“If we miss this opportunity, God help us.” Joe Manchin and Lisa Murkowski. Two moderate senators smack in the middle — and on either side — of a split 50-50 Senate. On our first episode of Playbook Deep Dive, the two friends open up in a rare interview with POLITICO’s Burgess Everett. They get personal: about reconciliation, frustration over the Senate’s hurdles — even why Murkowski hogs the best fishing holes. And Manchin reveals a major endorsement, heard first on this show.Subscribe to our new weekly politics show, Playbook Deep Dive, wherever you listen to podcasts.Rachael Bade is a co-author of POLITICO Playbook.Burgess Everett is co-congressional bureau chief at POLITICO.Adrienne Hurst is a producer for POLITICO audio.Annie Rees is a producer for POLITICO audio.Jenny Ament is senior producer for POLITICO audio.Irene Noguchi is the executive producer of POLITICO audio. Special thanks to Elana Schor, Anthony Adragna and Ben LefebvreSHOW NOTES Democrat Manchin backs Republican Murkowski's reelection, by Burgess Everett Learn more about your ad choices. Visit megaphone.fm/adchoices

Presenting a sponsored episode of “Global Translations”: Over the past year, businesses, employees and families across the globe were forced to rethink what it means to “go to work.” Now, with the COVID-19 vaccine rollout underway, many corporate leaders are focused on ensuring the return to work is equitable for all employees. Learn more about your ad choices. Visit megaphone.fm/adchoices

"Off Message" presents the second episode of the new season of POLITICO's podcast "Global Translations": Once there is a working Covid vaccine, manufacturers across the globe will need to scale up production to produce billions of doses — meaning billions of pharmaceutical-grade glass vials, rubber stoppers, packaging and storage and refrigeration. In a special airing of POLITICO's Global Translations podcast, hosts Luiza Savage and Ryan Heath look at the challenges of making enough vaccines for the world.Luiza Savage is the host of "Global Translations"Ryan Heath is a host of "Global Translations"Annie Rees is a producer for POLITICO AudioKara Tabor is a producer for POLITICO AudioJenny Ament is the senior producer for POLITICO AudioIrene Noguchi is the executive producer of POLITICO AudioSarah Owermohle is a POLITICO health reporter covering vaccines. Dr. Anthony Fauci is the director of the National Institute of Allergy and Infectious Diseases.Jim Robinson is a former MERCK executive (manufacturing lead for ebola project); currently with CEPI (Coalition for Epidemic Preparedness Innovations).Dan Diamond is a POLITICO health care reporter and the host of the "Pulse Check" podcast and newsletter. Check out and subscribe to POLITICO's Global Translations, POLITICO Pulse, and Global Pulse newsletters. Read Luiza Savage's article on why nationalism is the next big challenge for Covid-19 vaccines. Global Translations newsletter: https://www.politico.com/newsletters/global-translationsPOLITICO Pulse newsletter: https://www.politico.com/politicopulse/Global Pulse newsletter: https://www.politico.com/newsletters/global-pulsePOLITICO article: "The next vaccine challenge: Nationalism": https://www.politico.com/news/2020/10/28/covid-vaccine-challenge-nationalism-433023 Learn more about your ad choices. Visit megaphone.fm/adchoices

Human Rights Campaign president Chad Griffin assesses the record of Trump White House--and Ivanka Trump--on gay rights and what the Resistance has to learn. Tony-nominated Paula Vogel talks her play "Indecent" and anxieties about art in the age of Trump. Learn more about your ad choices. Visit megaphone.fm/adchoices

Small Business Administrator Linda McMahon discusses going from bankruptcy to WWE millions, the first time she met Donald Trump, staffing challenges and her mission to introduce more small business owners to the SBA. Learn more about your ad choices. Visit megaphone.fm/adchoices

Wyclef Jean’s advice for celebrities who want to get political: Don’t be like Kathy Griffin.Read up, said the musician of Fugees fame, and one-time aspiring celebrity-turned-president himself. And if you’re a high-profile person, think about how what you’re doing and saying might be interpreted, or maybe misinterpreted. Learn more about your ad choices. Visit megaphone.fm/adchoices

Mention President Donald Trump’s name and Nebraska Senator Ben Sasse closes his eyes, rocks back and forth on his heels in almost momentary pinched smile meditation, waiting for it to pass.He never liked Trump. He still doesn’t like Trump. And now that he’s promoting his new book, “The Vanishing American Adult,” he doesn’t want to talk about the American president’s not counting as an adult according to the principles he spends 300 pages laying out. Learn more about your ad choices. Visit megaphone.fm/adchoices

