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TitreDateDurée
Rheumatology/Psoriatic Arthritis Edition: Top Headlines for Week of September 23, 202426 Sep 202400:11:48
Lung Cancer Edition: Top Headlines for Week of September 16, 202419 Sep 202400:13:55

In this edition, FDA approves first subcutaneous anti-PD-L1 cancer immunotherapy, ivonescimab ‘may be a new standard’ and more.

Read the full coverage here:

FDA approves first subcutaneous anti-PD-L1 cancer immunotherapy

Ivonescimab extends PFS vs. pembrolizumab in advanced NSCLC, may be ‘a new standard’

Perioperative nivolumab improves outcomes in resectable NSCLC

Despite progress, barriers to lung cancer biomarker testing persist

Atezolizumab regimen ‘merits further study’ for unresectable NSCLC

References:

Forde PM, et al. Abstract 3589. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego.

Press Release

Ross HJ, et al. JAMA Oncol. 2024;doi:10.1001/jamaoncol.2024.1897.

Smeltzer M, et al. Abstract 3000. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego.

Zhou C, et al. Abstract 2700. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego.

DME/Retina Edition: Top Headlines for Week of September 9, 202412 Sep 202400:08:40

In this edition, enrollment and dosing complete in phase 1 trial of AIV007, popular benchmarks in clinical practice guidelines and more.

Read the full coverage here:

Enrollment, dosing complete in phase 1 trial of AIV007 for AMD, diabetic macular edema

OCT, visual acuity popular benchmarks in clinical practice guidelines for DME

First patient dosed in phase 2 trial of EC-104 implant for diabetic macular edema

OCS-01 eye drop for DME in second stage of phase 3 trial

Q&A: Susvimo delivers immediate durability after implantation in wet AMD

References:

Crawford C. Update on OCS-01: A novel topical drop for DME in phase 3 trials. Presented at: Clinical Trials at the Summit; June 8, 2024; Park City, Utah.

Healio Interviews

McAllister M, et al. Assessing the strength of clinical practice guidelines for managing diabetic macular edema — A systematic literature review. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm.

Press Release

Press Release

Rheumatology/Psoriatic Arthritis Edition: Top Headlines for Week of August 19, 202422 Aug 202400:11:18
Lung Cancer Edition: Top Headlines for Week of August 12, 202415 Aug 202400:15:14
DME/Retina Edition: Top Headlines for Week of August 5, 202408 Aug 202400:11:23

In this edition, sozinibercept combination therapy shows durability, comparable improvements with aflibercept and more.

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Sozinibercept combination therapy shows durability in patients with DME, neovascular AMD

VIDEO: Comparable improvements seen with aflibercept 8 mg vs. 2 mg in DME

DPP-IV, SGLT2 and GLP-1 drugs do not increase risk for diabetic macular edema

Eluminex doses first patient in phase 1b trial of EB-105 for diabetic macular edema

VIDEO: Port delivery system maintains visual, anatomic improvements in DME at 2 years

References:

Awh C. Port delivery system with ranibizumab for continuous treatment of diabetic macular edema: First readout of the phase 3 Pagoda trial year 2 results. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm.

Do D. Outcomes of patients with DME and baseline BCVA of 20/50 or worse or 20/40 or better treated with aflibercept 8 mg and 2 mg in the phase 2/3 PHOTON trial. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm.

Phu A, et al. J Diabetes Complications. 2024;doi:10.1016/j.jdiacomp.2024.108808.

Press Release

Steinle NC. Durability of combination therapy of sozinibercept (OPT-302), an anti-VEGF-C/-D ‘trap’ with ranibizumab in nAMD or aflibercept in DME. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm.

Rheumatology/Psoriatic Arthritis Edition: Top Headlines for Week of July 22, 202425 Jul 202400:11:11
Lung Cancer Edition: Top Headlines for Week of July 15, 202418 Jul 202400:12:40

In this edition, atezolizumab benefits PD-L1-selected patients with NSCLC, risks persist with e-cigarette use after quitting tobacco smoking and more.

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Adjuvant atezolizumab benefits PD-L1-selected patients with NSCLC

Lung cancer risks persist with e-cigarette use after quitting tobacco smoking

COPD, IPF end of life health care use differs from lung cancer

Tecentriq combination fails to improve survival in metastatic lung cancer

Risk for lung cancer reoccurrence may be associated with OSA-related hypoxemia

References:

Figueroa Rodriguez F, et al. 0468: CRASH: Cancer reoccurrence is accelerated by episodic hypoxemia. Presented at: SLEEP; June 1-5, 2024; Houston.

