ImmunoChat – Détails, épisodes et analyse

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Keywords:

Gut Microbiome, Autoimmunity, Lupus, Microbiome Research, Enterococcus gallinarum, Immunological Tolerance, Microbiome Therapies

Summary: 

In this episode of the Young Immunologist Podcast ImmunoChat, Pia Madeleine Leipe talks with Carina Brune about the role of the gut microbiome in the immune system and its connection to autoimmune diseases. They discuss the importance of gut microbes, the challenges in researching autoimmune diseases, and the potential therapeutic approaches emerging from microbiome research.

Takeaways:

• The gut microbiome plays a crucial role in regulating the immune system.
• Dysbiosis in the microbiome can lead to autoimmune diseases.
• Enterococcus gallinarum is a bacterium linked to the development of lupus.
• Future therapies may target microbiome modulation, including vaccines and phage therapy.

Please find here links to publications referred to in this Episode:  

General Info:

•  Family size, infection and atopy: the first decade of the 'hygiene hypothesis' | Thorax
• Host–microbiota interactions in immune-mediated diseases | Nature Reviews Microbiology

SLE and microbiome:

• Translocation of a gut pathobiont drives autoimmunity in mice and humans | Science
• Within-host evolution of a gut pathobiont facilitates liver translocation | Nature
• Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human | Science Translational Medicine
• Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders | Annals of the Rheumatic Diseases

 Phage therapy

• Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation: Cell

YouTube Video

Hinter den Kulissen des Tierlaboratoriums der Medizinischen Hochschule Hannover

Contact details

Carina Brune – University of Münster | LinkedIn

Immune-Microbiota Interactions Lab (@agkriegel.bsky.social) — Bluesky

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

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Keywords

HIV, immunology, virology, immunological niches, Cytotoxic CD4 T cells, , CD137, HIV reservoirs

Summary

In this episode of the Young Immunologist Podcast ImmunoChat, Pia Leipe engages with Dr. Anna Malyshkina to explore the complexities of HIV, its interaction with the immune system, and the innovative research being conducted to combat this virus. They discuss the roles of various immune cells, the challenges of antiretroviral therapy, and the significance of immunological niches where HIV can hide. Dr. Malyshkina shares insights into her research on cytotoxic CD4 T follicular helper cells and the potential of CD137 as a target for immunotherapy. 

Takeaways

• HIV primarily targets CD4 T cells, disrupting the immune system's coordination.
• Antiretroviral therapy suppresses HIV but does not eliminate it.
• Immunological niches provide safe harbors for HIV, complicating treatment.
• CD4 T follicular helper cells can be armed to target HIV.
• CD137 is a promising target for enhancing T cell responses.

Please find here links to publications referred to in this Episode:  

https://pubmed.ncbi.nlm.nih.gov/37965314/ 

https://pubmed.ncbi.nlm.nih.gov/37883584/

https://pubmed.ncbi.nlm.nih.gov/30635687/

https://pubmed.ncbi.nlm.nih.gov/30782653/ 

https://pubmed.ncbi.nlm.nih.gov/28798348/ 

https://pubmed.ncbi.nlm.nih.gov/26608920/

https://pubmed.ncbi.nlm.nih.gov/37910505/

Contact details

·      Dr. Anna Malyshkina 

·      LinkedIn: https://www.linkedin.com/in/anna-malyshkina-776324178/

·      Institute of Physiology Essen: https://www.uni-due.de/physiologie/

·      Institute for Virology Essen: https://www.uni-due.de/virologie/

·    ELAN Proposal UDE: https://www.unidue.de/med/promotionskolleg/evaluierte_projekte.php 

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

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Summary

This episode of the Young Immunologist podcast discusses mental health during a PhD journey. The guest, Julian, shares his personal experience with mental health issues during his PhD and the challenges he faced. He emphasizes the importance of having empathetic people around and finding support from others who have similar experiences. The episode also highlights the impact of academic pressure on mental health and the need for institutional support. The conversation concludes with three tips for dealing with stress and maintaining mental wellbeing. The conversation explores the topics of negative thinking, anxiety, overcoming mental health challenges, personal growth, self-acceptance, and seeking help and support.

Takeaways

• Having empathetic people around and finding support from others who have similar experiences is crucial for mental wellbeing during a PhD journey.
• Academic pressure and the fear of failure can contribute to mental health issues such as anxiety and depression.
• Seeking professional help and support from psychologists or therapists is important for managing mental health during a PhD.
• Being kind to oneself and acknowledging small successes is essential for maintaining mental wellbeing.
• The mindset and thinking process play a significant role in managing stress and maintaining mental health. Negative thinking can lead to anxiety and panic disorders.
• Challenging mental health issues is a process that takes time and effort.
• Facing and overcoming mental health challenges can lead to personal growth and self-acceptance.
• Seeking help and support from trusted individuals or professional resources is crucial in managing mental health.

Chapters

00:00
Introduction

02:18
Julian's PhD Project

03:55
Mental Wellbeing during PhD

07:14
Imposter Syndrome and Mental Struggles in Academia

10:15
First Signs of Mental Health Issues

17:14
Academic Pressure and Mental Health

19:00
Seeking Help and Support

23:19
Substance Abuse and Mental Health

29:00
Impact of Environment and Supportive Network

36:15
PI's Support and Empathy

39:04
Three Tips for Dealing with Stress

44:27
Negative Thinking and Anxiety

48:47
Overcoming Mental Health Challenges

50:59
Personal Growth and Self-Acceptance

51:26
Seeking Help and Support

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

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In this episode, Nora interviews Robert and Dimitra from TwentyOne Skills (https://lms.twentyoneskills.de/), a company that focuses on teaching scientists soft skills. https://www.linkedin.com/company/twentyoneskills/

Great article about soft sklls out from World economic forum:
https://www.weforum.org/agenda/2024/01/ai-value-soft-skills-workplace-jobs/

Takeaways

• Soft skills are essential for scientists to succeed in their careers and make a positive impact.
• The scientific world is evolving, and scientists need to adapt to new formats of communication and collaboration.
• Universities and research institutions should provide opportunities for scientists to develop soft skills and support their personal growth.
• PhD students and scientists can take the initiative to learn and develop soft skills that are relevant to their field and personal interests.
• Learning soft skills is a lifelong process, and scientists can continuously seek opportunities to improve their skills.

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Send us Fan Mail

Listen to our episode with the fabulous Dr. Natalie Grams, who talks about all aspects of homeopathy. We discuss the basic idea behind traditional German medicine, it's role in our model society, and it's potential harms as well.

Natalie used to practice homeopathy as well, but due to an accident recognised the harm of it. She shares all her knowledge and experience in the field.
We discuss in this episode:
Information Network Homeopathy: https://netzwerk-homoeopathie.info/
Natalie´s Podcast: https://detektor.fm/serien/grams-sprechstunde
Her book about homeopathy: https://www.amazon.com/Homeopathy-Reconsidered-Really-Helps-Patients/dp/3030005089

Listen to our podcast and take advantage of an international community of young immunologists.
Contact them via:
yEFIS email: yefis@efis.org

 yEFIS website registration: https://www.yefis.org/join-now/register/yefis-network-register-and-login.html

 yEFIS twitter: y_efis

 yEFIS LinkedIn: y-efis

 Twitter handle: @EurJImmunol

Apply to the DGFI travel award: 

https://dgfi.org/reisekostenbeihilfen/

The Podcast is hosted by Dr. Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de
https://twitter.com/norabalzer1

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Send us Fan Mail

Listen to our special episode with our European partner society, the yEFIS. https://www.yefis.org/
Here, we discuss the power of a community on the national and European level to support young immunologists on their path. My guests are Rami Bechara (@ramibechara), Santiago Costas, and Anne Hahn (@kuriosera) the power-engine behind yEFIS and the collaboration with EJI, the European Journal of Immunology.

Listen to our podcast and take advantage of an international community of young immunologists.
Contact them via:
yEFIS email: yefis@efis.org

 yEFIS website registration: https://www.yefis.org/join-now/register/yefis-network-register-and-login.html

 yEFIS twitter: y_efis

 yEFIS LinkedIn: y-efis

 Twitter handle: @EurJImmunol

Apply to the DGFI travel award: 

https://dgfi.org/reisekostenbeihilfen/

The Podcast is hosted by Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de
https://twitter.com/norabalzer1

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Send us Fan Mail

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Send us Fan Mail

Listen our special episode on animal research on the word week of lab animals and day of immunology. We compare the general ethic and regulations in animal research between two European countries. We will compare the German and the Swiss system. It is a pleasure to exchange with Dr. Roman Stilling from the initiative “Tierversuce verstehen” - understand animal research who will give us great insight into the principles and animal experiment ethics in Germany. The Swiss side is represented by Dr. Lena Siewert from the University of Basel.

https://www.tierversuche-verstehen.de/

The Podcast is hosted by Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de
https://twitter.com/norabalzer1

The podcast is supported by the German association of immunology (GDfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Send us Fan Mail

Aimed Analytics (https://www.aimed-analytics.com/) was founded by
Dr. Patrick Günther - https://www.linkedin.com/in/patrick-guenther/  https://twitter.com/patguenther1
Dr. Kevin Baßler - https://www.linkedin.com/in/kevin-ba%C3%9Fler-3a230592/
https://twitter.com/kevin_bassler
Jan Rudolph - https://www.linkedin.com/in/jan-rudolph/ https://twitter.com/janews

They have been supported by the Exist Start-Up Grant - https://www.exist.de/EXIST/Navigation/EN/Start-upFunding/EXIST-Business-Start-up-Grant/exist-business-start-up-grant.html
and by ENACOM transfer center - https://www.uni-bonn.de/de/forschung-lehre/transfercenter-enacom

The Podcast is hosted by Nóra Balzer - https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de
https://twitter.com/norabalzer1

The podcast is supported by the German association of immunology (GDfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

Send us Fan Mail

In Episode 0 we talk about the DGfI (German Association of Immunology) - Young Immunologist board members. Become a member today!  
https://dgfi.org/young-immunologists/   
https://www.linkedin.com/company/dgfi-yi/.  
https://twitter.com/YI_dgfi   

THE YI BOARD (2021-2023).  
Spokesperson - Sabrina B. Bennstein, 
Vice-Spokesperson - Tal Pecht, 
Katharina Glosse (geb. Bomans), 
Laila Kulsvehagen, 
Lorenz Kretschmer, 
Christos Nikolaou, 
Lucas Seccim Ribeiro 

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/