Immune – Détails, épisodes et analyse

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness.

Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Microglia shape cortical development and behavior (Cell)
• Neutrophil trapping by mast cells (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey.

Hosts: Cindy Leifer and Steph Langel

Guest: David Martinez

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Music by Tatami.
Logo image by Blausen Medical

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Content in this podcast should not be construed as medical advice.

Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Intranasal neomycin as antiviral (PNAS)
• Sexual dimorphism in skin immunity (Science)
• Maternal diet and infant respiratory health (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Depleting My-HSC rejuvenates aged immunity (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,  gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Adaptive immune responses preserved in hypervaccinated individual (Lancet)
• Synthetically glycosylated antigens for antigen-specific suppression of established immune responses (Nat Biomed Eng)
• Gut bacteria–derived serotonin promotes immune tolerance in early life (Sci Immunol)
• Immune correlates of viral control after SARS-CoV-2 challenge in adults (Sci Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Trans endothelial migration activates neutrophil killing (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

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Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

Guest: Juliet Morrison

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Download Immune 76 (48 MB .mp3, 67 min)
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• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Pleural macrophages move to the lung during influenza (PNAS)
• Time stamps by Jolene. Thanks!

Music by Steve Neal
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Guest: Ang Cui

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• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Immune Dictionary (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Carla R. Nowosad

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• MicrobeTV Discord Server
• B cells and the intestinal microbiome (Sem Immunol)
• B cell selection in gut germinal centres (Nature)
• B cell antigen internalization (Methods Mol Biol)
• Immune synapse architecture (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Become a patron of Immune!

• MicrobeTV Discord Server
• Immune cells in the human body (PNAS)
• Letters read on Immune 73
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv