Healthy Longevity – Détails, épisodes et analyse

Imagine taking your own stem cells from your hair follicles, preserving and banking them to rejuvenate your hair and skin when you start to notice those annoying signs of aging in the mirror. This is not science fiction; it's happening right now, and you will learn all about it in today's episode of Healthy Longevity from my guest biomedical engineer Drew Taylor, PhD, CEO of the regenerative medicine company Acorn Biolabs. 

Want to perform better tomorrow at anything you do? Then get a good night's sleep tonight. "Sleep plays a critical role in restoration for humans; it is the housekeeping process for our physiology that allows us to restore and start the next day," says sleep expert Sahil Chopra, MD, today's guest on Healthy Longevity with Florence Comite MD.

            Dr. Chopra is co-founder and chief medical officer for Empower Sleep, a virtual sleep care program that makes personalized multi-night sleep analysis and treatment accessible from home.

            Nearly 40% of adults report falling asleep during the day without meaning to at least once a month. Also, an estimated 50 to 70 million Americans have chronic, or ongoing, sleep disorders, according to the Centers for Disease Control and Prevention.

"If people don't sleep well, the likelihood of having cardiovascular disease … is higher, the possibility of cancer is six-fold higher," says Chopra. "Growth hormone levels are lower; cortisol dysregulation is higher. Circadian rhythms, if they are misaligned, result in a compromised metabolic state. REM sleep plays a critical role in emotional stability."

            If you're suffering from brain fog or nodding off at your desk after lunch, you'll want to tune in to discover how to dramatically improve your health and health trajectory by improving your sleep habits.  

You'll learn:

* Sleep debt builds slowly, so you may not recognize what it's doing to you.

* Why a one-night sleep study is not an effective way to diagnose a sleep disorder.

* Sleep trackers like Empower Sleep's medical-grade ring and consumer models like the Oura Ring provide patients with real-time analysis of their sleep quality in their own bed without spending a restless night in a sleep lab wired to a machine.

* Poor sleep is a gut punch, affecting the gut microbiome by disrupting the GI tract's normal nightly slow-down, which allows its epithelial lining to repair and recover.

* Lack of sleep compromises the immune system. Studies show that sleep-deprived people (getting four to six hours of sleep) don't respond to vaccines as well as people who get adequate sleep (seven to eight hours).

* During deep sleep stages, blood flow to the brain peaks through the glymphatic system, which clears the beta amyloid and tau proteins that are believed to play a role in Alzheimer's dementia.

* What to do an hour before bedtime and within 15 minutes of waking to reset a healthy circadian rhythm.

* Remedies for restless leg syndrome, including new technology that stimulates nerves in the legs to make the brain think that your lower limbs are moving.

* And much more!

About Florence Comite, MD

Dr. Comite began her medical journey at Yale University School of Medicine and continued at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale.

In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and subsequently expanded offices to Palo Alto and Miami Beach.

Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30.

Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.

Many women who can benefit from hormones are still sitting on the sidelines because of long-held misconceptions about health risks of hormone therapy. "We need to move on from that crazy debate that hormones are bad," says gynecologist and integrative medicine physician Felice Gersh MD, author of PCOS SOS and Menopause: 50 Things You Need to Know. "Estradiol is the elixir of life!" In this episode, Dr. Comite interviews Dr. Gersh about how insufficient hormones dramatically impact a woman's current and future health.

You'll learn…

·         Not only can hormone therapy ease hot flashes, sleep disturbance, and other symptoms of menopause, it reduces insulin resistance and cardiovascular disease risk in menopausal women, optimizes production of growth factors in the brain and supports bone health.

·         Breast cancer is more common after menopause when estrogen levels drop.

·         The close connection between PCOS and Menopause.

·         Chronic inflammation upregulates aromatase and changes estrogen into an unhealthy form called "estrone."

·         50% of women with PCOS have a first-degree relative who has PCOS.

