Performance Around the Clock episode 20 comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the pleasure to talk with Dr. Christoph Scheiermann who studies the role of circadian rhythms in immune response and how this impacts health and disease.  In particular, he’s known for his research on the recruitment and localization of leukocytes which is under circadian control.  This process plays a crucial role in immune response which can be leveraged to improve cancer immunotherapy and vaccination efficacy.  Learn more about his impactful research in this episode. Thanks for listening.

Guest:

Dr. Christoph Scheiermann

Full Professor

Department of Pathology and Immunology

Centre Medical Universitaire (CMU)

X (formerly Twitter): @ScheiermannLab

https://twitter.com/ScheiermannLab

Lab webpage:

http://scheiermannlab.de/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi.  Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior.  His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadianClock gene.  In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.

Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:

The Honma Prize in Biological Rhythms Research

NSF Presidential Young Investigator Award

Searle Scholars Award

Bristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia University

Fellow of the American Academy of Arts and Sciences

Member of the National Academy of Sciences

Member of the National Academy of Medicine

Gruber Neuroscience Prize at the Society for Neuroscience

Guest:

Dr. Joseph Takahashi

Chair of the Department of Neuroscience at UT Southwestern Medical Center

Loyd B. Sands Distinguished Chair in Neuroscience

X (formerly Twitter): @CircadianClocks

https://twitter.com/circadianclocks

UT Southwestern profile:

https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.html

Lab webpage:

https://labs.utsouthwestern.edu/takahashi-lab

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In this special, 10th episode of the Performance Around the Clock podcast, we have the honor of speaking with Professor Greg Lemke of the Salk Institute. We discuss his distinguished scientific career from the early beginnings to the discovery of TAM receptor tyrosine kinases. Enjoy.

Guest:

Dr. Greg Lemke

Françoise Gilot-Salk Chair and professor in the Molecular Neurobiology Laboratory

Salk Institute for Biological Studies

Laboratory: https://www.lemkelab.org/

Salk page: https://www.salk.edu/scientist/greg-lemke/

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 9 of Performance Around the Clock, we are delighted to talk to cardiologist, Dr. Elizabeth Sage Epstein again. Dr. Epstein and Dr. Panda discuss the role of cholesterol in cardiovascular disease risk. The conversation covers topics such as the absorption of fat and cholesterol in the body, the impact of LDL particles on plaque formation in coronary arteries, and the use of advanced cardiology techniques, such as NMR LipoProfile and calcium scoring, to assess cardiovascular health. Dr. Epstein emphasizes the importance of understanding cholesterol levels and how they contribute to the risk of cardiovascular disease, and also highlights the potential for lifestyle changes to reverse plaque development.

Guest:

Dr. Elizabeth Sage Epstein, Scripps Health, Integrative Cardiology Fellow

X (formerly Twitter): @lizziesageMD

https://twitter.com/lizziesageMD

Author:

A Beautiful Heart Cookbook: Heart-Healthy Recipes for a Long, Happy Life

https://www.amazon.com/Beautiful-Heart-Cookbook-Heart-healthy-Recipes/dp/1982234164

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/satchinpanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 8 of the Performance Around the Clock podcast, Dr. Satchin Panda has an enlightening conversation with Dr. Elizabeth Sage Epstein, a cardiologist and author. They discuss the importance of the heart and impact on overall health, preventive measures for chronic diseases, the cardiovascular system and the importance of cardiac health in young, active individuals.

Guest:

Dr. Elizabeth Sage Epstein, Scripps Health, Integrative Cardiology Fellow

X (formerly Twitter): @lizziesageMD

https://twitter.com/lizziesageMD

Author:

A Beautiful Heart Cookbook: Heart-Healthy Recipes for a Long, Happy Life

https://www.amazon.com/Beautiful-Heart-Cookbook-Heart-healthy-Recipes/dp/1982234164

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 7 of the Performance Around the Clock podcast, Dr. Panda talks with Dr. Michael Lam who is a pulmonologist and assistant professor at the UCSD in the Department of Medicine and in the Division of Pulmonary, Critical Care, and Sleep Medicine. They explore the science of the immune system and link with circadian rhythms, delving into the impact of sleep, light, and even meal timing on the body's immune system. They also discuss challenges faced in the ICU and strategies for improving recovery.

Guest:

Dr. Michael T Lam, (MD/PhD)

Assistant Professor

Division of Pulmonary, Critical Care, and Sleep Medicine

Department of Medicine

University of California, San Diego

https://profiles.ucsd.edu/michael.lam

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 6 of Performance Around the Clock, host Professor Satchin Panda interviews Dr. Horacio de la Iglesia, a sleep and circadian expert from the University of Washington. We discuss how circadian rhythms affect nearly every aspect of human physiology and behavior, from hormone levels to sleep-wake cycles. Dr. De la Iglesia shares insights from his research on ancestral populations like the Toba who live without electricity, as well as modern teenagers and the impact of light exposure, sleep deprivation, and delayed school start times. We discuss the need to educate the public and medical community about circadian health. The episode highlights how circadian biology can inform public policy and simple lifestyle changes we can make, like increasing natural daylight exposure, to improve health.

Guest:

Dr. Horacio de la Iglesia

Professor, University of Washington

X (formerly Twitter): @horacioIglesia

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 5 of the PATC podcast, ophthalmology expert Dr. Kajuha Shubota discusses key research on how light affects vision and overall health with host Dr. Satchin Panda. He explains how lack of time outdoors and violet light exposure is increasing myopia rates in children, and eyeglasses may exacerbate the issue. He shares how dry eye is linked to stress and lifestyle factors. For presbyopia, he discusses potential drug and lens replacement solutions to improve near vision. Throughout, Dr. Shubota emphasizes how the eye offers valuable insights into aging and diseases like Alzheimer’s, as improving ocular blood flow with light may boost brain function. He remains optimistic that innovations in glasses design and lighting can profoundly improve vision and wellbeing across all life stages.

