In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies.

00:00 - Introduction to Longevity Roadmap

03:08 - Case Study: A 70-Year-Old Patient's Health

12:07 - Understanding Lipid Management and Atherosclerosis

19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

Hey Sapio Fans,

I’ve got something really exciting for you today—a chance to win a full-body MRI worth $2,500!

This giveaway comes from my new podcast, Longevity Junky (that’s junky with a Y). It’s a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity.

This week’s episode is all about full-body MRIs from Prenuvo, a groundbreaking technology that can identify over 500 conditions—including deadly cancers and brain aneurysms—before they pose a serious threat to your health.

Here’s how you can enter to win this $2,500 Prenuvo MRI scan for free:

1. Go to Apple Podcasts and find the Longevity Junky podcast (that's "Junky" with a Y).
2. Leave a five-star review for the podcast.
3. Subscribe to the podcast.
4. Take a screenshot of your review.
5. Visit LongevityJunky.com (again, "Junky" with a Y).
6. Send the screenshot of your review along with a brief explanation of why you’d like a full-body MRI.

Winners will be announced in 2 weeks—stay tuned and good luck to everyone!

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity.

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal.

• 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life
• 0:03:33 - Average Age When Women Experience Menopause And Perimenopause
• 0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In Women: Premarin And Provera
• 0:13:47 - Benefits Of Hormone Replacement Therapy
• 0:17:12 - Understanding Perimenopause And Testosterone Decline In Women
• 0:22:55 - The Secret Female Hormone: How Testosterone Replacement Can Change Your Life By Dr. Kathy C. Maupin
• 0:23:57 - Hormone Pellet Replacement For Women
• 0:25:02 - Side Effects Of Testosterone Replacement In Women
• 0:27:09 - Benefits Of Testosterone Replacement In Women
• 0:30:57 - Acoustic Wave Therapy For Women

Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion. 

• 0:00:12 - Rob Hamilton’s Background 
• 0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time?
• 0:05:46 - Declining Testosterone Levels In Men Aged 35 To 40
• 0:09:23 - Testosterone Is An Anabolic Hormone
• 0:11:17 - Testosterone Is An Important Hormone To Maintain Health. 
• 0:18:37 - Replacing Testosterone Even If You Feel Like There's Nothing Wrong With You
• 0:19:50 - Options For Increasing Testosterone Levels 
• 0:20:28 - Tongkat Ali, Ashwagandha, And Other Supplements For Increasing Testosterone Levels
• 0:27:55 - Using Clomifene To Increase Testosterone Levels 
• 0:29:20 - How Much Variability On A Day-To-Day Basis Is There In Testosterone In Men?
• 0:30:53 - Options For Testosterone Replacement 
• 0:32:03 - Topical Testosterone Application And Side Effects 
• 0:33:13 - Injectable Testosterone
• 0:35:03 - Titrating Testosterone Pellets For Optimal Therapy 
• 0:37:33 - Risks Of Testosterone Replacement Options
• 0:44:04 - Human Growth Hormones
• 0:45:59 - The Challenges Of Prescribing Human Growth Hormones
• 0:50:28 -Testosterone Is A Necessary But Not Sufficient Component Of Good Erectile Function
• 0:51:02 - Atherosclerotic Cardiovascular Disease
• 0:52:46 - Phosphodiesterase Inhibitors
• 0:51:28 - GAINSwave Shockwave Therapy
• 0:57:05 - Erectile Function And Nerve Regeneration

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics.

• 0:00:29 - What Is Psilocybin?
• 0:01:42 - The Serotonergic Effects Of Psilocybin 
• 0:04:08 - Exploring The Effects Of Microdosing Psilocybin
• 0:09:16 - Microdosing And Euphoria
• 0:12:03 - Exploring Psychedelic Microdosing
• 0:15:31 - The Fadiman Protocol
• 0:17:10 - The Stamets Protocol
• 0:19:59 - Microdosing Ketamine And Serotonergic Function 

In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop.

• 0:00:39 - About Dr. Michael Mantz
• 0:02:47 - Studying With Famous Herbalists In Utah
• 0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements
• 0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integrative Medicine
• 0:08:43 - Ketamine Assisted Psychotherapy
• 0:11:06 - What Are Psychedelics?
• 0:12:49 - Understanding Ketamine's Mechanism
• 00:14:47 - Ketamine As A Dissociative Anesthetic
• 00:16:38 - Effects Of Ketamine On GABA
• 0:17:53 - Ketamine Working On The Nmda Receptors
• 0:19:44 - NMDA Receptors And Expanding Consciousness 
• 0:22:23 - Augmenting Psychotherapy With Ketamine 
• 0:28:37 - Placebo Effect And Inflection Points
• 0:33:35 - Clinical Depression And Its Symptoms
• 0:35:18 - SIG-E-CAPS And Dysregulations Of Sleep
• 0:37:24 - Is Depression Physiological Or Psychological?
• 0:39:56 - The Impact Of Depression On Perception
• 0:40:10 - Understanding Depression And Medication Options
• 0:47:39 - Effectiveness Of SSRIS In Treatment
• 0:52:38 - Ketamine Therapy And Treating Depression
• 0:54:44 - Western Medicine's Relationship With Psychedelics
• 1:01:55 - Today's Opioid Epidemic
• 1:04:26 - Psychedelics In Mental Health

Buck discusses studies on the effect of saunas for overall health and longevity.

• 0:01:35 - What's The Big Deal With Saunas?
• 0:02:03 - Kuopio Ischemic Heart Disease Study
• 0:04:44 - Sauna Benefits For The Body
• 0:04:53 - Heat Shock Proteins
• 0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor
• 0:09:05 - Saunas And Longevity
• 0:11:08 - Blood Glucose Spikes While In The Sauna
• 0:12:19 - Optimal Timing For Sauna Usage

Buck and Montecito Concierge Medicine’s Alan Viglione explore compelling studies revealing the profound impact of social connections on our longevity. Join us as we uncover the fascinating evidence that demonstrates how fostering relationships can unlock the secret to a longer, more fulfilling life.

• 0:00:09 - Last Pillar Of Longevity: Social Relationships
• 0:01:11 - Tribal Societies And The Common Goal Of Survival
• 0:01:29 - Human Beings Are Fundamentally Social Creatures
• 0:03:41 - Social Relationships And Physiological Determinants Of Longevity Across The Human Life Span
• 0:05:33 - Social Connectedness Is Powerful
• 0:07:47 - What Happens When You're Lacking Quality Relationships?
• 0:09:06 - How Social Relationships Have Shown Can Impact Health
• 0:11:28 - Ortisol: The Classic Stress Hormone
• 0:12:14 - Oxytocin: The Love Hormone
• 0:14:22 - Blue Zones As Parts Of The World Where People Seem To Live For A Longer Period Of Time
• 0:16:46 - Social Relationships Sustain Happiness
• 0:19:27 - Cortisol And The Obesity Epidemic
• 0:19:52 - Blue Light At Night And Cortisol Levels
• 0:20:18 - How Technology Leads To More Isolation

Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies. 

• 0:01:30 What we knew about Taurine before the study.
• 0:03:22 What is Taurine?
• 0:03:39 What new information did we learn from the study?
• 0:06:30 Why do multiple models matter when it comes to studies?
• 0:07:04 What is the mechanism between improvements in health span and longevity?
• 0:07:30 Cellular Senescence - what is it and why does it matter?
• 0:09:00 DNA damage in aging.
• 0:10:30 Connecting the dots between low taurine levels and poor health.
• 0:11:10 Steps Buck is taking since reading the study.

Shownotes:

• 1:02 What is Diagnostics when it comes to medicine?
• 2:35 What are some of the traditional Diagnostics used in Medicine 2.0?
• 4:11 - Summarize the basic screenings you should be getting starting at based on Medicine 2.0 guidelines
• 6:09 Why are PSA screenings controversial?
• 8:19 - Cardiovascular testing - medicine 2.0
• 8:53 - Medicine 3.0
• 9:26 What’s a Cardio IQ?
• 18:10 Genetic Screening
• 19:40 MTHFR Gene Mutation
• 21:58 APOE e3 and e4
• 23:00 ACTN Gene
• 24:06 Galleri® Test
• 27:27 Whole Body MRI
• 29.11 How difficult is it to get these tests?
• 32:07 Self Diagnostics and Medicine 3.0
• 32:53 Continuous Glucose Monitor
• 33:18 Medicine 3.0  and the variability between humans
• 38:13 Key Takeaways
• 43:51 Q&A
• 44:46 Cleery heart scan analysis

Shownotes:

• 0:01:04 Metformin and Diabetes
• 0:02:48 Metformin Monotherapy
• 0:06:46 Are There Any Geroprotective Benefits From Taking Metformin?
• 0:10:50 Benefits of Rapamycin and
• 0:12:14 Acarbose and Sugar Metabolism
• 0:16:28 SGL2 inhibitor Jardiance
• 0:20:37 Glucose Monitoring and Metformin

Shownotes:

• 0:01:54 Geroprotective Medication
• 0:09:51 Addressing Fear Of Medication
• 0:12:22 Preventing Cardiovascular Disease
• 0:15:27 PCSK9 Inhibitors
• 0:16:48 Cardio IQ Test
• 0:17:02 Cardiac Risk Algorithm
• 0:21:10 Metformin
• 0:26:09 Interventions Testing Program (ITP)
• 0:27:32 Rapamycin
• 0:29:52 Acarbose
• 0:31:46 Invokana
• 0:39:29 NMN Supplementation
•  

Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body’s autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustments, aimed at optimizing HRV and promoting long-term health.

00:12 What is Heart Rate Variability?

05:34 The Normal Range of HRV

08:39 Contributing Factors that Impact Your HRV

23:18 Tactics to Improve HRV

Shownotes:

• 0:01:31 The Importance Of Sleep For Health
• 0:03:41 Rapid Eye Movement (REM) Sleep
• 0:03:57 Non-REM Sleep
• 0:06:22 Sleep Problems and Links to Alzheimer's and Dementia
• 0:08:14 Glial–Lymph and Deep Sleep
• 0:10:14 REM Sleep And Brain Health
• 0:14:28 Sleep Apnea: Berlin questionnaire and STOP-Bang assessment
• 0:17:04 Oura Ring
• 0:17:57 Sleep Disruption and Cancer
• 0:23:26 Night Shift Work And Health Risks
• 0:24:28 Suprachiasmatic Nucleus (SCN) and the Sleepway Cycle
• 0:26:35 Sleep And Longevity
• 0:33:20 Improving Sleep Quality: Blue Light Avoidance
• 0:35:25 Adenosine and Caffeine
• 0:35:47 Improving Sleep Quality And Habits
•  

Our understanding of how to get the most out of exercise has evolved. A combination of cardio training with weight training can have a profound effect on longevity and quality of life. Learn how to get the most out of your exercise and what metrics you can track to measure your fitness!

Shownotes:

• 0:00:33 Hormesis and Challenging the Body
• 0:02:48 The Benefits Of Exercise
• 0:04:07 The Cardiovascular System
• 0:06:25 Levels Of Cardiovascular Exercise Intensity
• 0:06:35 Level One: Walking Down The Street
• 0:07:14 Level Two: A Hike And A Conversation
• 0:08:34 Level Three: Reaching Anaerobic Threshold
• 0:12:05 Level Four: Reaching Your Lactate Threshold
• 0:17:30 Level Five: High Intensity
• 0:19:16 HIIT training
• 0:27:06 Glycolysis From Anaerobic Training
• 0:31:42 VO2 Max As A Way To Test Metabolic Efficiency
• 0:36:32 Optimizing Exercise By Getting Baseline Labs
• 0:44:52 Heart Health Metrics

In this bonus Q&A episode Buck Joffrey dives a little deaper into one of the key Episode 2 topics - blood glucose and how it affects your body with Sapio Executive Producer Ben Hyatt.

Shownotes:

• 0:01:36 Understanding Glucose and Insulin Interaction
• 0:06:19 Food Combinations and Blood Sugar
• 0:10:56 Understanding Diabetes and Glycation
• 0:16:13 Diabetes and Testing

There is more to healthy eating than calories in and calories out. Learn the new science around eating to extend life including what to eat and when!

