Explorez tous les épisodes du podcast Nick Norwitz MD PhD - Metabolic Health & Longevity

For all the references, links, and a written breakdown, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/how-a-mothers-diet-rewrites-her-childrens?r=40ekz2 What your mother ate during pregnancy may shape your cardiovascular health today. New research published in Nature Cardiovascular Research reveals that a maternal Western diet—high in sugar and saturated fat—can epigenetically program her offspring to develop atherosclerosis and heart disease.In this video, I’ll break down how maternal nutrition impacts epigenetic bookmarks activate inflammatory genes, and why this matters for obesity, diabetes, and cardiovascular disease. We’ll also explore how ketogenic diets, healthier nutrition choices, and lifestyle interventions may help reverse this metabolic programming and support lifelong heart health.Most importantly, you’ll see why epigenetic legacy is not destiny. While we may inherit predispositions, lifestyle, nutrition, metabolic health strategies, still give us the power to fight inflammation, protect heart health, and rewrite our future.Chapters 0:00 – How Maternal Nutrition Shapes Offsprings’ Heart Health1:21 – New Study in Nature Cardiovascular Research2:10 – Study Methods: Diet and Epigenetics2:45 – Western Diet During Pregnancy Increases Heart Disease Risk4:33 – Epigenetics Analogy: Libraries, Books and Bookmarks5:34 – How Diet Triggers Epigenetic Changes Across Generations6:43 – Maternal Westernized Diet Promotes Inflammatory Epigenetic Priming7:58 – Solutions: Eat Well! Ketogenic Diets and Reversing Epigenetic Damage9:44 – Your Epigenetic Legacy Is Not Your Fate#obesity #cardiovasculardisease #hearthealth #epigenetics #inflammation #ketogenicdiet #NLRP3 #genetics #staycurious #metabolism #metabolichealth #educational #scienceexplained #naturecardiovascularresearch #atherosclerosis #ketoscience #dietandhealth #epigeneticinheritance #metabolichealth #prenatalnutrition #maternalhealth #fetalprogramming #generationalhealth #nutrigenomics #lifecoursehealth #nutritionresearch #westernizeddiet #chronicinflammation #nutritionmatters #preventivediet #scienceeducation #healthscience #longtermhealth #epigeneticrisk #healthylifestyle Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation with Mike Mutzel, MS from the High Intensity Health channel, we dive into some of the most interesting 2025 heart health studies. We explored the gut-heart axis, how body fat can alter blood vessel function and touch on oxidative stress, inflammation, the microbiome, protein, hormones and how they all relate to heart health. If you are interested in cardiovascular health nutrition, and metabolism, this one is for you!Chapter*Call our service line at 815-STAY-CUR (815-782-9287) or visit https://askchapter.org/staycurious*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Mike’s YouTube Channel: https://www.youtube.com/user/highintensityhealth For Deeper Dive’s into the Content Discussed:*Referenced Videos:Paper 1: Imidazole Propionate and Heart Health https://youtu.be/P7CZvAnB53E Autophagy and Depression https://youtu.be/MCCb5VkckU0 Paper 2: Aging, Phenylacetic Acid and Heart Health https://youtu.be/H0OaXcIobgM Young Blood and Longevity https://youtu.be/lTMjmHKc2Ys Paper 3: Myeloperoxidase, Obesity and Heart Health https://youtu.be/inTK-9DCxf0 *Other Referenced Content:Homovanillic Acid, Microbiome and Depression https://staycuriousmetabolism.substack.com/p/the-microbiomemood-link-a-three-ingredient?r=40ekz2 Dogs and health https://staycuriousmetabolism.substack.com/p/the-science-of-dogs-and-better-health?r=40ekz2 Leptin, Salt and Blood Pressure https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 Four Types of Diabetes (The Cliffhanger!): https://staycuriousmetabolism.substack.com/p/types-four-of-diabetes-what-new-technologies?r=40ekz2 Chapters:00:00 – Dipping into 2025 Heart Health Studies2:25 – The Shift in Heart Health Focus Beyond ApoB and LDL8:03 – Imidazole Propionate and Heart Health – And Internet Confusion22:15 – Chapter: Healthcare and Longevity 24:02 – Gut Health, Heart Health, Aging and Phenylacetic Acid 26:50 – Mechanisms to Improve Gut Metabolism and Lower Phenylacetic Acid37:45 – How Fat Tissue and Myeloperoxidase Impact Vascular Health43:23 – Final Reflections: A Systems View of Metabolic Health*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.#metabolichealth #mikemutzel #nicknorwitz #2025healthstudies #inflammation #phenylaceticacid #apob #hearthealth #lipidstudies #guthealth #sleepandmetabolism #insulinresistance #myeloperoxidase #autophagy #longevityscience #nutritionalbiochemistry #healthoptimization #functionalmedicine #healthscience #chronicinflammation #cardiovascularrisk #biomarkers #longevityresearch #metabolicmarkers #functionalmedicine #healthscience #chronicinflammation #cardiovascularrisk #biomarkers #longevityresearch #metabolicmarkers #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices

For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/can-we-trap-a-microbial-toxin-to?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMicroplastics and Cardiovascular Disease, Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 A new study has uncovered a surprising metabolic villain — D-lactate, the molecular twin of the lactate that fuels your muscles. Unlike L-lactate, D-lactate builds up in people with obesity and contributes to insulin resistance, fatty liver, and metabolic dysfunction. But scientists have now found a way to trap this molecule in the gut, potentially opening the door to a brand-new class of metabolic therapies. In this video, Nick Norwitz MD PhD explains the study, its implications for human health, and how certain probiotics and homemade yogurts could help reduce D-lactate levels naturally.Chapters:0:00 – The Evil Twin of Lactate: New Research Explained1:18 – L-Lactate vs D-Lactate: Why the Difference Matters2:43 – Elevated D-Lactate in Obesity: The Hidden Connection3:18 – How D-Lactate Worsens Blood Sugar and Metabolic Health4:00 – Gut Microbes: The Source of D-Lactate6:30 – The D-Lactate Trap: How Scientists Made Mice Poop It Out9:11 – What This Discovery Means for Metabolic Research9:42 – Practical Takeaways: What You Can Do Right Now#Lactate # microbiome #metabolichealth #fatloss #insulinsensitivity #diabetes #obesity #weightloss #educationa #staycurious #inflammation #yogurt #guthealth #biochemistry #metabolism #glucosecontrol #bloodsugar #fattyliver #insulinresistance #healthscience #nutritionresearch #probiotics #gutmicrobiome #scienceexplained #wellnessscience #hormones #metabolicsyndrome Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://pubmed.ncbi.nlm.nih.gov/29317623/Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1 Learn more about your ad choices. Visit megaphone.fm/adchoices

For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2 For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueStatins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.Chapters0:00 – Intro: Statins as a Misunderstood Tool1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease3:43 – Imaging Beats LDL and ApoB for Risk Stratification4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?5:33 – Reviewing the Pros and Cons of Statins6:43 – Paper 3, Statins Harm Mitochondria and Muscles7:55 – Paper 4, Statins Slash GLP-1 Levels9:00 – The Essential Social Dynamics of Statins You Need to Know11:15 – Conclusion, The Right Tool for the Right Job#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=200:12: Data “leak”0:50: Who am I? (For those who don’t know me)1:54: Lean Mass Hyper-Responders2:56: What (design and hypothesis)5:15: Why am I doing this?7:13 – 9:40: “How” (Lipid Energy Model)Other details and Final commentsLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSWinnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Inulin Video: https://youtu.be/blNLHsww_Qs Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBAIn this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.Chapters:0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD1:40 – The Coolest Fiber Paper Ever!21:19 – Probiotic That Binds Plastics22:52 – Keto Mouse Myths: A Shady Study Skews the Truth30:01 – Andrew Reflects on his Diary of a CEO Appearance 43:01 – Do Credentials Teach Curiosity, or Crush Them?#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch Learn more about your ad choices. Visit megaphone.fm/adchoices

JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwvOreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1XOreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices

For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Relevant Prior VideosLp(a) Background Video: https://youtu.be/iVwDJqJiTEY Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s MPO Video: https://youtu.be/inTK-9DCxf0 Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.Genes are not destiny. Metabolic health changes the story.Chapters0:00 – I Have Lp(a)… Oh No!1:47 – New Study on Waist-to-Hip Ratio and Lp(a)2:47 – High Lp(a) But Low WHR… Low Risk!3:31 – Look At This Graph! 4:28 – And Now Look at These Graphs!5:45 – Your Waist-to-Hip Ratio Goals7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?10:11 – Teasing the Protocol… See More at StayCurious Metabolism11:00 – Summarizing Key Points#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTYLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices

For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAIDescription:Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models. This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health. Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.Chapters:0:00 – Visceral Fat: More Than Storage1:03 – Can Fat Cause Depression? New Biology2:26 – The Obesity–Depression Loop3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain5:07 – miR-145-5p: The Molecular “Letter” Driving Depression9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltexthttps://authors.elsevier.com/sd/article/S0022-3166(23)72806-X Learn more about your ad choices. Visit megaphone.fm/adchoices

Dom D’Agostino Part 1 Interview: https://youtu.be/ksV9f4jSbLQ Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Sardine Diet Letter: https://staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2 Sardine Diet Video: https://youtu.be/_Th54GWd8WY Lived to 117 Letter: https://staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2 Lived to 117 Video: https://youtu.be/U7UY8ZPKNlM Stress Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Stress Makes Sugar Video: https://youtu.be/7ekVEYlKFfE This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits. We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker. And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.Chapters 0:00 – Welcome Back Professor D’Agostino 1:34 – Does Melatonin Suppress Your Hormones?6:27 – Real Benefits of Melatonin8:00 – Creatine for Brain Health10:24 – How to Reduce GI Upset from Creatine14:04 – How Did This Woman Live to 117?30:00 – Sardine Fasting: The Most Elite Form of Fasting#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to paper: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullAdrian Soto Mota MD PhD Tweet: https://x.com/AdrianSotoMota/status/1737733204734579062?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices

For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/the-true-story-of-the-cookie-that?r=40ekz2 Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/ What if Oreo cookies could lower cholesterol faster — and more powerfully — than a multi-billion-dollar statin drug? That’s the question I set out to test in a 5-month controlled self-experiment I ran as a Harvard Medical School student. And the results were so shocking they were eventually published in peer-reviewed literature.This video shares the full story — why my LDL cholesterol skyrocketed into the 500s after going ketogenic, the physiology behind the lean-mass hyper-responder phenomenon, and how adding 12 Oreo cookies per day dropped my LDL twice as much as high-dose statin therapy and in one-third of the time.But this isn’t just about cookies…This is a video about challenging assumptions, testing mechanisms, provoking curiosity, and using a viral headline to shine light on a deeply misunderstood physiological phenomenon.Chapters0:00 – I Used Oreo Cookies to Lower My LDL 1:06 – Why My Cholesterol Skyrocketed in the First Place 4:43 – The True Mechanism Behind the LDL Rocket ship7:53 – Why Oreos vs Statin Worked So Well11:00 – What Does this Oreo Cookie Cholesterol Drop Really Mean?12:33 – What is the Risk of High Cholesterol in People Like Me?14:08 – What We Now Know#cholesterol #LDL #hearthealth #metabolism #LMHR #lipidenergymodel #LEM #exercise #ApoB #cardiovasculardisease #obesity #staycurious #VLDL #triglycerides #metabolichealth #educational #metabolichealth #cholesterol #LDL #statins #ketodiet #lipidenergymodel #leanmasshyperresponder #metabolichealth #healthscience #ApoB #nutritionresearch #NickNorwitz #StayCurious #cardiovascularhealth #scienceeducation #cholesterolmyth Learn more about your ad choices. Visit megaphone.fm/adchoices

Prior Response video: https://youtu.be/ILuEO7Jc8TY?si=RCPFWtRDC09Pst5sLMHR CCTA study drop: https://youtu.be/IMkDwtJVeB0?si=yx-zbFnfkLNtZeuLOreovsStatin leak video: https://youtu.be/GHALacs44I8?si=9IOAgZTl3sMnVg6LPeter Libby Review: https://www.nature.com/articles/s41586-021-03392-8Norwitz et al 2021: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextCooper et al 2023: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices

For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/new-hope-for-alzheimers-can-apoe2?r=40ekz2 Lithium for Brain Health: https://staycuriousmetabolism.substack.com/p/lithium-and-alzheimers-the-harvard?r=40ekz2 Ketone Cleans the Brain, Video: https://youtu.be/oRaNzfHF_do Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 I carry two copies of APOE4 — the gene variant that increases Alzheimer’s risk 10–15-fold. For years, that terrified me. But emerging research provides hope. The study we will review suggests that adding APOE2 might quiet brain inflammation, reduce plaques, and help save neurons. In today’s video, I break down the research in simple terms and what this could mean for the future of Alzheimer’s therapy. Then I’ll share the evidence-based strategies that I personally use to protect my brain while we wait for next-generation gene therapies: lithium orotate, ketosis, omega-3s, and more.Chapters0:00 – Why I’m Determined to Prevent Alzheimer’s1:28 – An Incredible Picture of Neuroinflammation 2:06 – APOE2, APOE3, APOE4: What These Genes Really Mean3:54 – The Big Question: Is There an Antidote to APOE4?5:36 – APOE2 Therapy: Reduced Plaques and Silenced Neuroinflammation7:19 – Chapter: The Right Insurance Saves Money and Life-Years8:33 – My 3 Neuroprotection Essentials: Lithium, Ketosis and Omega-3s#alzheimersdisease #apoe4 #brainhealth #longevity #dementia #neuroscience #educational #staycurious #Alzheimers #BrainHealth #Neuroinflammation #CognitiveHealth #DementiaPrevention #APOE2 #Genetics #Longevity #Neuroscience #Metabolism #Ketosis #LithiumOrotate #Omega3 #HealthyBrainAging #StayCurious #Neuroprotection #Microglia #Amyloid #BrainOptimization*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices

What I liked: I like the concept of 'bringing the viewer along with the science.' I agree with the fact that the SAD eating pattern is problematic and that it would be an improvement to eat a whole food-based diet. I also (very much) acknowledge there are non-health related issues about food that we should have adult discussions about.What I didn't like: (1) This series wasn't really about the twin study. Data were only presented, a bit, in the last of the 4 episodes. (2) The advertised foods (fake meat, fake cheese, fake eggs) are cast as similar/identical, but simply aren't, nor were they the basis of the participant's diets.(3) The data presented were, I think, not all that impressive. And some data presented in the documentary could not be found in the paper, e.g. body composition.For more on the topic of Data Misrepresentation, see our new paper: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub Learn more about your ad choices. Visit megaphone.fm/adchoices

For a mini-masterclass in blood sugar control, see: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2 For the Stress Creates Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Statin Slash GLP-1 Video: https://youtu.be/6NomrgjK1yQIn this interview, Dr. Nick Norwitz MD PhD sits down once again with Dr. Andrew Koutnik PhD to unpack several groundbreaking research papers, including how psychological stress can cause your liver to make sugar from scratch, how different carbs and fibers impact bodies differently depending on metabolic health, how potatoes can tell you if you’re insulin sensitive, and more. If you’ve ever wondered how stress, nutrition, and biology collide to shape your health, this conversation might change the way you think about your body—and your mind.Chapters:00:00 — The new stress-sugar discovery01:10 — How your brain signals your liver to make glucose04:30 — The real mechanism behind “stress-induced sugar spikes”07:00 — Andrew’s story: TED Talk stress sent glucose up 100 mg/dL10:20 — How sprinting saved him from a glucose crash12:00 — What this means for diabetics and the general population14:30 — Why meditation changes your biology (not just mindset)16:00 — How obesity amplifies stress’s metabolic effects17:00 — The ‘semi-myth’ of fiber protection in insulin resistance21:30 — Personalized nutrition and CGM insights24:00 — Potatoes vs Grapes test for insulin resistance27:00 — GLP-1 dysfunction, statins, and “new species of diabetes”38:00 — The future of metabolic precision medicine#Cortisol #Glucose #BrainHealth #LiverHealth #Type1Diabetes #Type2Diabetes #Hormones #NutritionScience #Mitochondria #HealthOptimization #Neuroscience #Endocrinology #MetabolicFlexibility #LowCarb #KetogenicDiet #FunctionalMedicine #ChronicStress #Biohacking #HealthResearch #ScienceCommunication #Educational #Informative #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://pubmed.ncbi.nlm.nih.gov/38237807/0:00: intro 0:15: NEW paper!0:38: Low-Carb for various diseases0:57: LDL boogeyman1:17: Lean Mass Hyper-Responder #LMHR1:35: The BIG question2:11: Intro to NEW study, meta-analysis of RCTs2:46: BMI Results!4:43: Not the Saturated Fat!5:58: Lipid Energy Model 6:56: Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices

For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMost people think of plastic as an environmental problem—something that harms oceans, wildlife, and ecosystems. But emerging science is revealing something far more personal: microplastics don’t just pollute the planet— they may be poisoning your heart.A landmark study published in the New England Journal of Medicine found microplastics and nanoplastics embedded inside human arterial plaque. Even more alarming, patients with these particles inside their arteries had a 350% higher risk of heart attack, stroke, or death.This research suggests microplastics may drive cardiovascular disease through oxidative stress, inflammation, immune activation, and vascular damage. Under the microscope, jagged plastic fragments were found lodged inside macrophages—immune cells that normally clear debris—triggering inflammation and accelerating plaque instability.We also explore what you can do today—from reducing heat-exposed plastics, filtering water, and improving air quality, to emerging research on internal defense strategies aimed at binding microplastics before they’re absorbed. This isn’t fear. It’s empowerment. Knowledge isn’t meant to panic us—it’s meant to protect us. Stay curious.Chapters0:00 – Plastic Poisons the Heart. But There’s Good News!1:15 – Find More Information at StayCurious Metabolism 1:41 – A Landmark NEJM Study 2:42 – 350% Increased Risk of Heart Attack, Stroke and Death!4:15 – Microplastics Associate with Inflammation 5:02 – Microplastics Lodged in Macrophage Immune Cells6:41 – Comparison to LDL Cholesterol 8:15 – How to Reduce Your Exposure to Microplastics9:54 – A Probiotic That Shields You from Microplastics#microplastics #cardiovasculardisease #microbiome #hearthealth #heartdisease #NEJM #microplastics #hearthealth #cardiovasculardisease #nanoplastics #inflammation #science #longevity #metabolichealth #heartattack #stroke #healthscience #NickNorwitz #StayCuriousMetabolism Learn more about your ad choices. Visit megaphone.fm/adchoices

Paper link: https://www.mdpi.com/2218-1989/14/1/73Chapters0:00 – Intro0:28 – metabolic demonstration0:43 – Part I, the idea1:30 – LMHR triad 1:58 – Lipid Energy Model3:06 – Part II, the experimental design4:19 – Part III, results 6:00 – results summary 6:40 – Part IV, What’s Next? 7:37 – Thanks and Call to ActionAim: To tested the prediction -- consistent with the Lipid Energy Model (below) -- that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDL-C levels by a similar, or greater, magnitude than high-intensity statin therapy. Findings: Oreo supplementation (12 cookies/d) lowered LDL-C by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDL-C by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as high-intensity statin therapy for LDL cholesterol lowering in this LMHR subject.The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It's a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as 'productive provocation,' a form of 'legit-bait' that will hopefully help prompt discussions and larger-scale experiments that need to happen.6 select Prior publications1/ META of RCTs (new, 1/16/24)Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 **LINK: https://www.sciencedirect.com/science/article/pii/S0002916524000091**VIDEO: https://youtu.be/FcUUqGJBXFM2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768 LINK: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullVIDEO: https://youtu.be/OpOkeXVUotU?si=vHmfywr3CH27B2w53/ JCL editorialNorwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010 Link: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext4/ Lipid Energy ModelNorwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460 Link: https://pubmed.ncbi.nlm.nih.gov/35629964/Video: https://youtu.be/AkzxESsTJyM?si=A8lfhLXp_U1wPRdx5/ LMHR, first paperNorwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 Link: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext6/ Low Sat Fat LMHR case reportNorwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/Video: https://youtu.be/JSEqIsYBZxU?si=lJ0_dnDYlDzvNyjt Learn more about your ad choices. Visit megaphone.fm/adchoices

For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/this-study-redefines-fatherhood?r=40ekz2 Aspartame and Anxiety Video: https://youtu.be/VpCFdumr5rw What if exercise could rewire your sperm and change the destiny of your future children? Not just the number of sperm or how fast they swim — but the biological code you pass on being altered by your workouts.A recent Cell Metabolism study found that when male mice trained, their offspring — who never exercised — had more lean mass, stronger bones, better endurance, and healthier mitochondria. Even more surprising, they were more resilient to a junk-food diet. The mechanism is incredible: exercise changes microRNAs inside sperm, tiny molecular instructions that help shape how early cells build muscle, manage energy, and respond to metabolic stress. And when researchers looked at human males, most of these same microRNAs were present — suggesting this mechanism may operate in humans too. Exercise doesn’t just sculpt your body. It may sculpt who comes after you. Stay curious.Chapters:0:00 – How Exercise Rewrites Your Children’s Biology1:13 – Extra Insights in the StayCurious Newsletter1:50 – The New Cell Metabolism Study2:41 – Offspring of Exercising Fathers: Leaner, Faster, Stronger4:49 – The Mechanism: microRNA Reprogramming in Sperm6:32 – Mouse to Human: Is the Effect Conserved?7:49 – The Future of Engineered Health Inheritance9:35 – Functional Fitness: Targets That Actually Matter10:41 – Why I Avoid Aspartame (The Evidence)12:20 – Final Thought: Your Molecular Momentum#epigenetics #exercise #metabolichealth #microRNA #inheritance #longevity #fathershealth #fitnessscience #cellmetabolism #healthscience #NickNorwitz #StayCuriousMetabolism #biology #offspringhealth #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Prior Response Video: https://youtu.be/ILuEO7Jc8TY?si=x2nN2zHM0O1jFj9AOreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=yWjXiftfoN4Mg5az OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73 Learn more about your ad choices. Visit megaphone.fm/adchoices

Robb Wolf Interview Part 1: https://youtu.be/Wi-6KttZ54g LMNT “Scandal” Video: https://youtu.be/uI2ewgimH3g Salt, Leptin and Blood Pressure: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 Oleuropein and Calcium Signaling: https://youtu.be/ljuimrT2a1s In Part 2 of my conversation with Robb Wolf, we dig into one of the most misunderstood aspects of nutrition and metabolic health: electrolytes. Most people think electrolytes simply matter for athletes or hot summer workouts, but the reality is far more complex. We also get into the science behind sodium, why the old fear of salt never made sense mechanistically, and how obesity and leptin signaling influence salt sensitivity, and more. Chapters0:00 – Why Electrolytes Matter More Than You Think3:12 – Low-Carb, Insulin and Hidden Electrolyte Loss7:38 – How to Know If You’re Sodium Deficient11:25 – The Truth About Sodium, Obesity and Blood Pressure21:59 – How Much Sodium You Really Need29:13 – LMNT Transparency, Controversy and What’s Next#Electrolytes #Sodium #LMNT #RobbWolf #MetabolicHealth #KetoDiet #LowCarb #AncestralHealth #BloodPressure #Hypertension #InsulinResistance #Performance #Hydration #NutritionScience #PodcastInterview #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

0:00 – What Saturated Fat Myth?0:24 – 1) Effect Magnitude 1:16 – 2) The low-carb lipid ‘triad’1:37 – 3) Inverse association between BMI and LDL-C on low-carb2:13 – 4) High LDL-C on low sat fat diets, and the converse3:46 – 5) Meta-analysis of RCTsOreoVsStatin video: https://youtu.be/L1mMnnyJrgkOreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73Meta-analysis video: https://youtu.be/FcUUqGJBXFMMeta-analysis, Soto-Mota et al: https://www.sciencedirect.com/science/article/pii/S0002916524000091Interventional Trial, Cooper et al: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices

For the references, extra details and early access to context, see the newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/lowering-cholesterol-killed-a-study?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Description:What if lowering cholesterol didn’t save lives—but actually increased the risk of death?In this video, I break down a forgotten ‘gold-standard’ randomized controlled trial from the late 1960s and early 1970s: the Minnesota Coronary Experiment. This uniquely rigorous study tested whether replacing saturated fat (butter, beef) with vegetable oils rich in linoleic acid would reduce heart disease and mortality.The results were shocking. Cholesterol dropped—but deaths increased. Even more unsettling, the greater the cholesterol reduction, the higher the risk of death. Cardiovascular outcomes didn’t improve either. The cholesterol reducing diet was even associated with a trend towards increased atherosclerosis on autopsy. So why were these results buried for decades? Were they inconvenient? Misunderstood? Or simply too complex for a simple narrative?We’ll walk through the study design, the actual outcomes, and the major criticisms—then evaluate whether those critiques really hold up.Chapters:0:00 – The Trial That Vanished for 40 Years1:37 – Inside the Minnesota Coronary Experiment (Study Design)4:54 – Cholesterol Fell… Mortality Rose7:03 – Worse Arteries Despite Lower Cholesterol8:20 – What Other RCTs Show: The Meta-Analysis9:25 – Why These Results Never Changed the Guidelines10:10 – Major Criticisms of the Minnesota Coronary Experiment11:33 – The “Hidden Trans Fat” Explanation Examined13:19 – Does the Dropout Rate Undermine the Data?14:47 – When Cholesterol Lowering Became a Catastrophe16:11 – The One-Word Takeaway: Humility#seedoils #saturated fat #cholesterol #cholesterol #nutritionscience #hearthealth #dietaryfat #saturatedfat #seedoils #linoleicacid #cardiovascularhealth #metabolichealth #evidencebasednutrition #medicalhistory #nutritionmyths #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Meta of RCTs: https://youtu.be/FcUUqGJBXFM?si=Z2qQH85PNr2XagIEPaper: https://www.sciencedirect.com/science/article/pii/S0002916524000091OreoVsStatin: https://youtu.be/L1mMnnyJrgk?si=R6vWZSK5bD9CcrvNPaper: https://www.mdpi.com/2218-1989/14/1/73Lipid Energy Model: https://youtu.be/AkzxESsTJyM?si=bKrkR0Tc_any_eUgPaper: https://www.mdpi.com/2218-1989/12/5/460LMHR CCTA study data drop: https://youtu.be/IMkDwtJVeB0?si=o4WGsw82JBYLlyxE Learn more about your ad choices. Visit megaphone.fm/adchoices

For a written digest on the guidelines, see the StayCurious Metabolism Letter: https://staycuriousmetabolism.substack.com/p/the-new-dietary-guidelines-actually?r=40ekz2 The 2025–2030 Dietary Guidelines are being marketed as a major reset with a simple message: put “real food” back at the center of the American diet. And in a lot of ways, they do represent progress. But when you actually read what’s written, some of the most important details raise real questions. For example, the document still states that saturated fat should not exceed 10% of total daily calories.To separate signal from spin, I’m joined by Dr. Ty Beal PhD, who worked on the evidence review side of the Guidelines process, to explain what the scientific background documents actually say, what happens after scientists submit reviews, and why the final public-facing document can end up with compromises, inconsistencies, or imprecise terminology. If you want a clear, good-faith breakdown—what’s genuinely better, what still doesn’t add up, and what needs to be fixed next—this is the conversation.Professor William Harris Omega-3 Interview, Part 1: https://youtu.be/rZT4Y6T_0Vc Guidelines PDF: https://cdn.realfood.gov/DGA_508.pdf CHAPTERS:0:00 – 2025–2030 Dietary Guidelines: The “Biggest Reset” Explained1:10 – Meet Ty Beal, PhD (Scientific Review Author)2:06 – “Ending the War on Saturated Fat”… But the 10% Cap Stayed7:27 – Who Actually Writes the Guidelines? Science vs Bureaucracy9:05 – “Essential Fats” Confusion: Olive Oil, Butter, Beef Tallow12:22 – Real-World Impact: School Meals, SNAP, and Policy Levers16:34 – Key Takeaway So Far: Progress, But Messaging Still Conflicts18:11 – The “Pink Elephant” Problem: Bad Logic in Nutrition Policy18:56 – Sodium Limits + Whole Grains: Context Matters23:20 – “Empty Calories” Is a Myth (Metabolic Effects Still Count)24:16 – The Biggest Wins: Sugar, Protein Targets, Omega-3 for Pregnancy31:42 – What “Real Food” Means (and Why Definitions Get Messy)37:12 – What Needs to Happen Next (Policy + Research + Clarity)#dietaryguidelines #saturatedfat #MAHA #dairy #metabolichealth #processedfoods #butter #meat #steak #omega3 #realfood #vegetables #foodpolitics #essentialfats #tallow #seedoil #oliveoil #staycurious #SNAP #refinedgrains #NOVA #RealFood #NutritionScience #FullFatDairy #ProteinIntake #UltraProcessedFoods #AddedSugar #HeartHealth #NutritionPolicy #TyBeal #NickNorwitz #USDA #HHS Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://www.frontiersin.org/articles/10.3389/fneur.2023.1329541/full Learn more about your ad choices. Visit megaphone.fm/adchoices

For extra details and all references, see this newsletter: https://staycuriousmetabolism.substack.com/p/a-keto-diet-cured-my-inflammatory?r=40ekz2Description:There was a time when I was dying from inflammatory bowel disease. It was my rock bottom. Out of desperation, I tried a ketogenic diet—and within a week, everything changed. My symptoms stopped, inflammation markers dropped, and follow-up testing showed no active disease. In this video, I unpack what may have happened biologically. We walk through human and animal data showing how a ketogenic diet reshapes the gut microbiome, suppresses inflammatory TH17 immune cells, and reduces inflammation not just in the intestines, but system-wide. We even look at fecal transplant experiments demonstrating that the ketogenic microbiome itself can transfer anti-inflammatory effects.This isn’t a promise or a prescription. It’s a personal story, grounded in real data, that explores the tension between lived biology and what medicine has—or hasn’t—caught up to yet.Sometimes biology doesn’t wait for peer review.Chapters:0:00 – How a Ketogenic Diet Put My Inflammatory Bowel Disease into Remission1:36 – Human Trial: Keto Rapidly Reshapes the Gut Microbiome3:20 – Ketosis Suppresses Gut Inflammation and TH17 Immune Cells4:35 – Fecal Transplants Prove the Ketogenic Microbiome Is Causal6:50 – When Evidence-Based Medicine Lags Behind Biology8:37 – Real Patient Remissions from a Ketogenic IBD Case Series9:14 – Biology Doesn’t Wait for Peer Review — Stay Curious#keto #ketogenicdiet #guthealth #IBD #crohnsdisease #ulcerativecolitis #microbiome #inflammation #metabolichealth #nutritionscience #staycurious #ketoscience #lowcarblifestyle #healingwithfood #foodasmedicine #autoimmunedisease #gutbrainaxis #intestinalhealth #digestivehealth #chronicillness #functionalmedicine #nutritionresearch #humanbiology #immunehealth #microbiomesupport #inflammationscience #personalhealth #metabolicreset #clinicalnutrition #lifesavingnutrition #healthjourney Learn more about your ad choices. Visit megaphone.fm/adchoices

Meta of RCTs paper: https://www.sciencedirect.com/science/article/pii/S0002916524000091Meta of RCTs video: https://youtu.be/FcUUqGJBXFM?si=tzcIwgBCDV-kx1k_OreoVsStatin paper: https://www.mdpi.com/2218-1989/14/1/73OreoVsStatin video: https://youtu.be/L1mMnnyJrgk?si=EfNbfFxQTwxLhJaTLayne's video: https://youtu.be/2v7bk6c7o7s?si=unL2SZMCLK4WNHARA BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices

For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 We’ve been told to restrict salt because it increases blood pressure, but what does the science actually say? In today’s video, we dive into the fascinating biology of salt sensitivity and salt resistance. It’s not simply about your genes, but rather your fat cells. I’m going to reveal the secret of salt sensitivity, backed by data from top journals like Cell Metabolism and NEJM. Get ready to learn how fat impacts your blood pressure, and why understanding this can challenge conventional advice from your cardiologist and nephrologist. Whether you're dealing with high blood pressure or curious about metabolic health, this breakthrough science could change the way you think about your health and your diet. Chapters:0:00 – Why I’m Salt Resistant: Breaking Myths on Salt Sensitivity1:33 – The Status Quo on Salt: The Old Wisdom vs. New Science2:34 – Fat as an Endocrine Organ: The Role of Leptin 3:59 – The Hypothalamus: Mission Control for the Endocrine System5:12 – Leptin from Fat: How It Impacts the Blood-Brain Barrier and Blood Pressure6:46 – The Mechanistic Cascade: From Fat Cells to Increased Blood Pressure10:09 – Body Fat, Leptin, and Salt Sensitivity: The Human Data #saltsensitivity #bloodpressure #saltintake #fatcells #leptin #endocrinology #metabolichealth #bloodpressurecontrol #saltresistance #highbloodpressure #saltmyths #fatburning #healthytips #metabolicdisorders #endocrinehealth #nephrology #fatandhealth #cardiovascularhealth #saltandfat #nutritionfacts #bodyfat #scientificresearch #healthscience #saltmyths #healthoptimization #hearthealth #saltandhealth #saltmythsbusted #healthfacts #fatandhealth #leptinandbloodpressure #saltintakecontrol #endocrinefunction #cardiovascularresearch #metabolicinsights #saltfacts #bodyfatandhealth #bloodpressuremyths #saltintolerance #saltstudies #endocrinesystem #metabolichealthjourney #healthyhabits #metabolismscience #nutritionalhealth #bloodpressurerelief #saltcontrol #saltandfat #healthytipsandtricks #healthscientist #lifestylemedicine #stayhealthy #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Cooper et al. Thyroid in LMHR Women: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1326768/full NEJM, New Drug for NASH: https://www.nejm.org/doi/full/10.1056/NEJMoa2309000 OreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73 0:00 - New Drug for Fatty Liver and Overview 0:50 - T3 predicts LDL cholesterol on Keto 1:20 - Lipid Energy Model tie in 2:14 - Thyroid Hormone Receptor Beta 2:50 - NEW trial 3:50 - But LMHR don't have fatty liver 4:10 - The question? 4:48 - Provocative alternative possibility 6:18 - Why does this matter? CONTEXT!A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices

I Ate 1000 Sardines in a Month, Video: https://youtu.be/_Th54GWd8WY How Sardines Supercharged my Metabolism, Letter: https://staycuriousmetabolism.substack.com/p/the-weird-anti-insulin-hormone-that?r=40ekz2 Omega-6/3 Ratio Can Be Misleading, Letter: https://staycuriousmetabolism.substack.com/p/how-we-got-omega-fat-wrong-this-will?r=40ekz2 Best Omega-3 for the Brain, Letter: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864Discount Code: NickNorwitz for 10% offFatty Acid Research Institute: https://www.faresinst.org Description:In this conversation, I sit down with Professor William Harris, one of the world’s leading experts on omega-3 and omega-6 fatty acids, to cut through confusion around fish oil, seed oils, cardiovascular health, and brain health.We break down what omega-3 and omega-6 fats actually are, why their chemistry matters, and how they’re converted into powerful signaling molecules that influence inflammation, metabolism, heart disease, and neurological health. We also discuss the omega-6:3 ratio and the omega-3 index—why the ratio can be misleading, why higher omega-6 levels are not inherently harmful, and why low EPA and DHA are the real problem for most people. We discuss optimal omega-3 index targets, whether there’s a ceiling to benefits, how omega-3s relate to Alzheimer’s risk and brain aging, and what the data actually say about long-term outcomes.This is a nuanced, evidence-driven discussion meant to replace fear-based nutrition narratives with clarity, context, and better questions to ask about your own health.Chapters0:00 – Meet Omega-3 Expert: Professor Bill Harris1:21 – A High-Level Overview of Omega-3 and Omega-65:10 – Do Omega-3 Help Cardiovascular Health?9:19 – Limitations of Randomized Controlled Trials11:11 – Omega-6/3 Ratio vs Omega-3 Index12:12 – Optimal Levels on the Omega-3 Index15:28 – Why the Omega-6/3 Ratio Can be Misleading 21:20 – Seed Oils vs Omega-6. What Should we Do?22:20 – Practical Dietary Tips from Professor Harris25:11 – Omega-3 and Neuropsychological Health27:45 – Nuance about Navigating Personal Choices 29:30 – Professor Harris’s Personal Routine30:50 – What Really Matters for Longevity #omega3 #metabolichealth #sardinediet #omega6 #linoleicacid #PUFA #saturatedfat #hearthealth #brainhealth #staycurious #omegaquant #mitochondria #hormones #brainhealth #brainaging #dementia #EPA #DHA #ALA #salmon #seedoils #mitochondria #atherosclerosis #Apoe4 #Apoe #cholesterol #apoB #fishoil Learn more about your ad choices. Visit megaphone.fm/adchoices

Nature paper: https://www.nature.com/articles/s42255-024-00989-xHouse Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"10% off any item (non-bundle) with code "NICK10"My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nutsWnt, Alzheimer's: https://www.frontiersin.org/articles/10.3389/fnagi.2019.00184/fullCase Report: https://pubmed.ncbi.nlm.nih.gov/30972028/0:00 – New Study!0:30 – Channel Intro 0:40 – Wnt Signaling Background 1:37 – Sclerostin increases with age2:44 – Sclerostin crosses BBB3:20 – Sclerostin impairs cognition and synaptic plasticity4:56 – Sclerostin increases pathological Amyloid-Beta processing5:42 – Sclerostin negatively associated with cognition 6:09 – Blocking Sclerostin improves amyloid, plaque, and cognition6:47 – Bone Drug for Brain?7:15 – Surprising personal disclosure 8:28 – My first media partner: House of Macadamia (20% off)A BIG thank you to Mr. Andrew Degryse for his amazing work on my new thumbnails. Learn more about your ad choices. Visit megaphone.fm/adchoices

For the written breakdown with all the references and extra details, see: https://staycuriousmetabolism.substack.com/p/why-omega-3-supplements-dont-work?r=40ekz2 To try the Accentrate Omega Max supplement containing Lysoveta, click HERE: https://www.fenixhealthscience.com/staycuriousUse code StayCurious for 20% off.NAD+ for Alzheimer’s Prevention Letter:https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2Omega-3 Brain Metabolism Letter: Coming soon to https://staycuroiusmetabolism.com ... sorry, we changed the calendar orderCreatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Most omega-3 supplements fail to protect the brain—not because DHA is useless, but because it’s delivered in the wrong biochemical “package.” In this video, I break down the omega-3 paradox: fatty fish is consistently linked with better brain aging, yet many trials of DHA supplements show disappointing results.The key is transport. A specific form—lysophospholipid DHA (lysoDHA)—can use a dedicated brain transporter (MSFD2A). In animal studies, lysoDHA dramatically increases brain DHA, boosts BDNF (a major brain growth signal), and improves memory performance compared to conventional DHA forms that often end up in fat tissue instead.I’ll walk you through the evidence, explain why “DHA” isn’t one thing, and give an action plan: food strategies (fatty fish, roe, krill) and supplement considerations—especially if you carry ApoE4 and may break down DHA faster in the brain. We’ll also cover additional high-yield neuroprotective moves: exercise, creatine, and more.References + extra nuance are in the newsletter linked above.Chapters0:00 – Most Omega-3 Supplements Don’t Work1:38 – Video Roadmap: What We’re Going to Cover2:46 – Chapter 1. The Omega-3 Paradox: Why Omega-3 Supplements Fail4:40 – Chapter 2. Lyso-DHA is The Express Courier to the Brain5:51 – Lyso-DHA Boosts Brain DHA Levels Better 8:47 – Translating the Animal Data to Humans9:42 – Chapter 3. The Action Plan 10:28 – The Omega-3 Supplement I Use and Why12:45 – Chapter 4. Other Neuroprotective Strategies#Omega3 #DHA #BrainHealth #AlzheimersPrevention #APOE4 #FishOil #CognitiveHealth #Neuroprotection #BDNF #Longevity #NutritionScience #Supplements #StayCurious #MetabolicHealth #Omega3Index #Sardines #Salmon #KrillOil #Neuroscience #EvidenceBased Learn more about your ad choices. Visit megaphone.fm/adchoices

DISCLAIMER: This is NOT a "You Should" video. I am also NOT making claims about the dangers, or lack thereof, of high LDL is particular metabolic contexts (e.g. LMHR). However, I believe that when it comes to health more OPTIONS/TOOLS are generally better. Therefore, take this for what it's worth: information for you to act on (or ignore) as you see fit. House Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! "Clean and Simple" and "Mac-nificent"10% off any item (non-bundle) with code "NICK10"My Blog on Macadamia: https://ketodietapp.com/Blog/lchf/macadamia-nuts-king-of-keto-nuts0:00 -- Overview0:49 -- 2 phases1:20 -- Part Ia: Specific fibers4:10 -- Part Ib: Fatty acid profile8:30 -- Macadamia9:51 -- Part II 4 Levers for LMHR14:05 -- Ranking the 4 Levers14:29 -- "rock and hard place" patients16:50 -- Not Tribal, a collaboration Saturated Fat Meta-analysis: https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextOreoVsStatin: https://www.mdpi.com/2218-1989/14/1/73Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/Arabinoxylan paper: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00166-4Tahini dressing: https://ketodietapp.com/Blog/lchf/easy-keto-tahini-dressingTahini: https://amzn.to/42JFSai (Amazon)Icelandic Cod Liver: https://amzn.to/3I5j0bW (Amazon)Tazo Dark Chocolate with Ginger: https://amzn.to/49jMCOK (Amazon) Learn more about your ad choices. Visit megaphone.fm/adchoices

For more nuances, references and a written breakdown, join the StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/the-ldl-illusion-what-statin-trials?r=40ekz2 Statins and Mitochondrial Health: https://youtu.be/qHXMI3DudEc Breaking Statins (with a Hammer): https://youtu.be/cX7qzj4qazg Description:What if the number your doctor focuses on most isn’t actually predicting what matters? LDL cholesterol has become the central metric in cardiovascular medicine because it’s easy to measure and easy to change, and easy to standardize. But large-scale analyses suggest that reductions in LDL cholesterol may be a surprisingly weak predictor of real cardiovascular outcomes.In this video, I break down a major umbrella review published in the European Heart Journal covering nearly 200,000 patients across 20 randomized controlled trials. The core question is simple but uncomfortable: does lowering LDL cholesterol reliably predict fewer heart attacks, strokes, or deaths? The answer, based on the data, is not what most people expect.We also look at replication data from JAMA Internal Medicine, explore why statins may still help certain patients despite LDL being a poor surrogate marker, and explain the concept of pleiotropy—how drugs can work through multiple biological pathways unrelated to cholesterol.Chapter:0:00 – Why LDL Cholesterol Can Be Misleading (The Hot Chocolate Analogy)1:37 – New Meta-Analysis: 20 Randomized Controlled Trials Reviewed3:17 – Why LDL Reductions Failed to Predict Heart Outcomes4:37 – Replication Matters: Independent Trials Show the Same Pattern5:54 – One Pill, Many Effects: How Statins Work Beyond LDL9:45 – Final Takeaway: Why Surrogate Markers Can Mislead in Medicine#LDL #Cholesterol #HeartDisease #Statins #CardiovascularHealth #MetabolicHealth #Inflammation #ApoB #PrecisionMedicine #EvidenceBasedMedicine #HealthScience #MedicalEducation #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2309822 0:00 - New Microplastics Paper in NEJM! 0:47 - Methods 1:15 - Results 3:08 - 11 Solutions to reduce exposure *A criticism of the data in this paper will be that they are "associative." This was an "observational" trial, not an RCT. Technically, causality isn't proven. However, it's important to keep in mind that (1) You can't do an RCT on this topic with hard outcomes... you can't randomize a group a humans to microplastics exposure and then monitor for the outcomes of heart attack, stroke and death. (2) These data are consistent with prior work and have biological plausibility, i.e. there are data that microplastics can induce an inflammatory and immune response, signs of which we also see in this paper with the increase in immune cell activation markers and inflammatory cytokines (3) In general, the "cost" to reducing microplastics is inconvenience at most. If you choose to drink filtered tap water out of your own stainless steel bottle, rather than bottled, at absolute worst you get negligible health benefit and that water bottle doesn't end up in the ocean as pollution. Beat the microbead: https://www.beatthemicrobead.org/guide-to-microplastics/PFAS free: https://pfascentral.org/pfas-free-products/My favorite plastic-free tea company: https://yogiproducts.com/all-teas/ Learn more about your ad choices. Visit megaphone.fm/adchoices

For written details on this paper, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-art-of-a-heartbeat-one-of-the?r=40ekz2 Snyder Interview 1: https://youtu.be/mCrc4gfbK2o Snyder Interview 2: https://youtu.be/kMpGkg4zMOU Snyder Interview 3: This one!Snyder Interview 4: Coming Soon…Leptin Resistance Letter: https://staycuriousmetabolism.substack.com/p/obesitys-secret-letters-the-hidden?r=40ekz2 Gift Guide: https://staycuriousmetabolism.substack.com/p/saint-dr-nicks-holiday-gift-guide?r=40ekz2 This conversation with Stanford’s Professor Michael Snyder breaks down one of the most important exercise studies ever published — a deep, molecular look at what really happens inside your body when you work out. We explore how thousands of molecules shift in real time, why inflammation during exercise is actually a good thing, how omega-3 signaling, mitochondrial remodeling, nitric oxide pathways, and metabolic flexibility all come together in a coordinated “molecular choreography,” and why your insulin sensitivity can completely change how your body responds to the same workout. We also discuss VO₂ max, the difference between sprinting and steady-state cardio, how to think about recovery, and why exercise affects every organ in your body, from muscles to brain. If you want a deeper understanding of the biology behind fitness — and why personalized exercise matters — this interview is a must-watch. Stay Curious.Chapters0:00 – A Workout for Your Brain0:30 – Re-Introducing Professor Snyder1:30 – The Exercise Study That Changed Everything6:29 – The Four Molecular Response Clusters8:53 – The “Fitness Inflammatory Signature” Explained12:20 – Omega-3 Surges, Saturated Fats Drop16:30 – Why I Keep Re-Reading This Study17:40 – The Discovery of Lac-Phe (A New Appetite Signal)20:07 – Sprinting vs. Steady State: What Wins?25:40 – How Insulin Resistance Changes Your Exercise Response28:53 – The Exercise Graph That Blows People’s Minds34:40 – Exercise Isn’t About Calories — Here’s Why37:30 – Morning vs. Afternoon Exercise: What’s Best?40:53 – Post-Meal Walks and “Exercise Snacks”#ExerciseScience #MetabolicHealth #InsulinResistance #VO2max #MolecularFitness #StanfordResearch #MichaelSnyder #NickNorwitz #LongevityScience #FitnessMotivation #HealthOptimization #Omega3 #Inflammation #Metabolism #StrengthTraining #Sprinting #EnduranceTraining #Wearables #PersonalizedHealth #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

15% off any House of Macadamia products with code "NICK15"Affilitate Link: https://glnk.io/9ymmp/nicknorwitzphd Cao, Cell 2008: https://pubmed.ncbi.nlm.nih.gov/18805087/Chan, Jour Biol Chem 2015: https://www.jbc.org/article/S0021-9258(20)40251-0/fulltextGarg, Jour Nutr 2003: https://pubmed.ncbi.nlm.nih.gov/12672919/Chapters0:00 -- Intro1:09 -- Lipokines2:00 -- 1. Insulin Sensitivity2:43 -- 2. LDL, HDL, TG3:15 -- 3. Anti-inflammatory4:50 -- 4. Satiety 5:30 -- 5. Bone and Skin6:40 -- Complexities in studying POA8:20 -- Others reasons to love Macs!9:41 -- House of Mac*Roasting nuts at home: Roasting nuts is a tricky business. If you like roasted nuts, I suggesting using temperatures at or below 265 - 285 F (130 - 140 C) for 20 minutes. The temperature sensitivity of nuts derives from their fragile omega-6 fats. But because macadamia nuts are low in omega-6, they are more stable. Even at 150 °C/ 300 °F, macadamia are okay. In fact, if you roast equal amounts of macadamia and walnuts at 300 F, the macadamia will end up with 1/30th the oxidized fats (https://pubmed.ncbi.nlm.nih.gov/25766804/). Learn more about your ad choices. Visit megaphone.fm/adchoices

For all the references and extra details, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2Momentous CreatineUse code StayCurious for up to 35% off your first order at livemomentous.com or follow this link: https://www.livemomentous.com/discount/STAYCURIOUS?redirect=/collections/creatine&utm_source=youtube&utm_medium=sponcon&utm_campaign=nick-norwitz&utm_content=creatine When it comes to reputation, quality, and rigorous third-party testing, you really can’t go wrong with Momentous Creatine Monohydrate. It’s extensively tested for heavy metals and banned substances. My personal preference is their pure, unflavored, no dyes or sweeteners, micronized creatine monohydrateDESCRIPTION: Creatine is one of the most researched supplements in history—yet most people still misunderstand how it works and what it actually does.In this video, I break down creatine from first principles to real-world use. We start with the biochemistry: what creatine is and how it promotes muscle growth—cell hydration, satellite cells, gene expression—and review human randomized controlled trials showing increases in lean mass and even reductions in fat mass.From there, we go beyond muscle. Creatine plays a critical role in brain energy metabolism, and emerging data show benefits for memory, aging, depression, sleep deprivation, and possibly neurodegenerative disease. I walk through the human trial data, explain why higher doses are often needed for brain effects, and outline practical dosing strategies that maximize benefits while minimizing GI issues.We also clear up common myths about creatine—hair loss, kidney damage, cycling—and end with simple, evidence-based protocols you can actually use.Creatine Ice Cream Recipe Warm 1 pint (473 ml) of Heavy Cream in a pan.While the cream is warm, but not hot, add in 5 egg yolks and mix immediately. You don’t want the yolks to cook. If they do cook, start over (but keep your creamy egg accidents for a snack). Add vanilla, organic liquid stevia, and a pinch of salt to taste. Add four 5 g Scoops of creatine. The recipe makes about 3-4 servings. Obviously, you can double, triple or quadruple as you see fit.Here’s where you can get creative. In the batch shown I added Turkish coffee, but you can also add anything you want. Mint, melted chocolate or cocoa powder, berries. Make it your own.Then pile it into an ice cream maker and turn it on until it reaches the desired consistency. Chapters:0:00 – Creatine Panic at the Airport (Why It’s Misunderstood)1:15 – Roadmap: What Creatine Is, How It Works, Muscle and Brain2:00 – What Creatine Actually Is (Biochemistry Basics)4:00 – How Creatine Drives Muscle Growth and Performance6:13 – Creatine Mechanisms Recap (Energy, Cells, Genes)7:00 – Human Meta-Analysis: Creatine Increases Lean Mass8:21 – Evidence-Based Creatine Protocols and Practical Tips11:16 – Creatine for Memory, Aging and Brain Energy13:41 – Can Creatine Offset Sleep Deprivation Effects?14:46 – Optimal Dosing for Brain Health15:03 – Creatine Myths: Hair Loss, Kidneys, Steroids, Cycling17:10 – Behind the Scenes: How This Video Was Made#Creatine #MuscleScience #BrainHealth #Cognition #ExerciseScience #Metabolism #ATP #Hypertrophy #StrengthTraining #Longevity #Neuroscience #MentalHealth #SleepScience #SupplementScience #NutritionScience #HealthEducation #EvidenceBased #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Meta 41 RCTs (AJCN, 2024): https://ajcn.nutrition.org/article/S0002-9165(24)00009-1/fulltextFiber and IBD (Cell Host and Microbe, 2023): https://pubmed.ncbi.nlm.nih.gov/37967555/Diet Coke Study, PNAS 2022: https://www.pnas.org/doi/full/10.1073/pnas.2213120119 Microbiome and Sweeteners, Nature 2014: https://pubmed.ncbi.nlm.nih.gov/25231862/ OreoVsStatin, Metabolites 2024: https://www.mdpi.com/2218-1989/14/1/730:00 - Introduction0:55 - 1. Keto2:38 - 2. Saturated Fat4:31 - 3. Statin 6:22 - 4. Meat8:45 - 5. Fructose10:54 - 6. Fiber12:29 - 7. Seed oils 13:57 - 8. Diet Coke 16:11 - 9. LMHR and CVD risk 18:17 - 10. Diet and IBD 20:30 - 11. Carbohydrate Insulin Model 23:50 - 12. Oreo Vs StatinHouse Of Macadamia Landing Page: partner.houseofmacadamias.com/nick-norwitz**15% OFF All Bundles! 10% off any item (non-bundle) with code "NICK10" Learn more about your ad choices. Visit megaphone.fm/adchoices

For references, extra details and early access to data like these, see the StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-metabolic-origins-of-a-sweet?r=40ekz2 Sugar Diet, Video: https://youtu.be/IAc_7r_hVI8The Gene That Controls Sugar Cravings, Video: https://youtu.be/_gKEV7Wv8z4 Description:Why can some people effortlessly say no to dessert, while others feel pulled toward sugar like metabolic gravity?New research is revealing that sugar cravings aren’t a failure of willpower — they’re encoded in metabolism. In this video, we break down surprising new science showing how a gut-based nutrient sensor, specific microbes, and key hormones work together to dial sugar cravings up or down.You’ll learn how a fatty-acid receptor in the gut (FFAR4) influences sweet preference, how the microbiome and vitamin B5 fit into the picture, and how hormones like GLP-1 and FGF21 signal all the way from the gut to the brain to regulate sugar intake.We’ll also cover practical, evidence-based ways to work with your biology — not against it — if you struggle with intense sugar cravings.Chapters0:00 – The Sugar Black Hole: Why Cravings Feel Unstoppable2:30 – FFAR4: The Gut Receptor That’s Lower in Diabetes3:45 – How FFAR4 Genetics Shape Sugar Preference4:35 – Proving Causality: What Animal Experiments Reveal5:47 – What We Know So Far6:20 – The Gut Microbe and Vitamin That Control Cravings8:08 – The Full Gut–Liver–Brain Sugar Circuit10:20 – 3 Science-Backed Ways to Tame Sugar Cravings#sugaraddiction #sugarfree #neuroscience #metabolism #metabolichealth #FFAR4 #sucrose #glucose #GLP1 #Bvitamins #liverhealth #DHA #omega3 #SugarCravings #AppetiteControl #GutBrainAxis #Hormones #FGF21 #MicrobiomeScience #NutrientSensing #MetabolicFlexibility #InsulinSensitivity #BloodSugarControl #CravingControl #FoodSignals #NeuroscienceOfEating #PrecisionHealth #LongevityScience #HealthEducation #ScienceExplained #NutritionResearch #Biochemistry #MetabolicScience Learn more about your ad choices. Visit megaphone.fm/adchoices

Paper: https://www.nature.com/articles/s42255-023-00961-10:00 - Intro, Study on Milk and Diabetes0:47 - The Nature Metabolism Paper1:10 - LP vs LNP1:40 - LN vs LNP (GG) genetic coding2:50 - LNP + Milk Intake = Reduced Diabetes Risk4:18 - Why? Mechanism?7:00 - Zooming out... Learn more about your ad choices. Visit megaphone.fm/adchoices

For extra details, references, and early access to content, see the StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/new-science-identifies-the-specific?r=40ekz2 Referenced VideosTool Cool for Stool, Bile Acids: https://youtu.be/d0WuCIZxPxU Statins, GLP-1, (T)UDCA: https://youtu.be/6NomrgjK1yQ What if a simple molecule made by your gut could literally protect you from a heart attack? New research in Nature Cardiovascular Research reveals that a specific bile acid—DCA—produced by your own microbiome can reduce blood clotting, improve vascular health, and even protect heart tissue during a heart attack.People with coronary artery disease have lower levels of this molecule and fewer microbes that produce it. Lower DCA means “clottier” blood—and a higher chance of heart attacks and strokes. This video breaks down how DCA works, why your gut microbes matter more than you think, and how lifestyle factors may activate the same anti-clotting pathways.The full story is more intricate, more fascinating, and more hopeful than you might expect. StayCurious.Chapters0:00 – A Simple Molecule that Protects Your Heart1:27 – A Transparency Moment: Stay Curious Journey2:21 – Patients with Heart Disease Have Different Microbiomes and Bile Acids4:37 – Summary, So Far…5:05 – Higher DCA Associates Better Cardiovascular Outcomes6:00 – Is This Causal? Yes. Here’s the Mechanism7:00 – The Promise of Microbiome (Poop) Transplants!8:37 – Turning Insights into Action12:32 – Metabolism is Unified#HeartHealth #CardiovascularHealth #Microbiome #GutHealth #BloodClotting #Metabolism #BileAcids #TGR5 #Longevity #HealthScience #NickNorwitz #StayCurious #NatureResearch #StrokePrevention #heartattackprevention Learn more about your ad choices. Visit megaphone.fm/adchoices

First... PLEASE, watch to the end... there's a twist and I want you to see it, hear me out, and contemplate the "WHY" of this video. Not the "click bait" you may be expecting...Diet DetailsButter: 4.55 lbs butter = 2.064 kg. Using 102 kCal/Tbsp (14.2g/Tbsp) that's 145.35 Tbsp servings and ~ 14,825 Calories from Butter alone over the week (2,118 Butter Calories/day). Total daily Calories were 4,317 Calories/day. 81% Cal Fat, 18% Cal protein 1% Cal carbs. Based on my BMR, calculated using the Harris-Benedict equation (1,530 Cal/day) and providing 800 extra Calories/day for activity (a liberal estimate, as I resistance train up to 1 hour daily and don't current do much standard cardio), my daily surplus should have been 1,987 Calories/day and 13,909 Calories over the week. Using 3,500 "excess" Calories/lb I should have gained 4 lbs. But, I lost 0.8 lbs.Lp(a) dropped 10%. TSH was ~1 (which is normal for me). Insulin post-butter week was 3.5.0:00 - 4.5 lbs Butter in 1 Week0:42 - Lesson 11:24 - Lesson 22:03 - Lesson 33:08 - Why it's a Fail3:55 - *Bonus* content: Why This Video?Like this shirt? https://metabolismshirts.myspreadshop.com/all Learn more about your ad choices. Visit megaphone.fm/adchoices

For more details and all the references, see the associated letter: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2Referenced LettersStatin GLP-1 Letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2 Stress Literally Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2Referenced VideosMichael Snyder Interview 1: https://youtu.be/mCrc4gfbK2o Kale and Chocolate Video: https://youtu.be/Shfh8IaRTV4 Statin GLP-1 Video: https://youtu.be/6NomrgjK1yQ Red Light Video: https://youtu.be/X808Rg09JQM EMR TEK Affiliate Link: https://emr-tek.com/?snowball=NICK20Discount Code: NICK20 Description: What if a banana could spike your blood sugar more than a cookie? What if stress could literally force your liver to make sugar? And what if something as simple as light exposure after meals could lower blood glucose?In this video, I break down seven evidence-based ways to control blood sugar that go far beyond “just eat fewer carbs.” We’ll cover how post-meal walking activates insulin-independent glucose uptake, why meal order can reduce glucose spikes by over 70%, how stress directly signals the liver to produce sugar, and why foods like kale can spike glucose more than chocolate in some people.We’ll also dig into continuous glucose monitors, medication effects on blood sugar (including statins and GLP-1 drugs), the surprising benefits of allulose, and how breathing and meditation can directly reduce glucose production through a brain-to-liver neural pathway.All studies and references discussed in this video are linked in the written companion piece linked above.Chapters0:00 – How to control your blood sugar 1:03 – How a Postprandial Stroll Actually Works 3:05 – How Red and Infrared Light Actually Works3:42 – Macronutrient Order Matters. Here’s Why4:38 – Banana, Cookies, and Continuous Glucose Monitor5:30 – Know Your Medications and What They Do to Your Blood Sugar6:03 – Celebrating YOU! Thank You!7:22 – Allulose: Fructose’s Bizarre Twin 8:16 – The Liver-Brain Axis: How Stress Literally Makes Sugar#bloodsugar #diabetes #metabolichealth #obesity #metabolism #redlight #infraredlight #sugar #keto #lowcarb #fruit #microbiome #bloodsugar #glucose #insulinresistance #metabolichealth #diabetes #prediabetes #bloodsugarcontrol #glycemiccontrol #metabolism #healthscience #nutritionscience #precisionnutrition #microbiome #exercisephysiology #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Paper: https://www.nature.com/articles/s42255-024-00978-0BMJ human RCT: https://pubmed.ncbi.nlm.nih.gov/30429127/Video editing generously provided by Vincent at House of Macadamia http://partner.houseofmacadamias.com/nick-norwitz-15% Off All Bundles-10% off any item (non-bundle) with code "NICK10"0:00 - Fast vs Slow Metabolism, Intro0:37 - Defining the Question1:15 - New research in Nature Metabolism2:26 - Fusion and Fission2:44 - In obesity, Fission and Fusion are out of balance3:03 - Results5:35 - I'm Nerding out, Hard!6:45 - Relevance 7:58 - LCD metabolic advantageWHAT ABOUT specific dietary components and mitochondrial fusion? …Thanks to @AnouarElHaji on X (Twitter) for reminding me about this fantastic 2018 Nat Comm paper and asking me to comment. I LOVE community input!https://www.nature.com/articles/s41467-018-05614-6 (nb: I say remind because he points out “You used to have a YT video discussing this paper,” which I did, lol… TBT!)Overview of this other mito fusion paper: A set of experiments, including a double-blinded human RCT, showing that the saturated fat stearic acid (C18:0; this annotation means 18 carbon fatty acid with 0 double bonds) “[R]apidly and robustly causes mitochondrial fusion in people within 3 h after ingestion.” The authors conclude: Stearic acid “C18:0 [i]s a dietary metabolite that is sensed by our bodies to control our mitochondria… [consistent with data that C18:0 may] decreas[e] cardiovascular and cancer risk.”Rich sources of stearic acid include Tallow (~20g/100g) and Cocoa butter (34g/100g).For more details, see THIS X post: https://x.com/nicknorwitz/status/1774760972973908132?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices