Transfusion strategy for patients with acute brain injury, telehealth care, acute kidney injury after cardiac surgery, and weaning ventilatory support are the topics of 4 trials published in JAMA and presented at the 2024 European Society of Intensive Care Medicine meeting. JAMA Associate Editor Christopher Seymour, MD, MSc, joins Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss.

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Gastric cancer is a leading cause of cancer death globally. Chronic H pylori infection is the primary cause of gastric cancer, responsible for at least 80% of the new cases. Constanza Camargo, PhD, of the National Cancer Institute joins JAMA Associate Editor John M. Inadomi, MD, to discuss co-testing with FIT and H pylori stool antigen to help prevent gastric cancer.

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Ten percent of US adolescents use e-cigarettes, and many want to quit. However, evidence on the effectiveness of vaping cessation interventions is lacking. Amanda L. Graham, PhD, of the Truth Initiative discusses with JAMA Senior Editor Tracy Lieu, MD, MPH, how a tailored, interactive text message intervention increased vaping cessation among adolescents recruited via social media channels.

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Electronic health records (EHRs) hold great promise to assist clinicians, but current versions are less user-friendly than ideal. JAMA Associate Editor Tracy Lieu, MD, MPH, spoke with Kevin B. Johnson, MD, MS, University of Pennsylvania, and William W. Stead, MD, Vanderbilt University Medical Center, about how to improve EHRs to protect cognitive attention and optimize their potential to provide cognitive support to health care professionals.

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In this Author Interview, JAMA Deputy Editor Gregory Curfman, MD, discusses the state of coronary artery bypass surgery in 2022 with E. Magnus Ohman, MD, from Duke University. The conversation emphasizes methods to preserve patency of saphenous vein bypass grafts, the subject of an article in the August 9, 2022, issue of JAMA. Dr Ohman wrote the accompanying Editorial.

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On August 3, 2022, the US Department of Health and Human Services released 2 major reports in response to a presidential memo calling for a whole-of-government response to the SARS-CoV-2 sequelae known as “Long COVID." JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, discusses these new reports and the research and support needed to address this pervasive health concern with HHS Assistant Secretary for Health Rachel Levine, MD. Recorded July 29, 2022.

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Interview with Lori Pbert, PhD, USPSTF member and coauthor of Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Disease Risk Factors: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Senior Editor Kristin L. Walter, MD, MS.

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Exercise limitation is a cardinal manifestation of heart failure with reduced ejection fraction (HFrEF), but it is not consistently improved by any of the current guideline-directed medical therapies. JAMA Deputy Editor Gregory Curfman, MD, discusses whether omecamtiv mecarbil can improve peak exercise capacity in patients with HFrEF with Gregory D. Lewis, MD, from Massachusetts General Hospital, and Mark H. Drazner, MD, MSc, from University of Texas Southwestern Medical Center.

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JAMA Associate Editor Preeti Malani, MD, MSJ, discusses the transmission, diagnosis, and treatment of monkeypox and the 2022 outbreak with Jeannette Guarner, MD, and Carlos del Rio, MD, both of the Division of Infectious Diseases at Emory University’s School of Medicine. Read Transcript

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Patient safety is a national priority, but adverse events during hospitalization are hard to track and whether progress has been made over the past decade is unknown. JAMA Associate Editor Karen E. Joynt Maddox, MD, MPH, Washington University School of Medicine, discusses recent findings demonstrating decreases in hospital chart-abstracted adverse events and what’s next in patient safety in the wake of COVID-19, with Mark Metersky, MD, University of Connecticut Health Center, and Peter Pronovost, MD, PhD, University Hospitals, Shaker Heights, Ohio.

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In July 2022, Kirsten Bibbins-Domingo, PhD, MD, MAS, took on a new role as the 17th editor in chief of JAMA and the JAMA Network. In conversation with Nobel laureate Harold Varmus, MD, Bibbins-Domingo discusses her research background, approaches to leadership in health care, and the critical role that journals play in communication about public health and science.

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Observational data suggest that the risk of certain types of cancer may be increased in individuals with obesity and that this risk may be lower after bariatric surgery. JAMA Deputy Editor Gregory Curfman, MD, explores this in detail with Steven Nissen, MD, an author of a JAMA study on this topic, and Anita Courcoulas, MD, MPH, author of an accompanying editorial.

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Interview with John B Wong, MD, USPSTF member and coauthor of Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Deputy Editor Mary M. McDermott, MD.

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Gestational age estimation is foundational for obstetric care. In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Author Jeffrey Stringer, MD, University of North Carolina, joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps.

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Interview with Lisa Rotenstein, MD, MBA, author of A Learning Health System Agenda for Organizational Approaches to Enhancing Occupational Well-being Among Clinicians, and Clyde W. Yancy, MD, author of Resident Physician Wellness Postpandemic: How Does Healing Occur?. Hosted by JAMA Associate Editor Anne Cappola, MD.