Shownotes:

• 0:00:03 Pillars of Longevity: Diet and Nutrition
• 0:04:29 Caloric Restriction and Timing of caloric intake
• 0:09:29 Impact of Carbs on Intermittent Fasting
• 0:18:46 Managing Blood Sugar and Identifying Pre-Diabetes
• 0:19:49 The Importance of Hemoglobin A1c 
• 0:23:49 Personalized Response to Glucose Spikes
• 0:27:55 Eating Fads and Diets

An Introduction to the pillars on longevity and underlying science. Buck talks with Montecito Concierge Medicine’s Alan Viglione.

Shownotes:

• 0:00:31 Introduction to Sapio
• 0:03:53 Pillars of Longevity
• 0:04:17 Food and Nutrition
• 0:05:10 Exercise
• 0:06:33 Supplements that can make you live longer
• 0:08:29 Sleep
• 0:10:22 Diagnostics
• 0:10:57 Relationships

Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID.

02:07 What are Mitochondria?

05:05 Mitochondrial Dysfunction and Aging

12:13 Mitochondrial Genetics and Inheritance

14:54 Innovative Approaches to Mitochondrial Health

17:58 Pharmaceuticals and Supplements for Mitochondrial Support

Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplastics in daily life.

In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton.

Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/

Full episode in video available on YouTube:
https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw

Questions? Send us a message at:
www.longevityjunky.com

Follow us on social media:

Instagram: https://www.instagram.com/longevityjunkypodcast

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Twitter: https://x.com/longevity_junky

Tiktok: https://www.tiktok.com/@longevityjunkypodcast

Buck introduces his brand new podcast, Longevity Junky.

In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.

Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. The book 'Experiencing Flow' explores the relationship between mindfulness and flow and provides practical strategies for accessing flow in daily life.

00:13 The Definition of Flow

04:05 How Do We Have Flow?

08:25 Gettign In and Out of Flow

14:07 Mindfulness vs Flow   

Buck shares his recent experience with a retinal tear and detachment, emphasizing the importance of early diagnosis and treatment to prevent permanent vision loss. He explains the anatomy of the eye, the process of vitreous detachment, and the symptoms of retinal tear and detachment. Buck also discusses the risk factors for these conditions, including high myopia and previous eye surgery. He describes his surgical experience and the use of a gas bubble to reattach the retina. 

Link to Buck's Results:

https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing

 https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing

Section 1: Overview of Cholesterol Metabolism

• Cholesterol in the Body:
  • Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production.
  • It is produced endogenously in the liver and absorbed exogenously from dietary sources.
• Endogenous Production:
  • Cholesterol is synthesized in the liver through the mevalonate pathway.
  • Key intermediates: Lathosterol and Desmosterol, indicators of cholesterol production rate.
• Exogenous Absorption:
  • Dietary cholesterol is absorbed in the intestines along with plant sterols like Beta-sitosterol and Campesterol.
  • These sterols compete with cholesterol for absorption, reflecting dietary cholesterol absorption levels.

Section 2: Detailed Analysis of the Test Components

• Production Markers:
  • Lathosterol:
    • Precursor in the cholesterol biosynthesis pathway.
    • Elevated levels indicate increased hepatic cholesterol synthesis (overproduction).
    • Example: Lathosterol level of 329 µmol x 100/mmol in my study indicates hyperactive cholesterol production.
  • Desmosterol:
    • Another precursor in the synthesis pathway, contributing to total cholesterol production.
    • High levels reinforce the diagnosis of increased cholesterol production.
    • Example: Desmosterol level of 74 µmol x 100/mmol in my study supports elevated production.
• Absorption Markers:
  • Beta-sitosterol:
    • Plant sterol absorbed in the intestines, competes with cholesterol.
    • High levels suggest increased absorption of dietary cholesterol.
    • Example: Beta-sitosterol level of 120 µmol x 100/mmol indicates borderline absorption.
  • Campesterol:
    • Similar to Beta-sitosterol, reflects cholesterol absorption efficiency.
    • Elevated levels indicate increased absorption.
    • Example: Campesterol level of 113 µmol x 100/mmol within normal limits but suggests absorption could be a factor.
• Cholesterol Balance Score:
  • Ratio of production to absorption markers.
  • A higher score indicates predominant cholesterol production; a lower score indicates absorption as the main issue.
  • Example: Score of 2.4 suggests overproduction is the dominant issue.

