up with Nick and Tal to explain how they engineered E. coli to lyse within tumors and deliver an antibody that causes tumor regression in mice.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

203: A magnetotactic consortium under the sea22 Aug 201900:58:19

The TWiM team reveals thousands of small novel genes in the human microbiome, and a mutualistic symbiosis between marine protists covered with magnetosome-containing bacteria.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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202: This frass doesn't stink08 Aug 201901:01:41

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

Guest: Julie Wolf

Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction, and bacteria that degrade PET plastic.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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201: Microbiology papers for first year students26 Jul 201901:23:57

Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

200: In the company of Elio12 Jul 201901:01:26

Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms.

VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko

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199: PhD Balance28 Jun 201901:15:16

From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review.

Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt

Guests: Susanna L. Harrisand Alex Politis

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198: Unexpectedly pathogenic bacteriophages01 Jun 201901:00:23

The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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197: Intercellular microbial trade26 Apr 201901:10:25

The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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304: A New blue cheese-making fungus17 Feb 202400:57:34

TWiM reveals a new population in the blue cheese-making fungus Penicillium roqueforti and identification of a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli.

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196: I hear you29 Mar 201901:03:38

The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

195: Gingipain in the Alzheimer brain04 Mar 201901:14:32

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer's disease.

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194: Standard imperial procedure14 Feb 201901:05:27

Vincent RacanielloMichael Schmidt, Michele Swanson and Elio Schaechter

How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli.

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193: Persisters31 Jan 201901:00:45

The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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192: A Qtip for phages18 Jan 201901:06:22

The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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191: By the pulp of their teeth21 Dec 201801:01:36

The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria.

Hosts: Vincent Racaniello, Elio Schaechter,  Michael Schmidt,  and Michele Swanson

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190: Exosomes in your nose and in your gut07 Dec 201801:18:51

The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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189: Salmonella BonJovi16 Nov 201801:11:05

The TWiM team considers the state of the world's fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses.

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter, and Michele Swanson

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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188: Turducken antibiotics31 Oct 201801:20:45

The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome.

Hosts: Vincent Racaniello and Michael Schmidt

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187: Rounding up the bees19 Oct 201801:06:29

The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees.

Hosts: Vincent Racaniello, Elio SchaechterMichael Schmidt, and Michele Swanson

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303: Can Our Microbiome Break Our Hearts?03 Feb 202400:56:32

TWiM reveals a database of genome sequences of thousands of Mycobaterium tuberculosis, allowing association with resistance phenotypes to 13 antibiotics, and microbe-derived uremic solutes that enhance thrombosis potential in the host.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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186: Crypto-metamorphosis05 Oct 201801:13:24

The TWiM team describe the involvement of a microbiome in snail metamorphosis, and using Listeria to kill tumors.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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185: There's no moa Moa21 Sep 201801:08:22

The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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184: CRISPR-Cas immune systems07 Sep 201801:26:09

Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.

Host: Vincent Racaniello

Guest: Sam Sternberg

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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183: Two symbioses23 Aug 201800:57:04

The TWiMpeeps discuss two symbioses: a parasitoid bacterium of a heterotrophic protist, and fungal parasites in cicadas.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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182: A micro story with macro implications09 Aug 201801:05:47

The TWiM hosts reveal how to test antimicrobial susceptibility in less than 30 minutes, and a carbonate-sensitive phytotransferrin in diatoms that controls iron uptake.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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181: Dr. Warhol's Periodic Table of Microbes26 Jul 201800:58:01

Vincent speaks with John Warhol about state microbes, the Periodic Table of the Microbes, and why microbiology is cooler than astrophysics, but they have better TV shows.

Host: Vincent Racaniello

Guest: John Warhol

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180: Microbecentricity with Mark O. Martin13 Jul 201801:04:24

Vincent speaks with Mark O. Martin about microbial centricity, teaching undergraduates microbiology, lux art, painting with glowing bacteria, tardigrades and much more at ASM Microbe 2018.

Host: Vincent Racaniello

Guest: Mark O. Martin

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179: Viable but not culturable29 Jun 201801:16:05

The TwiModulators discuss aerosolization of bacteria and viruses in an ocean-atmosphere mesocosm, and how the common practice of decontaminating produce with chlorine produces viable but non-culturable pathogens.

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Multistate foodborne outbreak investigations (CDC)

178: Corals are sexy with Christina Kellogg15 Jun 201801:04:48

The TWiM team travels to ASM Microbe 2018 in Atlanta, Georgia to speak with Christina Kellogg about her career and her research on coral microbial ecology.

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

Guest: Christina Kellogg

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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177: Microbial sibling conflict01 Jun 201800:54:38

The TWiM team discuss bacteriophage evolution in a dairy plant, and killing of less fit cells among social microbes.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Elio Schaechter.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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302: Itching and Scratching and New Antibiotics20 Jan 202400:54:33

TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.

 

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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176: Elio has lots of colanic acid17 May 201800:59:48

Vincent, Michael and Elio note the passing of Stanley Falkow, give E. coli an archaeal membrane, and show how the microbiome can make worms live longer.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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175: Neomycin is antiviral02 May 201801:03:06

The TWiM team notes the passing of Allan Campbell, and explains how aminoglycoside antibiotics like neomycin enhance host resistance to viral infection.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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174: A Gathering Typhoid Storm19 Apr 201801:02:25

The TWiMsters explain why untreatable typhoid fever might be on the way, and the evolution of fungal virulence in tropical frogs.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

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