MS Compass: Guiding Clinical Care – Détails, épisodes et analyse

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MS Compass: Guiding Clinical Care

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Fréquence : 1 épisode/121j. Total Éps: 3

MS Compass: Guiding Clinical Care is a NeurologyLive podcast led by Lindsay Ross, MD, a board-certified neurologist specializing in multiple sclerosis and neuroimmunology at the Cleveland Clinic’s Mellen Center. The series centers on the unique clinical considerations facing women with MS, from emerging research and evolving treatment strategies to gaps in care that are gaining renewed attention. Through conversations with expert guests across neurology and related disciplines, Dr Ross examines how science, advocacy, and real-world practice are shaping the next era of MS care for women.

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Données mises à jour le 11/10/2026

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🇺🇸 États-Unis - Life Sciences
11/10/2026
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3: Cognitive Dysfunction in MS: Rethinking Assessment and Management

Épisode 3

vendredi 25 septembre 2026 • Durée 34:10

Welcome to the MS Compass: Guiding Clinical Care podcast. A clinician-focused podcast led by Lindsay Ross, MD, of Cleveland Clinic, exploring the research, care decisions, and evolving conversations shaping MS treatment for women.

In this episode of MS Compass: Guiding Clinical Care, host Lindsay Ross, MD, is joined by Rachel Galioto, PhD, a Cleveland Clinic neuropsychologist focused on neuroimmunology, to explore how clinicians can better recognize, assess, and manage cognitive concerns in people with MS.

Galioto discusses evolving evidence suggesting that the cognitive profile of MS may be changing in the modern treatment era, with memory and language difficulties potentially playing a greater role than historically appreciated. Ross and Galioto also examine how disease burden, sleep, mood, medications, pain, and other secondary factors can interact to affect cognition, emphasizing that cognitive dysfunction is rarely attributable to a single cause. The conversation concludes with practical guidance on medication review, addressing sleep problems, determining when formal neuropsychological testing is worthwhile, and using cognitive rehabilitation and compensatory strategies to reduce the impact of cognitive difficulties on everyday life.

Episode Breakdown:

0:00 – Introduction to cognitive dysfunction in MS and its impact on patients
1:00 – Defining cognitive dysfunction: brain fog, memory, word-finding problems, and processing speed
5:45 – Rethinking processing speed and limitations of the Symbol Digit Modalities Test
9:20 – How cognitive dysfunction changes across the MS disease course
11:20 – Lesion burden, brain atrophy, and the relationship between MRI findings and cognition
13:30 – Distinguishing MS-related cognitive dysfunction from secondary contributors
17:50 – How stress, mood, and other factors may amplify cognitive difficulties in MS
19:55 – Medication burden, polypharmacy, and therapies that may affect cognition
22:00 – Balancing cognitive effects with the need to effectively manage MS symptoms
23:00 – Sleep as an overlooked contributor to cognitive dysfunction and opportunities for intervention
26:00 – When clinicians should consider formal neuropsychological testing
28:45 – Using neuropsychological testing to guide rehabilitation, accommodations, and future care
30:15 – Key takeaways: addressing modifiable contributors and reducing the daily impact of cognitive dysfunction

Thanks for listening to the NeurologyLive® MS Compass: Guiding Clinical Care podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

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2: Sexual Dysfunction in MS: Practical Strategies for Assessment and Management

Épisode 2

vendredi 8 mai 2026 • Durée 36:00

In this episode of MS Compass: Guiding Clinical Care, host Lindsay Ross, MD, is joined by Tammy Kaplan, MD, assistant professor at Harvard Medical School and vice chair of education for neurology at Mass General Brigham, for a comprehensive discussion on sexual dysfunction in patients with multiple sclerosis. The conversation opens with an overview of the scope and prevalence of sexual dysfunction in MS, emphasizing its impact on quality of life and its frequent underrecognition in clinical practice.

Kaplan outlines a practical framework for understanding sexual dysfunction through primary, secondary, and tertiary contributors, before shifting into strategies for integrating sexual health discussions into routine clinical care. The episode also explores common barriers clinicians face, including time constraints and uncertainty around management, while offering actionable approaches to assessment, communication, and treatment. Additional discussion highlights symptom-specific management strategies, indications for referral, and emerging areas of research, including neuromodulation and hormonal considerations.

Episode Breakdown:

0:00 – Introduction to sexual dysfunction in MS and its impact on quality of life
2:05 – Defining sexual dysfunction: desire, arousal, and orgasm across the sexual cycle
4:20 – Prevalence of sexual dysfunction in MS and variability across studies
5:45 – Primary, secondary, and tertiary sexual dysfunction framework in MS
8:15 – How to assess sexual dysfunction: normalizing conversations and building it into routine care
10:35 – Practical communication strategies and discussing intimacy with patients and partners
16:30 – Identifying underlying causes: bladder dysfunction, medications, and secondary contributors

Thanks for listening to the ® MS Compass: Guiding Clinical Care podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit .

1: Managing Postpartum MS: Safety Data, Relapse Risk, and Real-World Practice

Épisode 1

lundi 26 janvier 2026 • Durée 38:38

In this initial episode of MS Compass: Guiding Clinical Care, host Lindsay Ross, MD, is joined by Edith Graham, MD, assistant professor of neurology at Northwestern University Feinberg School of Medicine, for an in-depth discussion on managing multiple sclerosis during breastfeeding. The conversation examines how postpartum care decisions are evolving as more safety, pharmacokinetic, and infant outcome data become available, particularly around the use of disease-modifying therapies during lactation. Drs Ross and Graham discuss the growing comfort with anti-CD20 monoclonal antibodies, how relapse risk and breastfeeding physiology factor into treatment timing, and the practical considerations clinicians weigh when counseling patients during this critical phase of MS care.

Episode Breakdown:

0:50 – How frequently clinicians continue disease-modifying therapy during breastfeeding
2:15 – Shifting from interferons to monoclonal antibodies in postpartum MS care
3:30 – Lactation physiology and what it means for monoclonal antibody transfer into breast milk
5:50 – Safety data for anti-CD20 therapies including ocrelizumab, ofatumumab, and rituximab
8:15 – Practical differences across anti-CD20 agents and how they influence treatment selection
13:50 – Adjusting infusion premedications to reduce infant exposure during breastfeeding
16:50 – The unique challenges of natalizumab use during the postpartum period
20:10 – Weaning physiology, premature infants, and remaining gaps in breastfeeding safety data
24:30 – Balancing breastfeeding-related relapse protection against postpartum relapse risk
26:55 – Why many clinicians are moving toward a “why not treat” mindset during breastfeeding

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MS Compass: Guiding Clinical Care – Détails, épisodes et analyse

Détails du podcast

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Historique des publications

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