LEVITY – Détails, épisodes et analyse

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LEVITY

Peter Ottsjö

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Forme & Santé

Fréquence : 1 épisode/15j. Total Éps: 26

LEVITY is a podcast offering high-quality, science-informed editorial content focused on aging science and radical life extension. This includes discussions on lifestyle, biotechnology, ethical considerations of life extension, healthcare innovations, research breakthroughs and the role artificial intelligence might play. Our mission is to explore and communicate the scientific and societal pathways toward solving aging.

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#25 What exactly is so bad about death?

Épisode 25

mardi 3 juin 2025 • Durée 02:13:03

We think that death is bad, but why exactly is it bad? We cannot suffer when we do not exist, so why would it be bad?

In this episode we have a long, deep conversation with Professor Travis Timmerman, whose philosophical work delves deeply into the nature and ethics of death. An Associate Professor at Seton Hall University, Professor Timmerman has become a prominent voice in contemporary discussions about whether death is bad for us, how we should understand the harm of dying, and what moral obligations we might have surrounding death and dying. His work engages both timeless questions and urgent contemporary debates—offering fresh insight into topics like the timing of death’s harms, the ethics of procreation, and our attitudes toward mortality.

What you'll learn in this episode:

✅ Why death is bad

✅ How it can bad to not have been born earlier

✅ What the ancient Mirror Argument gets wrong

✅ How it can be bad for a 95-year-old to die

✅ Whether we should wait to have children

✅ How an analytical philosopher thinks about death

🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership

🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com

--CHAPTERS--

00:00 introduction

00:50 Why is death bad? The Deprivation account

15:30 Lucretius

18:10 A reason to live is a reason to see death as bad

20:20 James Stacey Taylor vs Travis Timmerman

26:20 Deprivation account and mercy killing

29:20 Counter intuitive implications of the Deprivation Account - overdetermination of death

37:20 What would have happened if I had not died? Possible worlds and the badness of death

40:40 The badness of a 95-year-old to die

47:00 Thomas Nagel - death and normalcy

51:49 Reasons and the good and the bad

53:40 The Timmerman style of analytic philosophy

01:00:49 Philosophers and prolongevity in history

01:08:28 Philosophy as therapy

01:09:40 Time and intrinsic good - what matters most?

01:14:36 Is health overrated?

01:16:27 The eternal philosophical dialogue

01:17:56 If longevity were impossible, how would that change philosophy of death?

01:21:35 The Mirror Argument

01:26:55 Could I have been born earlier?

01:39:22 When should we have children?

01:42:47 Better never to have been?

01:48:09 A world without consciousness

01:52:27 Can we wish for the impossible?

02:02:07 Meta-philosophy and ironing out the wrinkles of the Deprivation account

02:03:00 What Travis is working on

02:08:02 What what we should read

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#24 Dr. Valter Longo - The BIG 2025 interview

Épisode 24

mardi 20 mai 2025 • Durée 01:56:47

There were two reasons why Dr. Valter Longo was featured so prominently in my longevity book Evigt Ung (2022).

First, if you had to name a single scientific thread running through the history of longevity research, calorie restriction is hard to beat. And few have done more to modernize and translate that insight into real-world practice than Longo.

Second, I hold Valter Longo in the highest regard. I've tried his Fasting-Mimicking Diet (FMD), I’ve followed his work on The Longevity Diet, and I find his scientific contributions both rigorous and unusually translational. He doesn’t just publish papers - he builds systems, tests interventions in clinical trials, and tries to implement science into healthcare.

In this conversation, we cover the science, history, and application of fasting, nutrition, and longevity - including new work on cancer, metabolism, and organ regeneration. We also discuss the philosophical and political obstacles that stand in the way of real change.

What you'll learn in this episode:

✅ The story of Longo’s early music career - and why he left it to study aging.

✅ How calorie restriction shaped modern longevity science.

✅ Why Biosphere 2 and Roy Walford's work was both inspiring and cautionary.

✅ The origins and mechanisms of the Fasting-Mimicking Diet.

✅ What Longo learned about autophagy, stem cells, and organ regeneration.

✅ Why protein intake before and after age 65 should be treated differently.

✅ What the media and doctors get wrong about obesity, food, and metabolism.

✅ The dangers of high-protein and ketogenic diets.

✅ Why Longo is deeply skeptical of TRT, growth hormone, and biohacking shortcuts.

✅ How fasting can enhance cancer treatment - and why Longo wrote his new book Fasting Cancer.

#23 Hilarious, brilliant and deadly serious: José Cordeiro's quest to defeat death

Épisode 23

mardi 6 mai 2025 • Durée 01:57:19

This is our first — and probably our last — episode where the guest has brought with him an actual punch card and proceeds to explain why it is, in fact, caca (which is Spanish for 💩, by the way).

Welcome to the wild world of José Cordeiro. Stick around and you might hear anecdotes about Robert Kennedy Jr. in Memphis 🎸, late-night karaoke sessions 🎤, and a man shouting “immortality!” to anyone and everyone. But behind the eccentric props and the shameless self-promotion (José didn’t just bring punch cards — he also brought his books 📚, his merch 👔, and his signature Death of Death tie — to the point where we had to clarify we’re not actually sponsored), there’s a deadly serious mission: José wants to end aging and defeat death.

A futurist, MIT-trained engineer, and bestselling author, José Cordeiro argues that humanity is on the brink of longevity escape velocity 🚀 — the moment when medical advances will start adding more years to our lives than time takes away. In this episode, we explore his bold predictions, from reversing aging by 2045 to launching a global “war on aging.” We cover the science 🔬, the politics 🏛️, the money 💰, and the wild optimism driving the longevity movement — with cryonics ❄️, Martians 👽, and €10 immortality claims all making appearances.

This might be our strangest — and most fascinating — conversation yet. Buckle up.

-- IN THIS EPISODE YOU'LL LEARN ABOUT --

✅ Why longevity escape velocity may be closer than we think

✅ How AI will aid longevity

✅ Why technological optimism is rational

✅ How the Covid pandemic was a relatively minor pandemic

✅ How the concept of work will change

✅ What the future of energy may be

✅ A personal history of Marvin Minsky, Ray Kurzweil and José Cordeiro

✅ Where to meet Cordeiro and demonstrate against aging

#22 Aging will be cured within 20 years — here's why | Prof. Derya Unutmaz

Épisode 22

mardi 29 avril 2025 • Durée 01:52:58

Lately, there's been growing pushback against the idea that AI will transform geroscience in the short term.

When Nobel laureate Demis Hassabis told 60 Minutes that AI could help cure every disease within 5–10 years, many in the longevity and biotech communities scoffed. Leading aging biologists called it wishful thinking - or outright fantasy.

They argue that we still lack crucial biological data to train AI models, and that experiments and clinical trials move too slowly to change the timeline.

Our guest in this episode, Professor Derya Unutmaz, knows these objections well. But he’s firmly on Team Hassabis.

In fact, Unutmaz goes even further. He says we won’t just cure diseases - we'll solve aging itself within the next 20 years.

And best of all, he offers a surprisingly detailed, concrete explanation of how it will happen:

building virtual cells, modeling entire biological systems *in silico*, and dramatically accelerating drug discovery — powered by next-generation AI reasoning engines.

🧬 In this wide-ranging conversation, we also cover:

✅ Why biological complexity is no longer an unsolvable barrier.

✅ How digital twins could revolutionize diagnosis and treatment.

✅ Why clinical trials as we know them may soon collapse.

✅ The accelerating timeline toward longevity escape velocity.

✅ How reasoning AIs (like GPT-4o, o1, DeepSeek) are changing scientific research.

✅ Whether AI creativity challenges the idea that only biological minds can create.

✅ Why AI will force a new culture of leisure, curiosity, and human flourishing.

✅ The existential stress that will come as AI outperforms human expertise.

#21 A Physicist's Controversial Take on Why Age Reversal Will Never Work | Peter Fedichev

Épisode 21

mardi 8 avril 2025 • Durée 01:28:15

Peter Fedichev is a visionary scientist, biotech entrepreneur, and physicist at the forefront of longevity research. With a background in theoretical physics, he has seamlessly merged cutting-edge science with real-world applications, making groundbreaking contributions to the fields of aging, biotechnology, and artificial intelligence in healthcare. As the co-founder and CEO of Gero, a pioneering biotech company, Fedichev is revolutionizing our understanding of biological aging, using AI-driven approaches to uncover ways to extend human lifespan and combat age-related diseases. His work has been featured in leading scientific journals, and his insights are shaping the future of personalized medicine and longevity science. Driven by a relentless curiosity and a passion for pushing the boundaries of human potential, Fedichev is not just studying aging - he’s working to redefine it.

🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership

🚀 Show notes for this episode is available here: https://reachlevity.com/p/age-reversal-will-never-work-a-controversial-take-from-a-physicist-5935af91034fd123

-- EPISODE HIGHLIGHTS --

✅ The founding of Gero

✅ The physics of aging

✅ Why age reversal will not work

✅ What SENS gets right

✅ What SENS gets wrong

✅ AI and the longevity industry

Hosted on Acast. See acast.com/privacy for more information.

#20 Want a quick $2 million? Help this guy find a longevity city! | Laurence Ion

Épisode 20

mardi 25 mars 2025 • Durée 01:54:50

In this episode of LEVITY, we speak with Laurence Ion, a tech entrepreneur whose experience with a rare genetic disease led him to tackle one of humanity's greatest challenges: aging.

Starting as a shy coder who 'couldn't talk to strangers,' Laurence has become a movement leader pioneering a bold new approach: creating specialized cities where extending human lifespan isn't just a goal - it's the future of humanity.

-- EPISODE HIGHLIGHTS --

✅ Laurence's personal journey with multiple hereditary exostoses and how it shaped his perspective on aging and mortality.

✅ The founding and evolution of VitaDAO, a decentralized science organization funding longevity research.

✅ How crypto-based communities are accelerating anti-aging research outside traditional funding models.

✅ The concept of special jurisdictions for medical innovation where regulatory frameworks can move at "warp speed".

✅ Viva City's vision to create physical communities and hubs focused on longevity.

✅ The $2 million recursive finder's fee for anyone who helps secure a location for the first major Viva City jurisdiction.

✅ How living in community environments like Zuzalu and Aevitas House naturally promotes healthier lifestyle choices.

✅ The Frontier Tower project - a 16-story "vertical village" designed for longevity-minded living.

✅ JellyfishDAO's mission to change cultural narratives around aging through film and media.

✅ The relationship between AI advancement and longevity research.

✅ How decentralized clinical trials could dramatically reduce the cost and time of bringing treatments to people.

✅ Real-world examples of companies already offering experimental longevity treatments in special jurisdictions.

#19 What are the chances humanity will survive this century? | Anders Sandberg

Épisode 19

mardi 11 mars 2025 • Durée 02:09:50

We have another amazing guest for this episode: Anders Sandberg is a visionary philosopher, futurist, and transhumanist thinker whose work pushes the boundaries of human potential and the future of intelligence. As a senior research fellow at Oxford University’s Future of Humanity Institute until its closing in 2024 Sandberg explores everything from cognitive enhancement and artificial intelligence to existential risks and space colonization. With a background in computational neuroscience, he bridges science and philosophy to tackle some of the most profound questions of our time: How can we expand our cognitive capacities? What are the ethical implications of radical life extension? Could we one day transcend biological limitations entirely? Known for his sharp intellect, playful curiosity, and fearless speculation, Sandberg challenges conventional wisdom, inviting us to imagine—and shape—a future where humanity thrives beyond its current constraints.

00:00 introduction

04:18 exersise & David Sinclair

06:10 Will we survive the century?

18:18 Who can we trust? Knowledge and humility

23:17 Nuclear armaggedon

39:51 Technology as a double-edged sword

44:30 Sandberg origin story

56:54 Computational neuroscience

01:00:30 Personal identity and neural simulation

01:05:24 Personal identity and reasons to want to continue living

01:09:39 The psychology of behind different philosophical intutions and judgments

01:17:48 Is death bad for Anders Sandberg?

01:25:00 Altruism and individual rights

01:31:29 Elon Musk says we must die for progress

01:35:10 Artificial Intelligence

#18 Aubrey de Grey | The Big 2025 Interview

Épisode 18

mardi 25 février 2025 • Durée 01:55:13

In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.

You'll also hear about:

His predictions for reaching Longevity Escape Velocity by the late 2030s

What he would change about Bryan Johnson's longevity algorithm

How reaching RMR could trigger a global "war on aging"

Why AI won't solve aging without proper experimental data

How Demis Hassabis is the smartest person Aubrey's ever met

His involvement in designing the XPRIZE Healthspan competition

His rebuttal to Mark Hamalainen's "replacement strategy" approach

The divide-and-conquer approach to aging and why it's superior

🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/

-- CHAPTERS --

00:00 Introduction and Welcome

03:15 The Background to LEV Foundation and the Robust Mouse Rejuvenation Studies

12:05 The Robust Mouse Rejuvenation Studies

18:10 Latest Results from the Mouse Rejuvenation Experiments

25:42 Reaching RMR soon and LEV in 12-15 years

33:47 Healthspanners in public - lifespanners in private?

37:03 The Replacement Strategy Debate with Mark Hamalainen

45:40 The Very, Very Difficult Challenge of Gradually Replacing the Brain

#17 How the $101M XPRIZE will reverse aging by 20 years | Jamie Justice

Épisode 17

mardi 11 février 2025 • Durée 01:50:20

Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging.

As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stakes? $81M for achieving a 20-year reversal of aging markers, with $71M and $61M prizes for lesser but still remarkable achievements.

Jamie shares her fascinating journey from studying crickets' lifespans in elementary school to leading groundbreaking aging research, including work on the TAME trial with metformin. She explains why they chose these specific biological systems to measure, how they'll determine success, and what kinds of interventions teams are exploring - from repurposed drugs to gene therapies.

We discuss:

* Why Peter Diamandis pushed for more ambitious goals

* How over 550 teams from 55 countries are approaching the challenge EDIT: Since we recorded this in late 2024 they've now reached over 600 teams.

* The role of biomarkers in measuring aging

* Why they chose to measure actual restoration rather than just preventing decline

* The challenges and opportunities in aging clinical trials

* Her vision for an integrated, multi-generational society that values aging populations

🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership

🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/

CHAPTERS:

00:00 Introduction

#16 Critical health signals your doctor is overlooking | David Luu

Épisode 16

mardi 28 janvier 2025 • Durée 01:52:41

A pediatric cardiac surgeon turned longevity pioneer, Dr. David Luu shares his journey from humanitarian medical missions to building a global network of physicians focused on prevention. Learn about critical health markers your doctor might be missing, how AI is transforming healthcare, the truth about longevity interventions, and why the future belongs to prevention rather than treatment. Plus, discover the vital link between community, lifestyle, and longevity, and why creating modern "blue zones" might be key to living longer, healthier lives.

🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership

🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/

CHAPTERS

00:00 Introduction 02:33 A Family Legacy in Medicine 10:41 From Heart Surgeon to Tech Innovator with JuiSci and Hearty 13:47 Building AI-Powered Medical Platforms 21:33 The Heart Fund: Surgery for Those in Need 35:06 The Role of AI in Healthcare 45:22 Creating Longevity Docs Community 01:07:13 Hidden Cardiovascular Risk Factors 01:10:38 The Lp(a) Test Everyone Should Know About

01:18:50 Why Call it ”Longevity Docs” When We Have No Approved Aging Interventions? 01:28:14 Different Levels of Longevity Interventions 01:38:42 Risk vs. Reward in Preventive Medicine 01:43:30 Building Modern Blue Zones 01:47:11 The Future of Medicine 01:52:07 Connecting with David

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LEVITY – Détails, épisodes et analyse

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