Section 3: Clinical Implications and Treatment Strategies

• Frequency of Overproduction vs. Overabsorption:
  • Common to see patients with either overproduction or overabsorption, but less commonly both.
  • Overproducers: Significant portion of hypercholesterolemia patients, especially those with genetic conditions like Familial Hypercholesterolemia.
  • Overabsorbers: Often have high-cholesterol diets or genetic predispositions.
• Treatment Implications:
  • Overproducers: Statins are first-line treatment; they inhibit HMG-CoA reductase in cholesterol synthesis.
  • Overabsorbers: Ezetimibe, which inhibits intestinal cholesterol absorption, can be effective.
  • Combination Therapy: Considered for mixed dyslipidemia cases.
• Case Examples:
  • Example of a patient with high production markers but borderline absorption: Statin therapy may be appropriate, with potential addition of Ezetimibe.
  • Example of a patient who is a high absorber but not a high producer: Dietary changes and Ezetimibe might suffice without statins.

Section 4: Physiological Mechanisms and Genetic Considerations

• Pathophysiology of Cholesterol Production:
  • Overproduction may result from genetic mutations (LDL receptor or PCSK9) or conditions like insulin resistance.
• Pathophysiology of Cholesterol Absorption:
  • Increased absorption could be due to genetic polymorphisms (NPC1L1 gene), leading to higher dietary cholesterol absorption.

Section 5: Practical Application in Clinical Practice

• Incorporating the Test into Clinical Workflow:
  • Integrate the Boston Heart Cholesterol Balance Test for patients with unexplained hypercholesterolemia or non-responders to standard therapy.
  • Tailor treatment based on whether a patient is an overproducer, an over absorber, or both.
• Patient Communication:
  • Explain test results in an understandable way, emphasizing personalized treatment plans.

An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge research and bold predictions shaping the longevity landscape. Tune in to explore a future where living to 1000 might just be possible.

Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine as an anti-inflammatory treatment for coronary artery disease and atrial fibrillation.

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in measuring the risk of cardiovascular disease. He explains how APO-B can penetrate the blood vessel wall and trigger an immune response, leading to the formation of plaque and potential heart attacks. Buck recommends keeping APO-B levels below 60 milligrams per deciliter to reduce the risk of atherosclerosis. He also mentions the importance of testing for lipoprotein little A (Lp(a)) levels, as high levels of Lp(a) are a major risk factor for atherosclerotic cardiovascular disease.

Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each. 

Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.

In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gene editing, such as its use in treating sickle cell anemia and other genetic diseases, as well as the potential for human longevity, including targeting genes associated with aging and reversing epigenetic age.

Topics include:

00:25 Protein Intake for Longevity

12:40 Tips to Improve Sleep Quality

22:52 Is Robert F. Kennedy Jr. Controlled by a Worm

Topics include:

00:40 Is Weightloss Simply Calories In and Out?

07:10 Stem Cell Injections for NBA Players?  

14:60 Statins for Lowering Cholesterol

23:19 The Impact of Nature and Nurture on Longevity

Buck Joffrey, MD discusses the concept of resilience with Stephen Sideroff, PhD. Topics include bouncing forward from stress and practical techniques to restore balance, nurture growth, and slow down the aging process.

01:35 Defining Resilience and the Ability to Adapt

08:21 Physical Balance and Mastery: Restoring Balance in the Nervous System

15:26 Self-Relationship: How It Changes Your Physiology

21:47 Resilience and Longevity

23:16 Emotion Balance and Mastery

02:00 Stem Cells 101

08:18 The Mechanism Behind 

16:47 Stem Cells For Cancer

29:22 How Do Stem Cells Make You Live Longer?

46:25 FDA Indications

50:30 The Price

Buck discusses the concept of longevity clinics with the CEO of Humanaut.

Show Notes:

03:53 What Does Humanaut Do?

06:07 The Team Behind Humanaut

14:49 How Does the Program Work?

This Black Friday and Cyber Monday, I want to share something truly meaningful—the opportunity to invest in your health or the health of someone you love.

The Longevity Roadmap Course has already transformed lives, uncovering critical health issues and empowering participants to reverse conditions like borderline diabetes and optimize their health. It’s no exaggeration to say this course has already saved years of good-quality life.

This year, why not give the ultimate gift—the gift of health and time? Imagine helping a loved one discover a brighter, healthier future with a life-changing resource tailored to empower them for decades to come.

Black Friday & Cyber Monday Special: For a limited time, I’m offering 20% off the Longevity Roadmap Course, which includes three months of biweekly one-on-one coaching with me. This offer is good through Cyber Monday, so don’t wait—act now!

The tools, science, and coaching included in this course can:

• Help prevent or reverse common conditions like heart disease and diabetes.
• Unlock strategies to add years of vibrant, good-quality life.
• Give peace of mind knowing you or your loved one is on the best path forward.

This isn’t just an investment in health—it’s an investment in time with the people who matter most.

Make this holiday season truly unforgettable by giving a gift that will last a lifetime—or longer.

Sign Up Now and Use the Coupon Code Blackfriday2024 at Checkout to Get 20% Off – Offer Ends Cyber Monday!

Here’s to a longer, healthier, and happier future—for you and your loved ones.

– Buck

P.S. Want to learn more? Book a call with me on longevityroadmap.com and let's talk!

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism.

Also included is a discussion on the role of human pheromones and attraction.

Show Notes:

01:20 Facial Attraction & Cues

08:30 Facial Symmetry

11:12 The Averageness of Facial Features

13:59 Clear and Unblemished Skin

15:44 Sexual Dimorphic Traits

22:23 Smell and Pheromone

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI.

Show Notes:

01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease?

04:58 Why the Study that Claimed the Correlation Was Wonky

08:02 Why There May Be Some Truth in the Studies

14:03 What to Do With Mixed Data and Opinions?

15:49 The Best Protein Intake?

22:32 Why Full Body MRI?

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer’s Disease.

Show Notes:

03:08 Why the Keto Diet?

04:15 How Does the Keto Diet Help You Lose Weight?

05:51 Other Benefits of the Keto Diet

09:14 How Does High Blood Sugar Result in Insulin Resistance?

11:44 What Defines a Keto Diet

16:13 Lifestyle VS Intervention

19:02 The Concern with High Cholesterol with the Keto Diet

24:11 Treating Alzheimer’s with the Keto Diet

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians.

01:18 HIV

05:26 Hepatitis

09:20 HPV

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat.

Show Notes:

00:47 Is It Fine That I Sleep Too Much?

08:08 The 40hz Gamma Frequency and How It Relates to Brain Health

13:28 The Anti-Aging Effects of Human Growth Hormone

20:31 Reconsideration of How to Fast

29:22 Potentially Harmful Effect of NMN

33:08 Visceral vs Subcutaneous Fat

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet.

Show Notes: 

01:10 Types of Fasting

03:31 Why Fasting is Beneficial From a Cellular Level

07:00 Intermittent Fasting VS Fast Mimicking Diet

14:05 How Does Fasting Help Cancer Patients

20:37 What Is in the Fast Mimicking Diet

33:38 Pills and Supplements for Fasting Mimicking Diet

41:23 Time-Restricted Feeding Based on Circadian Rhythm

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life

Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people’s health.

Show Notes:

01:35 Dr. Lufkin’s Personal Journey to Question the Medicine Establishment

04:14 When Did People Start to Take Metabolic Syndrome Seriously?

08:33 What Exactly is Metabolic Syndrome from a Physiological Standpoint?

10:21 The Balance Between Building and Breaking Down in the Metabolic System

14:41 Time-Restricted Feeding and Ketogenic Diet

28:31 The Role of Medications and Supplements

30:51 Lifestyle and Exercise as Intervention

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment.

Show Notes:

00:58 What Really is Healthspan?

05:06 Biological Age VS Chronological Age

07:41 The Factors that Determine Biological Aging

12:08 What Happens When You Artificially Suppress These Factors

16:58 What is Phenomics and how can it predict diseases?

24:21 How Can You Do Self Tests?

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges in bringing their nanomedicine to market.