·         While excess testosterone is blamed for PCOS, polycystic ovary syndrome is primarily a condition caused by not enough estradiol.

·         "You can't heal without hormones, but until you're healed, you won't make the hormones," says Dr. Gersh.

·         Why you should take estradiol in cream or patch form, not orally.

Hormone optimization, often referred to as HRT or hormone replacement therapy, has the power to transform women's lives—but despite its benefits, many women remain hesitant to pursue it due to unfounded fears. In Part II of her guest appearance on Healthy Longevity, gastroenterologist and long-COVID expert Robin Rose, MD, shares real-life case studies that reveal the tangible impact of hormone optimization. Combined with insights from Dr. Comite's decades of endocrinology experience, these patient stories demonstrate how personalized treatment, regular monitoring, and education can make all the difference in a woman's health journey. 

You'll Learn… 

• The reasons why so many women hesitate to embrace bioidentical hormone optimization therapies yet will take synthetic hormones for birth control without thinking twice.  

• The biggest misconceptions about estrogen, progesterone, and testosterone—and what the science actually says.  

• Real-life case studies that showcase the power of personalized hormone management. 

• How long COVID (and even the COVID vaccine) can throw hormones off balance, especially in young women. 

• The critical role of tracking hormone levels and making precise adjustments over time. 

• How hormone optimization can reverse biological aging and protect your heart, brain, and bones.  

The pandemic is not a distant memory for the 17 million US adults who the CDC says suffer from "long-haul COVID." Gastroenterologist Robin Rose, MD, an expert in treating long COVID says "the gut is ground zero" for the virus's notorious spike protein and the protein's conduit to every cell in the body. In this episode, Dr. Comite interviews this practitioner of next-generation precision healthcare about our microbiome's role in aging and the downstream effects of COVID on our health.  

 You'll learn… 

• The COVID-19 spike protein can bind to 22 cell receptors and can impact 300 biological pathways in the body, triggering chronic disease and accelerating aging. 

• How spike proteins get inside cells, transforming them into "zombie cells."  

• That spike proteins from mRNA vaccines as well as the virus itself destroy bifidobacteria, one of the most beneficial bugs in our gut. 

• About natural compounds that work synergistically along biological pathways to move the spike protein out of the body.  

• How "leaky gut" develops and its impact on organs and the immune system. 

• The critical importance of regular blood tests and "knowing your body."  

• Dr. Rose's three free guaranteed health boosters: Community, gratitude, and movement. 

"Weight gain is not about lack of willpower; it's biology," says obesity doctor and GLP-1 expert Alexandra Sowa, MD. In this episode, the author of the new book The Ozempic Revolution: A Doctor's Proven Plan for Success to Help You Reverse Obesity, End Yo-Yo Dieting, Protect Yourself from Disease, cuts through the confusion surrounding GLP-1 medications and tells listeners what her most successful and happiest patients do to reap the full health benefits of these game-changing peptides. Dr. Sowa is the founder of the telehealth clinic SoWell Health. 

You'll learn… 

• Why "try harder" is terrible medical advice.  

• The differences between GLP-1 drugs like Ozempic, Wegovy, Monjuro and Zepbound. 

• How GLP-1s quiet the "food noise" in your brain.  

• Are GLP-1s right for you? 

• How to get your prescription covered.  

• How to eat and exercise to minimize symptoms and gain the best results.  

• The future of GLP-1s and how they may help eliminate chronic disease. 

Dr. Comite began her medical journey at Yale University School of Medicine and continued with at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. 

In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach. 

Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30.  

Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.  

Looking to make 2025 your healthiest year ever? "You can take control of your health by changing the way your genes express themselves," says Florence Comite, MD. "Your genes don't have to be your destiny." In this episode, Dr. Comite switches seats with her guest, Deepti Agarwal MD, who interviews Comite about her career as a forward-thinking endocrinologist and innovator in Precision Medicine. Dr. Agarwal is an anesthesiologist, integrative medicine physician, and Director of Interventional and Integrative Pain Management at Case Integrative Health in Chicago. 

You'll learn… 

• How aging changes your body (beginning around age 30), specifically how the hormone testosterone declines by 1 to 3 percent per year in both men and women and what that means for your health.  

• Why your doctor needs to know your health story to make a difference in your health path. You'll learn the elements necessary to write your health story.  

• About the "poor man's genetic test," the most underutilized tool for longevity.  

• Why the way to losing weight is moderation, not deprivation, and starting meals with protein to manage cravings for carbs. 

• How to be proactive about your health to prevent the disorders of aging—heart disease, diabetes, osteoporosis, and more. 

Dr. Comite began her medical journey at Yale University School of Medicine and continued with at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. 

In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach. 

Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30.  

Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.  

Peptides are becoming more and more popular, not only among biohackers, but people who just want to boost their health a notch or two. What are peptides? In short, they're chains of amino acids that can be combined to form proteins that trigger specific beneficial cellular functions, such as reducing inflammation, improving skin health, and growing muscle. In this episode of Healthy Longevity, Dr. Comite interviews Neil Paulvin, DO, a Manhattan physician specializing in anti-aging and regenerative medicine who's known as "Dr. Peptide" for his expertise in peptide therapy.  

You'll learn…  

• How Dr. Paulvin combines personalized functional medicine, peptide and hormone therapy, and biohacking techniques to help patients improve their healthspan and perform at their best.  

• Dr. Paulvin's three favorite peptides for longevity. 

• The free, in-home health hack that will dramatically improve anyone's energy, mood, and cognitive function.  

• Best peptides for weight loss, brain health, inflammation, healing gut lining. and more.  

• The skin rejuvenating benefits of GHK Copper  

If you are a stress-aholic, you need to put more "O" in your life. The "O" in orgasm also is the "O" in oxytocin, the hormone of love and connection, says Anna Cabeca DO, an OBGYN, best-selling author, and expert in hormones and menopause known as The Girlfriend Doctor. In this episode of Healthy Longevity, Dr. Comite interviews Dr. Cabeca about how boosting oxytocin can help women counteract the stress hormone cortisol, lower risk of diabetes, supercharge sexual desire and function, and more! 

You'll learn…  

• How Dr. Cabeca turned her life (and health) around after the tragic death of her toddler son and breakup of her marriage, which triggered early menopause. 

• Stress messes up our adaptive hormones—as cortisol goes up, oxytocin goes down.  

• 5 simple ways to boost oxytocin naturally to help your body repair itself.  

• How eating alkaline foods can rebalance your acidic physiology leading to weight loss, improved sleep and mood, and relief from brain fog and hot flashes. 

• The morning and evening routine that resets your circadian rhythm.  

• About new oxytocin-boosting treatments to combat vaginal dryness, clitoral atrophy and improve orgasm. 

Lorenzo Thione is an entrepreneur, expert in Artificial Intelligence, a celebrated storyteller. and Broadway producer four-times nominated for and twice winner of Tony Awards. For someone so busy, it's remarkable he finds the time to stay as laser focused on his health as he appears. But is he really doing all he could to optimize his body? In this episode of Healthy Longevity, Dr. Comite analyzes Thione's recent blood work to see if his biomarkers reveal he's as healthy on the inside as he looks on the outside.  

You'll learn…  

• How Thione, a technology expert and self-quantifier, uses wearable devices and other health data point to inform his lifestyle decisions.  

• How testosterone optimization therapy improved Thione's energy, libido, and more! 

• Dr. Comite's recommendations for improving his low levels of magnesium, a mineral that's essential for gut and brain and plays a role in over 300 critical functions in the body.  

• Insights about homocysteine and why some people need methylated forms of vitamin B12.  

•  Why family health history has been called a poor man's genetic test.