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In this episode of “At the Bench”, we are interviewing one of our show’s co-hosts, Dr. David McCulley. David is a neonatologist and developmental biologist at the University of California, San Diego and in this show he talks about what motivated him to build a research program investigating the genetic and developmental mechanisms responsible for congenital diaphragmatic hernia (CDH). David directs an NIH-supported study to determine the genetic mechanisms responsible for abnormal lung and pulmonary vascular development in patients with CDH. He describes the mentorship and collaborative research experiences that have shaped his career path. David also talks about the work that he is doing along with the Society for Pediatric Research and the co-hosts of this program, Dr. Misty Good and Dr. Betsy Crouch, to encourage and promote pediatric physician-scientist career development.
Some highlighted papers:
Stokes, G., Li, Z., Talaba, N., Genthe, W., Brix, M.B., Pham, B., Wienhold, M.D., Sandok, G., Hernan, R., Wynn, J., Tang, H., Tabima, D.M., Rodgers, A., Hacker, T.A., Chesler, N.C., Zhang, P., Murad, R., Yuan, J.X., Shen, Y., Chung, W.K., McCulley, D.J. Rescuing lung development through embryonic inhibition of histone acetylation. Science Translational Medicine. 2024 Jan 31;16(732). Epub 2024 Jan 31. https://pubmed.ncbi.nlm.nih.gov/38295182/
Qiao, L., Wynn, J., Yu, L., Hernan, R., Zhou, X., Duron, V., Aspelund, G., Farkouh-Karoleski, C., Zygumunt, A., Krishnan, U.S., Nees, S., Khlevner, J., Lim, F.Y., Crombleholme, T., Cusick, R., Azarow, K., Danko, M.E., Chung, D., Warner, B.W., Mychaliska, G.B., Potoka, D., Wagner, A.J., Soffer, S., Schindel, D., McCulley, D.J., Shen, Y., Chung, W.K. Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes. Genetics in Medicine. 2020 Dec;22(12):2020-2028. https://pubmed.ncbi.nlm.nih.gov/32719394/
