In Our Time: Science – Détails, épisodes et analyse

Melvyn Bragg and guests discuss the most abundant lifeform on Earth: the viruses that 'eat' bacteria. Early in the 20th century, scientists noticed that something in their Petri dishes was making bacteria disappear and they called these bacteriophages, things that eat bacteria. From studying these phages, it soon became clear that they offered countless real or potential benefits for understanding our world, from the tracking of diseases to helping unlock the secrets of DNA to treatments for long term bacterial infections. With further research, they could be an answer to the growing problem of antibiotic resistance.

With

Martha Clokie Director for the Centre for Phage Research and Professor of Microbiology at the University of Leicester

James Ebdon Professor of Environmental Microbiology at the University of Brighton

And

Claas Kirchhelle Historian and Chargé de Recherche at the French National Institute of Health and Medical Research’s CERMES3 Unit in Paris.

Producer: Simon Tillotson

In Our Time is a BBC Studios Audio Production

Reading list:

James Ebdon, ‘Tackling sources of contamination in water: The age of phage’ (Microbiologist, Society for Applied Microbiology, Vol 20.1, 2022)

Thomas Häusler, Viruses vs. Superbugs: A Solution to the Antibiotics Crisis? (Palgrave Macmillan, 2006)

Tom Ireland, The Good Virus: The Untold Story of Phages: The Mysterious Microbes that Rule Our World, Shape Our Health and Can Save Our Future (Hodder Press, 2024)

Claas Kirchhelle and Charlotte Kirchhelle, ‘Northern Normal–Laboratory Networks, Microbial Culture Collections, and Taxonomies of Power (1939-2000)’ (SocArXiv Papers, 2024)

Dmitriy Myelnikov, ‘An alternative cure: the adoption and survival of bacteriophage therapy in the USSR, 1922–1955’ (Journal of the History of Medicine and Allied Sciences 73, no. 4, 2018)

Forest Rohwer, Merry Youle, Heather Maughan and Nao Hisakawa, Life in our Phage World: A Centennial Field Guide to Earth’s most Diverse Inhabitants (Wholon, 2014)

Steffanie Strathdee and Thomas Patterson (2019) The Perfect Predator: A Scientist’s Race to Save Her Husband from a Deadly Superbug: A Memoir (Hachette Books, 2020)

William C. Summers, Félix d`Herelle and the Origins of Molecular Biology (Yale University Press, 1999)

William C. Summers, The American Phage Group: Founders of Molecular Biology (University Press, 2023)

Melvyn Bragg and guests discuss the planet which is closest to our Sun. We see it as an evening or a morning star, close to where the Sun has just set or is about to rise, and observations of Mercury helped Copernicus understand that Earth and the other planets orbit the Sun, so displacing Earth from the centre of our system. In the 20th century, further observations of Mercury helped Einstein prove his general theory of relativity. For the last 50 years we have been sending missions there to reveal something of Mercury's secrets and how those relate to the wider universe, and he latest, BepiColombo, is out there in space now.

With

Emma Bunce Professor of Planetary Plasma Physics and Director of the Institute for Space at the University of Leicester

David Rothery Professor of Planetary Geosciences at the Open University

And

Carolin Crawford Emeritus Fellow of Emmanuel College, University of Cambridge, and Emeritus Member of the Institute of Astronomy, Cambridge

Producer: Simon Tillotson In Our Time is a BBC Studios Audio production

Reading list:

Emma Bunce, ‘All (X-ray) eyes on Mercury’ (Astronomy & Geophysics, Volume 64, Issue 4, August 2023)

Emma Bunce et al, ‘The BepiColombo Mercury Imaging X-Ray Spectrometer: Science Goals, Instrument Performance and Operations’ (Space Science Reviews: SpringerLink, volume 216, article number 126, Nov 2020)

David A. Rothery, Planet Mercury: From Pale Pink Dot to Dynamic World (Springer, 2014)

Paul Erdős (1913 – 1996) is one of the most celebrated mathematicians of the 20th century. During his long career, he made a number of impressive advances in our understanding of maths and developed whole new fields in the subject.

He was born into a Jewish family in Hungary just before the outbreak of World War I, and his life was shaped by the rise of fascism in Europe, anti-Semitism and the Cold War. His reputation for mathematical problem solving is unrivalled and he was extraordinarily prolific. He produced more than 1,500 papers and collaborated with around 500 other academics.

He also had an unconventional lifestyle. Instead of having a long-term post at one university, he spent much of his life travelling around visiting other mathematicians, often staying for just a few days.

With

Colva Roney-Dougal Professor of Pure Mathematics at the University of St Andrews

Timothy Gowers Professor of Mathematics at the College de France in Paris and Fellow of Trinity College, Cambridge

and

Andrew Treglown Associate Professor in Mathematics at the University of Birmingham

The image above shows a graph occurring in Ramsey Theory. It was created by Dr Katherine Staden, lecturer in the School of Mathematics at the Open University.

Melvyn Bragg and his guests discuss one of the simplest and most remarkable of all molecules: water. Water is among the most abundant substances on Earth, covering more than two-thirds of the planet. Consisting of just three atoms, the water molecule is superficially simple in its structure but extraordinary in its properties. It is a rare example of a substance that can be found on Earth in gaseous, liquid and solid forms, and thanks to its unique chemical behaviour is the basis of all known life. Scientists are still discovering new things about it, such as the fact that there are at least fifteen different forms of ice.

Hasok Chang Hans Rausing Professor of History and Philosophy of Science at the University of Cambridge

Andrea Sella Professor of Chemistry at University College London

Patricia Hunt Senior Lecturer in Chemistry at Imperial College London.

Producer: Thomas Morris.