Interview with Katrina Erika Donahue, MD, MPH, coauthor of Screening for Primary Open-Angle Glaucoma: US Preventive Services Task Force Recommendation Statement, and Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Deputy Editor Mary M. McDermott, MD.

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As the White House’s COVID-19 Response Coordinator, Ashish Jha, MD, MPH, plays a critical role in the federal government’s continued response to the pandemic. In this Q&A with JAMA Associate Editor Preeti Malani, MD, Jha details current thinking and federal planning around additional boosters, testing trends, and treatment for COVID-19.

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Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Screening for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Senior Editor Kristin Walter, MD.

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After serving as commissioner of the US Food and Drug Administration (FDA) under President Obama, Robert M. Califf, MD, recently returned to the role, overseeing a critical federal agency that regulates food, drugs, therapeutics, and medical devices in the US. In a wide-ranging discussion with JAMA Deputy Editor Gregory Curfman, MD, Califf discusses COVID-19 vaccine modifications, the FDA’s approach to evaluating evidence, and efforts to combat health misinformation. Recorded April 26, 2022.

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Interview with John B. Wong, MD, USPSTF member and coauthor of Aspirin Use for Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Deputy Editor Gregory Curfman, MD.

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Misinformation about COVID-19 (such as around vaccines, masks, and ineffective drugs) has circulated widely during the pandemic, and much of this misinformation is protected by the Free Speech Clause of the First Amendment. Professor of Surgery and Perioperative Care and Professor of Law William M. Sage, MD, JD, from the University of Texas at Austin, is interviewed in this JAMA podcast.

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Electrocardiographic markers of atrial myopathy are associated with dementia, but it is unclear whether 2-dimensional echocardiographic––defined LA function and size are associated with dementia. JAMA Senior Editor Philip Greenland, MD, discusses study findings with Wendy Wang, MPH, and Lin Yee Chen, MD, authors of Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia

As the largest public insurance program in the US, Medicare has an outsize influence in how many people in the US access and receive health care. Recently appointed Director of Center for Medicare Meena Seshamani, MD, PhD, joins JAMA Associate Editor Karen Joynt Maddox, MD, for a discussion of equitable, patient-centered approaches to health care delivery, and how her own experiences as a physician have illuminated how she leads the program.

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Interview with Lori Pbert, PhD, USPSTF member and coauthor of Screening for Eating Disorders in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement

Biomarkers for Alzheimer disease (AD) provide insight into disease processes and may aid clinical diagnosis for individuals with cognitive impairment. Author Stephen Salloway, MD, MS, of Brown University joins JAMA Deputy Editor Christopher Muth, MD, to discuss 2 articles and an accompanying editorial about blood biomarkers for AD and potential implications for clinical practice.

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Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Atrial Fibrillation: US Preventive Services Task Force Recommendation Statement. Hosted by Gregory Curfman, MD.

Three members of President Biden’s former COVID-19 Advisory Board—Luciana Borio, MD, Ezekiel Emanuel, MD, PhD, and Mike Osterholm, PhD—discuss their recent JAMA Viewpoints, providing their ideas on strategies for public health as COVID-19 transitions from pandemic to endemic. Hosted by JAMA Associate Editor Preeti Malani, MD.

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Former CDC Executive Secretariat of the Advisory Committee on Immunization Practices Amanda Cohn, MD, joins JAMA Associate Editor Preeti Malani, MD, for the latest on the need for vaccination and boosters, vaccine misinformation, and tackling the pandemic from a global perspective. Recorded January 6, 2022.

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Interview with Michael Cabana, MD, USPSTF member and coauthor of Screening and Interventions to Prevent Dental Caries in Children Younger Than 5 Years: US Preventive Services Task Force Recommendation Statement.

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Infectious disease experts Adam Lauring, MD, PhD, and Carlos del Rio, MD, join JAMA Associate Editor Preeti Malani, MD, MSJ, for a discussion of the newly emerged Omicron variant, the potential for a 2021-2022 "twindemic" with flu, and the latest COVID-19 clinical updates. Recorded December 1, 2021.

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Phil Fontanarosa, MD, MBA, interim editor in chief of JAMA, interviews Harvey V. Fineberg, MD, PhD, from the Gordon and Betty Moore Foundation, and Abraham Verghese, MD, from Stanford University School of Medicine, about diagnostic excellence and a new series on this topic in JAMA.

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Individuals who experience systemic, structural, institutional, and social barriers within society deserve better and more convenient health care access. This idea should be central when advancing efforts to achieve health equity. JAMA Editorial Board member Raina M. Merchant, MD, speaks with Courtney R. Lyles, PhD, and Urmimala Sarkar, MD, about approaches toward improving digital health equity and with Utibe R. Essien, MD, about enhancing targeted efforts toward realizing pharmacoequity.

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Health care expenses that arise from largely nonclinical functions, such as coding and billing and administration, cost the US health care system almost $1 trillion annually. Michael Chernew, PhD, from Harvard Medical School Department of Health Care Policy, and David Cutler, PhD, from Harvard University Department of Economics, join JAMA Associate Editor Karen Joynt Maddox, MD, MPH, from Washington University School of Medicine to discuss some basic fixes and simplifications that could reduce administrative spending by an estimated $265 billion.

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• Waste in the US Health Care System

Interview with Jason A. Abbott, and Fiona G Li, authors of Effect of Fractional Carbon Dioxide Laser vs Sham Treatment on Symptom Severity in Women With Postmenopausal Vaginal Symptoms: A Randomized Clinical Trial

Death rattle, defined as noisy breathing caused by the presence of mucus in the respiratory tract, is common among dying patients. Harriette van Esch, MD, from the Erasmus Medical Center, the Netherlands, and Jared R. Lowe, MD, from the University of North Carolina, join JAMA Associate Editor Ethan Basch, MD, to discuss evidence about use of prophylactic scopolamine butylbromide to reduce the death rattle.

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Ulcerative colitis can significantly decrease quality of life. A third of patients have persistent symptoms with tumor necrosis factor inhibitors and nearly 1 in 5 patients will be hospitalized within 5 years of diagnosis. Author Gilaad G. Kaplan, MD, MPH, of the University of Calgary joins JAMA Associate Editor John M. Inadomi, MD, to discuss Risankizumab for Ulcerative Colitis.

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Canadian law gives the country’s individual provinces and territories primary responsibility for coronavirus containment and mitigation. JAMA Associate Editor Preeti Malani, MD, MSJ, from the University of Michigan and Allan S. Detsky, MD, PhD, from the University of Toronto, Ontario, Canada, discuss the national pandemic experience, including public health responses to infection and vaccine allocation, from fall 2020 through summer 2021.

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• COVID-19 in Canada: Experience and Response to Waves 2 and 3

Interview with Aaron B. Caughey, MD, USPSTF member and coauthor of Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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Interview with Martha Kubik, PhD, RN, USPSTF member and coauthor of Screening for Chlamydia and Gonorrhea: US Preventive Services Task Force Recommendation Statement

While health disparities have gained growing attention in recent years, much work is still needed, as inequities continue to have a direct and measurable negative influence on patients in historically disadvantaged communities. David Satcher, MD, PhD, Francisco Cigarroa, MD, and Howard Koh, MD, MPH, join moderator Ebony Boulware, MD, MPH, to discuss the vital importance of the visibility of all races and ethnicities in research, medical schools, and health care. They propose potential solutions, including the recruitment of and support for more physicians who look like their patients, who care enough, know enough, have the courage to make a difference, and who will persevere until changes are made.

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Noninvasive ventilation (NIV) may help COVID-19 patients in respiratory failure avoid invasive mechanical ventilation but may also lead to delays in intubation with potential for worse clinical outcomes.

Domenico L. Grieco, MD, of Fondazione Policlinico Agostino Gemelli IRCCS in Rome, Jesse B. Hall, MD, of the University of Chicago, and Laveena Munshi, MD, MSc, of Sinai Health System/University Health Network of the University of Toronto join JAMA's live Q&A series to discuss helmet NIV, high-flow nasal oxygen, and other NIV modalities in the management of hypoxic coronavirus patients. Recorded March 25, 2021.

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Interview with Kimberly Maxfield, PhD, author of Precision Dosing—A Clinical and Public Health Imperative

Interview with Chien-Wen W. Tseng, MD, USPSTF member and coauthor of USPSTF Recommendation: Screening for Hearing Loss in Older Adults

Coronavirus trends, variants, vaccines, treatment, and more. JAMA Associate Editor Preeti Malani, MD, MSJ, also from the University of Michigan, and Emory University School of Medicine's Carlos del Rio, MD, return to JAMA's Q&A series to discuss the latest in COVID-19 medicine and public health. Recorded March 15, 2021.

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Lisa A. Cooper, MD, MPH, of Johns Hopkins University School of Medicine; Clyde W. Yancy, MD, MSc, of Northwestern University, and David R. Williams, PhD, MPH, of Harvard T.H. Chan School of Public Health, join JAMA Editor in Chief Howard Bauchner, MD, to discuss racism and structural racism in health care and medicine. Recorded March 16, 2021.

Interview with Thomas R. Frieden, MD, MPH, author of National Initiatives to Prevent Myocardial Infarction and Stroke

What are the ovarian cancer risks associated with endometriosis subtypes? Author Karen C. Schliep, PhD, MSPH, of the University of Utah joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Endometriosis Typology and Ovarian Cancer Risk.

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Interview with Michael J. Barry, MD, author of USPSTF Recommendation—Screening for Lung Cancer

Genetic variants of the SARS-CoV-2 virus are emerging but so far do not seem to have caused breakthrough infections in people with previous infection or in those who have been vaccinated. John P. Moore, PhD, of Weill Medical College of Cornell University in New York, joins JAMA's Q&A series for an update on the latest variants and what you need to know. Recorded March 4, 2021.

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Interview with Christopher J.L. Murray, MD, DPhil, author of The Potential Future of the COVID-19 Pandemic: Will SARS-CoV-2 Become a Recurrent Seasonal Infection?