Guest:

Dr. Kazuo Tsubota

Professor, Department of Ophthalmology, Graduate School of Medicine, Keio University

Profile: http://tsubota.ne.jp/en/profile/profile.html

Lab page: https://tsubota-lab.com/en/

Host:

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 4 of the podcast, Dr. Tinh-Hai Collet, a physician and principal investigator at Geneva University Hospital, discusses with Dr. Satchin Panda his experience combining lifestyle interventions like meal timing and circadian rhythms with medicine to manage chronic conditions in patients. We discuss Dr. Collet's research on time-restricted eating, including a 6-month randomized controlled trial in Switzerland. We also discuss implementing lifestyle changes like intermittent fasting under medical supervision, potential side effects, impacts on conditions like diabetes and hypertension, and the importance of spreading circadian health knowledge among more physicians. Overall, this conversation highlights the potential for optimizing meal timing and circadian rhythms, alongside medication when needed, to improve health outcomes.

Guest:

Dr. Tinh-Hai Collet

Diabetes Center of the Geneva University Hospital (HUG)

https://www.unige.ch/medecine/diabetescentre/membres/dr-tinh-hai-collet

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 3 of this podcast, sleep and circadian rhythm expert, professor Frank Scheer discusses how our internal body clocks regulate physiology and behaviors in a 24-hour cycle. He explains how measures like dim light melatonin onset and cortisol rhythms provide insights into circadian timing. The discussion covers how factors like light exposure, meal timing, and sleep impact circadian rhythms and health. Dr. Scheer shares research on misaligning behaviors and physiology through social jet lag, night shifts, and mistimed eating. He suggests strategies like optimizing meal timing and light exposure to realign circadian rhythms. Overall, the discussion highlights how adjusting daily behaviors can improve circadian alignment, metabolism, mood, and wellbeing. Enjoy.

Guest:

Dr. Frank Scheer

Professor of Medicine, Brigham and Women's Hospital

Division of Sleep and Circadian Disorders at Harvard

X (formerly Twitter): @harvardsleepmed

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 2 of Performance Around the Clock features Dr. Juleen Zierath who is a Professor of Physiology at the Karolinska Institutet and the University of Copenhagen. We discuss with Dr. Zierath about using exercise as medicine for metabolic diseases like obesity, diabetes, and cardiovascular disease. This includes how exercise affects multiple organs and systems in the body, improving insulin sensitivity, bone density, cognition, and more. Dr. Zierath shares research on optimal timing of exercise for blood sugar control, showing benefits from afternoon exercise over morning for diabetics. We also cover personalized exercise prescriptions, prenatal and preconception exercise impacts, and the importance of societal support and public policy in enabling exercise. The episode provides some scientific evidence and advice for using exercise to boost health.

Guest:

Dr. Juleen Zierath

Professor of Physiology at Karolinska Institutet and the University of Copenhagen.

X (formerly Twitter): @JuleenRZierath

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram:

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In this episode of Performance Around the Clock, host professor Satchin Panda interviews Dr. Hiroki Ueda, a circadian rhythm researcher at the University of Tokyo medical school and the RIKEN research institute in Japan. We discuss Dr. Ueda's pioneering work using genomics and imaging techniques to study how genes that regulate circadian rhythms turn on and off at different times of day in various tissues and organs. This research helps explain how disrupted circadian rhythms negatively impact human health and performance. Dr. Ueda also describes his development of novel genetic tools and microscopic imaging methods to analyze sleep/wake cycles and diseases in animal models. He emphasizes the importance of sleep for optimal brain function and shares new approaches his team is taking to make sleep measurements more practical and scalable for clinical use. Overall, the episode highlights Dr. Ueda's groundbreaking research expanding our understanding of circadian biology and sleep to improve human health.

Guest:

Dr. Hiroki Ueda

Graduate School of Medicine, University of Tokyo

Team Leader, Riken BDR

Twitter/X: @hiroking1975

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 18, the final episode from the Cell Symposia meeting on Exercise Metabolism in Lisbon, features Dr. Bret Goodpaster. As the Scientific Director at AdventHealth's Translational Research Institute, Dr. Goodpaster is a leading expert in exercise physiology and metabolism. In this episode, he shares his insights on exercise, muscle, aging, and the athlete’s paradox. We also delve into two major scientific projects - HealthABC (Health, Aging Body and Composition) and MoTrPAC (Molecular Transducers of Physical Activity Consortium). HealthABC explores risk factors for functional decline in older adults, including muscle aging. MoTrPAC is a large consortium created to understand the molecular mechanisms of physical activity on health benefits. We hope you will find this episode intellectually stimulating. Thank you for listening.

Guest:Dr. Bret Goodpaster

Scientific Director at Advent Health’s Translational Research Institute

https://www.adventhealthresearchinstitute.com/team/bret-goodpaster

Host:Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 17 of the Performance Around The Clock podcast comes from the Cell Symposia meeting on Exercise Metabolism in Lisbon. We were honored to host Dr. Bente Klarlund Pedersen and to talk about her brilliant career from her seminal research on myokines to "exercise as medicine". Dr. Pedersen also tells us about how she uses her knowledge of exercise to educate the public and effect policy changes.Guest:Dr. Bente Klarlund PedersenDirector of Centre for Physical Activity Research (CFAS)https://www.inflammation-metabolism.dk/X (formerly Twitter): @benteklarlundphttps://x.com/benteklarlundpHost:Dr. Satchin PandaX (formerly Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/

Episode 16 of the Performance Around the Clock podcast comes from the Cell Symposium on Exercise Metabolism in Lisbon, Portugal and features Dr. Mark Febbraio who is the head of Cellular and Molecular Metabolism Laboratory at Monash Institute of Pharmaceutical Sciences. His research focuses on understanding mechanisms associated with exercise, obesity, type 2 diabetes and cancer with an aim towards developing novel drugs to treat lifestyle related diseases. In this episode, we hear about how he transitioned from a triathlete into a researcher in exercise science. We also learn about the link between exercise and inflammation and leveraging this knowledge to treat disease. Enjoy!

Guest:

Dr. Mark Febbraio

Professor, Drug Discovery Biology

Cellular and Molecular Metabolism Laboratory

Monash Institute of Pharmaceutical Sciences

X (formerly Twitter): @FebbraioMark

https://twitter.com/FebbraioMark

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

This week’s episode of the Performance Around the Clock podcast (episode 15) comes from the Cell Symposium on Exercise Metabolism in Lisbon, Portugal. Dr. Amber Mueller, scientific editor at Cell Metabolism and co-organizer of the symposium talks to us about life as a scientific editor and about the field of exercise metabolism. Enjoy!

Guest:

Dr. Amber Mueller

Scientific Editor at Cell Metabolism

X (formerly Twitter): @AmberMuellerPhD

https://twitter.com/AmberMuellerPhD

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: hhttps://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 14 of the Performance Around the Clock podcast, Dr. Laura van Rosmalen, a WuTsai scholar and postdoctoral researcher at the Salk Institute joins us to talk about her work with voles and seasonal rhythms, diurnality, nocturnality and energy balance, and a surprising connection with RED-S (Relative Energy Deficiency in Sport). Enjoy!

Guest:

Dr. Laura van Rosmalen

WuTsai scholar

Salk Institute for Biological Studies

X (formerly Twitter): @RosmalenLaura

https://twitter.com/RosmalenLaura

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Dr. Amita Sehgal, a Howard Hughes investigator studying circadian rhythms and sleep, joins episode 13 of the podcast this week to talk about her career including the discovery of the Drosophila TIM gene and her pivotal role in the development of Drosophila as a model for the study of sleep. Enjoy!

Guest:

Dr. Amita Sehgal

John Herr Musser Professor in the neuroscience department at the Perelman School of Medicine at the University of Pennsylvania

https://www.med.upenn.edu/sehgallab/

X (formerly Twitter): @amitaseh

https://twitter.com/amitaseh

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In this episode of the Performance Around the Clock podcast, we welcome Dr. Michael McCarthy, a biological psychiatrist at UCSD and the Veterans Medical Research Foundation. We talk about the latest in psychiatry and how circadian rhythms may be involved. Enjoy.

Guest:

Dr. Michael McCarthy

Profiles:

UCSD: https://profiles.ucsd.edu/michael.mccarthy

VA: https://www.vmrf.org/copy-of-pi-chitra-mandyam-1

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In episode 11 of the Performance Around the Clock podcast, we have the privilege of speaking with Professor John Hogenesch - a neuroscientist/genome biologist/chronobiologist at UC Department of Pediatrics at the Cincinnati Children’s Hospital Medical Center. Dr. Hogenesch talks about applying the “principles of circadian biology to hospital medicine”. Enjoy!

Guest:

Dr. John Hogenesch

Professor, UC Department of Pediatrics

Cincinnati Children’s Hospital Medical Center

https://www.cincinnatichildrens.org/bio/h/john-hogenesch

X (formerly Twitter): @jbhclock

https://twitter.com/jbhclock

Host:

Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://twitter.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 21 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  This week’s guest is Dr. Achim Kramer who developed an assay (BodyTime) to determine internal circadian time.  He talks about the development of the assay and how it can be used in circadian medicine.  Dr. Kramer is Head of Chronobiology at Charité – Universitätsmedizin Berlin, the largest research hospital in Europe. Thank you for listening.

Guest:

Dr. Achim Kramer

Head of Chronobiology at Charité – Universitätsmedizin Berlin

Lab website:

https://www.achim-kramer-lab.de/

Body clock test:

https://www.bodyclock.health/

BodyTime

High-accuracy determination of internal circadian time from a single blood sample

https://pubmed.ncbi.nlm.nih.gov/29953415/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 22 of the Performance Around the Clock podcast is another episode from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  We are honored to host this week’s guest, Dr. Charlotte Förster, who epitomizes perseverance in her long scientific career studying circadian rhythms  We’ll talk about her work to understand  the circadian clock at the molecular and neuronal level, how the clock synchronizes with the day/night cycles and how the clock controls behavior.  You’ll also hear about her fascinating research on the synchronization of menstrual cycles with lunar cycles and its implications.  Dr. Förster is a professor in Neurobiology and Genetics at the University of Würzburg.  Thank you for listening.

Guest:

Dr. Charlotte Forster

Chronobiology Professor, Neurobiology and Genetics, University of Würzburg

Lab website:

https://www.biozentrum.uni-wuerzburg.de/en/neurogenetics/research/wg-foerster/charlotte-foerster/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In episode 23, we are joined by Dr. Emily Manoogian, one of the foremost experts on Time-Restricted Eating (TRE), to discuss her latest research on TRE in adults with metabolic syndrome. We will explore how to implement TRE and its various benefits. Dr. Manoogian will also share insights on using the myCircadianClock app in her clinical trials to track TRE and other circadian metrics. For more information, you can visit the myCircadianClock website at www.mycircadianclock.org. If you are interested in participating in a Type 2 Diabetes and TRE study, please get in touch with Dr. Manoogian at preventivecvresearch@health.ucsd.edu. Her latest study was published in the Annals of Internal Medicine: (https://pubmed.ncbi.nlm.nih.gov/39348690/). Thank you for tuning in.

Time-Restricted Eating in Adults with Metabolic Syndrome: A Randomized Control Trial

https://www.acpjournals.org/doi/10.7326/M24-0859

Guest:

Dr. Emily Manoogian

Hillblom Fellow, Staff Scientist at the Salk Institute for Biological Studies

X (Twitter): @EmilyManoogian

Clinical Trials with Dr. Pam Taub: 

https://cardiology.ucsd.edu/research/labs/taub/research/clinical-trials.html#TRE-x-T2D-Study 

myCircadianClock website:

www.mycircadianclock.org

Participate in a Type 2 Diabetes Study by emailing:

preventivecvresearch@health.ucsd.edu 

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 24 of the Performance Around The Clock podcast.  We resume our series from the Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  In this episode, we are joined by Dr. Annie Curtis, a professor at the Royal College of Surgeons in Ireland (RCSI), who studies the intersection between circadian rhythms and the immune system.  We talk about how the timing of infection affects the immune response and the implications for vaccinations.  In addition, we hear about the intriguing role of mitochondria in this immune response. Thanks for listening.

Guest:

Dr. Annie Curtis

Associate Professor

Royal College of Surgeons in Ireland (RCSI)

School of Pharmacy and Biomolecular Sciences

Principal Investigator of the Tissue Engineering Research Group (TERG)

Executive Committee for the Irish Society for Immunology between 2016-2020

L’Oreal Women in Science Fellowship in 2017

SFI Career Development Award in 2017

Irish Research Council Laureate Award in 2018

President of the Irish Society for Immunology 2020-2022

SFI Frontiers Award in 2021

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

We continue our series from the Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico.  In episode 25 of the Performance Around The Clock podcast, we have the pleasure of speaking with Dr. Phyllis Zee, one of the world’s experts on sleep.  Dr. Zee is a Director of the Center of Circadian and Sleep Medicine at Feinberg School of Medicine at Northwestern University.  She is also the Chief of Sleep Medicine in the Department of Neurology and Benjamin and Virginia T. Boshes Professor of Neurology.  In this episode, she talks about sleep disorders, using melanopsin as a chronobiotic, the interesting connection between melatonin and glucose metabolism and the establishment of circadian health clinics. Thanks for listening. 

Guest:

Dr. Phyllis Zee

Director, Center for Circadian and Sleep Medicine

Feinberg School of Medicine at Northwestern University

Chief of Sleep Medicine in the Department of Neurology

Benjamin and Virginia T. Boshes Professor of Neurology

X (Twitter): @PhyllisZee

https://x.com/phylliszee

Profile:

https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=13785

International Association of Circadian Health Clinics

https://circadianhealthclinics.com/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 26 of the Performance Around The Clock podcast comes from the GSA (Gerontological Society of America) meeting in Seattle. We are delighted to host, Dr. Jamie Justice, who is the Executive Vice President of the Health Domain at XPRIZE Foundation and adjunct professor in Gerontology and Geriatric Medicine at the Wake Forest University School of Medicine. We talk about her career in gerontology, expertise with biomarkers and XPRIZE Healthspan. Join us for an enlightening conversation about aging and learn about the big XPRIZE Healthspan initiative. Thank you for listening.

Guest:

Dr. Jamie Justice

Executive Vice President of the Health Domain at XPRIZE Foundation

Adjunct Professor in Internal Medicine Section on Gerontology and Geriatric Medicine, and Sticht Center on Healthy Aging and Alzheimer’s Prevention at Wake Forest University School of Medicine (WFUSM)

- Jarrahi Research Scholars Fund in Geroscience Innovation

- 2022 Vincent Cristofalo Rising Star in Aging Research

- 2022 NIA Nathan W Shock Awardee

XPRIXE profile:

https://www.xprize.org/about/people/jamie-justice-ph-d

XPRIZE Healthspan:

https://www.xprize.org/prizes/healthspan

TAME study:

https://pubmed.ncbi.nlm.nih.gov/30151729/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Happy 2025! Episode 27 of the Performance Around The Clock podcast is our last from the Society for Research on Biological Rhythms (SRBR) meeting in San Juan, Puerto Rico.  We are excited to have Dr. Till Roenneberg on the podcast.  Dr. Roenneberg is emeritus professor of chronobiology at the Institute of Medical Psychology at Ludwig-Maximilian University (LMU) in Munich, Germany.  He has dedicated most of his career to investigating the effects of light on circadian clocks, sleep, and health and is known for his seminal work with chronotypes and social jetlag.  Hear all about his work on chronotypes and social jetlag in this episode. Thank you for listening. If you enjoy this episode or podcast, please like, subscribe or comment. Thank you.

Guest:

Dr. Till Roenneberg

Prizes and Awards:

1987 Harvard-Hoops Prize for Excellence in Teaching

1993 Honma Prize "Outstanding contributions to the field of chronobiology”

1998 "Aschoff's Ruler" Research Prize

2004 Silver Medal (University of Munich)

2011 Professional Lighting Design Recognition Award for Research and Education

2012-2015 President European Biological Rhythms Society

2013 Science Book Award of the British Medical Association Board

2016 Galileo Award Italian Science Book Prize

2018 Innovation in Academia Award (University of Kent)

2019 Ambassador of Sleep (German Sleep Foundation)

2024 Daylight Award for Daylight Research

Profile:

https://www.mcn.uni-muenchen.de/members/regular/roenneberg/index.html

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science:https://mycircadianclock.org/

The Performance Around the Clock podcast episode 28 features  special guest Mukesh Bansal.  Bansal is a visionary entrepreneur in the fields of digital commerce, wellness and technology.  An IIT Kanpur graduate, Bansal's journey began with Myntra, an online fashion retailer that revolutionized apparel shopping in India.  His vision extended beyond e-commerce, leading him to co-found Cure.fit, a health and wellness platform.  Bansal's impact is further amplified through his venture studio, MerakiLabs, where he supports innovative startups including notable companies like Skyroot Aerospace and Groww. As an avid learner and reader, he put his insights to paper with books like "No Limits,"  and “Hacking Health”. Join us for an enlightening conversion with Bansal on his career and insights into wellness. If you like this episode, please like, follow or subscribe. Thank you for listening.

Guest:

Mukesh Bansal

X (Twitter):

https://x.com/mukeshbansal06

Sparx podcast:

https://www.youtube.com/@sparxbymukeshbansal

No Limits:

https://www.amazon.com/No-Limits-Science-High-Performance-ebook/dp/B0B5LCRC8D

Hacking Health:

https://www.amazon.com/Hacking-Health-Only-Youll-Healthiest/dp/0670097136

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations:https://panda.salk.edu/giving/

Research:https://www.salk.edu/scientist/satchidananda-panda/

More science:https://mycircadianclock.org/

Episode 29 of the Performance Around the Clock Podcast is our second episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle.  We are privileged to host Dr. Steven Austad who is a leading expert in aging biology. Dr. Austad is a Distinguished Professor and Chair of Biology at the University of Alabama at Birmingham, Director of UAB's Nathan Shock Center of Excellence in the Basic Biology of Aging and Senior Scientific Director of the American Federation for Aging Research (AFAR).  His varied career from large cat training, longevity field work with opposums, calculating the age of greenland sharks, to work with numerous other species gives Dr. Austad a unique view on longevity and aging.  He developed the Longevity Quotient (LQ) which is simplified measure that enables normalized comparisons of various species' longevity.  Learn all about his work on longevity and aging in this episode.  If you like this episode, please like or follow/subscribe.  Thank you for listening.

In addition to authoring over 200 scientific articles and more than 150 newspaper columns on science. Dr. Austad has been a recipient of numerous awards such as:

Fifth Nathan A. Shock Award

Robert W. Kleemeier award

Purdue University Outstanding Alumnus Award

Irving S. Wright Award of Distinction

Fondation IPSEN Longevity Prize

Caroline P. and Charles W. Ireland Prize for Scholarly Distinction.

He is also a fellow of the Gerontological Society of America (GSA) and the American Association for the Advancement of Science (AAAS). In 2021, he was appointed Protective Life Endowed Chair of Health Aging Research at the University of Alabama at Birmingham.

Guest:

Dr. Steven Austad's

X (formerly Twitter): @StevenAustad

https://x.com/StevenAustad

UAB Faculty Page

https://www.uab.edu/cas/biology/people/faculty/steven-n-austad

Books:

“Why We Age”

https://www.amazon.com/Why-We-Age-Science-Discovering/dp/0471148032/

"Methuselah's Zoo."   

https://www.amazon.com/Methuselahs-Zoo-Nature-Living-Healthier/dp/B0CL5D1SY7/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations:https://panda.salk.edu/giving/

Research:https://www.salk.edu/scientist/satchidananda-panda/

More science:https://mycircadianclock.org/

We continue our series from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle.  Episode 30 of the Performance Around the Clock Podcast, features Dr. Courtney Peterson, a leading researcher in the field of intermittent fasting and time-restricted eating (TRE).  Dr. Peterson is an Associate Professor at the University of Alabama at Birmingham where she was notably the first to test early time-restricted eating (eTRE) in humans. Dr. Peterson is the principal investigator of numerous clinical trials on TRE, including the largest randomized controlled trial of intermittent fasting in individuals with type 2 diabetes. Her research combines chronobiology, nutrition, and metabolism and aims to develop dietary interventions to combat cardiometabolic diseases.  Learn all about her research in this episode. If you like this episode, please like, comment or subscribe.  Thank you for listening.

Guest:

Dr. Courtney Peterson

Associate Professor University of Alabama Birmingham

X (Twitter): @CourtneyP_PhD

Profile:

https://scholars.uab.edu/3393-courtney-peterson 

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

https://pubmed.ncbi.nlm.nih.gov/29754952/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Coming from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are excited to welcome Dr. Nathan LaBrasseur for the 31st episode of the Performance Around the Clock podcast. Dr. LaBrasseur is the director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic and an expert on senescence and aging. He's an author of the book "Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled" an updated guide on healthy aging. In this episode, learn about the latest in aging and senescence particularly therapeutics for senescent cells - senotherapeutics. Senotherapeutics can be broken down into senolytics which selectively kill senescent cells and senomorphics which suppress senescence-associated secretory phenotype (SASP) to reduce the negative effects of senescence. Thank you for watching. If you like this episode, please like, comment or subscribe.

Guest:

Dr. Nathan LaBrasseur

Director of the Robert and Arlene Kogod Center on Aging @MayoClinic

X (Twitter): @NKLeBRASSEUR

https://x.com/nklebrasseur

Profile:

https://www.mayo.edu/research/faculty/lebrasseur-nathan-k-ph-d-m-s/bio-00055041

Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled

https://www.amazon.com/Mayo-Clinic-Healthy-Aging-Comprehensive/dp/B0BQYKS8ND

Host:

Dr. Satchin PandaX (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In our last episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are honored to host Dr. John Newman and Dr. Brianna Stubbs, both experts in ketone metabolism and aging.  Dr. Newman is a geriatrician and researcher at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF.  His research focuses on how ketone bodies, small molecules that our bodies make for energy during fasting or exercise, also work as molecular signals to control inflammation and gene expression.  Dr. Brianna Stubbs is an expert in exogenous ketone metabolism and the Director of Translational Science at the Buck Institute for Research on Aging. She's a former competitive rower and two-time world champion, and she completed her PhD in metabolic physiology at the University of Oxford, where she studied the metabolic effects of ketone esters.  Learn all about their work translating ketone research into the field. If you like this episode or podcast, please like, comment or follow. Thank you for listening.

Guests:

Dr. John Newman

Division of Geriatrics at UCSF

Assistant Professor Buck Institute for Research on Aging

X (Twitter): @geriscidoc

https://x.com/geriscidoc

Profile:

Division of Geriatrics at UCSF

https://profiles.ucsf.edu/john.newman

https://medicine.ucsf.edu/people/john-newman

Buck Institute for Research on Aging

https://www.buckinstitute.org/lab/newman-lab/

Dr. Brianna Stubbs

Director of Translational Science at Buck Institute for Research on Aging

X (Twitter): @briannastubbs

https://x.com/briannastubbs

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/
More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast.  In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden.  Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism.  Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries.  Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years.  If you like this episode, please like, comment or subscribe.  Thank you for listening.

Guest:

Dr. Susan Golden

Director, Center for Circadian Biology

Chancellor's Associates Chair (III) in Molecular Biology

Distinguished Professor

X (Twitter): @susanksgolden

https://x.com/susanksgolden

Profile:

UCSD:

https://biology.ucsd.edu/research/faculty/sgolden

Wikipedia:

https://en.wikipedia.org/wiki/Susan_Golden

Paper:

Circadian orchestration of gene expression in cyanobacteria

https://pubmed.ncbi.nlm.nih.gov/7601351/

Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondo

https://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.html

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 34 of the Performance Around the Clock.  In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies.  Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection.  If you like this episode, please like, comment or follow.  Thank you for listening.

Guest:

Dr. Pamela Maher

Research Professor at the Salk Institute

Cellular Neurobiology Laboratory

Profile:

https://www.salk.edu/scientist/pamela-maher/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 35 of the Performance Around the Clock podcast. We’re joined by Dr. Hemal Patel, a distinguished Professor and Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego (UCSD) and a VA Research Career Scientist. Holding a Ph.D. in Pharmacology and Toxicology, Dr. Patel's extensive research career has focused on caveolin and mitochondrial biology. In this episode, he discusses the critical role of cell membranes and mitochondria in cellular energy and disease, highlighting how his lab developed a non-invasive blood-based assay for mitochondrial function. This innovative assay, developed through the NASA Twin Study, can assess overall energetic health and disease states without invasive biopsies. Dr. Patel also shares his work on the therapeutic potential of the protein caveolin in conditions like heart disease and neurodegeneration (ALS, Alzheimer's, Parkinson's), and how his recent research has expanded to explore the mind-body connection through the transformative work of Dr. Joe Dispenza. We also talk about how his longtime interest in philosophy and religion has influenced his life and career. Please join us for an wonderful conversion between Dr. Panda and Dr. Patel. If you like this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Hemal Patel

Professor and Vice-Chair Department of Anesthesiology, UC San Diego School of Medicine

VA Research Career Scientist

Profile:https://clre.ucsd.edu/faculty/hemal-patel/

Instagram:@hemalpatelphd

https://www.instagram.com/@hemalpatelphd

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 36 of the Performance Around the Clock podcast. In this episode, Dr. Panda hosts Professor Geoff Wahl who is a renowned cancer scientist who conducted foundational research at the Salk Institute for 46 years. His long history in cancer research has focused on understanding the fundamental cellular and genetic mechanisms driving cancer, with an emphasis on the role of stem cells and the p53 tumor suppressor gene in breast and pancreatic cancers. Dr. Wahl also served as the president of the American Association of Cancer Research (AACR), utilizing the position to raise public awareness of the terrible toll of cancer and increase grassroots funding for research. Here, Professor Wahl highlights the crucial role of "foundational research" in combating cancer - explaining that cancer is a group of diseases, not a single one, where cells lose the ability to regulate division, with the most lethal factor being metastatic spread to distant organs. While research in breast cancer has led to effective targeted therapies for primary tumors, like Herceptin for HER2-positive cancers, there is a critical need for more research funding and a greater focus on understanding and treating metastatic cancers and intratumoral heterogeneity, which are major causes of mortality. Highlighting the value of funding foundational research, Dr. Tony Hunter’s work at the Salk Institute on tyrosine kinases has ultimately led to life-saving drugs like Gleevec, contributing to the 33% drop in the U.S. cancer death rate since 1991. We hope you enjoy this episode. If you want to support this channel, please like, comment, follow or donate. Thank you for listening.

Guest:

Dr. Geoff Wahl

Professor Emeritus Salk Institute

Profile:

https://www.salk.edu/scientist/geoffrey-wahl/

Cancer statistics, 2023

https://pubmed.ncbi.nlm.nih.gov/36633525/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 37 of the Performance Around the Clock comes from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany.  We welcome Professor Anna Krook, a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet.  Professor Krook is an internationally recognized leader in metabolism, skeletal muscle and insulin biology. 

In this episode, we discuss Professor Krook’s research journey, which began with her Ph.D. work on insulin and the insulin receptor gene, identifying rare mutations that cause severe inherited insulin resistance. She then focused on the dysregulation of insulin action seen in Type 2 diabetes, noting that muscle is the main site where insulin action goes wrong.  The conversation dives into the fascinating role of the circadian clock in regulating insulin, glucose, and muscle.  Dr. Krook explains that while healthy muscle mitochondria show a functional rhythm that peaks in the afternoon, this crucial rhythm is absent in muscle cells from people with Type 2 diabetes.  We cover her landmark study showing that for type 2 diabetic men doing high-intensity interval training, exercise in the afternoon led to lower blood glucose control and a beneficial "legacy effect" the next day. In contrast, morning exercise resulted in higher blood glucose levels for that entire day and the next. This negative effect may be linked to higher inflammatory markers and stress markers circulating in the plasma after morning exercise.  Please join us for an insightful conversation between Dr. Satchin Panda and Dr. Krook on optimizing exercise timing for metabolic health. If you enjoy this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Anna Krook

Karolinska Institutet

Professor of Integrative Physiology

Chair of the Strategic Research Programme in Diabetes

Profile:

https://ki.se/en/people/anna-krook

Integrative Physiology group:

⁠https://ki.se/en/fyfa/integrative-physiology⁠

Paper highlight:

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

⁠https://pubmed.ncbi.nlm.nih.gov/30426166/⁠

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: ⁠https://mycircadianclock.org/

Episode 37 of the Performance Around the Clock comes from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany.  We welcome Professor Anna Krook, a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet.  Professor Krook is an internationally recognized leader in metabolism, skeletal muscle and insulin biology. 

In this episode, we discuss Professor Krook’s research journey, which began with her Ph.D. work on insulin and the insulin receptor gene, identifying rare mutations that cause severe inherited insulin resistance. She then focused on the dysregulation of insulin action seen in Type 2 diabetes, noting that muscle is the main site where insulin action goes wrong.  The conversation dives into the fascinating role of the circadian clock in regulating insulin, glucose, and muscle.  Dr. Krook explains that while healthy muscle mitochondria show a functional rhythm that peaks in the afternoon, this crucial rhythm is absent in muscle cells from people with Type 2 diabetes.  We cover her landmark study showing that for type 2 diabetic men doing high-intensity interval training, exercise in the afternoon led to lower blood glucose control and a beneficial "legacy effect" the next day. In contrast, morning exercise resulted in higher blood glucose levels for that entire day and the next. This negative effect may be linked to higher inflammatory markers and stress markers circulating in the plasma after morning exercise.  Please join us for an insightful conversation between Dr. Satchin Panda and Dr. Krook on optimizing exercise timing for metabolic health. If you enjoy this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Anna Krook

Karolinska Institutet

Professor of Integrative Physiology

Chair of the Strategic Research Programme in Diabetes

Profile:

https://ki.se/en/people/anna-krook

Integrative Physiology group:

https://ki.se/en/fyfa/integrative-physiology

Paper highlight:

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

https://pubmed.ncbi.nlm.nih.gov/30426166/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 38 of the Performance Around the Clock features another guest from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany. We are joined by Professor Andrew Miller, a Professor at the University of Edinburgh and the Chair of the Systems Biology Center for Engineering Biology. Professor Miller is a seminal figure in plant biology whose early work served as the inspiration for host Dr. Satchin Panda to enter the field of plant circadian rhythms.In this episode, we explore Professor Miller’s scientific journey, beginning with his fascination with interacting genetic systems and his move to New York to study plant-microbe symbiosis. The conversation highlights his groundbreaking development of rhythmic bioluminescence using the luciferase protein to visualize the plant clock in real-time. This innovation allowed researchers to identify the genes building the plant clock without killing the specimens, a technique that revolutionized the field.We dive into the critical role the circadian clock plays in agriculture, from measuring day length to trigger flowering to helping crops like barley adapt to the unique growing seasons of Scotland. Professor Miller also explains the fascinating connection between the clock and metabolic timing, detailing how plants use their internal timer to manage starch degradation overnight to avoid starvation before dawn.The discussion moves toward the future of the field, including the creation of "digital twins" through mathematical modeling to predict how specific genomes will perform in various climates. We also touch upon Professor Miller's work with the UK government's ACRE committee, advising on the policy and safety of genetically edited crops to meet the challenges of climate change and food security. Please join us for this wide-ranging and inspiring conversation. If you enjoy this episode, please like, comment, or subscribe. Thanks for watching.Guest:Dr. Andrew MillerUniversity of EdinburghProfessor of Systems BiologyChair of the Systems Biology Center for Engineering BiologyPaper highlight:Circadian clock mutants in Arabidopsis identified by luciferase imaginghttps://pubmed.ncbi.nlm.nih.gov/7855595/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: ⁠https://mycircadianclock.org/⁠

In episode 39 of the Performance Around The Clock podcast, we are joined by Professor Alex Webb from the University of Cambridge, a leading expert in plant cell signaling and circadian clocks.  The episode was recorded at the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany.  Professor Webb shares his journey from psychology to plant physiology, discussing how a shared inspiration from researcher Andrew Miller led both him and also host Dr. Satchin Panda into the field of circadian rhythms.

We explore the foundational history of biological clocks, starting with the 18th-century "wine cellar" experiment by De Mairan that first proved plants possess an internal oscillator. Professor Webb explains the complex behaviors of plants, such as the "yin and yang" of diurnal and nocturnal flowering to match pollinators, and the phenomenon of "sweaty plants"—how the circadian clock regulates stomata to balance carbon intake with water loss. We also discuss the metabolic math plants perform to survive the night, a process that explains why pumpkins actually grow in the dark. The conversation turns to "chronoculture," a concept focused on using circadian knowledge to optimize agriculture and meet the urgent goal of doubling food production by 2050. We examine how humans have inadvertently selected for clock mutations in crops like tomatoes and wheat—specifically the L3 gene—to adapt them to new environments. Finally, we discuss the "Plants for Space" program and how innovations in vertical farming for the International Space Station can teach us how to build sustainable, closed-loop food systems for our own "spaceship," Earth.

Please join us for this fascinating discussion on the rhythms of the plant world. If you enjoy this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Alex Webb

Head of Circadian Signal Transduction Group

University of Cambridge

Profile:

https://www.plantsci.cam.ac.uk/directory/alex-webb

BlueSky:

https://bsky.app/profile/alexwebblab.bsky.social

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/
More science: ⁠https://mycircadianclock.org/⁠

In episode 40 of the Performance Around The Clock podcast, we are joined by Dr. Emily Manoogian, a leading clinical researcher focused on optimizing human health through the timing of food intake (time-restricted eating) and circadian rhythm regulation.  Dr. Manoogian was recently honored with the Young Investigator Award for her seminal studies on circadian disruption among shift workers and interventions to mitigate its effects. We begin the episode by defining the complex reality of shift work—whether fixed, rotating, or split shifts—and how working outside typical hours challenges the human body.

Dr. Manoogian and Panda explore the cascading health effects of "circadian disruption," distinguishing between acute annoyances and chronic risks that build up over months and years. Dr. Manoogian explains how being active and eating when the body expects rest can lead to insulin resistance, cardiovascular disease, mood disorders, and even increased cancer risk. We also discuss the broader societal impacts, from the "social jetlag" affecting students and new parents to the unique stressors faced by frontline workers like firefighters and nurses.

The conversation highlights actionable science, focusing on the "Healthy Heroes" study conducted with San Diego firefighters. Dr. Manoogian shares how Time-Restricted Eating (TRE)—limiting food intake to a 10-hour window—significantly reduced VLDL (bad cholesterol). reduced blood sugar levels, improved blood pressure and improved emotional stability in this high-stress population. Dr. Manoogian is currently studying a different shift work group with the ongoing "Shift Study" for nurses, which is using continuous glucose monitoring to test if optimizing meal timing and low-glycemic snacks can protect the cardiometabolic health of night-shift workers.

Please join us for this vital discussion on optimizing health for those who keep our society running around the clock. If you enjoy this episode, please like, comment, or follow. Thanks for listening.

Guest:

Dr. Emily Manoogian

Hillblom Fellow, Staff Scientist at the Salk Institute for Biological Studies

Young Investigator Award Winner, Working Time Society

myCircadianClock website:

www.mycircadianclock.org

Healthy HEROES study:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9536325/

SHIFT study:

Participate by emailing:

research@mycircadianclock.org

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: ⁠https://mycircadianclock.org/⁠

In this episode of the Performance Around The Clock podcast, recorded at the European Biological Rhythms Society Congress in Lubeck, Germany, we are joined by Professor Rae Silver from Columbia University. Professor Silver is an iconic figure in circadian biology whose foundational research helped characterize the suprachiasmatic nucleus (SCN)—the brain's master circadian clock.

We explore Professor Silver’s scientific journey, beginning with her early fascination with the perfectly timed, shared parental behaviors of doves and pigeons. The conversation highlights how this curiosity eventually led to her groundbreaking SCN transplant experiments in hamsters.  By transplanting the clock of a "fast-running" donor into a "slow-running" host, her work definitively proved that the SCN controls circadian behavior.  We dive into her revolutionary discovery that the SCN communicates its timing not just through neural synapses or "roads," but through "rivers and oceans"—secreting diffusible signals into the cerebrospinal fluid via a specialized portal blood vessel system.

The discussion moves toward the profound clinical implications of this fluid communication network, including its connection to the brain's glymphatic system, waste clearance during sleep, and neurovascular diseases like Alzheimer's. We also touch upon the exciting future of the field, from the power of chronotherapy in optimizing cancer treatments to the massive economic and health benefits of lifestyle interventions like time-restricted eating and light management to combat diabetes. Finally, Professor Silver shares invaluable career advice for young scientists about balancing high-risk experiments with reliable projects, and the importance of cultivating a lifelong passion outside of the lab.

Please join us for this wide-ranging and inspiring conversation. If you enjoy this episode, please like, comment, or subscribe. Thanks for listening.

Guest: 

Professor Rae Silver, Columbia University

Helene L. and Mark N. Kaplan Professor of Natural & Physical Sciences

Chair of the Neuroscience Program

https://psychology.columbia.edu/content/rae-silver

Host: 

Dr. Satchin Panda 

X (Twitter): @SatchinPanda 

https://x.com/SatchinPanda 

Instagram: @satchin.panda https://www.instagram.com/satchin.panda/

Links: 

Donations: https://panda.salk.edu/giving/ 

Research: https://www.salk.edu/scientist/satchidananda-panda/ 

More science: ⁠https://mycircadianclock.org/⁠

Episode 42 of the Performance Around The Clock podcast comes from the European Biological Rhythms Society Congress in Lubeck, Germany.  We are joined by Professor Ueli Schibler, an icon in the circadian field whose foundational discoveries helped establish fundamental principles in the field of circadian rhythms.

This episode explores Professor Schibler’s scientific journey, marked by serendipity and a philosophy of keeping an open mind to unexpected observations.  The conversation highlights how an initial failure to replicate a transcription factor experiment led to the groundbreaking realization that DBP (D-box binding protein) was the first mammalian transcription factor found to exhibit a circadian oscillation. We dive into his lab's revolutionary findings, including the surprise discovery that individual cells, such as fibroblasts, possess their own self-sustained circadian clocks that can be entrained by a simple serum shock.  Dr. Schibler and Panda also explore his seminal experiments demonstrating that food acts as a primary time-giver, or zeitgeber, capable of entraining circadian clocks in peripheral tissues like the liver. The discussion moves toward the profound clinical implications of his foundational work, touching upon the massive potential of chronotherapy to optimize cancer treatments, such as timing the delivery of PD-1 immune checkpoint inhibitors. Finally, Professor Schibler shares invaluable advice for young scientists about avoiding "bandwagon" research, and discusses his fascinating future hypotheses regarding cancer homeostasis and why germline DNA is virtually immortal.

Please join us for this wide-ranging and inspiring conversation.  If you enjoy this episode, please like, comment, or subscribe. Thank you for listening.

Guest: 

Professor Ueli Schibler, University of Geneva 1984-2015

2013 Aschoff’s Rule Prize Winner

2012 Aschoff and Honma Prize Winner

2000 Louis-Jeantet Prize Winner

1996 Otto Naegeli prize for medicine

Host: 

Dr. Satchin Panda 

X (Twitter): @SatchinPanda 

https://x.com/SatchinPanda 

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links: 

Donations: https://panda.salk.edu/giving/ 

Research: https://www.salk.edu/scientist/satchidananda-panda/
More science: ⁠https://mycircadianclock.org/⁠