In a programme first broadcast in 2013, Melvyn Bragg and his guests discuss absolute zero, the lowest conceivable temperature.  In the early eighteenth century the French physicist Guillaume Amontons suggested that temperature had a lower limit.  The subject of low temperature became a fertile field of research in the nineteenth century, and today we know that this limit - known as absolute zero - is approximately minus 273 degrees Celsius.  It is impossible to produce a temperature exactly equal to absolute zero, but today scientists have come to within a billionth of a degree.  At such low temperatures physicists have discovered a number of strange new phenomena including superfluids, liquids capable of climbing a vertical surface.

With:

Simon Schaffer Professor of the History of Science at the University of Cambridge

Stephen Blundell Professor of Physics at the University of Oxford

Nicola Wilkin Lecturer in Theoretical Physics at the University of Birmingham

Producer: Thomas Morris

Melvyn Bragg and his guests discuss the life and work of the Victorian anthropologist and archaeologist Augustus Pitt-Rivers. Over many years he amassed thousands of ethnographic and archaeological objects, some of which formed the founding collection of the Pitt Rivers Museum at Oxford University. Inspired by the work of Charles Darwin, Pitt-Rivers believed that human technology evolved in the same way as living organisms, and devoted much of his life to exploring this theory. He was also a pioneering archaeologist whose meticulous records of major excavations provided a model for later scholars.

With:

Adam Kuper Visiting Professor of Anthropology at Boston University

Richard Bradley Professor in Archaeology at the University of Reading

Dan Hicks University Lecturer & Curator of Archaeology at the Pitt Rivers Museum at the University of Oxford.

Producer: Thomas Morris.

Melvyn Bragg and his guests discuss comets, the 'dirty snowballs' of the Solar System. In the early 18th century the Astronomer Royal Sir Edmond Halley compiled a list of appearances of comets, bright objects like stars with long tails which are occasionally visible in the night sky. He concluded that many of these apparitions were in fact the same comet, which returns to our skies around every 75 years, and whose reappearance he correctly predicted. Halley's Comet is today the best known example of a comet, a body of ice and dust which orbits the Sun. Since they contain materials from the time when the Solar System was formed, comets are regarded by scientists as frozen time capsules, with the potential to reveal important information about the early history of our planet and others.

With:

Monica Grady Professor of Planetary and Space Sciences at the Open University

Paul Murdin Senior Fellow at the Institute of Astronomy at the University of Cambridge

Don Pollacco Professor of Astronomy at the University of Warwick

Producer: Thomas Morris.

Melvyn Bragg and his guests discuss the history of crystallography, the study of crystals and their structure. The discovery in the early 20th century that X-rays could be diffracted by a crystal revolutionised our knowledge of materials. This crystal technology has touched most people's lives, thanks to the vital role it plays in diverse scientific disciplines - from physics and chemistry, to molecular biology and mineralogy. To date, 28 Nobel Prizes have been awarded to scientists working with X-ray crystallography, an indication of its crucial importance.

The history of crystallography began with the work of Johannes Kepler in the 17th century, but perhaps the most crucial leap in understanding came with the work of the father-and-son team the Braggs in 1912. They built on the work of the German physicist Max von Laue who had proved that X-rays are a form of light waves and that it was possible to scatter these rays using a crystal. The Braggs undertook seminal experiments which transformed our perception of crystals and their atomic arrangements, and led to some of the most significant scientific findings of the last century - such as revealing the structure of DNA.

With:

Judith Howard Director of the Biophysical Sciences Institute and Professor of Chemistry at the University of Durham

Chris Hammond Life Fellow in Material Science at the University of Leeds

Mike Glazer Emeritus Professor of Physics at the University of Oxford and Visiting Professor of Physics at the University of Warwick

Producer: Natalia Fernandez.

Melvyn Bragg and his guests discuss Fermat's Last Theorem. In 1637 the French mathematician Pierre de Fermat scribbled a note in the margin of one of his books. He claimed to have proved a remarkable property of numbers, but gave no clue as to how he'd gone about it. "I have found a wonderful demonstration of this proposition," he wrote, "which this margin is too narrow to contain". Fermat's theorem became one of the most iconic problems in mathematics and for centuries mathematicians struggled in vain to work out what his proof had been. In the 19th century the French Academy of Sciences twice offered prize money and a gold medal to the person who could discover Fermat's proof; but it was not until 1995 that the puzzle was finally solved by the British mathematician Andrew Wiles.

With:

Marcus du Sautoy Professor of Mathematics & Simonyi Professor for the Public Understanding of Science at the University of Oxford

Vicky Neale Fellow and Director of Studies in Mathematics at Murray Edwards College at the University of Cambridge

Samir Siksek Professor at the Mathematics Institute at the University of Warwick.

Producer: Natalia Fernandez.

Melvyn Bragg and his guests discuss the cell, the fundamental building block of life. First observed by Robert Hooke in 1665, cells occur in nature in a bewildering variety of forms. Every organism alive today consists of one or more cells: a single human body contains up to a hundred trillion of them.

The first life on Earth was a single-celled organism which is thought to have appeared around three and a half billion years ago. That simple cell resembled today's bacteria. But eventually these microscopic entities evolved into something far more complex, and single-celled life gave rise to much larger, complex multicellular organisms. But how did the first cell appear, and how did that prototype evolve into the sophisticated, highly specialised cells of the human body?

With:

Steve Jones Professor of Genetics at University College London

Nick Lane Senior Lecturer in the Department of Genetics, Evolution and Environment, University College London

Cathie Martin Group Leader at the John Innes Centre and Professor in the School of Biological Sciences at the University of East Anglia

Producer: Thomas Morris.