Status Epilepticus: Part II Special Guest: Jason Vilar, PharmD, BCCCP @TheBrainPharmD   03:40 – Definitions/Terminology 14:30 – Landmark status epilepticus (SE) literature 21:30 – Emergent ASM SE pharmacotherapy 26:00 – DDI management/TDM 33:55 – Refractory status epilepticus (RSE) treatment 48:15 – Medication safety considerations and weaning 58:00 – EEGs for PharmD’s 68:10 – Inhaled anesthetics 74:30 – Studies on the horizon/take-home points   Reference List: https://pharmacytodose.com/wp-content/uploads/2024/08/status-epilepticus-part-ii-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series April 2024 Special Guests: Katherine Kessel, PharmD Ming May Zhang, PharmD, BCPS   04:05 – RCT’s 21:28 – Reviews/Prospective observational 35:25 – Guidelines/Post-hoc 43:00 – Retrospective/ SRMA 64:54 – PharmD-featured/Sweet Emotion   2024 Award Nomination Ballot: https://forms.gle/HG1ytSHjrcRCW3SA9 Reference List: https://pharmacytodose.com/wp-content/uploads/2024/08/april-2024-lrs-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series January 2024 Special Guests: Haley Torr, PharmD Nick Tran, PharmD   06:55 – Featured Articles 32:55 – PAD-IS articles 37:10 – Cardiology articles 46:00 – Heme articles 51:40 – Potpourri articles 60:05 – Pharmacist-featured articles 67:30 – Sweet Emotion articles   Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/jan-2024-lrs-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Acetaminophen Overdose Special Guest: Jimmy Leonard, PharmD, DABAT Poison Center: 1-800-222-1222 05:11 – Patient Case Intro 06:46 – Pathophysiology and Nomogram 21:55 – GI Decontamination 29:10 – Labs & Signs/Symptoms 35:55 – Historical Treatments 37:10 – N-acetylcysteine (NAC) 66:30 – Adjunctive Treatments 77:50 – Ultimate Take-Away  Reference List: https://pharmacytodose.files.wordpress.com/2023/04/acetaminophen-overdose-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Feb 2023 Special Guest: Rhea Soltau, PharmD 04:10 – Featured Articles 34:50 – Cardiovascular 51:32 – Neurology 55:00 – PharmD 74:10 – Fun Article of the Month Reference List: https://pharmacytodose.files.wordpress.com/2023/04/feb-lrs-2023-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: PROCOAG trial Special Guest: Scott Dietrich, PharmD, BCCCP  Rapid reaction episode discussing the PROCOAG study looking at 4-factor prothrombin complex concentrate (PCC) use in trauma patients at risk of massive transfusion published in JAMA. We go into the outcomes, European v. American trauma management, PCC dosing, effect of viscoelastic testing, and much more.   PROCOAG trial: https://pubmed.ncbi.nlm.nih.gov/36942533/ Reference List: https://pharmacytodose.files.wordpress.com/2023/04/procoag-rapid-reaction-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: CAPE COD trial Special Guest: Carolyn Magee Bell, PharmD, BCCCP, FCCM  Rapid reaction episode covering the CAPE COD trial which looked at the use of hydrocortisone in ICU CAP patients published in NEJM. We discuss outcomes, pertinent findings, questions remaining, ultimate take-aways, fun facts, and much more. CAPE COD trial: https://pubmed.ncbi.nlm.nih.gov/36942789/ Reference List: https://pharmacytodose.files.wordpress.com/2023/04/cape-cod-rapid-reaction-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Emergency Medicine Clinical Pearls and EMPoweRx Conference  Special Guest: Megan Rech, PharmD, MS, BCCCP, FCCM, FCCP   https://empowerx-conference.com https://rutgers.cloud-cme.com/course/courseoverview?P=0&EID=17157&formid=2931 https://empharmnet.org/ 03:35 – EMPoweRx Conference 12:28 – TXA in Epistaxis 21:40 – DDAVP in Antiplatelet-Associated ICH 34:47 – Awareness with Paralysis Reference List: https://pharmacytodose.files.wordpress.com/2023/03/em-pearls-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Heart Failure: Part II Special Guest: Cait Kulig, PharmD  https://cards.rxexplained.com/ 07:55 – Transitions of Care 17:35 – HFrEF GDMT 48:35 – HFpEF GDMT Reference List: https://pharmacytodose.files.wordpress.com/2023/03/heart-failure-part-ii-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Jan 2023 Special Guest: Austin Roe, PharmD 04:15 – Featured Articles 40:18 – Cardiovascular 53:05 – Neurology 57:45 – Infectious Diseases 71:12 – PharmD Reference List: https://pharmacytodose.files.wordpress.com/2023/01/lrs-dec-2022-references.pdf Full article list: https://docs.google.com/document/d/1ZDGStSjlCWg8eCCCrIHQlChyI2Y5Jrwr8cRNYIzFeIc/edit?usp=sharing PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: ANNEXA-4 Special Guest: Brian Gilbert, PharmD, MBA, BCCCP, BCPS, FCCM Discussion about the ANNEXA-4 final study results including some of our biggest takeaways, future directions, and more. ANNEXA-4: https://pubmed.ncbi.nlm.nih.gov/36802876/ Reference List: https://pharmacytodose.files.wordpress.com/2023/03/annexa-4-rapid-reaction-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Heart Failure: Part I Special Guest: Cait Kulig, PharmD  https://cards.rxexplained.com/ 06:15 – Definitions 13:48 – ADHF 29:50 – Diuresis and Diuretic Resistance 52:45 – IV Vasoactives Reference List: https://pharmacytodose.files.wordpress.com/2023/03/heart-failure-part-i-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Top Cardiology Trials with Cardioscripts Special Guests: Tracy Macaulay, PharmD, BCCP, FACC, FCCP @SchwietTMax Elisabeth Wang, PharmD, BCCP @Val_Smartan Nathan Wayne, PharmD, BCPS, BCCP @TweetlessNathan 13:45 – Top Landmark Trials 32:50 – Top New Trials 50:00 – Top Grab Bag/Random Trials Reference list: https://pharmacytodose.files.wordpress.com/2023/03/top-cardiology-trials-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: PROWESS-SHOCK Special Guest: Paul Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS @paulszumita   03:30 – Background studies/Setting the scene 30:25 – PROWESS-SHOCK discussion/Where are we now   Paul Szumita joins to highlight a June Trial of the Week “Drotrecogin alfa (activated) in adults with septic shock” published in the New England Journal of Medicine in 2012. To fully understand the discussion regarding drotrecogin alfa, Paul and I review the mechanism of action and its proposed action in the treatment of sepsis. Then we review earlier studies and the controversy behind the FDA approval process. Finally, we go into detail on what Clinical Pharmacists were tasked with doing at the time based on treatment protocols or hospital restrictions. Then we dive into the Trial of the Week, discussing the study design and results. What was the mood in ICUs and Pharmacy Departments after this publication? How much did our sepsis care improve from PROWESS to PROWESS-SHOCK? What lessons did we learn with the Xigris FDA approval process? Is there a patient population that could still benefit from drotrecogin alfa treatment? Plus, trial fun facts, issues with calculating APACHE II scores, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/06/prowess-shock-trial-of-the-week-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 SCCM PharmD Star Researchers 03:10 – Restrictive Resuscitation in Patients with Sepsis: A Systematic Review with Trial Sequential analysis with Sylvia Stefanos, PharmD  10:50 – Incidence of Acute Kidney Injury in Traumatic Brain Injury Patients Treated with Hypertonic Saline with Jesse Briscoe, PharmD 19:42 – Comparison of Factor Products for Uncontrolled Bleeding Related to Cardiac Surgery with Lauren Caldwell, PharmD, BCCCP 28:00 – Validation of Heparin-Induced Thrombocytopenia Risk Stratification Tools in Post-Surgical Cardiovascular Patients with Shahristan Kokoy, PharmD, BCPS 39:16 – Naloxone Co-prescribing for Emergency Medicine and Trauma Patients at High-risk for Opioid Overdose with William Peppard, PharmD, BCPS, FCCM 52:20 – Incidence of Detectable Drug Levels with Inhaled Aminoglycoside Therapy in Critically Ill Adults with Jenny Schultheis, PharmD, BCPS, BCCCP 63:28 – Evaluation of Achieving Targeted Vancomycin Levels in Augmented Renal Clearance with Sydney Wilson, PharmD 73:30 – Vancomycin and Piperacillin/tazobactam or Cefepime and Sepsis-Associated AKI Trajectory with Michael Behal, PharmD, BCCCP PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 SCCM PharmD Speakers Part II 02:18 – Acute Ischemic Stroke Mgmt Updates with Salia Farrokh, PharmD, BCCCP, FNCS 13:30 – Ketamine’s Role in Opioid-Sparing Analgesia with Luma Succar, PharmD, BCCCP 24:00 – Incorporating Lidocaine in Multimodal Pain Regimens with Chelsea Lopez, PharmD, BCCCP 43:19 – Choice of Analgesic/Sedatives in ABCDEF bundle with Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP 58:54 – Constipation in the Critically Ill with Melissa Santibañez, PharmD, BCCCP 74:40 – Practical Aspects of Immunotherapy in the ICU Heather May, PharmD, FCCM, BCPS, BCCCP 92:27 – Updates on CAR-T Products and Toxicity Management with Anne Rain Brown, PharmD, BCCCP, FCCM 103:37 – Immunomodulator Drug Highlights with Tuqa Alkhateeb, PharmD, PhD 118:18 - Empiric Anerobic Antibiotics in the ICU with Kevin Betthauser, PharmD, BCCCP 134:37 – Pharmacotherapy Adjustments in Obesity with Bethany Shoulders, PharmD, BCCCP PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 SCCM PharmD Speakers Part I 03:46 – PAH Pharmacotherapy with Diana Lemieux, PharmD, BCCCP 17:01 – USA v. EU AF Mgmt. with Cait Kulig, PharmD 30:25 – Caring for Special Populations in the ED with Erin Wieruszewski, PharmD, BCCCP 42:26 – Medical Treatments to Consider with RV Failure in VV ECMO with Patrick Wieruszewski, PharmD, BCCCP 57:30 – Toxicology Year in Review with Rachel Wein, PharmD, BCPS 65:40 – Effect of IV Fluids on Microcirculation with Susan Smith, PharmD, BCPS, BCCCP, FCCM 75:15 – Finding Fluid Stewardship in the ICU & Phases of Fluid Management in the ICU with Anthony Hawkins, PharmD, FCCM PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Recap of 2023 SCCM Congress Special guest: W. Anthony Hawkins, PharmD, FCCM, BCCCP   SF review, unique sessions, speaker perspective, FCCM/awards, Dr. Glaucomflocken, late-breaking studies, exhibit hall, receptions, our favorite sessions and more.     PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Dec 2022   00:26 – Life/podcast update; 08:40 – Top 5; 24:50 – BP management; 28:55 – IV fluids; 31:40 – Lost in my mind; 39:28 – Front of the fridge   Reference List: https://pharmacytodose.files.wordpress.com/2023/01/lrs-dec-2022-references.pdf     PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Apr 2022 Special Guests: Philip Jacobson, PharmD and Andi Ray, PharmD   07:10 – 6-pack of studies; 45:20 – Don’t go breaking my heart; 55:20 – Ventilator blues; 65:00 – Front of the fridge Pt I and II   Reference List: https://pharmacytodose.files.wordpress.com/2022/10/lrs-apr-2022-references.pdf     Full Article List: https://docs.google.com/document/d/1EcldymfgaszAcKmYlr6wYt4XRI5_GFhQo4DeqrGAfAE/edit?usp=sharing   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Mar 2022 Special Guests: Paige Miller, PharmD and Jontae Warren, PharmD   05:00 – 6-pack of studies; 45:00 – Lost in my mind; 55:20 – When we were young; 66:50 – Don’t go breaking my heart; 79:40 – Front of the fridge   Reference List: https://pharmacytodose.files.wordpress.com/2022/09/lrs-mar-2022-references.pdf   Full Article List: https://docs.google.com/document/d/1X43sqQX9IYRKJ2hGSp5gneqzL0OQcxeGJMGgKs2Bu54/edit?usp=sharing     PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

PCCs for PharmDs Part II Special Guest: Scott Dietrich, PharmD, BCCCP @PCC_PharmD   Reference List: https://pharmacytodose.files.wordpress.com/2022/08/pccs-for-pharmds-part-ii-references.pdf   04:45 – Fixed dose PCC; 11:58 – Time to administration; 15:00 – 3-factor v. 4-factor PCC; 19:12 – 4-factor PCC v. 4-factor aPCC; 30:36 – No anticoagulation reversal; 33:36 – PCC in surgery; 37:40 – PCC in trauma; 40:51 – PCC v. andexanet alfa; 54:10 – Guideline recommendations; 62:00 – Future studies; 69:10 – Take home points   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Things We Wish We Knew During Residency   Special Guests: ACCP Critical Care PRN Officers Leslie Hamilton, PharmD, FCCP, FCCM, FNCS, BCPS, BCCCP;  Mojdeh Heavner, PharmD, BCPS, BCCCP, FCCM;  Susan Smith, PharmD, BCCCP, BCPS   03:25 – ACCP Critical Care PRN discussion 28:35 – Residency roundtable   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Feb 2022 Special Guests: Aaron Hunsaker, PharmD and Kelsey Rhoten, PharmD   05:41 – 6-pack of studies; 46:09 – Dust in the wind; 55:20 – Under pressure; 65:04 – Lost in my mind; 74:54 – Front of the fridge   Reference List: https://pharmacytodose.files.wordpress.com/2022/06/lrs-feb-2022-references.pdf   Full Article List: https://docs.google.com/document/d/18g5UqJqMGvm_q9qfTiEuETV34TMaWRWbQbKzfi_vbDA/edit?usp=sharing     PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series 2023 Year-In-Review Special Guests: Jacquelyn Crawford, PharmD @jacuronium Kathleen Hartman, PharmD @HartKate8   04:30 – Neurology 11:05 – Cardiology 18:50 – Cardiac Arrest 26:30 – Pulmonary 35:00 – Sepsis 44:05 – Endocrine/Renal 52:30 – Trauma 61:05 – Infectious Diseases   Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/yir-2023-lrs-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Jan 2022 Special Guests: Michael Behal, PharmD and CJ Wilson, PharmD   08:13 – 6-pack of studies; 60:20 – Every breath you take; 68:35 – Under pressure; 76:43 – Lost in my mind; 84:10 – Front of the fridge   Reference List: https://pharmacytodose.files.wordpress.com/2022/06/lrs-jan-2022-references.pdf   Full Article List: https://docs.google.com/document/d/1Z2FDNWO6uhJjYINdnTn_ruBJHOT9s-etPyNFYmJokD0/edit?usp=sharing   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Nov/Dec 2021 Special Guests: Callee Brooks, PharmD and Andy Jatis, PharmD   05:00 – 6-pack of studies; 48:25 – Ventilator blues; 60:10 – Lost in my mind; 72:38 – Don’t go breaking my heart; 81:42 – Front of the fridge   Reference List: https://pharmacytodose.files.wordpress.com/2022/05/nov_dec-2021-references.pdf   Full Article List: https://docs.google.com/document/d/1E-inQwnlcNqkvq6q657UdFEZ4x9Zd_Bi_ii0iOALS3Q/edit?usp=sharing   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Management of Beta Blocker and Calcium Channel Overdose Special Guest: James Leonard, PharmD, DABAT @leonardjbrx   Reference List: https://pharmacytodose.files.wordpress.com/2022/04/bb-and-ccb-overdose-references.pdf   Topics covered: Activated charcoal, Hemodynamics, Calcium, High dose insulin, Lipid emulsion therapy, Glucagon, Pharmacotherapy for refractory cases, Advanced therapies   “What would really happen: Medicine in the movies” Old School Knives Out Wedding Crashers   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

I wanted to talk to the Friends of the Pod about what's been going on behind the scenes and what to expect in the future. PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com   Learn more about your ad choices. Visit megaphone.fm/adchoices

2021 Surviving Sepsis Campaign Guideline Updates Special Guests: Carolyn Bell PharmD, BCCCP and Brittany Bissell, PharmD, PhD, BCCCP, FCCM   Reference List: https://pharmacytodose.files.wordpress.com/2022/02/2021-sepsis-guideline-updates-references.pdf   05:00 – General thoughts and historical perspective; 12:10 – qSOFA; 14:44 – Author diversity; 19:10 – IV fluids; 27:15 – Vasopressors; 33:12 – Antibiotics (and antifungals); 46:10 – Adjunctive treatments; 57:40 – Hopes for future guidelines; 61:35 – Gender inequity and sexual harassment in pharmacy   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Sept/Oct 2021 Special Guests: Sara Groome, PharmD, BCIDP and Alyssa Sykuta, PharmD, BCCCP   Reference List: https://pharmacytodose.files.wordpress.com/2022/02/sept_oct-2021-references.pdf   06:10 – Sepsis 6-pack; 47:55 – In my blood; 59:55 – Ventilator blues; 72:00 – Review Room; 82:38 – Front of the Fridge   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series July/August 2021 Special Guests: Hannah Brokmeier, PharmD and Natalie Haddad, PharmD   Reference List: https://pharmacytodose.files.wordpress.com/2022/01/july_aug-2021-references.pdf   06:45 – 6-pack of studies; 46:20 – Ventilator blues; 57:30 – Don’t go breaking my heart; 68:30 – Front of the fridge   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Vasoactives in Septic Shock Part II Special Guest: Patrick M. Wieruszewski, Pharm.D., BCCCP   Reference List: https://pharmacytodose.files.wordpress.com/2021/12/vasoactives-in-septic-shock-ii-references.pdf   02:51 – Background into vasodilatory shock and its outcomes; 04:14 – Signs/symptoms of septic shock; 05:09 – Norepinephrine as first-line vasopressor; 09:05 – Using second-line vasopressors; 17:04 – Human physiology and hemodynamics; 21:02 – More important: time to treatment or vasopressor choice; 22:16 – Taking biomarkers/genetic markers from the research lab to clinical practice; 28:22 – Vasopressin use in septic shock; 43:14 – Angiotensin II updates; 66:00 – Epinephrine in septic shock; 69:32 – Vasopressor stewardship; 72:40 – One wish for septic shock management   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Introduction to Mechanical Ventilation Special Guests: Andrea Sikora Newsome, PharmD, BCPS, BCCCP, FCCM   Reference List: https://pharmacytodose.files.wordpress.com/2021/11/mechanical-ventilation-references.pdf   05:49 – Indications for mechanical ventilation; 12:45 – Principles of critical care; 16:40 – Review of respiratory cycle; 20:04 – Common terminology (Tidal volume, FiO2, PEEP); 32:01 – Ventilator modes; 39:15 – Pressure v. volume control; 47:00 – Inspiratory pressure, plateau pressure, and autoPEEP; 51:50 – Ventilator weaning; 61:00 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series May/June 2021 Special Guests: Nikko Bonavoglia, PharmD and Alyssa White, PharmD   Reference List: https://pharmacytodose.files.wordpress.com/2021/09/may_june-2021-references.pdf   06:40 – Six pack of studies; 41:00 – Anticoagulation/Reversal “Let it Bleed”; 55:40 – Sepsis with a sprinkle of random “Start Me Up”; 69:35 – PADIS “Ventilator Blues”; 78:50 – Pharmacist-driven studies “Front of the Fridge”   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Ketamine for EM Agitation Special Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd   Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021. We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more.   Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Targeted Temperature Management (TTM) Special Guests: Scott Benken, PharmD, BCPS-AQ Cardiology, FCCM   Reference List: https://pharmacytodose.files.wordpress.com/2021/08/ttm-references.pdf   08:05 – Preferred nomenclature; 09:20 – TTM history; 11:30 – Optimal temperature; 14:45 – Ways to lower temperature; 17:20 – Guideline recommendations; 20:50 – TTM2 trial; 28:05 – Future areas of research; 33:05 – TTM PK/PD changes; 39:50 – Shivering; 45:10 – Rapid-fire questions; 58:30 – Creating electronic TTM protocols; 61:15 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Mar/Apr 2021 Special Guests: Ashley Barlow, PharmD and Brooke Barlow, PharmD   Reference List: https://pharmacytodose.files.wordpress.com/2021/07/mar_apr2021-references.pdf   07:19 – Six-pack of studies; 48:15 – Sepsis; 59:14 – Pain, agitation, delirium, and neuromuscular blockade; 73:50 – Infectious diseases and pharmacokinetics; 82:36 – Pharmacist-driven studies   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Sequence Intubation (RSI) Special Guests: Haley Peters, PharmD, BCCCP   Show Notes: https://pharmacytodose.files.wordpress.com/2021/06/rsi-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/06/rsi-references.pdf   05:05 – Over-arching considerations; 09:45 – Neuromuscular blockers; 31:35 – Pre-induction agents; 46:46 – Induction agents; 72:23 – Obesity dosing considerations; 81:21 – Difficult airways; 84:30 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Jan/Feb 2021 Special Guests: Abagail Kirwen, PharmD and Paige Morgan, PharmD   Reference List: https://pharmacytodose.files.wordpress.com/2021/05/jan_feb2021-references.pdf   07:13 – Six-pack of Studies; 39:06 – Review Room; 52:20 – Glance at the Guidelines; 61:58 – Kinetics Corner; 73:37 – Front of the Fridge   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Updates in COVID-19 Pharmacotherapy Special Guests: Amy Dzierba, PharmD, FCCM, FCCP, BCCCP Mitchell Buckley, PharmD, FASHP, FCCM, FCCP, BCCP   Show Notes: https://pharmacytodose.files.wordpress.com/2021/04/covid19-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/04/covid19-references.pdf   03:25 – Tocilizumab; 22:21 – Corticosteroids; 37:50 – Anticoagulation; 72:50 – Potpourri/Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ICU Liberation (ABCDEF) Bundle Special Guest: Joanna Stollings, PharmD, FCCM, BCPS, BCCCP   Show Notes: https://pharmacytodose.files.wordpress.com/2021/04/icu-liberation-bundle-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/04/icu-liberation-bundle-references-ii.pdf    03:48 – What is the ABCDEF bundle?; 08:35 – Barriers to bundle implementation; 12:14 – Excluding patients; 14:18 – A: Assessing/preventing/treating pain; 20:27 – B: Spontaneous awakening/breathing trials; 26:27 – C: Choice of sedation; 38:40 – D: Assessing/prevention/treating delirium; 42:09 – E: Early mobility/exercise; 45:40 – F: Family engagement and involvement; 49:16 – Importance of multidisciplinary involvement; 52:58 – Bundle implementation with COVID-19; 60:21 – Advice for those looking to implement the ICU Liberation Bundle; 64:30 – Pharmacist’s role in successful bundle implementation   PharmacyToDose.Com @PharmacyToDose on Twitter PharmacyToDose@Gmail.com   Learn more about your ad choices. Visit megaphone.fm/adchoices

Hypertensive Crises (Emergency/Urgency) Special Guest: Deepali Dixit, PharmD, BCPS, BCCCP, FCCM   Show Notes: https://pharmacytodose.files.wordpress.com/2021/02/htn-crises-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/02/htn-crises-references.pdf    06:50 – Diagnosis; 09:17 – Clinical presentation; 11:14 – Common causes; 13:36 – HTN urgency management; 17:50 – HTN emergency BP goal; 23:26 - IV push v. continuous IV infusions; 28:30 – Aortic dissection/Esmolol; 34:10 – Acute ischemic stroke/Hydralazine; 40:25 – Intracranial hemorrhage/Nicardipine; 44:48 – ACS/Labetalol; 49:20 – ADHF/Nitrates; 56:08 – Miscellaneous medication pearls; 59:33 – Pregnancy treatment; 64:10 – Take-home points   4th Annual Multidisciplinary Tri-State Critical Care Virtual Symposium Details: https://rutgers.cloud-cme.com/course/courseoverview?P=5&EID=8158   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Oncologic Emergencies Special Guest: Siu Yan Amy Yeung, PharmD, BCPS, BCCCP   Show Notes: https://pharmacytodose.files.wordpress.com/2021/02/oncologic-emergencies-show-notes-1.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/02/oncologic-emergencies-references.pdf   06:00 – Oncologic emergency overview; 10:12 – Tumor lysis syndrome; 46:40 – Hypercalcemia of malignancy; 67:12 – Superior vena cava syndrome; 75:05 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trauma Alert Part II: ICU Management Special Guest: Melanie Smith Condeni, PharmD, BCPS, BCCCP   Show Notes: https://pharmacytodose.files.wordpress.com/2021/01/trauma-alert-icu-management-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/01/trauma-alert-icu-management-references.pdf   05:25 – Pain, agitation, and delirium management; 24:30 – VTE prophylaxis; 48:47 – Open fracture antibiotics; 52:16 – Identifying infections; 57:03 – Neurostorming; 66:42 – TBI clinical pearls; 82:34 – Bowel regimens; 87:14 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Practice-Based Research Special Guest: Alex Flannery, PharmD, FCCM, BCCCP, BCPS   Show Notes: https://pharmacytodose.files.wordpress.com/2021/01/practice-based-research-show-notes-1.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2021/01/practice-based-research-references-1.pdf   04:17 – Defining practice-based research; 06:02 – Importance of research; 12:38 – Developing infrastructure that supports research; 18:59 – Finding a good research idea; 22:15 – Research v. MUE; 25:48 – Reducing duplicate research studies; 28:00 – Developing an idea into a study; 31:52 – Study design resources; 35:23 – Research funding; 43:12 – Statistics; 47:05 – Manuscript publishing; 52:15 – Implementing results from practice-based research; 55:00 – Most common research pitfalls; 59:04 – Student/resident research mentorship; 62:00 – Practice-based research networks; 64:40 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Sanford Guide Q&A Special Guest: Doug Black, PharmD   04:40 – Doug’s background/Sanford guide introduction 14:20 – Print v. digital guide/included content 34:35 – Tables/tools highlights 41:55 – Doug’s favorites/conclusions   Sanford Guide Website: https://web.sanfordguide.com/   PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Alcohol Withdrawal Disorder Special Guest: Kent Owusu, PharmD, BCCCP, BCPS   Show Notes: https://pharmacytodose.files.wordpress.com/2020/12/alcohol-withdrawal-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2020/12/alcohol-withdrawal-references.pdf   05:50 – Consequences of alcohol withdrawal; 06:56 – Diagnosis/Pathophysiology; 11:15 – Treatment goal; 12:20 – Alcohol for withdrawal prevention; 15:30 – Benzodiazepine treatment considerations; 25:45 – Monitoring tools; 30:40 – Phenobarbital; 38:50 – Dexmedetomidine; 43:20 – Ketamine; 47:40 – Propofol; 51:43 – Valproic Acid and Gabapentin; 58:25 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trauma Alert Part I: Acute Management Special Guest: Brian Gilbert, PharmD, BCCCP, BCPS   Show Notes: https://pharmacytodose.files.wordpress.com/2020/11/trauma-part-1-show-notes.pdf   Reference List: https://pharmacytodose.files.wordpress.com/2020/11/trauma-part-1-references.pdf   05:12 – Pre-arrival preparation; 14:19 – Pharmacist role on trauma team; 15:40 – Primary survey; 23:37 – Massive transfusion protocol; 27:00 – Viscoelastography; 40:34 – PCC administration and dosage; 44:40 – Calcium; 51:00 – RSI/PAD considerations; 56:10 – Open fractures and antibiotics; 58:37 – Elevated ICP management; 62:37 – Take-home points   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2020 ACCP Annual Meeting Recap Special Guest: Anthony Hawkins, PharmD, BCCCP   Reference List: https://pharmacytodose.files.wordpress.com/2020/11/2020-accp-annual-meeting-references.pdf   06:30 – Virtual v. in-person meetings; 30:35 – BIG announcement!; 34:15 – Poster sessions; 47:00 – Scientific sessions   PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices