MS Living Well: Key Info from Multiple Sclerosis Experts – Détails, épisodes et analyse

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MS Living Well: Key Info from Multiple Sclerosis Experts

Barry Singer, MD

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Fréquence : 1 épisode/45j. Total Éps: 57

Barry Singer, MD, Director of The MS Center for Innovations in Care at Missouri Baptist Medical Center, interviews global expert guests about the latest treatments, innovations and tips for people living with multiple sclerosis.

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The Science of MS Supplements

Saison 7 · Épisode 8

mardi 18 novembre 2025 • Durée 36:43

Many people living with multiple sclerosis are interested in whether vitamins, supplements, or nutrition can play a supportive role in long-term brain and immune health. Two areas that have received growing research attention are alpha-linolenic acid, a plant-based omega-3 fatty acid found in foods like flaxseed and walnuts, and vitamin D, a hormone-like nutrient involved in immune regulation that is often low in people with MS. With so much information online, it can be difficult to know what is truly supported by research versus what is based on personal stories or assumption. New studies are helping us understand these topics more clearly.

We explore new insights from large-scale cohort studies and randomized clinical trials assessing the potential role of alpha-linolenic acid and high-dose vitamin D supplementation in early MS. Biomarker-based findings show an association between higher alpha-linolenic acid levels and reduced relapse risk and disability progression over long-term follow-up. The D-Lay MS trial demonstrated a reduction in disease activity in people living with MS receiving high-dose vitamin D early in their condition.

Jamie Holloman MD, neurologist at The MS Center for Innovations in Care, interviews:

Marianna Cortese MD PhD, Senior Research Scientist, Department of Nutrition at Harvard T.H. Chan School of Public Health

Professor Éric Thouvenot, Head of the Neurology Department, Nîmes University Hospital, France

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Reengineering Hope: CAR-T Therapy for Multiple Sclerosis

Saison 7 · Épisode 7

mardi 14 octobre 2025 • Durée 44:08

CAR-T therapy, short for chimeric antigen receptor T-cell therapy, is already transforming treatment for blood cancers like lymphoma and leukemia and is now being tested in early trials for multiple sclerosis. In this approach, a person's own T cells (or sometimes donor T cells) are collected and reengineered in the lab with a special "chimeric" receptor on their surface. Once infused back into the body, these "designer" T cells can specifically hunt down B cells, including those hiding in the brain and spinal cord that may drive progressive MS. This is a key difference since current B-cell depleting antibody treatments don't reach effectively into the central nervous system.

Like any powerful therapy, CAR-T is not without risks. Side effects can include serious infections, cytokine release syndrome (fever, chills, body aches), and even neurological symptoms like confusion or seizures. Still, the early results in MS patients are remarkable, bringing fresh hope for those with progressive disease. Beyond MS, CAR-T is being explored across autoimmune neurological diseases from myasthenia gravis to stiff person syndrome, opening a promising new frontier in care.

Barry Singer MD, Director of the MS Center for Innovations in Care, interviews:

Jeffrey Dunn MD, Clinical Professor and Chief of Neuroimmunology in the Department of Neurology & Neurological Sciences at Stanford University

Amanda Piquet MD, Professor of Neurology and Céline Dion Foundation Endowed Chair at the University of Colorado Anschutz School of Medicine

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MS & The Spinal Cord

Saison 6 · Épisode 6

mardi 20 août 2024 • Durée 39:50

The spinal cord serves as the main communication highway between the brain and body. Did you know that 80% of people with multiple sclerosis have spinal cord lesions on MRI? These lesions can disrupt specific neural pathways, leading to common MS symptoms like numbness, weakness, impaired coordination, balance issues, bladder problems, constipation, and sexual dysfunction. For instance, damage to the corticospinal tract on one side of the spinal cord can weaken an arm or leg.

A remarkable autopsy study revealed that nearly 90% of people with MS still had active inflammation in the spinal cord. This finding brings new hope for potential treatments, even for older and progressive MS patients. Advances in imaging technology, including more powerful MRI scanners (3 Tesla and higher), are enhancing our ability to see inside the spinal cord, which is as thin as a pinky finger. Improved spinal cord imaging is driving the development of new therapies in clinical trials and helping identify those at risk for worsening disability, ultimately guiding better treatment decisions.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Gabriele De Luca MD DPhil, Professor of Clinical Neurology and Experimental Neuropathology, University of Oxford, United Kingdom

Bruce Cree MD PhD, Professor of Neurology at University of California, San Francisco School of Medicine

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Uncommon Multiple Sclerosis Symptoms

Saison 6 · Épisode 5

mardi 7 mai 2024 • Durée 35:54

Awareness of the more uncommon multiple sclerosis symptoms can lead to an earlier diagnosis and appropriate treatment. For instance, experiencing electrical shock sensations when bending the neck forward, known as Lhermitte's sign, may indicate an attack on the cervical spinal cord. Likewise, excruciating bolts of pain across either side of the face, called trigeminal neuralgia, can be caused by a MS relapse. The MS hug, an unfriendly, squeezing sensation around the torso, can respond to muscle relaxants and nerve pain medications. Some MS symptoms, like tingling in legs, only surface when exercising or overheated (Uhthoff's phenomenon).

Vertigo, a spinning sensation, can be a sign of MS, especially when lasting days and accompanied by other symptoms like gait imbalance, facial numbness and double vision. Brainstem attacks may also lead to swallowing issues and shaky vision. While MS bladder issues are commonly addressed, bowel problems, including constipation, urgency, incontinence and trouble evacuating, should not be overlooked. Overcoming stigma is essential to treat sexual dysfunction.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Mary Ann Picone MD, Medical Director, MS Center at Holy Name Medical Center, Teaneck, New Jersey

Bruce Hughes MD, Director of the Ruan Multiple Sclerosis Center, MercyOne, Des Moines, Iowa

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Harnessing AI: Transforming MS Care

Saison 6 · Épisode 4

mardi 9 avril 2024 • Durée 39:01

Prepare to be intrigued by the groundbreaking intersection of artificial intelligence (AI) and multiple sclerosis care! By combing through extensive databases, including genetic information and real patient records, AI can forecast with remarkable accuracy the likelihood of MS onset. In the near future, AI could even serve as a guiding light for clinicians and MS patients in selecting the most suitable disease-modifying therapies, armed with predictive algorithms tailored for each individual.

But the marvels of AI don't stop there. In a recent study, AI detected an astonishing 93% of new and enlarging T2 brain lesions in MRI scans, far surpassing the 58% accuracy rate of routine radiology reads. Artificial intelligence is also making waves in drug development and early clinical trial design, accelerating the quest for innovative therapies to combat MS.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Tal Arbel PhD, Professor, Department of Electrical and Computer Engineering, McGill University, Montreal

Michael Barnett MBBS (Hons) FRACP PhD, Professor in Neurology, University of Sydney and Director of the MS Society Clinic & MS Clinical Trials Unit at the Brain and Mind Centre

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Navigating MS with Other Medical Conditions

Saison 6 · Épisode 3

mardi 19 mars 2024 • Durée 42:17

Living with multiple sclerosis isn't just about managing the condition itself, but often involves navigating a myriad of additional health concerns known as comorbidities. Individuals with MS face a higher risk of experiencing new relapses when dealing with comorbidities like high cholesterol or depression. Furthermore, autoimmune diseases such as psoriasis and inflammatory bowel diseases like Crohn's disease and ulcerative colitis are more prevalent among those with MS. There is even a heightened risk of bladder cancer.

Interaction of MS treatments and other common conditions like high blood pressure (hypertension), high cholesterol and diabetes are addressed. Experts share how immunotherapies used for other autoimmune diseases may benefit or actually worsen MS disease activity. Crucial information is shared on cancer treatment concerns in individuals with MS. Adopting healthy lifestyle behaviors is essential to minimize the development of these comorbidities.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Ruth Ann Marrie MD PhD, Professor of Medicine and Community Health Sciences at University of Manitoba, Canada

Mark Cascione, MS neurologist, South Tampa MS Center, USA.

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Hormones and Multiple Sclerosis

Saison 6 · Épisode 2

mardi 27 février 2024 • Durée 38:26

Sex hormones, such as estrogens and testosterone, affect each individual's journey living with multiple sclerosis. While both genders face equal MS risk before puberty and after menopause, women experience up to three times higher risk during their reproductive years. Pregnancy generally brings less relapses, potentially attributed to high estriol levels. However, navigating treatment decisions well while trying to conceive and after delivery requires finesse and expertise. Equip yourself with the latest women's health info regarding MS, covering topics from birth control and fertility treatments to menopause and osteoporosis.

Testosterone has important anti-inflammatory and neuroprotective benefits in multiple sclerosis. Nevertheless, men are at higher risk for disability progression then women. Declining testosterone levels over time (called andropause) and Y chromosome genes may tilt the scales towards disability. Listen to current testosterone research including potential remyelination benefits.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Maria Houtchens MD, founding director of the Women's Health Program at the Brigham MS Center and Associate Professor of Harvard Medical School in Boston, USA

Jorge Correale MD, Head of Neuroimmunology and Demyelinating Diseases at the Dr. Raúl Carrea Institute of Neurological Research in Buenos Aires, Argentina

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Revolutionizing Multiple Sclerosis Care: B-Cell Therapy

Saison 6 · Épisode 1

mardi 30 janvier 2024 • Durée 39:48

In a paradigm-shifting discovery, researchers uncovered that B cells, not T cells, wield significant influence on orchestrating neurological damage in MS. Join UCSF Professor Dr. Stephen Hauser as he shares the remarkable odyssey from hurdles to triumphs of developing B cell monoclonal antibody treatment for multiple sclerosis. Disease impact, safety concerns and personalization of MS treatment of these medications including Ocrevus (ocrelizumab), Kesimpta (ofatumumab) and Briumvi (ublituximab) are highlighted.

Brain-penetrant BTK inhibitor therapies that may offer more direct targeting of B cells within the central nervous system, potentially unlocking new possibilities in treating progressive forms of MS. Professor Heinz Wiendl explores the connection between Epstein-Barr virus infection of B cells and the initiation and progression of MS including trials investigating strategies to target EBV-infected B cells. Pioneering approaches like CAR-T therapy and brain shuttle techniques provide optimism for the next generation of MS treatment.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Stephen Hauser MD, Professor of Neurology at the University of California, San Francisco (UCSF) and Director of the UCSF Weill Institute for Neurosciences

Heinz Wiendl MD, Professor of Neurology and Chair of the Department of Neurology at the University Hospital of Muenster in Germany

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Recipe for Resilience: The Blind Cook and NMOSD

Saison 5 · Épisode 10

mardi 19 décembre 2023 • Durée 38:12

Christine Ha, an award-winning blind chef and restauranteur, shares her experience grappling with neuromyelitis optica spectrum disorder (NMOSD). Facing relapses with the inability to walk and feed herself that challenged her independence, she leaned on the support from family and friends. As she lost her sight due to optic neuritis in both eyes, Ms. Ha had to embark on a journey of rediscovery in the kitchen, starting with the fundamentals. Winning MasterChef Season 3 marked a turning point, propelling her culinary career forward despite the obstacles posed by her disability.

NMOSD is an autoimmune disease in which an antibody attacks water channels on astrocyte cells in the optic nerves, spinal cord and sometimes the brain. Attacks or relapses can be devastating and incomplete recovery from attacks is typical. Like Ms. Ha, some people living with the condition can be misdiagnosed with multiple sclerosis. A blood test for the aquaporin-4 antibody is key to getting diagnosed correctly early. Since 2019, highly effective treatment options have been FDA-approved that reduce relapses by 77-94%.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Christine Ha, "The Blind Cook". Her first cookbook, Recipes from My Home Kitchen, was a New York Times best-seller. Ms. Ha's first restaurant in Houston, The Blind Goat, was named a semi-finalist for 2020 Best New Restaurant in America by the James Beard Foundation. She was also named a James Beard finalist for Best Chef in Texas in 2022.

Michael Levy MD PhD, Associate Professor at Harvard Medical School and Director of the Neuroimmunology Clinic and Research Laboratory

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Making Strides: Enhancing MS Mobility

Saison 5 · Épisode 9

mardi 10 octobre 2023 • Durée 37:40

Wherever you are on your multiple sclerosis journey, there are many reasons to be optimistic about the future of mobility. Our experts, both holding doctorates in physical therapy, offer invaluable guidance on enhancing your walking abilities through targeted exercise and specialized therapy. Learn how to reduce the risk of falls, alleviate spasticity, and build endurance for a more active life.

Cutting-edge technology, from wearable electrical stimulation devices to incredible exoskeletons, are revolutionizing mobility for those living with MS. Discover how neuromodulation, in conjunction with physical therapy, can pave the way for new neural pathways. Virtual reality and anti-gravity treadmills are redefining therapy options for those people with advanced MS. Moreover, gain insights into conquering travel challenges, empowering individuals living with multiple sclerosis to venture out into the world.

Barry Singer MD, Director of The MS Innovations in Care, interviews Gretchen Hawley DPT, The MSing Link and Annie Morrow DPT, Director of the Stephen A. Orthwein Center.

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MS Living Well: Key Info from Multiple Sclerosis Experts – Détails, épisodes et analyse

Détails du podcast

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Apple Podcasts

Spotify

Liens partagés entre épisodes et podcasts

Other5

Qualité et score du flux RSS

Historique des publications

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Podcasts et contenus similaires

Podcasts Similaires Basées sur le Contenu

Apple Podcasts

Spotify

Other5

Podcasts Similaires Basées sur le Contenu