Physiological Reviews Podcast – Détails, épisodes et analyse

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Physiological Reviews Podcast

American Physiological Society

Sciences

Fréquence : 1 épisode/57j. Total Éps: 35

Each episode of the Physiological Reviews podcast features commentary and discussion of newly published articles in the journal, which provides state-of-the-art, comprehensive, and high-impact coverage of timely issues in the physiological and biomedical sciences. Physiological Reviews articles appeal to physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with special interest in pathophysiology. The journal is very useful in teaching and research because it provides non-biased and clearly written updates on important developments.

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https://journals.physiology.org/toc/physrev/0/0
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Xenotransplantation from Genetically Modified Pigs to Humans

Épisode 21

lundi 17 juin 2024 • Durée 36:45

In our latest episode, Physiological Reviews Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews authors Dr. Leigh Peterson (Executive Vice President for Product Development and Xenotransplantation at United Therapeutics Corporation) and Professor Sir Magdi Yacoub (Professor of Cardiothoracic Surgery at the National Heart and Lung Institute at Imperial College London, and Founder and Director of Research at the Harefield Heart Science Centre and Aswan Heart Centre). The authors have published a comprehensive review on xenotransplantation. Listen as they discuss the steps necessary to immunologically modify pigs to avoid acute rejection and minimize chronic rejection, as well as the main differences between the GalSafe and the 10GE pigs described in the article. Given that the American Physiological Society launched their Women’s Health Research Initiative in spring 2024, we discuss how xenotransplantation and women’s health research are connected. What are the next important developments in this field? Listen to find out more.

Leigh Peterson, Magdi Yacoub, David Ayares, Kazuhiko Yamada ,Daniel Eisenson, Bartley P. Griffith, Muhammad Mohiuddin, Will Eyestone, J. Craig Venter, Ryszard T. Smolenski, and Martine Rothblatt Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review Physiological Reviews, published June 7, 2024. DOI: 10.1152/physrev.00041.2023

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Community-Acquired Bacterial Coinfections and COVID-19

Épisode 20

jeudi 25 avril 2024 • Durée 47:07

In our latest episode, Dr. Farrah Kheradmand (Baylor College of Medicine) interviews Dr. Kevin Harrod (University of Alabama at Birmingham) about his article by Patton et al. on community-acquired bacterial coinfections and COVID-19. In the early days of the pandemic when physicians were treating critically ill COVID patients, there was no standard definition for bacterial coinfections in this cohort. However, as the field has moved forward with understanding how bacterial coinfections contribute to the mortality of COVID patients, Dr. Harrod and co-authors have worked to refine the definition of bacterial coinfections to provide a more unified way to report the prevalence of this important clinical problem. While it is often necessary to treat critically ill hospitalized COVID patients with antibiotics before sampling or culture results, Dr. Harrod and co-authors identify that this may mask the true prevalence of bacterial coinfections. Listen as Dr. Kheradmand and Dr. Harrod discuss linkages between carriage, viral infection, and secondary bacterial infections, as well as the pathophysiological ways that fungi may coinfect COVID patients. Are patients with underlying cystic fibrosis more prone to COVID infection? Listen now to learn more.

Michael John Patton, Amit Gaggar, Matthew Might, Nathaniel Erdmann, Carlos J. Orihuela, and Kevin S. Harrod Community-acquired bacterial coinfections and COVID-19 Physiological Reviews, published October 16, 2023. DOI: 10.1152/physrev.00010.2023

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Systematic Reviews for Basic Scientists: A Different Beast

Épisode 11

vendredi 2 décembre 2022 • Durée 28:29

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Prof. John P.A. Ioannidis about his editorial “Systematic Reviews for Basic Scientists: A Different Beast,” which focuses on the importance of systematic reviews in scientific research.

Prof. Ioannidis is Professor of Medicine, of Epidemiology and Population Health, and, by courtesy, of Statistics and Biomedical Data Science at Stanford University. He is one of the most cited scientists in the world and is an elected member of numerous national academies. Prof. Ioannidis in an Associate Editor of Physiological Reviews.

Introduction of Prof. Ioannidis [1:26]
Author’s background [3:08]
Discussion of reproducibility in science [5:35]
Discussion of sample size in research [7:31]
What exactly is a systematic review, and how can it address bias? [10:41]
Do systematic reviews have a place in basic research, or should they be used mostly in clinical science? [13:29]
What is a “living review”? [15:35]
What does the future hold for the format of review articles? [18:34]
The importance of collaboration in science [21:50]
Advice for early-career researchers [24:57]

Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available.

Browse recent articles on our website.

Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it.

The Superoxide Radical Switch in the Biology of Nitric Oxide and Peroxynitrite

Épisode 10

mercredi 2 novembre 2022 • Durée 41:08

Physiological Reviews Associate Editor Prof. Giovanni Mann speaks with Prof. Rafael Radi about his review article “The superoxide radical switch in the biology of nitric oxide and peroxynitrite,” about the life of a scientist, and about advice for early-career researchers.

Prof. Radi is Professor, Chair, and Director of the Centro de Investigaciones Biomédicas (CEINBIO) at the Universidad de la República in Montevideo, Uruguay. Prof. Radi has made significant contributions to our understanding of the mechanisms of nitric oxide-dependent toxicity through its interaction with superoxide anions and the formation of peroxynitrite. He has characterized the biological chemistry of peroxynitrite, its effects on mitochondrial dysfunction and apoptosis, and its role in pathology.

Introduction of Prof. Radi [0:45]
Author's background [2:40]
Advice to early-career investigators seeking to take on a career in research [10:07]
Discussion of collaboration between professional organizations that facilitates sharing of research among early-career researchers from different countries [13:57]
Insight into the sources of superoxide, and which in particular Prof. Radi believes contributes primarily to the role of superoxide acting as a ‘radical switch’ [16:37]
The importance of physiologically relevant oxygen levels in the interplay of nitric oxide, oxygen, and peroxynitrite during experiments [20:54]
From a translational perspective, can this area of inquiry make any contributions to benefit patients? [25:13]
Will basic and clinical scientists be able to target specific activators or inhibitors of nitric oxide synthase(s) or nitric oxide donors to individual organs or tissues? [29:07]
Formation of peroxynitrite under lower oxygen levels [31:28]
Advice for young people interested in pursuing basic science and/or medicine as a career [35:33]

Subscribe to the podcast on Apple Podcasts, Google Podcasts, , and to receive immediate notification when new episodes are available.

Pregnancy and the SARS-CoV-2 Pandemic

Épisode 9

mardi 4 octobre 2022 • Durée 39:56

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Prof. Rebecca M. Reynolds, Prof. Sarah J. Stock, and Prof. Hilary O. D. Critchley about their editorial “Pregnancy and the SARS-CoV-2 Pandemic,” published in the July 2022 issue of Physiological Reviews.

The authors also have contributed a review article on this topic, “Pregnancy and COVID-19,” which was one of the most highly cited articles published in the journal in 2021.

Prof. Reynolds is Professor of Metabolic Medicine at the University of Edinburgh. Her research looks at the ways in which early development in utero can affect health and disease. Prof. Stock is Professor of Maternal and Fetal Health at the University of Edinburgh. Her research examines efforts at reducing preterm birth, stillbirth, and other complications in pregnancy. Prof. Critchley has held a Personal Chair in Reproductive Medicine at the University of Edinburgh since 1999. She is Head of the Deanery of Clinical Sciences at the University of Edinburgh, she is Co-Director of the Medical Research Council Centre for Reproductive Health, and she is Consultant Gynaecologist at the Royal Infirmary in Edinburgh. Her research is aimed at improving our understanding of the basic science of the uterine endometrium. She is an Associate Editor of Physiological Reviews.

Author introductions [0:41]
Efficacy of vaccination in diminishing the severity and long-term consequences of COVID-19 [6:44]
Does COVID-19 vaccination cause any significant side effects for the pregnant woman or the fetus? [8:08]
Are women who are pregnant at higher risk for COVID infection, and can the virus cross the placenta? [15:53]
Does SARS-CoV-2 affect the development of preeclampsia? [21:19]
What kinds of treatments are available -- and safe -- for pregnant women with COVID? Are there any animal models in which interventions may be tested? [24:05]
What other work is being conducted on this topic? [28:38]
Discussion of the effects of SARS-CoV-2 infection or COVID vaccination on menstruation [31:27]
Closing remarks [35:59]

A Tale of Two Epidemics: HIV and SARS

Épisode 8

mardi 7 juin 2022 • Durée 26:53

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Michael Saag, MD, of the University of Alabama at Birmingham (UAB) about his editorial “Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science.”

Dr. Saag is Associate Dean for Global Health in the School of Medicine, Director of the UAB Center for AIDS Research and a Professor of Medicine in the Division of Infectious Diseases. He also is the principal investigator of the CFAR Network of Integrated Clinical Systems (CNICS), a network of centers sharing electronic health record data to integrate clinical information from persons infected with HIV. In addition, Dr. Saag is the founding director of the UAB 1917 HIV Clinic, one of the leading HIV clinics in the United States.

Dr. Saag's experience in treating patients with HIV, and advances in HIV treatment [2:50]
Why is there no vaccine for HIV? [4:50]
Is there an animal vector for SARS-CoV-2 as was the case for SARS-CoV-1? [8:17]
What exactly is “long COVID,” and what are its implications for public health? [12:06]
Why do vaccinated individuals still contract SARS-CoV-2? [17:08]
Final thoughts [22:04]

Subscribe to the podcast here.

Browse recent articles on our website.

Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it.

Follow the journal on Twitter and on Facebook.

Listen to other podcasts produced by the American Physiological Society.

Human Airway Mucus

Épisode 7

mercredi 13 avril 2022 • Durée 15:09

To follow up on our recently published AIP manuscript “Physiology and Pathophysiology of Human Airway Mucus” (https://doi.org/10.1152/physrev.00004.2021), we were able to connect with senior author Dr. Richard Boucher.

In this podcast, Physiological Reviews Editorial Ken Adler and Dr. Boucher have an interesting conversation on pathogenesis and future therapies in lung and airway diseases. They discuss everything from mucin genes to Cystic Fibrosis.

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How close are we to the achieving the bioengineering of the Six-Million Dollar Man?

Épisode 6

vendredi 10 décembre 2021 • Durée 16:37

Advances in our understanding of brain function, along with the development of neural interfaces that allow for the monitoring and activation of neurons, have paved the way for brain machine interfaces (BMI), which harness neural signals to reanimate the limbs via electrical activation of the muscles, or to control extra-corporeal devices, thereby bypassing the muscles and senses altogether. BMIs consist of reading out motor intent from the neuronal responses monitored in motor regions of the brain and executing intended movements using bionic limbs, reanimated limbs, or exoskeletons. BMIs also allow for the restoration of the sense of touch by electrically activating neurons in somatosensory regions of the brain, thereby evoking vivid tactile sensations and conveying feedback about object interactions. In this podcast associate editor Jeff Diamond is joined by authors Chethan Pandarinath and Sliman Bensmaia as they discuss " The Science and Engineering behind sensitized brain-controlled bionic hands."

The review of this fascinating topic can be found on our PRV website: https://journals.physiology.org/doi/abs/10.1152/physrev.00034.2020

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The Physiological Control of Eating

Épisode 5

jeudi 4 novembre 2021 • Durée 23:08

Deputy Editor Dr. Willis Samson takes a deep dive into the complex universe that control the behavior and mechanisms of eating. He is joined by the authors of our recent published review "The Physiological Control of Eating: Signals, Neurons, and Networks" by Alan G. Watts, Scott E Kanoski, Graciela Sanchez-Watts and Wolfgang Langhans. Learn about the advances of this complicated process and the possible therapeutics for the future.

Watts AG, Kanoski SE, Sanchez-Watts G, Langhans W. The Physiological Control of Eating: Signals, Neurons, and Networks. Physiol Rev. 2021 Sep 6. doi: 10.1152/physrev.00028.2020. Epub ahead of print. PMID: 34486393.

https://journals.physiology.org/doi/abs/10.1152/physrev.00028.2020

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Discussion on Asthma with PRV Associate Editor Sally Wenzel

Épisode 4

mercredi 6 octobre 2021 • Durée 18:36

Dr. Sadis Matalon, editor in Chief and Dr. Sally Wenzel discuss Asthma and her PRV review

Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?

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Physiological Reviews Podcast – Détails, épisodes et analyse

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