The Pain Beat – Détails, épisodes et analyse

This 16th episode of The Pain Beat highlights the work of a vibrant consortium of pain researchers working on a project known as Acute to Chronic Pain Signatures (A2CPS). A2CPS is focused on the identification of biomarkers to predict which patients will transition from acute to chronic pain, and which patients living with chronic pain can improve their quality of life with management (see related PRF news story). The Pain Beat invited several Primary Investigators from A2CPS to talk about the work of the consortium, and how listeners of The Pain Beat can get involved themselves!

Podcast participants include:

• Kathleen Sluka, PT, PhD, FAPTA, A2CPS Principal Investigator; University of Iowa, USA
• John Burns, PhD, A2CPS Principal Investigator; Rush University Medical Center, Illinois, USA
• Chad Brummett, MD, A2CPS Principal Investigator; University of Michigan, USA
• Michael Olivier, PhD, A2CPS Principal Investigator; Wake Forest University, North Carolina, USA.
• Stephani Sutherland, PhD, A2CPS Communications Director; Johns Hopkins University, Maryland, USA (moderator)

This 15th episode of The Pain Beat is the third and final of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, part one of this series here, and part two of this series here). In this episode, The Pain Beat spoke with a group of collaborators and former mentees to discuss what the discoveries mean for the somatosensory field, as well as stories and insights about what it was like working with Drs. Julius and Patapoutian during that time.

Podcast participants include:

• Allan Basbaum, PhD, FRS, University of California, San Francisco, USA
• Diana Bautista, PhD, University of California, Berkeley, USA
• Alexander Chesler, PhD, National Institutes of Health, Maryland, USA
• Ellen Lumpkin, PhD, University of California, Berkeley, USA
• Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

For the fifth episode, The Pain Beat gathered together a group of pain researchers virtually to discuss how the mammalian nervous system encodes sensory modalities related to touch, pain and temperature. Are there labeled lines? Is there population coding? Do the mechanisms differ by location – the brain, spinal cord or periphery?

Podcast participants include: Diana Bautista, PhD, UC Berkeley, US; Nicholas Betley, PhD, University of Pennsylvania, Philadelphia, US; Adam Hantman, PhD, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, Virginia, US; Mark Hoon, PhD, National Institutes of Health (NIH), NIDCR, Bethesda, US; Taylor Sheahan, PhD, University of Pittsburgh, US (moderator)

For the fourth episode, The Pain Beat gathered together a group of pain researchers via Zoom to discuss the use of human tissue in pain research and prospects for clinical translation of new knowledge emerging from this approach. Podcast participants include:

• Steve Davidson, PhD, University of Cincinnati, US
• Michael Hildebrand, PhD, Carleton University, Ottawa, Canada
• Clifford Woolf, MB, BCh, PhD, Boston Children’s Hospital and Harvard Medical School, Boston, US
• Laura Stone, PhD, University of Minnesota, Minneapolis, US
• Alex Chamessian, MD, PhD, Washington University School of Medicine in St. Louis, US (moderator)

A group of pain researchers gather to discuss ideas and issues related to the transition from acute to chronic pain.

Editor’s Note: Welcome to the second episode of The Pain Beat, PRF’s new monthly podcast series! Supported by a generous grant from The MAYDAY Fund, The Pain Beat brings together the world’s leading pain investigators in order to spark dialogue and debate around important ideas in pain research. Guided by Rebecca Seal, Scientific Director of The Pain Beat, these podcasts feature open and spirited discussion about the hottest topics in pain and how the field moves forward from here.

For the second episode, The Pain Beat gathered together a group of pain researchers in Keystone, Colorado, US, where two joint Keystone Symposia, Somatosensation: From Detection to Perception and Pain: Aligning the Target, were being held from February 2-5, 2020. The podcast participants include:

• Allan Basbaum, University of California San Francisco, US
• Robert Gereau, Washington University School of Medicine, US
• Yarimar Carrasquillo, National Institutes of Health, US
• Stephani Sutherland, PRF freelancer (moderator)

The group found a quiet spot amidst the hubbub of the meeting to discuss whether optogenetics and chemogenetics are feasible approaches to pain treatment, and if so, how effective they might be. The podcast also includes brief introductions to these two approaches.

Welcome to the inaugural episode of The Pain Beat, The IASP Pain Research Forum's new monthly podcast series! Supported by a generous grant from The MAYDAY Fund, The Pain Beat brings together the world’s leading pain investigators in order to spark dialogue and debate around important ideas in pain research. Guided by Rebecca Seal, Scientific Director of The Pain Beat, these podcasts feature open and spirited discussion about the hottest topics in pain and how the field moves forward from here.

For the first episode, The Pain Beat gathered together a group of pain researchers in Keystone, Colorado, US, where two joint Keystone Symposia, Somatosensation: From Detection to Perception and Pain: Aligning the Target, were being held from February 2-5, 2020. The podcast participants include:

• Alexander Chesler, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, US
• Ardem Patapoutian, Scripps Research, La Jolla, US
• Sarah Ross, University of Pittsburgh, US
• Cheryl Stucky, Medical College of Wisconsin, Milwaukee, US
• Stephani Sutherland, PRF freelancer (moderator)

The group found a quiet spot away from the hubbub of the meeting to discuss the following question: What biological levels should be targeted to produce the most effective pain therapies: molecules, cells, circuits, or systems? 

This 14th episode of The Pain Beat is the second of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, and part one of this series here). In this episode, The Pain Beat spoke with Nobel Prize laureate Ardem Patapoutian and Bertrand Coste, Aix-Marseille University, France, to discuss their discovery of mechanically sensitive ion channels – Piezo1 and Piezo2.

Podcast participants include:

• Ardem Patapoutian, PhD, Scripps Research, California, USA
• Bertrand Coste, PhD, Aix-Marseille University, France
• Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 13th episode of The Pain Beat is the first of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, and PRF related news story here). In this episode, The Pain Beat spoke with Nobel Prize laureate David Julius and Michael Caterina, Johns Hopkins University School of Medicine, Maryland, USA, to discuss their discovery of TRPV1. The conversation provides insight regarding their thought processes and problem solving, the enduring challenges of scientific discoveries, and the fun they had along the way.

Podcast participants include:

• David Julius, PhD, University of California, San Francisco, USA
• Michael Caterina, MD, PhD, Johns Hopkins School of Medicine, Maryland, USA
• Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)