The Life Sciences Revolution – Détails, épisodes et analyse

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The Life Sciences Revolution

Alex Wise

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Fréquence : 1 épisode/91j. Total Éps: 9

Take a deep dive to the forefront of scientific breakthroughs, entrepreneurial happenings, and disruptive medical technologies with Alex Wise. The LSR podcast brings you experts in biotechnology, company management, and venture capital to shed light on the medical revolutions shaping our lives. Special thanks to Jank Setup for providing their song, "In Motion," for the intro and outro to the podcast! The Life Sciences Revolution Podcast is sponsored by Korion Life Sciences

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Données mises à jour le 04/07/2026

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Dr. Noshir Pesika: Biomimicry & the Realm of Nature-Inspired Science

Épisode 8

vendredi 14 juillet 2023 • Durée 39:02

In this episode, Alex chats with Dr. Noshir Pesika, a specialist in biomimicry.

Noshir is a Chemical and Biomolecular Engineering professor at Tulane University, where he focuses his research on creating novel products based on the natural world.
His research is centered around the concept of biomimicry - the idea that nature has spent millennia designing, testing, and iterating products for highly specialized functions. By analyzing the micro and nano-level structure and design of these products, we can better understand how they work and how we may be able to recreate them for human use.

We discuss:

What is biomimicry, and how to design useful devices with these ideas
Concepts behind reverse engineering natural products
Noshir's workflow for identifying systems for potential application
Tangible examples of biomimicry in life sciences and the world around us
Cartilage-inspired low friction systems and their applications in medical devices
Gecko-inspired adhesives and their applications
Future advancements in the field of biomimicry and research to be on the lookout for
Noshir's path - moving from Mauritius and career advice for those listening

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Dr. Esteban Plata: Breaking Down the Pharmaceutical Development Pathway

Épisode 7

vendredi 10 février 2023 • Durée 54:02

In this episode, Alex chats with Dr. Esteban Plata, an expert in pharmaceutical development.

Esteban is the former vice president of Western Europe and Canada for AbbVie, one of the world’s largest pharmaceutical companies. He’s spent nearly two decades working on the company’s commercial development side where he’s held VP and general manager roles across a wide range of geographies such as Turkey, Japan, Spain, and the Asia-Pacific region. He holds a Ph.D. in Biotechnology from the National research council in Spain and is an expert in everything pharma and drug commercial development.

We discuss:

Esteban's background and AbbVie's history
Introduction to drug development and the clinical approval pathway
Clinical trials and the role of pharmaceutical companies in providing new medicines for society
Honing in on a company's indication of choice
The evolution of surrogate markers for an early-stage understanding of a therapy's potential
Pharmaceutical geographic span and local fit
Learning to live anywhere in the world and how to learn to fit in with a new culture as a business professional
Pharmaceutical patent cliffs and internal vs external innovation
Big pharma-small biotech M&A rates
Adaptive regulatory pathways, clinical trial efficiency, and dealing with different global regulatory bodies

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Dr. Robert Montgomery: The Future of Organ Transplantation

Épisode 6

vendredi 2 décembre 2022 • Durée 57:41

In this episode, Alex chats with Dr. Robert Montgomery, one of the world's foremost organ transplantation and research experts.

Dr. Montgomery is the Chairman and Professor of Surgery at NYU Langone Health and is the Director of the NYU Langone Transplant Institute, one of the US' top transplant centers. Dr. Montgomery has been at the forefront of organ transplantation for decades as both a surgeon and a patient. He was the first surgeon to receive an implantable defibrillator after a genetic heart condition caused multiple cardiac arrests. Later, he received a heart transplant as a patient in the first clinical trials with hepatitis C-positive hearts. He was part of the teams that developed the laparoscopic procedure for live kidney donation, conceived the idea of domino-paired donations, created the Hopkins protocol for desensitization, and, more recently, completed the first successful investigational kidney and heart xenotransplantations.

We discuss:

The life & death & life & death & life of Robert Montgomery: the story of his heart
The state of the organ transplantation field: problems with quantity, quality, and consistency
How does the US organ transplant waitlist work?
Different organ sources: live donors, deceased donors, altruistic donors, domino transplants, hepatitis-C positive donors
The opioid epidemic in the context of organ transplantation: a harrowing source of organs
Cutting-edge research: how xenotransplantations and bioartificial organs can solve the organ transplantation crisis
Advanced surgical methods: robotics and AI in organ transplants
How to style your mustache with the world's foremost expert in organ transplantation

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Martin Varsavsky: Infertility & the Ethics of Working in the Fertility Space

Épisode 5

jeudi 23 juin 2022 • Durée 41:23

In this episode, Alex chats with Martin Varsavsky, a serial entrepreneur in the realm of fertility and the founder of Prelude Fertility, the largest fertility clinic network in North America. Before working in the fertility space, Martin was the founder of various companies in the renewables and telecommunications space, many of which have reached unicorn valuations well past the billion-dollar mark.

We discuss:

What does it mean to be infertile and what is IVF (in vitro fertilization)? Why is infertility on the rise and what are the options to work around it?
What is Prelude Fertility, what services are provided, and who are the typical patients who come to Prelude?
Is it advisable for all young people prophylactically freeze gametes?
What made you switch to working in the fertility space from your other ventures? What is it like being on the patient side of your own venture?
Martin's other fertility ventures: Overture Life/overhauling the fertility clinic benchtop and Gameto
Different types of fertilization: natural vs ICSI
The ethics of working in the fertility realm: CRISPR babies, discarding embryos, genetic testing embryos, abortions, and access to fertility services
Advice for entrepreneurs and blazing your own path

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Dr. Gustavo Stolovitzky: How Artificial Intelligence Enables Precision Medicine

Épisode 4

lundi 14 mars 2022 • Durée 01:07:19

In this episode, Dr. Cuesta chats with Dr. Gustavo Stolovitzky, a thought leader in the realm of computational biology and a pioneer in the realm of precision medicine. Gustavo was the director of IBM's translational systems biology and nanobiotechnology program, an adjunct professor at both the Icahn School of Medicine and Columbia University, and is currently the Chief Scientific Officer at Sema4, a data-driven precision medicine company.

We discuss:

What is precision medicine: the historical and conceptual origins as well as the direction the field is moving today
How the synergy of artificial intelligence and advancements in synthetic biology are enabling precision medicine
Obstacles in artificial intelligence and how they are impeding the growth of precision medicine
Using deep learning in medicine: supervised learning, explainable AI, and overfitting algorithms
The DREAM challenges and how crowdsourcing solutions in computational biology can help solve issues in precision medicine
How will AI fit into the clinical landscape
Sema4 and how data is translated from concept to clinical practice
Intellectual property and how to protect your algorithms in precision medicine
What is the best path to break into precision medicine

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Dr. Alexander Kushnir: An Introduction to Heart Diseases & How to Treat Arrhythmias

Épisode 3

mercredi 5 janvier 2022 • Durée 39:42

In this episode, Alex chats with Dr. Alexander Kushnir, a cardiac electrophysiologist, about different types of heart diseases. We focus on Dr. Kushnir's specialty of electrical disorders of the heart, better known as arrhythmias, and how electrophysiologists fix these conditions.

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Philip Scheltens: The Science of Dementia & How it Will Impact The World

Épisode 2

dimanche 25 juillet 2021 • Durée 39:54

In this episode, Alex talks with Dr. Philip Scheltens, a neurologist, professor of cognitive neurology, and one of the world's foremost thought leaders on the topic of dementia and neurodegenerative diseases as a whole. He has authored over 1000 publications in peer-reviewed journals and is one of the most-cited scientists in the world.

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Intro to the Life Sciences Revolution Podcast

dimanche 25 juillet 2021 • Durée 02:58

Welcome to the life sciences revolution podcast, where we take a deep dive to the forefront of scientific breakthroughs, entrepreneurial happenings, and disruptive medical technology. We are living through the beginnings of an exponential revolution. The past few decades have shown incredible advancements across the realms of biology, computation, and biotechnology. This growth has primed the field of life sciences to explode with new technologies, all of which will have a direct impact on your life from both a medical and financial perspective. Covid mRNA vaccines, CAR-t cancer treatments, and ground-breaking gene therapies are just the tip of the íceberg. In the near future, modern medicine will encapsulate even your wildest medical dreams. The fine line between science fiction and science fact has already begun to disintegrate, and eventually, the distinction will no longer be díscernable. The life sciences revolution podcast is all about the intersections of medicine, fínance, and investing in the real-world applications of novel scientific technologies. We bring you an exciting line-up of the best scientists, financiers, and world-leading experts to shed light on the ecosystems they participate in. The realm of life sciences is on the cusp of a revolution: so join us as we seek out these innovative breakthroughs all across the fields of biotechnology, precision medicine, and life sciences as a whole.

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Eduardo Bravo: How to Run a Biotech Company & the European SPAC Realm

Épisode 1

jeudi 15 juillet 2021 • Durée 39:52

In this episode, Alex chats with Eduardo Bravo about this experience as the CEO of various biotechnology companies, as a chairman/board member of others, and as the sponsor of the first biotech-related SPAC in Europe.

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The Life Sciences Revolution – Détails, épisodes et analyse

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