The Functional Breeding Podcast

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What is the coefficient of inbreeding (COI) and why does it matter?

Épisode 56

lundi 9 septembre 2024 • Durée 39:32

This week you get just me (Jessica Perry Hekman) talking at you! I'm talking about the coefficient of inbreeding (COI), a measurement of genetic diversity that's commonly mentioned in discussions of individual and breed health. I talk about what it is, how to interpret it, how to get the measurement done for your own dog(s), why we care about it, and give the take-home messages from some papers with evidence for its importance in dog specifically. COI is not the only thing you should be breeding for, and it's rarely even the most important thing - but it's something we should keep in mind when we are working in closed gene pools.

NOTE: Oops, I said in the episode that the MDR1 mutation is recessive. It's not - it's incompletely dominant, meaning that dogs can be affected even with only one copy of the mutant allele. I apologize - please note the mistake as the correct information is important here.

I mention some previous podcast episodes with related material - you can find them here: Alison Skipper, PhD on the history of breed registries: https://functionalbreeding.podbean.com/e/alison-skipper-phd-the-history-of-breed-registries/
Mary Peaslee, MD, MPH, on breeding for population health: https://functionalbreeding.org/breeding-for-population-health/

The papers:

https://functionalbreeding.org/the-impact-of-inbreeding-on-litter-size/ - Chu ET, Simpson MJ, Diehl K, Page RL, Sams AJ, Boyko AR. Inbreeding depression causes reduced fecundity in Golden Retrievers. Mammalian Genome. 2019 Jun 1;30(5):166-72. - "The least inbred dogs had an average litter size of 8 puppies, while the most inbred dogs had an average litter size of 6-7 puppies. On average, with each 10% increase in inbreeding, the litter size decreased by one puppy."
https://functionalbreeding.org/inbreeding-depression-and-lifespan/ - Yordy J, Kraus C, Hayward JJ, White ME, Shannon LM, Creevy KE, Promislow DEL, Boyko AR. Body size, inbreeding, and lifespan in domestic dogs. Conserv Genet. 2020 Feb;21(1):137-148. - mixed breed live on average 1.2 years longer than size matched purebreds
https://www.sciencedirect.com/science/article/abs/pii/S1090023313004486 - O'Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Longevity and mortality of owned dogs in England. Vet J. 2013 Dec;198(3):638-43. doi: 10.1016/j.tvjl.2013.09.020 - again, mixed breed live on average 1.2 years longer than size matched purebreds
https://link.springer.com/article/10.1186/s40575-020-00086-8 - Urfer SR, Kaeberlein M, Promislow DEL, Creevy KE. Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States. Canine Med Genet. 2020 Jun 16;7:7. - breeds with lower COI have 3-6 month longer expected lifespans
https://functionalbreeding.org/size-genetic-diversity-lifespan/ - Kraus C, Snyder-Mackler N, Promislow DEL. How size and genetic diversity shape lifespan across breeds of purebred dogs. Geroscience. 2023 Apr;45(2):627-643. - + 1% heterozygosity -> + 31 days of life
https://functionalbreeding.org/the-effect-of-inbreeding-body-size-and-morphology-on-health-in-dog-breeds/ - Bannasch, D., Famula, T., Donner, J. et al. The effect of inbreeding, body size and morphology on health in dog breeds. Canine Genet Epidemiol 8, 12 (2021). - 30kg dog: 0->40% COI -> 10% increase in veterinary care visits; 5kg or 60kg: 37% increase
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007361 - Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. - purebred more likely to be affected, mutts to be just carriers

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REPLAY: Jane Lindquist: Puppy Culture

Épisode 55

mardi 27 août 2024 • Durée 01:11:19

I will have new content for you all soon - but for now, enjoy one from the archives!

--

Jane Lindquist is the founder and owner of Puppy Culture, a widely used educational resource for raising and socializing puppies. She herself breeds and competes with bull terriers. As it turns out, she is very thoughtful when it comes to how to apply science to the raising of puppies. We had a wide ranging conversation, at times nerdy, at times philosophical. You can learn more about Puppy Culture at www.puppyculture.com, and more about Jane's breeding program, Madcap Bull Terriers, at www.madcapbullterriers.com.

Find this episode's transcript at functionalbreeding.org/jane-lindquist-puppy-culture/

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Breeding for Companion Personalities: Carolyn Kelly, RN and Erica Pytlovany, KPA CTP

Épisode 46

lundi 22 janvier 2024 • Durée 01:15:10

Carolyn Kelly is a registered nurse with over 30 years of experience in human health including in labor and delivery, and in mental health. She also holds a Masters Degree in Nursing Leadership. She runs a mixed breed companion dog program, Old Mission Retrievers. Erica Pytlovany, KPA CTP, is an experienced behavioral consultant at WOOFS! Dog Training Center in Virginia. She runs the Boson Dog Project, a mixed breed companion dog program, with her wife, Laura Sharkey. I got together with Carolyn and Erica to talk about what companion personalities look like in dogs and why they focus their breeding programs on achieving them.

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Claire Wade, PhD and Sophie Liu, DVM: The Doberman Genetic Diversity Paper

Épisode 45

lundi 8 janvier 2024 • Durée 01:25:18

This week I'm talking to Drs Claire Wade and Sophie Liu about their paper on genetic diversity in the Doberman breed. Dr Claire Wade is the Chair of Computational Biology and Animal Genetics at the University of Sydney, where she studies canine behavioral genetics. Dr Sophie Liu is a veterinarian specializing in behavior and the founder of the Doberman Diversity Project, about which she's spoken previously on this podcast. Both of them are passionate about dogs not just as part of their careers but as part of their lives. They joined me to talk through the findings in their paper, which sheds some light on the complicated story of health and genetic diversity in Dobermans.

Wade, Claire M., Robin Nuttall, and Sophie Liu. "Comprehensive analysis of geographic and breed-purpose influences on genetic diversity and inherited disease risk in the Doberman dog breed." Canine Medicine and Genetics 10.1 (2023): 1-17. https://cgejournal.biomedcentral.com/articles/10.1186/s40575-023-00130-3

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Lisa Wagner: Breeding Frenchies for Health

Épisode 44

mardi 14 novembre 2023 • Durée 46:10

I've wanted to interview Lisa Wagner about her breeding program for a while now. I keep hearing about the great work she is doing to address health issues in her French bulldogs, and I was so enthusiastic to get a chance to ask her for more details. Lisa is a CKC registered breeder. Her breeding program is called Of Autumn, and you can most easily reach her on Facebook.

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Sarah Stremming, CDBC: The Dog Sourcing Crisis

Épisode 43

mardi 31 octobre 2023 • Durée 01:10:48

This episode is jointly released through the Functional Breeding Podcast and Cog Dog Radio, which is hosted by Sarah Stremming. Sarah is an internationally known dog behavior consultant with a special niche working with sports dogs. She consults at The Cognitive Canine, teaches online courses on dog behavior, and hosts the Cog Dog Radio Podcast. I sat down with Sarah to talk about the recent news that SPCA Tampa Bay has partnered with a pet store and a puppy broker - and what we think this means we all should REALLY be talking about. Although the shelter's pilot program was paused due to community feedback before we released the episode, we feel the issues we discuss in here are still critical ones to ensuring the welfare of the dogs we share our lives with.

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Jessica Hekman, DVM, PhD: State of the Functional Dog Collaborative

Épisode 42

vendredi 16 juin 2023 • Durée 59:30

This episode, Ji Khalsa is interviewing me, Jessica Hekman, DVM, PhD. I'm a veterinarian turned behavioral geneticist turned teacher and founder of the Functional Dog Collaborative, or FDC. I graduated from Tufts Veterinary School in 2012 with a dual veterinary and master's degree, which was on stress in hospitalized dogs. I completed a veterinary shelter medicine specialty internship at Maddie's Shelter Medicine Program at the University of Florida. I completed a PhD in Genetics, Genomics, and Biomedical Sciences in Kukekova Lab at the University of Illinois, studying genetic differences in the stress system in lines of foxes bred to be less afraid of humans compared to foxes bred to be aggressive. I did post-doctoral work at the Broad Institute of MIT and Harvard, and now teach online for Virginia Tech and run the FDC. Ji asked me to talk about the FDC - how it's coming, what we're doing, what we need help with. So here it is!

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Laura Sharkey, PhD and Carolyn Kelly, RN: We All Have the Same Goals

Épisode 41

jeudi 1 juin 2023 • Durée 59:20

This week we have Laura Sharkey and Carolyn Kelly back on the podcast. They are the co-founders of the Copilot Pet Dog Breeding Cooperative, and I always love to talk to them because of their fascinating insights into breeding dogs to be really good pets. We're talking about social media culture and how we love it and hate it - and how all of us love dogs and have the same goals even if we have such different perspectives sometimes on how to get where we're going.

Below are some links that were mentioned in the episode:

Morrill, Kathleen, et al. “Ancestry-inclusive dog genomics challenges popular breed stereotypes.” Lay summary at https://functionalbreeding.org/2022/06/03/breed-behavior-and-mutt-genomics/ with a link to the original paper.
Chen, Frances L., et al. "Advancing genetic selection and behavioral genomics of working dogs through collaborative science." Frontiers in Veterinary Science (2021): 1017. https://frontiersin.org/articles/10.3389/fvets.2021.662429/full
The Copilot Breeding Cooperative: https://functionalbreeding.org/copilot-coop/
The Companion Dog Project: https://www.companiondogproject.com/
Ji's essay about temperament testing: https://www.midwoofery.com/amp/is-temperament-testing-really-worth-the-effort

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Ji Khalsa, MS: Guardian Homes

Épisode 40

jeudi 18 mai 2023 • Durée 44:18

This week we have Ji Khalsa back on the podcast. Ji is the founder of Midwoofery, a highly respected science-based educational resource for responsible dog breeders. She has a Masters degree in Microbiology and Biochemistry from Arizona State University, including independent studies in the link between canine genetics and behavior. She has decades of experience in breeding, including working dogs and companions. I asked Ji to talk to us about guardian homes - why are they useful for breeders and how do they help improve dog welfare?

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Alison Skipper, PhD: the history of breed registries

Épisode 39

mardi 2 mai 2023 • Durée 01:35:05

This week we welcome back Dr. Alison Skipper to talk about the history of breed registries. Dr. Skipper is a veterinarian and historian at the Royal Veterinary College, London. She has an interest in the history of the health and welfare of purebred dogs. She works as a veterinarian at Crufts, has been on Kennel Club committees, and is very involved in the purebred dog world. Her perspective on the history of breed registries was a much demanded followup from her previous episode with us!

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