On The Pen With Dave Knapp – Détails, épisodes et analyse

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Christopher and Laraine Durham of @TheDownsized join Dave to discuss the Zepbound vials arrival and the changes to the Zepbound savings card!

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RO TOOLS TO HELP YOU:
Ro Body: ro.co/otp
#ReportTheShortage - ro.co/supply-tracker
#OptInForObesity - See if you're covered ro.co/checker

Madison Muller Article on Zepbound Vial Pricing:
https://www.bloomberg.com/news/articles/2024-08-27/eli-lilly-is-now-selling-zepbound-weight-loss-drug-at-50-discount?srnd=undefined

Search Zepbound Pricing:
https://www.goodrx.com/zepbound/what-is

Empoloyer Form Letter to Add Obesity Coverage:
https://www.onthepen.com/post/optinforobesity-how-petitioning-your-employer-can-break-the-barriers-to-obesity-treatment

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Eli Lilly

• Eli Lilly sent cease and desist letters to providers of research grade GLP-1s
• Exclusive news from onthepen.com that has not been covered by any other source
• https://www.onthepen.com/post/generic-versions-of-zepbound-how-recent-news-affects-their-future

Him & Hers:

• Him & Hers giving GLP medications without consulting with a doctor
• https://hntrbrk.com/hims/

Price for generic liraglutide/Victoza (multiple tiktok videos):

• Note: podcast last week announced generic liraglutide from Tera Pharma
• Prices as low as $225 for two pens
• https://www.goodrx.com/liraglutide?form=carton&dosage=2-pens-of-18mg-3ml&quantity=1&label_override=liraglutide

TROA

• Scaled-back TROA bill is passed out of the US House Ways and Means Committee 
• This version would limit coverage to people who had been taking a weight loss drug for a year prior to enrolling in Medicare
• https://www.nbcnews.com/health/health-news/house-committee-passes-bill-allow-medicare-cover-weight-loss-drugs-rcna159248

BI 3034701 (tiktok video):

• Boehringer Ingelheim and Gubra start phase 1 trial of BI 3034701 which is retatrutide competitor (GLP-1/GIP/glucagon)
• https://www.boehringer-ingelheim.com/science-innovation/human-health-innovation/phase-1-start-novel-triple-agonist-obesity-treatment

Support the show

Our Book Has Been Released!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

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Novo Nordisk expansion in the US:
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=168528

Generic liraglutide
https://www.onthepen.com/post/teva-launches-first-ever-generic-glp-1-a-game-changer-for-diabetes-and-weight-management

New Wegovy Coupon:
https://www.wegovy.com/coverage-and-savings/save-on-wegovy.html

New Mounjaro Card (tiktok video)
https://mounjaro.lilly.com/savings-resources

Tirzepatide (tiktok video):
https://www.reuters.com/business/healthcare-pharmaceuticals/weight-loss-drug-zepbound-resolves-sleep-apnea-up-52-patients-lilly-says-2024-06-21/

Petrelintide
https://www.onthepen.com/post/introducing-petrelintide-discover-the-promise-of-amalyn-agonist-medications-for-weight-loss

Gut bacteria:

• Interesting research that shows that type-2 diabetics have more microbiome in their gut that suppresses incretin hormones like GLP-1. This is more evidence that #glp1 medications fix what is biologically broken
• https://www.onthepen.com/post/glp-1-slow-responders-gut-bacteria-may-hold-the-key

DACRA:
https://ir.vikingtherapeutics.com/2024-06-24-Viking-Therapeutics-Presents-Preclinical-

Support the show

Our Book Has Been Released!
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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

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PBM Reform Form Letter: 

• Link to the Letter: https://www.onthepen.com/post/pbm-reform-form-letter-for-elected-representatives

Express scripts (tiktok video on PBM reform):

• Link to my video: https://www.youtube.com/watch?v=l0g6RwViOxc

Michigan (tiktok video)

• Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-12/michigan-s-largest-insurer-to-drop-weight-loss-drug-coverage

Accessibility

• Link: https://www.benefitspro.com/2024/06/13/8-ways-to-use-behavioral-science-to-address-obesity/?slreturn=20240614174121

Vivani (tiktok)

• Link: https://www.businesswire.com/news/home/20240613953589/en/Vivani-Medical-Announces-FDA-Clears-Investigational-New-Drug-Application-and-Lifts-Clinical-Hold-for-NPM-119-a-Miniature-Long-Term-Subdermal-GLP-1-Drug-Implant

Diet on GLP-1:

• Link: https://www.upi.com/Health_News/2024/06/11/Ozempic-Wegovy-nutrition-requirements/4931718111093/
• Link: https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24067?domain=p2p_domain&token=ZXK7NJV6GEXBQQHGZ6TH

Online GLP-1s:

• Link: https://www.npr.org/sections/sho

Support the show

Our Book Has Been Released!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

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Eli Lilly's phase 2 SYNERGY-NASH study shows tirzepatide effectively resolves MASH and improves fibrosis, offering hope for millions. Read more here: https://www.onthepen.com/post/tirzepatide-shows-promise-in-treating-mash-key-findings-from-the-synergy-nash-study

Support the show

Our Book Has Been Released!
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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

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Ro.co/supply-tracker

FDA shortage update (tiktok video):
Link:https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

EASL (European Association for the Study of the Liver) 2024 in Milan Italy
Link: https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
Link: https://www.biospace.com/article/mash-clash-between-lilly-and-boehringer-zealand-takes-center-stage-at-easl24/

Walgreen:
Link: https://www.benefitspro.com/2024/06/03/walgreens-will-conduct-clinical-trials-for-boehringer-ingelheims-new-obesity-drug/?slreturn=20240610103336

Kroger (tiktok video):
Link: https://www.aol.com/news/kroger-health-revamps-weight-management-132122808.html

Eli Lilly Clinical trial:
Link: https://clinicaltrials.gov/study/NCT06373146?term=tirzepatide&aggFilters=status:act%20rec&rank=6

Eli Lilly CFO:
Link: https://www.prnewswire.com/news-releases/lilly-announces-departure-of-anat-ashkenazi-chief-financial-officer-302163882.html

China:
Link: https://www.benzinga.co

Support the show

Our Book Has Been Released!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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https://ro.co/weight-loss/supply-tracker
https://www.youtube.com/watch?v=mL_krAas70k

Novo Nordisk Advertising:

• Novo Nordisk launches new advertising campaign "The Power of Wegovy"
• This advertisement includes the new indication for reduction of cardiovascular risk
• For 2023, the #5 advertising spend for a drug was Rybelsus at $191 million.  The #6 advertising spend was Ozempic at $187.4 million (increase of 6% from 2022). More than 40% of the 2023 ad spend for Ozempic  went to online video platforms (i.e. social media like youtube)
• Link: https://www.youtube.com/watch?v=dhretLXYkZ4

Structure Therapeutics GSBR-1290

• GSBR-1290 is a small molecule GLP-1 pill
• In a 12-week phase 2 clinical study, a tablet formulation of GSBR-1290 had a weight-loss of 6.9%. This is comparable to Eli Lilly's phase 2 results for olforglipron
• At Week 12, 67% of GSBR-1290 treated participants achieved ≥6% weight loss and 33% achieved ≥ 10% weight loss, compared to 0% for placebo
• Also developing next generation combination GLP-1 candidates together with GIP, amylin, glucagon and apelin oral small molecules
• Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-03/structure-reports-early-oral-weight-loss-drug-data-adding-allure

Elon musk tweet:

• Elon Musk tweeted: Just make a lot of Ozempic/Mounjaro. It’s not inherently expensive. The health benefits of reducing obesity far exceed the downside of GLP-1 inhibitors. We evolved under starving conditions and now make food that is plentiful and delicious. Whether that food is “processed” does matter, but is not a game changer
• This tweet has currently been seen 325,500 times

Shanghai Stem Cell Type 2 Diabetes Treatment
https://www.scmp.com/news/china/science/article/3263878/chinese-scientists-report-world-first-they-cure-patients-diabetes-cell-therapy

Support the show

Our Book Has Been Released!
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USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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🤝 Visit Our Sponsor!
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Zachariah Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health, he joins #OnThePen to talk all things #mounjaro #zepbound #wegovy #ozempic 

Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health.

https://ro.co/weight-loss/supply-tracker/

ro.co/OTP

Support the show

Our Book Has Been Released!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

DNF10 Peptide Supplement I Use: https://integrativepeptides.com/AFFILITATES/OTP
USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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BECOME A MEMBER:
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MORE COMMUNITY!
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🤝 Visit Our Sponsor!
GLP-1 Ro Body Plan: https://www.ro.co/otp
Report The Shortage: https://www.ro.co/supply-tracker
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and...

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On The Pen News: https://www.onthepen.com/blog

SHOW NOTES:
Ozempic study in New England Journal of Medicine:
Link: https://www.bloomberg.com/news/articles/2024-05-24/novo-s-ozempic-slashes-risk-of-death-in-kidney-disease-study

Support the show

Our Book Has Been Released!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

DNF10 Peptide Supplement I Use: https://integrativepeptides.com/AFFILITATES/OTP
USE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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Ca$h App: ManOnMounjaro

BECOME A MEMBER:
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MORE COMMUNITY!
📺 Watch Our Weekly Live Show: onthepen.tv
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🤝 Visit Our Sponsor!
GLP-1 Ro Body Plan: https://www.ro.co/otp
Report The Shortage: https://www.ro.co/supply-tracker
Does your insurance cover GLPs? https://www.ro.com/checker

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and...