Rep. Tom Reed and Rep. Josh Gottheimer say that President Trump can get the biggest tax reform package in history done in conjunction with the largest infrastructure package, and that he can get it through with bipartisan support by early 2018. Reed and Gottheimer aren’t crazy—they’re the co-chairs of the bipartisan Problem Solvers Caucus, and they insist their day has come. The voters who elected Trump demand it. Learn more about your ad choices. Visit megaphone.fm/adchoices

L.A. Mayor Eric Garcetti sits down with Isaac Dovere to discuss his relationship with Donald Trump, what he learned about politics from his father and what his hopes are for his own political career. Plus, Isaac is joined by California Playbook author Carla Marinucci for insight into Garcetti's possible career moves. Learn more about your ad choices. Visit megaphone.fm/adchoices

Chicago Mayor Rahm Emanuel believes everyone in Washington is too focused on the craze around President Trump and unable to see what’s actually going on—and what’s not. Emanuel says that “America’s word and America’s reliability is now in question,” and the turmoil and drama surrounding the West Wing has over shadowed major events like the proposed upheaval to the tax code, mounting tensions with North Korea and Oval Office invites for anti-democratic leaders. Learn more about your ad choices. Visit megaphone.fm/adchoices

Actress and political activist Sophia Bush sits down with Isaac Dovere in New Orleans to discuss fighting for what she believes in (even if that means losing followers), standing up against sexism in the work place and why her social anxiety is "through the roof." Learn more about your ad choices. Visit megaphone.fm/adchoices

Arkansas Senator Tom Cotton sits down with Isaac Dovere to discuss his love of Abraham Lincoln, how he cultivated such a friendly relationship with the Trump White House and what he learned from his time in the military. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ohio Gov. John Kasich sits down with Isaac Dovere this week to discuss the development of his faith, the difficulty of losing both his parents at a young age to a drunk driver and the moment he met President Nixon and the incredible amount of compassion he witnessed from him. Learn more about your ad choices. Visit megaphone.fm/adchoices

"POLITICO's Off Message" brings you a special episode of POLITICO's new podcast series "Global Translations." From closed factories to closed borders, the Covid-19 pandemic exposed the fragility of our systems, creating a period of scarcity where demand skyrocketed — from freezers to PPE — and we couldn't supply items fast enough. In this episode of "Global Translations", POLITICO hosts Luiza Savage and Ryan Heath take a deep dive with experts into global supply chains and what "decoupling" and "reshoring" are all about when it comes to America’s reliance on China and the rest of the world.Luiza Savage is the host of "Global Translations". Ryan Heath is a host of "Global Translations".Annie Rees is a producer for POLITICO Audio.Kara Tabor is a producer for POLITICO Audio.Jenny Ament is the senior producer for POLITICO Audio.Irene Noguchi is the executive producer of POLITICO Audio. Adegoke Oke is a professor of supply chain management at Arizona State University.Tom Duesterberg is a senior fellow at Hudson Institute. He is an expert on trade and foreign policy. David Wertime is POLITICO's editorial director for China and author of the China Watcher newsletter. Check out and subscribe to POLITICO's Global Translations and China Watcher newsletters, and Luiza Savage's in-depth piece on how the pandemic is forging a new consensus on globalization. Global Translations: https://www.politico.com/newsletters/global-translations China Watcher: https://www.politico.com/newsletters/politico-china-watcher Supply chain tug-of-war article: https://www.politico.com/news/2020/10/21/pandemic-forging-new-consensus-globalization-430605 Learn more about your ad choices. Visit megaphone.fm/adchoices

In Donald Trump, author Margaret Atwood  and actress Elisabeth Moss see an eerie echo of her novels. Activist Stephanie Schriock is fighting to ensure that they're wrong.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Former Reagan and Bush diplomat Elliott Abrams sounds off on Steve Bannon, President Trump’s about-face on Syria and the boss he almost had. Learn more about your ad choices. Visit megaphone.fm/adchoices

Seattle Mayor Ed Murray joins Off Message to discuss the city's lawsuit against the federal government on the sanctuary cities, how a monk encouraged him come out as a young man and what President Trump doesn't understand about the immigrant community. Learn more about your ad choices. Visit megaphone.fm/adchoices

Republican strategist Roger Stone says he’s apologized to Paul Manafort for getting him involved in all the inquiries about possible Russian connections to Donald Trump’s presidential campaign. But Stone says he hasn’t apologized for anything he’s done himself—not to Trump, and not to anyone else. There’s nothing to apologize for, in his mind. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Virginia congressman says it shouldn’t take a PhD to see what’s wrong with how his own party is handling the health care situation.  He also discusses the importance of civics classes, if Paul Ryan is a conservative and his take on "fake news." Learn more about your ad choices. Visit megaphone.fm/adchoices

