Explorez tous les épisodes du podcast The Root Cause Medicine Podcast

What if the real problem with hormones isn’t what’s broken… but what’s being missed? In this conversation, Dr. Cheryl Burdette invites us to rethink everything we’ve been taught about hormonal health. Instead of chasing isolated lab values or treating systems in silos, she introduces a more useful question: what if hormones only make sense when you look at how they talk to each other? We explore the concept of the hormonal matrix—a lens that connects thyroid, adrenal, and reproductive hormones into one dynamic, interdependent network. Because in the body, nothing operates alone. Signals overlap. Pathways intersect. And small imbalances can ripple across systems in ways we don’t always measure. This systems-based perspective isn’t just philosophical—it’s increasingly supported by emerging research on the cross-talk between the HPTA axis, the gut, and broader metabolic and immune signaling. When you zoom out, patterns start to appear. And when you see the pattern, your clinical decisions can change. This episode is about shifting from fragments to frameworks—and why that shift may open up entirely new possibilities for understanding and supporting hormonal health.

Are your patients putting Salmonella in their morning smoothie? That’s essentially what happened recently when people added what they believed was a safe, antioxidant-packed greens powder to their daily routine. The ingredient? Moringa. Moringa leaf powder is often marketed as a nutrient-dense botanical containing vitamins, minerals, antioxidants, and plant compounds that may support general wellness. For many people, it feels like an easy health habit: add a scoop to a smoothie and start the day feeling proactive about nutrition. But recently, moringa powder was linked to Salmonella infections that resulted in hospitalizations. In this episode, we chat through what clinicians needs to know to keep their clients safe.

A recent analysis of 22 St. John’s Wort supplements purchased online found that only one actually matched its label for the key compound hypericin. Several products contained little to none of the active ingredient, and some appeared to use synthetic dyes to mimic the color of hypericin, potentially misleading simple testing methods (Now, 2025). Why does this matter? Because when a supplement doesn’t contain the ingredient it claims, patients may not receive the support they expect. That can lead to wasted money, confusing clinical outcomes, and lost trust in integrative care. In this episode of the Root Cause Medicine Podcast, we’re joined by Dr. Eric Viegas, Medical Product Manager at Fullscript, to unpack what this report means for clinicians and patients. We discuss how ingredient discrepancies can happen—from plant sourcing and manufacturing to risks in online marketplaces—and how practitioners can help protect patients from misleading products. We also explore what clinicians should look for when choosing supplements, including validated testing methods, Certificates of Analysis, and quality standards that help ensure products contain what the label promises.

In this episode of the Root Cause Medicine Podcast, we explore a growing clinical reality: patients now have immediate access to advanced bloodwork but not necessarily interpretation with a clinician. In this conversation, we introduce Fullscript Journeys, the provider-led answer to direct-to-consumer lab platforms. With lab testing, AI-supported interpretations and wellness plans, and seamless follow-ups, Journeys empowers providers to deliver a modern patient experience — without compromising clinical guidance.

On this episode of Root Cause Medicine, we’re honored to share the story of Dr. Emlah Tubuo, PharmD, MS, an integrative pharmacist who came to the U.S. in 2003 with $300 in her wallet and built what many of us wish existed in every community: a pharmacy designed around whole person care. Dr. Emlah explains how growing up around infectious disease in Cameroon shaped her prevention-first mindset, and how arriving in the U.S. revealed a different challenge: chronic disease that silently progresses for years before symptoms demand urgent intervention.

Creatine is one of the most extensively researched nutrients in sports, metabolic, and brain health, yet parents and practitioners alike have questions about its use in children and adolescents. In this episode, Dr. Kate Kresge speaks with Jeff Gladd, MD, Chief Medical Officer at Fullscript, to clarify how creatine functions in normal physiology, what the research shows about pediatric safety, and how clinicians can guide families with confidence. Together, they explore growth-related energy needs and practical clinical considerations—offering an evidence-informed framework for responsible conversations about creatine use in youth.

In this Root Cause Medicine podcast episode, we explore emerging concerns around ashwagandha-associated drug-induced liver injury (DILI). While ashwagandha remains one of the most widely used adaptogens in integrative medicine, recent international case reports have highlighted rare but clinically meaningful hepatic adverse events. This episode equips clinicians with a mechanistic understanding of potential risk factors, extraction methods that may increase vulnerability, and practical strategies for patient screening, education, and monitoring—without dismissing the therapeutic value of this foundational herb.

Nearly one in three adults will experience a voice disorder at some point in their lifetime, often without realizing it may be connected to their overall health (Stachler et al., 2018). In this episode, we sit down with integrative otolaryngologist Dr. Linda Dahl to unpack how subtle changes in vocal tone, stamina, and clarity can serve as early clues to what’s happening systemically - from inflammation and hormonal shifts to nervous system stress, reflux, and microbiome changes - and what to do next depending on what you hear. From simple in-office listening strategies and targeted questions to appropriate referrals, lab considerations, and integrative support options, this episode helps clinicians effectively resolve common voice issues using a whole person approach.

In part two of our SIBO series, we’re joined again by Dr. Allison Siebecker to focus on what often determines whether patients stabilize or relapse: nutritional management and supportive care during and after SIBO treatment. We explore how to use prokinetics to support migrating motor complex function, when digestive aids like bile acids and enzymes may be appropriate, and how to apply SIBO dietary frameworks as personalized, flexible tools—not rigid rules. We also cover practical approaches to suspected yeast/dysbiosis overlap, how to support gut barrier integrity without worsening fermentation, and the key myths that can derail outcomes. This episode helps clinicians move from “eradication mode” to sustainable, integrative SIBO care.

The research around SIBO is evolving, and 2026 has brought more subtypes, testing and treatment options than ever before. Our guest this week, Dr. Allison Siebecker, is an expert in conventional and natural approaches to SIBO, helped to open one of the first integrative SIBO centers in the nation, and frequently teaches physicians about how to effectively treat even the toughest cases of SIBO, ISO, IMO and more. Today, we explore how hydrogen, methane (IMO), and hydrogen sulfide–associated (ISO) pattern-typing can help us choose treatment options that help to decrease SIBO symptoms effectively. We discuss how impaired motility - particularly dysfunction of the migrating motor complex - can impact symptom persistence and relapse in addition to microbial type and load, and why we should address it in treatment plans. Dr. Siebecker also reviews the newest advances in SIBO testing, breath test interpretation, and how long to test depending on what you’re looking to discover. If SIBO has felt like a guessing game in your practice, or if you’re just looking to stay on the leading edge, this episode offers a clearer, physiology-driven framework grounded in education that will help your clients get and stay well.

This episode of the Root Cause Medicine Podcast features host Dr. Kate Kresge, ND in conversation with Dr. Jeff Gladd, MD, Chief Medical Officer at Fullscript and an integrative primary care physician. Together, they unpack three timely topics for whole-person clinicians: emerging human data on urolithin A as a mitophagy-activating postbiotic that may support mitochondrial function and immune aging; how to help patients engage with the “fiber maxing” trend in a safe, sustainable way that supports metabolic health, GI function, and diet adherence; and a new industry survey showing that 94% of pharma leaders are running or exploring direct-to-patient (DTP) programs, with implications for GLP-1 therapy access, continuity of care, and the clinician’s central role in guiding treatment decisions. (Nature)

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge is joined by Dr. Eric Viegas, a leader in supplement safety at Fullscript, for a timely and evidence-informed discussion on lead exposure in protein powders and nutritional supplements. Amid rising media attention and consumer concern, the conversation unpacks how and why trace amounts of lead can appear in supplements, how different regulatory thresholds (Prop 65 vs. USP/ICH) should be interpreted clinically, and what toxicologically relevant exposure actually means. Clinicians will gain practical insight into cumulative lead exposure, patient risk stratification, and how Fullscript is advancing supplement quality through enhanced testing, transparency, and practitioner-facing safeguards.

In this “Health or Hype” rapid-fire episode, Dr. Kate Kresge teams up with Dr. Chris Sands, DPT, OCS, and Dr. Gabe Kresge, DPT, to sort running fact from fiction. They break down why strength training rarely “bulks up” runners and more often boosts efficiency, why single-leg strength better reflects the true demands of running than squats alone, and why minimalist shoes (and cushioning) should be chosen based on individual capacity and a gradual transition. They also address joint health—explaining why moderate, well-programmed running isn’t automatically “wear and tear”—and close with a practical prevention message: running assessments can catch issues before pain starts, and most injuries trace back to training load and under-recovery more than biomechanics.

This episode of the Root Cause Medicine Podcast explores the Modern Running Assessment, an evidence-informed, data-driven framework for evaluating runners’ biomechanics, load tolerance, and performance capacity. Host Dr. Kate Kresge interviews Dr. Chris Sands, DPT, OCS, and Dr. Gabe Kresge, DPT, from Kinetic Physical Therapy to examine how modern tools—dynamometry, force plate testing, slow-motion gait analysis, cadence and vertical oscillation metrics, and single-leg endurance testing—provide objective information that visual observation alone may miss. These measurable insights help clinicians better understand strength-to-body-weight ratios, inter-limb asymmetries, foot-strike loading patterns, and fatigue-related movement changes, offering a clearer picture of the factors that may influence running efficiency, durability, and injury risk.

We’re launching a new series that brings the insights that Fullscript Chief Medical Officer Dr. Jeff Gladd normally shares only with our internal team—now open to the entire integrative and functional medicine community. This month, Dr. Gladd breaks down three emerging clinical priorities with immediate relevance to whole-person care. He covers why the American College of Cardiology is now recommending high-sensitivity CRP (hs-CRP) for universal cardiovascular screening, how grip strength paired with BMI is outperforming traditional biomarkers in predicting metabolic decline and all-cause mortality risk, and what new evidence tells us about saffron as supportive care for patients experiencing SSRI-related sexual side effects.

This episode features Dr. Neda Gioia, OD, CNS®, IFMCP, a pioneer in integrative eye care who blends optometry, clinical nutrition, and functional medicine to advance preventive vision strategies. Clinicians will learn how gut-eye axis mechanisms, AI-driven oculomics, sex-hormone transitions, and nutrient patterns influence ocular inflammation, retinal biomarkers, and whole-system health. Dr. Gioia illustrates how modern imaging (including emerging AI models), stool and hormone testing, and nutrient evaluation can support earlier identification of risk patterns and more personalized, prevention-forward care for patients across the lifespan.

In this inspiring episode of the Root Cause Medicine Podcast, Dr. Kate Kresge welcomes Dr. Cynthia Libert, a board-certified family physician, functional medicine expert, and creator of The Joy Prescription. Together they explore the biochemistry of joy, how gratitude reshapes brain connectivity, and how positive emotion can help to modulate inflammation, support neuroplasticity, and protect cognitive health. Clinicians will learn practical ways to integrate “joy prescriptions” into patient care, using evidence-informed tools to foster resilience and prevent burnout.

In this episode of The Root Cause Medicine Podcast, Dr. Kate Kresge interviews Dr. Chris Magryta and Dr. Erik Lundquist about Advanced Blood Labs 201—a course designed to help clinicians interpret metabolic and immune biomarkers across pediatric and adult populations. They explain how to use tests like C-peptide, adiponectin, leptin, and glutathione to identify early metabolic stress, and explore immune indices such as SII (Systemic Immune Inflammation Index) and SIRI (Systemic Inflammation Response Index) to uncover inflammation trends in both children and adults.

James Greenblatt explores the evolving science of low-dose lithium as a neuroprotective intervention — highlighting its potential to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s disease. He emphasizes that safe, nutritional lithium (2-10 mg) can support brain health by reducing neuroinflammation, promoting neuroregeneration, and stabilizing mood—without the risks associated with pharmaceutical doses. Clinicians are encouraged to assess lithium status through hair mineral analysis, monitor thyroid and kidney function, and consider environmental and dietary influences on endogenous lithium levels. By integrating low-dose lithium into a comprehensive, individualized care plan—including lifestyle modifications and targeted testing—practitioners can leverage this simple mineral to support mental clarity, impulsivity regulation, and long-term cognitive resilience.

James Greenblatt explores the evolving science of low-dose lithium as a neuroprotective intervention — highlighting its potential to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s disease. He emphasizes that safe, nutritional lithium (2-10 mg) can support brain health by reducing neuroinflammation, promoting neuroregeneration, and stabilizing mood—without the risks associated with pharmaceutical doses. Clinicians are encouraged to assess lithium status through hair mineral analysis, monitor thyroid and kidney function, and consider environmental and dietary influences on endogenous lithium levels. By integrating low-dose lithium into a comprehensive, individualized care plan—including lifestyle modifications and targeted testing—practitioners can leverage this simple mineral to support mental clarity, impulsivity regulation, and long-term cognitive resilience.

True longevity requires metabolic flexibility, but how can we help our clients get there? This episode previews personalized metabolic health and longevity strategies from Dr. Rob Downey and Monique Class, presenters at Fullscript Forward 2025. Dr. Downey discusses how metabolic phenotyping, stress/HRV context, and GI patterns can inform evaluation, while Monique describes low-dose (microdosed) GLP-1 approaches, titration by response, and gradual tapering within lifestyle-first care model help them achieve impactful results for their clients. The conversation explores objective monitoring (labs, body composition), muscle-preserving movement, and structured workflows that may help patients sustain progress after medication changes. This episode is for informational and educational purposes only.

This episode of The Root Cause Medicine Podcast explores how the 2025 GLP-1 prescribing advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society can act as a catalyst for whole-person metabolic care—rather than just symptom management. Lara Zakaria, IFMCP, pharmacist and functional medicine practitioner, breaks down the new consensus guidelines and highlights opportunities to integrate nutrition counseling, strength training, and lab monitoring to support muscle preservation, nutrient adequacy, and patient safety. You’ll hear Lara’s practical approach—starting with screening for eating disorders and nutrient status before prescribing—and learn how to design workflows that make guideline implementation realistic in busy clinical settings. Providers will leave with evidence-informed strategies to improve patient outcomes, minimize side effects, and support sustainable behavior change around GLP-1 therapy.

This episode of The Root Cause Medicine Podcast takes a deep dive into postpartum care—challenging the idea that one six-week checkup is enough. Serena Saeed-Winn, CNM, WHNP, IBCLC, shares how earlier postpartum visits may help identify concerns such as thyroid changes, support lactation comfort through therapeutic breast massage and lymphatic techniques, and guide gentle scar care for improved comfort and pelvic floor recovery. You’ll also hear insights on hormonal shifts, nutrient needs, and postpartum mental health considerations—plus practical strategies to engage partners and build collaborative care teams. Providers will leave with actionable, evidence-informed ideas to better support families during this critical transition.

In this episode of The Root Cause Medicine Podcast, Dr. Kate Kresge welcomes Dr. Asare Christian, MD, a pain medicine and rehabilitation specialist, to explore the complex physiology of migraines and how a root-cause or functional medicine approach can transform treatment. They discuss the various triggers, including hormonal fluctuations, gut health, inflammation, and environmental toxins, as well as innovative natural therapies, supplements, and device options that empower patients to take control of their headache management. This conversation offers a comprehensive view of migraine care beyond conventional medications, emphasizing education, prevention, and personalized strategies for lasting relief.

In this episode, Dr. Kate Kresge welcomes Dr. Christy Evans, an OB/GYN with a passion for functional women’s health. They discuss how pregnancy transforms every body system, the importance of a comprehensive lifespan approach to women's health, and the innovative methods Dr. Christy uses at Almond OB/GYN. She shares her journey from accountant to physician, the significance of addressing root causes behind common symptoms, and how holistic care can optimize vitality and long-term health. Plus, insights into postpartum recovery, PCOS, and practical strategies to support women at every stage of life.

In this episode, Dr. Kate Kresge is joined by Dr. Ellen Vora to explore holistic approaches to anxiety beyond physiological root causes. They discuss how mindful movement, play, connection, and emotional regulation—such as cry therapy—can serve as powerful tools in managing true anxiety. Emphasizing the importance of integrating mind, body, and spirit, this conversation offers practical strategies for clinicians and individuals looking to deepen their understanding and treatment of anxiety.

In this episode, Dr. Kate Kresge welcomes Dr. Eric Viegas back to discuss the often-overlooked details surrounding the quality and safety of omega-3 supplements. While omega-3s are celebrated for their benefits in cardiovascular health, inflammation, and cognition, contamination and oxidation can undermine their efficacy and even pose health risks. They explore the pivotal role of rigorous testing, manufacturing standards, and how practitioners can guide patients to choose high-quality, safe omega-3 products in a landscape filled with variable quality claims.

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge interviews Kristin Oja, DNP, founder of STAT Wellness, one of the first clinics in the U.S. to combine functional medicine and movement under one roof. Kristin shares her remarkable journey from personal trainer to nurse practitioner to entrepreneur—growing STAT from backyard bootcamps into a thriving multi-location practice redefining modern healthcare. Kristin dives into why muscle mass is a vital sign, how data and personalization are at the heart of STAT’s model, and what it takes to build a clinic that truly supports patients and staff. From lab testing and team culture to scaling with integrity, this episode is both inspiring and tactical—especially for practitioners looking to chart their own course in functional medicine.

In today's episode of The Root Cause Medicine Podcast, Dr. Kate Kresge dives into men's health, neurology, and fertility with Dr. Eric Yarnell. You’ll hear us discuss: 1. Testosterone and its impact on the male body 2. The dangers of relying on Internet medical information 3. Addressing male factors in infertility treatment 4. The role of herbal medicine in optimizing testosterone production 5. High testosterone and prostate conditions 6. How diet and gut health influence prostate health Dr. Eric Yarnell is the President of Northwest Naturopathic Urology, focusing on men's health, urology, and nephrology. He is also a Professor at Bastyr University in the Department of Botanical Medicine, alongside running two businesses in botanical medicine and publishing. He is the author of numerous texts and articles, including Natural Approach to Gastroenterology, Natural Approach to Urology, Natural Approach to Prostate Conditions, and Naturopathic Nephrology. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge welcomes back Dr. Cheryl Burdette—naturopathic physician, educator, and founder of Precision Point Diagnostics—for a deep dive into one of the most evidence-backed biomarker bundles in functional medicine: the Gut, Oxidation & Stress panel. Dr. Burdette explains how ten underutilized but highly predictive biomarkers—including anti-LPS antibodies, zonulin, 8OHdG, F2-isoprostanes, glutathione, and more—can give clinicians a full-body snapshot of inflammation, leaky gut, immune dysregulation, and oxidative stress. She discusses how each marker ties into chronic conditions from cardiovascular disease to autoimmunity to neuroinflammation—and exactly how to intervene when these labs are out of range. This is a must-listen masterclass for any practitioner working with chronic illness, mystery symptoms, or “normal” labs that don’t tell the whole story. You’ll Hear Them Discuss: - Why LPS antibodies are one of the most predictive markers in medicine today - How oxidative stress contributes to cardiovascular disease, autoimmunity, and brain fog - What 8OHdG, zonulin, secretory IgA, and glutathione tell us about barrier integrity - The surprising links between gut dysfunction and GLP-1, mood, and immune balance - Case studies showing biomarker-guided interventions that worked - How to boost glutathione (and what forms work best) - When to re-test and what lab shifts to look for - Advanced testing for food sensitivity: IgG subclasses, complement, and tolerance vs. reactivity - Natural GLP-1 agonists, bitters, fiber, and bile as part of metabolic healing

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge is joined by Dr. Jessica Christie, a licensed naturopathic doctor, clinical nutritionist, and integrative fertility expert, to discuss a diagnosis that frustrates both patients and practitioners: unexplained infertility. Dr. Christie explains that “unexplained” can sometimes mean “we haven’t found the root cause yet,” and she walks us through six of the most common hidden causes of fertility struggles—from subclinical hypothyroidism and nutrient deficiencies to autoimmune markers and environmental toxin exposure. Whether you’re a patient searching for answers or a practitioner looking for a more complete workup, this conversation offers evidence-based strategies, powerful case examples, and a hopeful message: unexplained doesn’t mean unsolvable. You’ll hear them discuss: - Why “unexplained infertility” is a diagnosis of exclusion—and what it often misses (Abdallah et al., 2020) - Six common, often-overlooked root-cause contributors to fertility struggles - How research links subclinical hypothyroidism with IVF success rates (Cho et al., 2015) - The immune markers linked to miscarriage and implantation failure (Demir et al., 2009; Shahbazi et al., 2019; Sauer et al., 2010; Jalilvand et al., 2023; Edassery et al., 2010) - Why gut and vaginal dysbiosis matter for egg quality and implantation (Patel et al., 2022; Tersigni et al., 2014; Blancafort & Llácer, 2023) - The micronutrients most essential for fertility—and most commonly deficient (Skoracka et al., 2021; Ji et al., 2023) - How to approach detoxing safely when trying to conceive (Jain & Singh, 2022; Pizzorno, 2017; NCCIH, 2019) - Real patient stories that show what’s possible with root-cause medicine

In today's episode of The Root Cause Medicine Podcast, we're gonna go over what to do when your kid gets sick, including what to do, what not to do, and how you can address the top 25 acute childhood concerns using an integrative approach with Dr. Elisa Song. You’ll hear us discuss: 1. Integrative approaches to pediatric health 2. Post-antibiotic recovery for your kids 3. Engaging your vagus nerve to enhance your health 4. Breathing exercises for children 5. Homeopathy and natural remedies for children's health Dr. Elisa Song is a holistic pediatrician and pediatric functional medicine expert who has helped over 1,000 children thrive by combining conventional pediatrics with functional medicine, homeopathy, essential oils, and Traditional Chinese Medicine. She is the Founder of Healthy Kids Happy Kids, a trusted online resource for holistic pediatric advice. Dr. Song is also the Founder and Holistic Pediatrician at Whole Family Wellness. Her new book, Healthy Kids, Happy Kids: An Integrative Pediatrician’s Guide to Whole Child Resilience, offers practical insights on how to nurture resilient children. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge sits down with Dr. Eric Viegas, a naturopathic doctor and Fullscript’s Medical Product Manager, to pull back the curtain on the world of supplement quality and safety. From raw ingredient sourcing to manufacturing audits, Dr. Viegas explains what CGMP really means, how Fullscript ensures product integrity, and why certifications like NSF and third-party testing matter. You’ll learn how to evaluate your supplements for quality, what common industry terms really mean (or don’t), and what to avoid—like potentially dangerous sports nutrition products and under-tested trendy gummies. Whether you’re a clinician or a supplement-savvy consumer, this episode offers practical insights to help you navigate the supplement landscape with confidence. You’ll hear them discuss: - What CGMP certification actually means—and why it matters - The hidden dangers of poor manufacturing practices and counterfeit products - Why Fullscript’s catalog is CGMP-certified across all 375+ brands - How and why supplements like turmeric are tested for purity, potency, and contamination - The surprising problems with gummies and “pharmaceutical grade” claims - Which third-party certifications actually mean something (and which don’t) - Why the supplement industry is regulated—but not in the way most people assume - How Fullscript handles recalls, audits, and adverse event reports - What every provider and consumer should know before recommending or taking a supplement

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge sits down with functional immunology expert and educator Dr. Samuel Yanuck to explore one of the most overlooked systems in chronic illness: the immune system. With clarity and compassion, Dr. Yanuck breaks down how immune dysregulation can contribute to complex conditions like depression, neuropathy, migraines, chronic fatigue, and even cardiovascular disease. From brain inflammation and mast cell activation to Epstein-Barr virus and mold, Dr. Yanuck offers a new way of thinking about biology—where inflammation isn’t just a symptom, but a system that can be measured, understood, and treated. You’ll here them discuss: - Why immunology could be at the root of nearly every chronic illness - The immune pathways that connect depression, anxiety, brain fog, and fatigue - What PANS, PANDAS, and autoimmune encephalitis really are—and why they’re often misdiagnosed - How gut, brain, and immune health form a feedback loop - The labs you should run if you suspect chronic immune dysfunction - A framework for evaluating chronic viral infections like EBV and CMV - Natural immune modulators: Chinese skullcap, astragalus, quercetin, sulforaphane, and more - Why personalized immune workups—not protocols—create results Guest Bio: Dr. Samuel Yanuck is a functional medicine clinician and expert educator in functional immunology. He is the creator of Cogence Immunology, a comprehensive online training program that has educated over 9,000 clinicians in over 60 countries. His approach blends immunology, clinical experience, and systems thinking to help providers and patients uncover the true drivers of chronic illness. Dr. Yanuck is also the co-founder of the Yanuck Center for Life and Health in North Carolina, where he sees patients and helps clinicians find root-cause solutions to immune dysfunction through mentorship and collaboration. His work is helping reshape how the next generation of practitioners understand inflammation, autoimmunity, and healing. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge sits down with neurologist and bestselling author Dr. Dale Bredesen to challenge everything we think we know about brain aging. Dr. Bredesen shares why age-related cognitive decline is not just treatable but in many cases preventable—and even reversible. Drawing on decades of lab research and clinical success, he outlines the root causes of cognitive decline and introduces the listener to the "cognoscopy," a powerful tool for early detection. With practical, science-backed insights on inflammation, insulin resistance, environmental toxins, and the emerging brain microbiome, this is a masterclass in 21st-century brain health. You’ll here them discuss: - Why cognitive decline is often preventable—and sometimes reversible - The three key drivers of cognitive decline: inflammation, energy deficit, and toxicity - How to use the "cognoscopy" to catch signs of dementia early - The role of the brain’s microbiome and oral health in neurodegeneration - Why mold, metals, and mycotoxins are underestimated threats - New blood biomarkers like pTau217, GFAP, and NFL - Supplements that support brain health, including magnesium threonate and omega-3s - How to tailor treatment using functional lab testing and wearables - Stories of patient recovery—and what makes the difference Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this episode of The Root Cause Medicine Podcast, we’re joined by Dr. Elisa Song—pediatrician, integrative medicine expert, and author of Healthy Kids, Happy Kids. With a deep commitment to helping children thrive, Dr. Song shares how gut health forms the foundation of pediatric wellness and why holistic care is essential in addressing the chronic health challenges kids face today. We dive into how the microbiome shapes immunity, mood, and behavior, and why addressing nutrition, lifestyle, and environmental factors is crucial for long-term health. Dr. Song also breaks down five core pillars for nurturing a healthy gut in children and reveals the surprising ways added sugar and ultra-processed foods impact the developing brain. You’ll learn: - The role of gut health in preventing and managing childhood conditions - Five foundational habits to support your child’s microbiome - How sugar and processed foods disrupt children's brain and gut function - The link between gut health and mental wellness in kids - What lab tests can help assess and guide pediatric gut health interventions This episode is a must-listen for parents, caregivers, and healthcare providers who want to raise healthy, resilient children through informed, integrative strategies. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this episode of The Root Cause Medicine Podcast, we’re joined by Dr. Allen Sussman—seasoned endocrinologist, educator, and author of Saving the Art of Medicine. With over three decades of experience, Dr. Sussman shares how evidence-based medicine can enhance patient care when it's combined with empathy, open-mindedness, and critical thinking. We explore how research can be misinterpreted, the value of integrating complementary approaches, and how true healing requires more than just following protocols—it requires understanding the person behind the diagnosis. You’ll learn: - How evidence-based medicine influences clinical decisions - The difference between statistical and clinical significance - The value of listening to patients and tailoring care - Why biases in studies must be considered when applying data - How alternative and integrative approaches may complement conventional care This episode is a must-listen for healthcare providers and curious patients alike who want to understand how medical evidence can be both scientific and compassionate. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this heartfelt farewell episode of The Root Cause Medicine Podcast, Dr. Kate Kresge and Dr. Carrie Jones sit down to share a major announcement: Dr. Carrie is stepping down as co-host to launch her own podcast, Hello, Hormones. This episode is full of reflection, laughter, and excitement as Dr. Carrie shares why now is the time to follow her calling to educate, empower, and entertain through hormone-focused conversations. With a book coming in 2026, thousands of hormone tests analyzed, and decades of clinical and teaching experience, Dr. Carrie is ready to deliver education that’s practical, hilarious, and deeply needed. You’ll hear them discuss: - Why Carrie is pivoting to launch Hello, Hormones - The vision for her new podcast: education, sass, and science - How misinformation around hormones (and cancer) persists - What women need to know about perimenopause, fertility, and metabolic health - Her certifications and clinical experience across naturopathic endocrinology - Her skincare, castor oil, and longevity tips (because glow matters too!) - The myth she wants to bust (hint: it’s about hormone fearmongering) - Why “you’ve always had the power” is her guiding truth

In this episode of The Root Cause Medicine Podcast, Dr. James Greenblatt—psychiatrist, educator, and author—shares his personalized, functional medicine approach to supporting individuals with eating disorders. Drawing from over 30 years of clinical experience, Dr. Greenblatt explains how nutrient deficiencies, malnutrition, and genetic individuality play a major role in mental health conditions like anorexia, bulimia, and binge eating disorder. He also discusses the importance of lab testing and how personalized supplementation and nutrition strategies can be used alongside therapy and medication. You’ll learn: Why micronutrient testing is important in eating disorder care How deficiencies in zinc, omega-3s, and B vitamins may impact brain function What role genetics, celiac disease, and gut health might play How to use testing to guide individualized support plans Why the “nutrition by addition” approach can be a game-changer for recovery This episode offers a compassionate, science-backed perspective for clinicians, families, and anyone interested in integrative mental health care. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In this episode of The Root Cause Medicine Podcast, Dr. Anthony Crifase is joined by Brandy Zachary, DC, IFMCP, Clinical Director at Body Love Cafe. They discuss the root cause of food sensitivities, the difference between food sensitivities and allergies and the future of food sensitivity treatment.

In this episode of the Root Cause Medicine Podcast, Dr. Carrie Jones sits down with seasoned compounding pharmacist Sara Hover, RPh, to demystify the world of personalized medications. They dig into how compounding pharmacies offer tailored solutions for hormone therapy, acne, hair loss, weight loss, and more—and why this approach can be life-changing for patients who’ve hit dead ends with conventional medicine. Sarah shares eye-opening stories, from hormone creams and sublingual weight loss medications to pediatric popsicles and custom thyroid solutions, showing just how flexible and powerful compounding can be. What You’ll Learn: - What compounding pharmacies actually do—and why it matters - Why the finished compounded meds aren’t FDA-approved (and why that’s okay) - How bioidentical hormone therapy transforms women's health - Solutions for allergies to common fillers like red dye or peanut oil - Fun and effective delivery forms: lozenges, topical creams, even popsicles - Hair loss, acne, eczema, and anti-aging compounding options - The surprising science behind sublingual GLP-1s for weight loss - How to find (or help your doctor become) a compound-friendly provider Sara Hover, RPh is a compounding pharmacist with 30 years of experience and a specialty in hormone replacement therapy. She serves as a lead educator at PCCA, where she trains pharmacists and providers on the latest in compounding innovations. Sarah is passionate about personalized, patient-centered care—and believes no one should be told they're "crazy" when a tailored medication might be the real solution. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In today's episode of The Root Cause Medicine Podcast, we navigate the importance of brain health and preventing cognitive decline with Louisa Nicola. You’ll hear us discuss: 1. How women in their 30s and 40s can prevent Alzheimer's 2. Why exercise is the best preventive tool against Alzheimer's disease 3. The surprising benefits of resistance training for your brain health 4. Nutrition insights for enhancing brain health 5. Why the best thing for a healthy aging brain is social connections Louisa is a neurophysiologist and human performance coach. She is the Founder of Neuro Athletics, a consulting firm that works with top athletes worldwide, leveraging EEG scans, lab tests, and cognitive assessments to optimize performance. Louisa's insights delve deep into the minds of elite NBA and MLB stars. Additionally, she serves on the board of Momentous, Tonal, and Klora. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In today’s episode of The Root Cause Medicine Podcast, Dr. Kate Kresge sits down with Dr. Ellen Vora to discuss a revolutionary framework for understanding anxiety—not as a disorder, but as a message from the body or soul. They explore the difference between false anxiety, which stems from physiological imbalances like blood sugar crashes, sleep disruption, and inflammation, and true anxiety, which often points to deeper emotional or existential truths. You’ll hear them discuss: - Why anxiety is the beginning of an inquiry—not a final diagnosis - The difference between “false” (body-based) and “true” (purpose-driven) anxiety - How nutrient deficiencies and gut imbalances can mimic psychiatric symptoms - The surprising mental health effects of hormonal birth control - How to use food as medicine to support neurotransmitter balance and calm - The dangers of benzodiazepines—and how to taper with the help of functional medicine - The power of psychobiotics, circadian rhythm, and inflammation reduction - Why GABA, inositol, and phosphatidylcholine are key to recovery - How to approach anxiety with both compassion and curiosity

In today's episode of The Root Cause Medicine Podcast, we explore various topics related to immune resilience and reducing sickness in children with Dr. Chris Magryta. You’ll hear us discuss: 1. Why kids are getting sick so often 2. How to boost immune resilience in children 3. The superfoods your child needs 4. Tips for limiting screen time and improving sleep in children 5. Nurturing a healthy gut and brain development in children Addressing allergies and intolerances in children 6. Effective parenting approaches and resources for nurturing children's health Dr. Chris has been practicing medicine in North Carolina for 24 years, viewing each child as a catalyst for improving human health. He is an Integrative Pediatrician at Salisbury Pediatric Associates and the Medical Director of Standard Process. Additionally, Dr. Chris serves as the Chairman of Children First of North Carolina and hosts Dr. M’s Women and Children First podcast, where he interviews experts on maternal and child health, focusing on upstream anthropology and root cause analysis for change.

In today's episode of The Root Cause Medicine Podcast, Dr. Carrie Jones sits down with Ben Azadi to discuss metabolic flexibility, fat-burning versus sugar-burning states, and why traditional calorie-focused approaches to weight loss often fail. You'll hear them discuss: - Why 93% of Americans are metabolically unhealthy - The difference between sugar burners and fat burners - How obesogens and toxins contribute to weight loss resistance - The role of fasting insulin and blood glucose in evaluating metabolic health - Why “calories in, calories out” is overly simplistic - How fasting, ketosis, and metabolic flexibility help restore health - Practical steps to shift from sugar-burning to fat-burning in 7 days - The power of gratitude and mindset in sustainable health change Ben Azadi is the founder of Keto Kamp, author of the upcoming book Metabolic Freedom, and a leading voice in the fasting and keto space. After transforming his own health and weight, Ben has gone on to educate thousands globally on how to unlock fat-burning metabolism, address root causes of metabolic disease, and optimize wellness through diet, mindset, and functional practices. His work centers on empowering individuals to achieve what he calls “metabolic freedom”—the ability to thrive using fat, not sugar, as fuel.

In today's episode of The Root Cause Medicine Podcast, we discuss the powerful connection between nutrition and mental health with Dr. Uma Naidoo. You’ll hear us dive into: The impact of food on mental health How to manage anxiety through nutrition and lifestyle Using food as medicine for mental well-being What is metabolic psychiatry? How your diet controls your brain and sleep Dr. Uma is a Harvard-trained psychiatrist, professional chef, nutrition specialist, author, and MasterClass instructor. She is also the Founder and Director of the Nutritional Psychiatry Service at Massachusetts General Hospital (MGH). Known as Harvard's Mood Food Expert, Dr. Uma is a national best-selling author of “This Is Your Brain On Food” and “Calm Your Mind with Food.” Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In today's episode of The Root Cause Medicine Podcast, Dr. Kate Kresge sits down with Dr. Devan Szczepanski to explore her revolutionary triangular approach to functional medicine that has transformed thousands of lives. You'll hear us discuss: 1. How the Triangle Method combines genomics, metabolic testing, and gut analysis 2. Why genomic testing provides crucial personalized insights for treatment 3. The practical applications of reformative medicine in clinical settings 4. How to prioritize interventions based on comprehensive testing Dr. Szczepanski is a board-certified family medicine physician and founder of Reformative Medicine, where she teaches clinicians her Triangle Method of gastrointestinal, genomic and metabolic testing to help patients uncover the root causes of their symptoms. After leaving corporate medicine to start her own practice, she developed a unique system combining genomics, metabolic testing, and gut analysis that aims to deliver personalized care designed to support wellness through measurable insights. Dr. Szczepanski now operates three clinics across Florida and Louisiana and has developed a training program to share her effective approach with other practitioners. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In today's episode of The Root Cause Medicine Podcast, we explore the often-overlooked importance of emotional health during the menopause transition with Dr. Paul Conti. You’ll hear us discuss: 1. How trauma often leads to shame and self-blame 2. The emotional and psychological changes during menopause 3. Building resilience through introspection and curiosity 4. The stigma surrounding mental health issues 5. The importance of seeking professional support and external feedback Dr. Paul M. Conti, a Stanford University School of Medicine graduate, combines extensive clinical expertise with a holistic approach to psychiatry. With training from Stanford and Harvard, where he served as Chief Resident, Dr. Conti specializes in treating mental illness and life stressors, recognizing the pervasive impact of trauma on individuals and communities. Beyond clinical practice, he offers consulting services in personal, business, and legal contexts. Dr. Conti is also acclaimed for his book, "Trauma: The Invisible Epidemic," which distills his insights on healing from trauma, aiming to educate and empower a broader audience.

In today's episode of The Root Cause Medicine Podcast, Dr. Carrie Jones welcomes Dr. Caitlin Czezowski to explore the lymphatic system's complex role and its crucial connections to detoxification, hormone balance, and overall wellness. What You’ll Learn: 1. How the lymphatic system functions as the body's "sewage system" 2. Why lifestyle factors can impair lymphatic function 3. The "Specific Seven" lymph node protocol for daily drainage 4. How hormones interact with the lymphatic system and impact fertility 5. Why tongue ties and breathing patterns can significantly affect lymphatic drainage and overall health 6. The science behind lymphatic drainage techniques Dr. Caitlin Czezowski is known for her focus on lymphatic health and support for the body’s natural detoxification pathways. As the founder of Doc Talks Detox, she has developed practical protocols designed to help support healthy lymphatic flow, including her signature "Specific Seven" lymph node-clearing technique. Dr. Czezowski blends traditional medical training with accessible strategies aimed at helping individuals support their lymphatic system and overall wellness. Her work helps translate complex health concepts into actionable steps, making the topic of lymphatic health more approachable for a broad audience. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

In today's episode of The Root Cause Medicine Podcast, Dr. Lauren Hernandez and Dr. Devan Szczepanski join Dr. Kate Kresge to explore: 1. How to identify early signs of chronic illness in children 2. Why traditional pediatric testing often misses crucial health markers that could prevent chronic conditions 3. The "Triangle of Health" framework for pediatric functional medicine 4. How to use genetic testing to determine the most appropriate formula and dietary choices for infants and young children 5. Why conventional approaches to ADHD, anxiety, and digestive issues may be missing underlying genetic and metabolic factors Dr. Lauren Hernandez and Dr. Devan Szczepanski are pioneering practitioners at NuWell Medicine, where Dr. Hernandez serves as CMO of KidsWell, their specialized pediatric service line. With vast backgrounds in pediatric medicine, they have developed an innovative "triangle of health" approach that combines comprehensive blood work, metabolic, gut microbiome analysis, and genomic testing to provide personalized care for children. Their work has transformed traditional pediatric practice by incorporating functional medicine principles and precision testing to address chronic childhood conditions before they become severe health challenges. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide