The Parkinson’s Research Podcast: New Discoveries in Neuroscience – Détails, épisodes et analyse

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The Parkinson’s Research Podcast: New Discoveries in Neuroscience

The Michael J. Fox Foundation for Parkinson’s Research

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Fréquence : 1 épisode/14j. Total Éps: 32

In this podcast, The Michael J. Fox Foundation for Parkinson’s Research brings you right to the cutting edge of neuroscience to discuss the latest discoveries in the field of neuroscience, with a focus on Parkinson’s disease (PD). We are working at the forefront of PD research to accelerate scientific breakthroughs by providing funding opportunities, tools and resources to develop new treatments, find cures and improve quality of life for people living with Parkinson’s disease. If you’re a scientist, clinician or industry professional interested in gaining in-depth insights into the latest advances in basic science, translational research and clinical trials for new therapies and therapeutics, this show is for you. Our host Dr. Marie McNeely interviews experts on topics such as the impacts of genetics, mechanisms of neurodegeneration, neuroimaging, biomarkers, diagnostics, applications of machine learning and artificial intelligence, drug development, novel treatment technologies and more. Subscribe to stay up to date on key developments in neuroscience, neurology, neurodegeneration and Parkinson’s disease research.

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#32

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https://www.michaeljfox.org/podcasts
60 partages
http://michaeljfox.org/podcasts
2 partages
http://michaeljfox.org/funding
1 partage

https://podcasts.apple.com/us/podcast/the-michael-j-fox-foundation-parkinsons-podcast/id666513729
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22: Investigating Light Therapy For Sleep and Motor Function in People with PD with Beatrix Feigl

Épisode 22

mardi 3 septembre 2024 • Durée 41:20

Sleep disturbances, such as insomnia, sleep fragmentation, excessive daytime sleepiness, and REM sleep behavior disorder are common in people with Parkinson's disease (PD). Poor sleep quality can also impact other domains of function, including motor function. Prior research has shown that a type of photoreceptor cell in the retina, called melanopsin cells, provide the main light signals to the brain to initiate sleep, and function of these cells is impaired in PD. Dr. Beatix Feigl and her colleagues developed a novel light therapy intervention that selectively activates the melanopsin photoreceptor cells, and in this episode, she discusses the results of a recent randomized controlled trial evaluating the efficacy of this melanopsin photoreceptor-directed light therapy on sleep and circadian rhythm, as well as motor behaviors. She also discusses her earlier work on melanopsin cells that led to the development of standard measures to assess their function. Beatrix is an Ophthalmologist and an Associate Professor in the School of Biomedical Sciences and Center for Vision and Eye Research, as well as the Faculty of Health, at the Queensland University of Technology.

This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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21: The Autophagy-Lysosomal Pathway and Development of Relevant PD Biomarkers with Zhenyu Yue

Épisode 21

mardi 20 août 2024 • Durée 31:54

Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for monitoring autophagy-lysosome activity. In this interview, Dr. Zhenyu Yue describes his research investigating the cellular and molecular mechanisms for Parkinson's disease and other neurodegenerative diseases, focusing on their work examining the regulation of the autophagy-lysosomal pathway, potential therapeutic targets, and MJFF-funded research that aims to develop sensitive, robust autophagy-lysosome assays to facilitate the discovery of biomarkers for PD using stem cell-derived neurons and biofluids. Zhenyu is the Aidekman Research Professor in the Department of Neurology and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. He is also the Director of the Center of Parkinson’s Disease Neurobiology and Director of Basic Research of Movement Disorders at Mount Sinai.

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12: Accelerating Discovery by Developing and Distributing Research Tools with Nicole Polinski

Épisode 12

mardi 2 avril 2024 • Durée 33:42

The Michael J. Fox Foundation for Parkinson's Research established its Research Tools Program to address gaps in the field and common challenges surrounding the development of reagents and models that slowed the initial stages of promising research projects. In collaboration with many partners and stakeholders, the Research Tools Program helps ensure that scientists around the world have access to high-quality reagents, models, and more. These tools have been instrumental in launching novel research projects to better understand Parkinson's disease and to develop promising new treatment strategies. This episode features Dr. Nicole K. Polinski, Director of Research Resources at The Michael J. Fox Foundation for Parkinson’s Research. In our conversation, she discusses her role in the organization, the wide variety of tools available through the Research Tools Program, and how academic and industry researchers can share their insights and feedback on current tools and future directions for tool development.

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11: The Importance of Sex and Gender Factors in Neurodegenerative Disease Research and Care with Antonella Santuccione Chadha

Épisode 11

mardi 19 mars 2024 • Durée 46:33

Increasing evidence supports the presence of sex and gender differences in neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. There is a critical need to more closely examine sex and gender differences in all stages of research, therapeutic development, and clinical treatment to enable better outcomes through precision medicine approaches. This episode focuses on the relevance of sex and gender factors in Parkinson's disease and efforts to transform scientific research, policy, and healthcare to identify and address needs based on sex and gender. Our guest Dr. Antonella Santuccione Chadha discusses her work with the Women’s Brain Project, their recent roundtable on enhancing care in Parkinson’s disease, and the organization's goals for the future. Antonella is a medical doctor with experience spanning positions in clinical care, academic research, the Swiss Agency for Therapeutic Products (regulatory), and industry leadership and consultation for large pharmaceutical companies and smaller start-up companies. She is currently Co-Founder and Pro Bono Chief Executive Officer of the Women’s Brain Project, an international non-profit organization studying sex and gender determinants to brain and mental health.

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10: Understanding Genetics, Pathology, and Progression in Parkinson's Disease and Atypical Parkinsonian Syndromes with Huw Morris

Épisode 10

mardi 5 mars 2024 • Durée 43:54

Atypical Parkinsonian Syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies are often initially diagnosed as Parkinson's disease. Incorrect, incomplete, or delayed diagnoses are barriers to beginning the most appropriate treatment early in the disease course. More research is needed to facilitate early diagnoses, understanding of disease pathogenesis, and monitoring of disease progression. However, largescale, collaborative initiatives are making meaningful progress in understanding genetic contributors to disease pathology and progression in Parkinson's disease. Our guest in this episode, Dr. Huw Morris, has spent more than twenty five years researching Parkinson's disease and parkinsonian syndromes, and he shares highlights from recent work, including studies on the genetics and pathogenesis of Parkinson’s disease and other parkinsonian syndromes. Huw is Professor of Clinical Neuroscience at University College London Institute of Neurology, as well as an Honorary Consultant Neurologist at the Royal Free Hospital and the National Hospital for Neurology and Neurosurgery Queen Square.

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9: Examining the Proposed Biological Definition of Neuronal Alpha-Synuclein Disease and Staging System with Lana Chahine

Épisode 9

mardi 20 février 2024 • Durée 38:04

For many years, Parkinson's disease and dementia with Lewy bodies have been defined using clinical features. With recent advances in biomarkers, particularly the alpha-synuclein seed amplification assay that allows us to detect misfolded and aggregated alpha-synuclein in cerebrospinal fluid, it is now possible to identify the presence of pathological neuronal alpha-synuclein in living patients. With input from diverse stakeholders, a new biological definition of neuronal alpha-synuclein disease (NSD) has been proposed, along with an integrated staging system (NSD-ISS). In this interview, we discuss the development of this biologic definition for Parkinson’s disease and the staging system with Dr. Lana Chanine, one of the lead authors of the recently published manuscript in The Lancet Neurology that describes this work. It is important to note that the NSD and NSD-ISS are for research purposes only right now, and they are not ready to be implemented in the clinic. Lana is a Movement Disorders Neurologist and Associate Professor of Neurology at the University of Pittsburgh.

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8: Managing Risk for Drug Discovery and Development in Parkinson's Disease with Kalpana Merchant

Épisode 8

mardi 6 février 2024 • Durée 01:07:19

There is a pressing need to develop safe and effective disease-modifying and symptomatic treatments for Parkinson's disease. Through improvements in our understanding of the pathophysiology of the disease, as well as genetic risk factors, new potential treatment targets have emerged. However, bringing a promising new compound from the lab through all of the steps of drug development is a long, difficult, and resource-intensive process. In recent years, collaborative efforts and advances in biomarkers have led to important breakthroughs that have the potential to facilitate the development of new drugs for Parkinson's disease. In this episode, Dr. Kalpana Merchant draws from over two decades of pharmaceutical industry experience to share progress in drug discovery and development for Parkinson’s disease and other neurodegenerative conditions. Kalpana is President and Chief Scientific Officer at TransThera Consulting, which provides guidance on drug discovery and translational strategies to biopharma startup companies. She is also an Adjunct Professor at Northwestern University’s Feinberg School of Medicine, a member of the Oregon Innovation Council, a Scientific Advisor at The Michael J. Fox Foundation, and she serves on advisory panels at the National Institutes of Health.

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7: Using Neuroimaging and Biomarkers to Improve Neurodegenerative Disease Diagnosis and Assessment with John Seibyl

Épisode 7

mardi 16 janvier 2024 • Durée 52:41

In neurodegenerative conditions such as Parkinson's disease (PD), patients often do not receive a diagnosis until the hallmark motor symptoms begin to manifest. This can be a decade or more after substantial changes start occurring in the brain. A major goal of the PD research field has been to develop methods for earlier detection and intervention. Over the years, there have been substantial advances in neuroimaging techniques and biological biomarkers that have allowed us to more accurately identify patients with Parkinson's disease, including the recent development of the alpha-synuclein seed amplification assay. In this episode, Dr. John Seibyl discusses his early work on neuroimaging in Parkinson's disease through to the groundbreaking, large-scale clinical trials he is involved with for assessing the impacts of neuroprotective drugs for Parkinson's disease as well as Alzheimer's disease. He also shares his perspectives as a researcher and a patient with Parkinson's disease. John is Chairman of the Board, Co-Founder, and Senior Scientist of the Institute for Neurodegenerative Disorders in New Haven, Connecticut. He is also a board-certified physician in both Psychiatry and Nuclear Medicine, and he is an Adjunct faculty member in Neurology at Yale University School of Medicine.

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6: Impacts and Goals of the Global Parkinson's Genetics Program with Christine Klein

Épisode 6

mardi 2 janvier 2024 • Durée 44:53

A substantial portion of people with Parkinson's disease (PD) have a family history of the disease, and new findings continue to improve our understanding of relevant genetic variants. These discoveries are key for clarifying the mechanisms that lead to Parkinson's disease as well as the development of new therapies. The Global Parkinson's Genetics Program (GP2) was established to gather and integrate genetic and clinical data from diverse participants around the world to expand our knowledge of the genetic architecture of PD. In this episode, Dr. Christine Klein discusses her experiences as Co-Leader of the Monogenetic Network of GP2, including the early days of setting up this large-scale collaboration, important achievements to date, and priorities and considerations going forward. She also shares recent findings from her own research on genetic variants related to Parkinson's disease. Christine is Director of the Institute of Neurogenetics and of the Section of Clinical and Molecular Neurogenetics at the Department of Neurology, as well as the Schilling Professor of Neurology at the University of Lübeck in Germany. She is also Co-Director of the Monogenetic Network of GP2.

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5: The Role of Inflammation and Immune Responses in Neurodegeneration with Malú Gámez Tansey

Épisode 5

mardi 19 décembre 2023 • Durée 51:37

A growing body of evidence is expanding our understanding of the links between inflammation, our immune responses, brain health, and neurodegeneration. In particular, several genes associated with Parkinson's (including LRRK2) are known to be involved in inflammation, and peripheral inflammation has been shown to influence brain function and contribute to the development of neurodegenerative diseases. Better understanding the roles of inflammation and our immune responses in Parkinson's disease is important for developing new treatments and strategies to slow or prevent disease progression. In this episode, Dr. Malú Gámez Tansey talks about her research at the intersection of immunology, neuroscience, and genetics. She describes new findings and current projects in her lab, discusses advances in neuroimmunology, and shares her insights on important areas of opportunity in the field. Malú is the Norman and Susan Fixel Chair in Parkinson's Disease, Professor of Neuroscience and Neurology, and Director of the Parkinson's Foundation Research Center of Excellence at the University of Florida College of Medicine. She's also editor-in-chief of Nature Partner Journal Parkinson's Disease.

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The Parkinson’s Research Podcast: New Discoveries in Neuroscience – Détails, épisodes et analyse

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