The New York congressman discusses his experience coming to the United States as a nine-year-old boy, his take on fellow New Yorker President Donald Trump, his love for foreign affairs and more. Learn more about your ad choices. Visit megaphone.fm/adchoices

Former Secretary of Homeland Security Michael Chertoff sits down with Isaac Dovere to discuss the country's most pressing security concerns, how to be prepared for the unexpected, his experiences with 9/11 and Hurricane Katrina, and how he thinks the Trump administration is holding up.  Learn more about your ad choices. Visit megaphone.fm/adchoices

The former Democratic National Committee Interim Chair Donna Brazile sits down with Isaac Dovere in the midst of the election in Atlanta. Brazile opens up about the toll the 2016 election hacks took on her personally, how her good rapport with Donald Trump turned sour and addresses the CNN flap. Learn more about your ad choices. Visit megaphone.fm/adchoices

Former Labor Secretary Tom Perez discusses his fight to become the new chair of the Democratic National Party and the many mistakes made in the 2016 presidential election. Perez discusses the upcoming election to lead a party on the mend, the milestones reached under President Obama which are on their way to the chopping block under President Trump and the desperate need to redefine the mission of a faltering political party. Learn more about your ad choices. Visit megaphone.fm/adchoices

ABC's Chief White House Correspondent Jon Karl has a front row to the Trump White House. And despite what the president has said about the "unfair media", Karl says this administration has been incredibly accessible and open. He also says reporters can fall victim to groupthink and get caught up in thinking about traditions Trump is breaking more than thinking about why the traditions were there in the first place.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Rahm Emanuel — former Chicago mayor and former chief of staff to President Barack Obama — talks to POLITICO founding editor John Harris about his new book, "The Nation City: Why Mayors Are Now Running the World," his "toy phone" in Bill Clinton's White House and his thoughts on the 2020 field. Learn more about your ad choices. Visit megaphone.fm/adchoices

The two Democratic congressmen sit down with Isaac Dovere over some beers to discuss why they felt compelled to start the Blue Collar Caucus, what Republicans really think of Donald Trump and how they're going to help Democrats understand what they missed about the electorate in 2016. Learn more about your ad choices. Visit megaphone.fm/adchoices

POLITICO's Isaac Dovere sits down with New York Congressman Hakeem Jeffries to discuss his experience with detainees at JFK Airport, the similarities between Donald Trump and Richard Nixon, and how Democrats plan on pushing back against the White House.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Isaac Dovere sits down with Heritage Foundation's John McDonald for an in-depth discussion on how the next Supreme Court justice is chosen, what sets the best candidates apart from the rest and Donald Trump's Constitutional politics. Learn more about your ad choices. Visit megaphone.fm/adchoices

Meet the Press host Chuck Todd sits down with Glenn Thrush to discuss his father's influence on his career, why he regrets allowing Donald Trump to call in to the Sunday show and the public's perception of the media. Learn more about your ad choices. Visit megaphone.fm/adchoices

Minnesota congressman Keith Ellison sits down with Glenn Thrush to discuss growing up in Detroit, fighting Muslim stereotypes, what led him to Louis Farrakhan as a young man and why he's best suited for the top DNC post.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Ohio congressman Tim Ryan sits down with Glenn Thrush to discuss how mindfulness influences his everyday life, why losing to Nancy Pelosi for House minority leader was the "best professional experience" of his life and how Democrats need to tweak their messaging in order to reach working class people.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Media Matters founder and long-time Clinton friend David Brock sits down with Glenn Thrush for a 2016 post-mortem. Brock criticizes the Clinton campaign's press strategy, lays out tactics for Democrats going forward and opens up about how pizza-gate has affected his day-to-day life. Learn more about your ad choices. Visit megaphone.fm/adchoices

Americans for Tax Reform founder Grover Norquist sits down with Glenn Thrush to discuss how anti-communism books inspired his political career at 10 years old, his take on Donald Trump's politics and why he believes America does best with less government.  Learn more about your ad choices. Visit megaphone.fm/adchoices

New York Times reporter and friend Maggie Haberman sits down with Glenn Thrush to discuss how they began their career together in New York City Hall and how the tabloid culture shaped Donald Trump. Haberman also sheds light on Trump's angry tweeting, cabinet picks and management style. Learn more about your ad choices. Visit megaphone.fm/adchoices

In honor of Election Day, Glenn Thrush takes a look back at his favorite moments on the show - interviews that framed the narrative, made news, gave insight into the candidates' mindsets or, at least, gave us a laugh. Learn more about your ad choices. Visit megaphone.fm/adchoices

We're bringing you an episode of POLITICO's Global Translations, a show about big global problems that will take a certain amount of creativity to solve.  Driven by a public clamoring for action and pressure from corporate CEOs, lawmakers are noting an evolution in attitudes toward climate action among some of their Republican colleagues – a subtle but significant shift in tone that could pave the way for modest legislation this year. Guests include:Rep. Earl Blumenauer (D-OR)Rep. Francis Rooney (R-FL)Sen. Chris Coons (D-DE)Catherine McKenna, Canada’s first foreign minister for climate and the environmentDan Byers, U.S. Chamber of CommerceIf you like the episode, check out the show wherever you listen.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Data gurus Mark Stephenson and John Hagner sit down with Glenn Thrush to discuss early voting and absentee ballots - what the trends say about campaign strategies and the electorate.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Astronaut Mark Kelly sits down with Glenn Thrush to discuss his lifelong experience with guns, from having two parents in law enforcement to being shot at while in Navy and, of course, the act of gun violence that left his wife, Gabby Giffords, in critical condition. Kelly opens up about the importance of having civil conversations with those who adamantly disagree with you and what needs to be done to stop gun violence.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Kansas Secretary of State Kris Kobach sits down with Glenn Thrush in Topeka, Kansas, to discuss the challenges of being a conservative at Harvard, what has driven Kobach to make immigration reform his life's work, his take on the Trump tapes and voter fraud. Learn more about your ad choices. Visit megaphone.fm/adchoices

Saturday Night Live's Colin Jost and Michael Che sit down with Glenn Thrush in 30 Rock for an unvarnished conversation about hating on Donald Trump, what Hillary Clinton is like behind the scenes and growing up in New York City. These guys are hilarious and their take on Trump might just surprise you.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Hillary Clinton’s communications director Jen Palmieri sits down with Glenn Thrush in the Brooklyn headquarters to talk debate prep and which Donald Trump the campaign is expecting on the stage Monday night. Palmieri also opens up about her time working with Elizabeth Edwards and discusses why Hillary has a hard time connecting with voters. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jill Stein: Trump may have 'memory problem' by POLITICO Learn more about your ad choices. Visit megaphone.fm/adchoices

Author and political commentator Ann Coulter delves into what in her genetic makeup allows her to endure and even delight in being called unsavory names (most recently at the Comedy Central Roast). Coulter also discusses why she is so drawn to Donald Trump and what influence she's had over his immigration platform. Learn more about your ad choices. Visit megaphone.fm/adchoices

Neera Tanden: Hillary Clinton's anger translator by POLITICO Learn more about your ad choices. Visit megaphone.fm/adchoices

Former British Prime Minister Tony Blair sits down with Glenn Thrush in London to discuss the relationship between American and British politics, his close relationship with the Clintons, Brexit, and the danger of approaching politics with a closed-mind. Learn more about your ad choices. Visit megaphone.fm/adchoices

John Dickerson: Don't blame media for Donald Trump's rise by POLITICO Learn more about your ad choices. Visit megaphone.fm/adchoices

To get the inside view from the only people in the world who know what it’s like to run in a primary field so large -- and do so in the shadow of Donald Trump -- we invited the strategists for four of the top GOP primary campaigns of 2016 into a Washington cigar bar, a literal smoke-filled room, to talk shop. Which Democratic candidate has the most raw political talent? What weaknesses of Donald Trump's would they exploit in 2020? And why is everybody still so ticked off about the Virginia primary? Guests Danny Diaz (from the Bush campaign), Beth Hansen (Kasich), Jeff Roe (Cruz), and Terry Sullivan (Rubio). Learn more about your ad choices. Visit megaphone.fm/adchoices

Senator Chris Murphy made a name for himself when he held a 15 hour filibuster calling for gun control reform. The freshman senator sits down with Glenn Thrush in Philadelphia to discuss how the Sandy Hook shooting jolted him into action - giving his work in the Senate and life purpose. Learn more about your ad choices. Visit megaphone.fm/adchoices

Bernie Sanders campaign manager Jeff Weaver sits down with Glenn Thrush in Philadelphia to discuss growing up in Vermont, his love of comic-books, Clintonism and what Sanders understands about politics that she doesn't. Learn more about your ad choices. Visit megaphone.fm/adchoices

Hillary Clinton campaign manager Robby Mook sits down with Glenn Thrush in Philadelphia to discuss how they came together with the Sanders camp, why voters may not trust Clinton until after she's elected and the Russians hacking DNC emails. Learn more about your ad choices. Visit megaphone.fm/adchoices