Kim Y, et al. Association of electronic cigarette use after conventional smoking cessation with lung cancer risk: A nationwide cohort study. Presented at: American Thoracic Society International Conference; May 18-22, 2024; San Diego.

Press Release

Suen AO, et al. Am J Respir Crit Care Med. 2024;doi:10.1154/ajrccm-conference.2024.209.1_MeetingAbstracts.A5040.

Wakelee HA, et al. Abstract LBA8035. Presented at: ASCO Annual Meeting; May 31-June 4, 2024; Chicago.

DME/Retina Edition: Top Headlines for Week of July 8, 202411 Jul 202400:10:22

In this edition, FDA approves Vabysmo prefilled syringe for retinal diseases, 4D Molecular Therapeutics updates on retinal disease candidates and more.

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FDA approves Vabysmo prefilled syringe for retinal diseases

VIDEO: 4D Molecular Therapeutics shares update on retinal disease candidates

FDA approves Eylea biosimilar FYB203/Ahzantive

VIDEO: Oral therapy improves central subfield thickness in DME in early-stage study

ANI Pharmaceuticals to acquire Alimera Sciences

References:

Agrawal R. RZ402: Initial results from a phase 2 study of a novel, orally administered PKal inhibitor in patients with DME. Presented at: Clinical Trials at the Summit; June 8, 2024; Park City, Utah.

Healio Interviews

Press Release

Press Release

Press Release

Editor's note: At the 1:35 mark, we mention that Vabysmo will be available later this year. This specifically applies to Vabysmo pre-filled syringe. There is a currently available formulation already on the market.

Rheumatology/Psoriatic Arthritis Edition: Top Headlines for Week of June 24, 202427 Jun 202400:10:14

In this edition, extensive psoriasis and IBD history predict difficult-to-treat psoriatic arthritis, targeted therapies demonstrate low risk for serious infection and more.

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Extensive psoriasis, IBD history predict difficult-to-treat psoriatic arthritis

Targeted psoriatic arthritis therapies demonstrate low risk for serious infection

VIDEO: Dermatologists, rheumatologists share care in psoriasis, psoriatic arthritis

Patients with arthritis at higher risk for poor nutrition regardless of function

FDA approves Rinvoq for JIA, psoriatic arthritis in children aged 2 years and older

References:

Bastard L, et al. RMD Open. 2024;doi:10.1136/rmdopen-2023-003865.

Bennett R, et al. Sci Rep. 2024;doi:10.1038/s41598-024-58370-7.

Husni ME. Update in the treatment of psoriatic arthritis. Presented at: Medical Dermatology Therapy Update III; May 29-31, 2024; Cleveland.

Press Release

Vassilakis KD, et al. Rheumatology. 2024;doi:10.1093/rheumatology/keae263.

Lung Cancer Edition: Top Headlines for Week of June 17, 202420 Jun 202400:15:04

In this edition, screening program identifies airways disease in previously undiagnosed COPD, positive results show benefits of subcutaneous bispecifics and more.

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Lung cancer screening program identifies airways disease in previously undiagnosed COPD

Positive results in lung cancer show benefits of subcutaneous bispecifics

Adagrasib delays progression of pretreated KRAS-mutant lung cancer

Durvalumab extends survival in limited-stage small-cell lung cancer

Osimertinib delays progression ‘way more’ than hoped in EGFR-mutant lung cancer

References:

Bernstein E, et al. JCO Precis Oncol. 2024;doi:10.1200/po.23.00447.

Leighl NB, et al. Abstract LBA8505. Presented at: ASCO Annual Meeting; May 30–June 3, 2024; Chicago.

Ramalingam SS, et al. Abstract LBA4. Presented at: ASCO Annual Meeting; May 31-June 4, 2024: Chicago.

Seigo MA, et al. Pulmonary comorbidities, respiratory symptoms, and spirometry in a real-world, urban lung cancer screening program. Presented at: American Thoracic Society International Conference; May 17-22, 2024; San Diego.

Spigel DR, et al. Abstract LBA3. Presented at: ASCO Annual Meeting; May 31-June 4, 2024: Chicago.

DME/Retina Edition: Top Headlines for Week of June 3, 202406 Jun 202400:10:27

In this edition, AI model helps predict anti-VEGF response in DME, Merck to acquire EyeBio and more.

Read the full coverage here:

VIDEO: AI model helps predict anti-VEGF response in diabetic macular edema

Merck to acquire EyeBio

VIDEO: IOP remains stable up to 48 weeks with aflibercept 8 mg for DME

Phase 2 study of potential DME oral therapy meets primary endpoints

FDA approves aflibercept biosimilars Yesafili, Opuviz

References:

Barakat MR. Intraocular pressure outcomes with intravitreal injection of aflibercept 8 mg and 2 mg in patients with diabetic macular edema through week 48 of the phase 2/3 PHOTON trial. Presented at: Association for Research in Vision and Ophthalmology meeting; May 5-9, 2024; Seattle.

Luvisi J. Using a convolutional neural network to predict response of diabetic macular edema to intravitreal anti-vascular endothelial growth factor. Presented at: Kiawah Eye; May 30-June 1, 2024; Kiawah Island, South Carolina.

Press Release

Press Release

Press Release

Rheumatology/Psoriatic Arthritis Edition: Top Headlines for Week of May 20, 202423 May 202400:08:48

In this edition, difficult-to-treat psoriatic arthritis 'not all about the therapies', Samsung biosimilar comparable to etanercept and more.

Read the full coverage here:

Difficult-to-treat psoriatic arthritis 'not all about the therapies'

Samsung biosimilar comparable to etanercept for psoriatic arthritis outcomes at 1 year

Boehringer Ingelheim, Quallent partner to expand Humira biosimilar access

VIDEO: Mitigating risk for psoriatic arthritis in patients with psoriasis

FDA approves high-concentration, citrate-free form of interchangeable biosimilar Cyltezo

References:

Healio Interview

Łosińska K, et al. Arthritis Care Res. 2024;doi:10.1002/acr.25345.

Ogdie-Beatty A. Psoriatic Arthritis in 2024. Presented at The Congress of Clinical Rheumatology East; May 9-12, 2024; Destin, Florida (hybrid meeting).

Press Release

Press Release

Lung Cancer Edition: Top Headlines for Week of May 13, 202415 May 202400:13:04
DME/Retina Edition: Top Headlines for Week of May 6, 202409 May 202400:09:54

In this edition, FDA accepts new drug application for Eluminex, most mentors in vitreoretinal subspecialty are men and more.

Read the full coverage here:

FDA accepts investigational new drug application for Eluminex DME treatment

Most mentors in vitreoretinal subspecialty are men

Carotid artery stenosis linked to retinal changes in patients with diabetic retinopathy

AI-assisted technology makes retinal imaging 100 times faster, with greater contrast

FDA clears fully autonomous AI for portable diabetic retinopathy screening

References:

Das V, et al. Commun Med. 2024;doi:10.1038/s43856-024-00483-1.

Lee CY, et al. BMC Ophthalmol. 2024;doi:10.1186/s12886-024-03391-z.

Press Release

Press Release

Shah SM, et al. Demographics and productivity trends among academically affiliated female vitreoretinal specialists in the United States. Presented at: Real World Ophthalmology; April 27, 2024 (virtual meeting).

Rheumatology/Psoriatic Arthritis Edition: Top Headlines for Week of April 22, 202425 Apr 202400:13:32
Lung Cancer Edition: Top Headlines for Week of April 15, 202418 Apr 202400:12:10
DME/Retina Edition: Top Headlines for Week of April 8, 202411 Apr 202400:12:28

In this edition, PALADIN study navigates IOP-lowering surgery in DME patients, small-molecule eye drop well-tolerated as treatment for retinal vascular diseases and more.

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PALADIN study: Navigating IOP-lowering surgery in DME patients for optimal outcomes

Small-molecule eye drop safe, well-tolerated as treatment for retinal vascular diseases

VIDEO: Reduction of vascular leakage, hyperreflective foci greater with faricimab

VIDEO: Real-world study shows durability of fluocinolone acetonide implant in DME

Early safety, efficacy results positive for Restoret in DME, wet AMD

References:

Chin Yee DS, et al. Outcomes in eyes requiring IOP-lowering surgery after treatment with the 0.19-mg fluocinolone acetonide implant for DME: The PALADIN study. Presented at: American Academy of Ophthalmology meeting; Nov. 3-6, 2023; San Francisco.

Graff JM. Biomarkers for vascular stability and inflammation demonstrate the benefit of dual Ang-2/VEGF-A inhibition with faricimab phase 3 trials in DME. Presented at: Retina 2024; Jan. 13-19, 2024; Wailea, Hawaii.

Minaker S. The 0.19mg fluocinolone acetonide (FAc) implant reduces the recurrence of edema by providing long-term control of retinal thickness variability in patients with DME: The 3-year PALADIN study. Presented at: Retina 2024; Jan. 13-19, 2024; Wailea, Hawaii.

Press Release

Press Release

Lung Cancer Edition: Top Headlines for Week of March 11, 202414 Mar 202400:12:07
Lung Cancer Edition: Top Headlines for Week of February 12, 202415 Feb 202400:13:31
Lung Cancer Edition: Top Headlines for Week of January 15, 202418 Jan 202400:10:49

In this edition, FDA places hold on cell therapy trial after patient death, selpercatinib delivers superior outcomes and more.

Read the full coverage here:

FDA places hold on trial of cell therapy for lung cancer after patient death

Selpercatinib delivers superior outcomes, may ‘reduce the burden of NSCLC’

First-line immunotherapy benefits patients of all races with NSCLC equally

Never-smoker lung cancer survivors require targeted surveillance

Cemiplimab plus chemotherapy improves outcomes in metastatic NSCLC

References:

Baramidze A, et al. Abstract 1495P. Presented at: European Society for Medical Oncology Congress; Oct. 20-24, 2023; Madrid.

Choi E, et al. JAMA Netw. Open. 2023;doi:10.1001/jamanetworkopen.2023.43278.

Lee M, et al. J. Natl Compr Canc Netw. 2023;doi:10.6004/jnccn.2023.7064

Press Release

Zhou C, et al. N Engl J Med. 2023;doi:10.1056.NEJMoa2309457.

Dermatology Edition: Top Headlines for Week of December 18, 202321 Dec 202300:08:09
Dermatology Edition: Top Headlines for Week of December 4, 202307 Dec 202300:10:11
Dermatology Edition: Top Headlines for Week of November 13, 202316 Nov 202300:07:52

In this edition, dermatologists ‘uniquely positioned’ to aid human trafficking victims; FDA approves Cosentyx for hidradenitis suppurativa and more.

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Dermatologists ‘uniquely positioned’ to recognize, aid human trafficking victims

FDA approves Cosentyx as first IL-17A inhibitor for hidradenitis suppurativa

FDA approves Stelara biosimilar for treatment of psoriasis, multiple inflammatory diseases

RECELL system efficacious in vitiligo repigmentation

Isotretinoin efficacious in seborrheic dermatitis treatment

References:

Elbuluk N. Optimizing melanocyte cell transplant procedure for treatment of vitiligo. Presented at: American Society for Dermatologic Surgery Annual Meeting; Nov 1-5, 2023; Chicago.

Kourosh S. The role of dermatologic surgeons in advocating for those affected by human trafficking. Presented at: American Society for Dermatologic Surgery Annual Meeting; Nov 1-5, 2023; Chicago.

Press Release

Press Release

Tan MG, et al. Isotretinoin for the management of moderate to severe seborrheic dermatitis. Presented at: American Society for Dermatologic Surgery Annual Meeting; Nov 1-5, 2023; Chicago.

Prostate Cancer Edition: Top Headlines for Week of November 6, 202307 Nov 202300:10:48

In this edition, multicancer detection tests show promise; lifestyle counseling appointments benefit cancer survivors; use of low-value drugs for patients with cancer, and more.

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Multicancer detection tests show promise, but questions linger about their accessibility

Shared medical appointments for lifestyle counseling benefit cancer survivors

Industry payments to physicians spur use of low-value drugs for patients with cancer

Study shows link between ultraprocessed foods and mortality risk

Radiation oncologist appointed to leadership role at NYU Langone’s Perlmutter Cancer Center

References:

Mitchell AP, et al. BMJ. 2023;doi:10.1136/bmj-2023-075512.

Press Release

Westgate C, Fischer J. What primary care physicians need to know about multicancer early detection tests. Presented at: OMED; Oct. 5-8, 2023.

Winters LN. The development of an advanced practice nurse and registered dietician-led lifestyle medicine shared medical appointment program for cancer survivors. Presented at: Lifestyle Medicine 2023; Denver; Oct. 29-Nov. 1, 2023.

Zhao Y, et al. Am J Prev Med. 2023;doi:10.1016/j.amepre.2023.09.005.

Dermatology Edition: Top Headlines for Week of October 30, 202302 Nov 202300:11:50

In this edition, FDA approves Bimzelx for plaque psoriasis; roflumilast foam improves quality of life in patients with seborrheic dermatitis and more.

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FDA approves Bimzelx for treatment of moderate to severe plaque psoriasis

Roflumilast foam improves quality of life in patients with seborrheic dermatitis

Opzelura effective, well tolerated in children aged at least 2 years with atopic dermatitis

Treatment for onychomycosis prescribed at only 20% of visits, impacting quality of life

Study: Important to weigh berdazimer gel benefits vs. risks in molluscum contagiosum

References:

Calvi IP, et al. Pediatr Dermatol. 2023;doi:10.1111/pde.15419.

Chu D. et al. Poster. Effect of roflumilast foam 0.3% on quality of life in patients with seborrheic dermatitis: patient-reported outcomes from the STRATUM phase III trial. Presented at: AMCP Nexus; Orlando.

Peck GM, et al. J Drugs Dermatol. 2023;doi:10.36849/JDD.6770.

Press Release

Press Release

Dermatology Edition: Top Headlines for Week of October 16, 202319 Oct 202300:08:34

In this edition, FDA issues complete response letter for relabotulinumtoxinA; mucocutaneous manifestations may signal COVID-induced inflammatory disease in children and more.

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FDA issues complete response letter for relabotulinumtoxinA for frown lines, crow’s feet

Mucocutaneous manifestations may signal COVID-induced inflammatory disease in children

FDA approves Zoryve for pediatric psoriasis

Colloidal oatmeal, prescription cream comparable in Black children with atopic dermatitis

FDA issues complete response letter for lebrikizumab for eczema treatment

References:

Imam B. Mucocutaneous clinical manifestation of multi-system inflammatory syndrome in children (MIS-C). Presented at: Skin of Color Update; Oct. 6-8, 2023; New York.

Lisante TA, et al. J Dermatolog Treat. 2023;doi:10.1080/09546634.2023.2241587.

Press Release

Press Release

Press Release

Prostate Cancer Edition: Top Headlines for Week of October 9, 202310 Oct 202300:13:40
Dermatology Edition: Top Headlines for Week of October 2, 202305 Oct 202300:12:26
Dermatology Edition: Top Headlines for Week of September 18, 202321 Sep 202300:12:36
Dermatology Edition: Top Headlines for Week of September 4, 202307 Sep 202300:11:30
Prostate Cancer Edition: Top Headlines for Week of August 28, 202301 Sep 202300:13:54

In this edition, ‘equitable access’ to care may reduce racial disparities in survival; exercise may improve sexual function among men with prostate cancer; image-guided adaptive prostate radiation therapy for short-term toxicities, and more.

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‘Equitable access’ to care may reduce racial disparities in prostate cancer survival

Exercise may improve sexual function among men with prostate cancer

Image-guided adaptive prostate radiation therapy reduces risk for short-term toxicities

Recent developments in advanced prostate cancer space pave way for future breakthroughs

Radiation plus intensive systemic therapy improves outcomes in prostate cancer subset

References:

Bossi A, et al. Abstract LBA5000. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Galvao DA, et al. Abstract 71. Presented at: ASCO Breakthrough; Aug. 3-5, 2023; Yokohama.

Leeman JE, et al. Cancer.2023;doi:10.1002/cncr.34836.

Sayegh N, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.26546.

Sharifi N, et al. J Clin Oncol. 2023;doi:10.1200/JCO.2022.40.16_suppl.5022.

Dermatology Edition: Top Headlines for Week of August 21, 202324 Aug 202300:10:15
Dermatology Edition: Top Headlines for Week of August 7, 202310 Aug 202300:10:49
Leukemia Edition: Top Headlines for Week of July 31, 202303 Aug 202300:11:39
Dermatology Edition: Top Headlines for Week of July 24, 202327 Jul 202300:10:10
Leukemia Edition: Top Headlines for Week of July 17, 202320 Jul 202300:11:56
Dermatology Edition: Top Headlines for Week of July 10, 202313 Jul 202300:12:34
Leukemia Edition: Top Headlines for Week of July 3, 202306 Jul 202300:12:35

In this edition, CAR-T trial for leukemia paused after patient death; obesity may increase risk for blood cancer; new CAR T-cell therapies ‘waiting’ for patients with leukemia and more.

Read the full coverage here:

Seattle Children’s pauses trial of CAR-T for leukemia after patient death

Obesity may increase risk for blood cancer

VIDEO: New CAR T-cell therapies ‘waiting in the wings’ for patients with leukemia

VIDEO: Jaktinib shows promise in treatment of myelofibrosis

Venetoclax regimen not superior to standard therapy alone for older patients with CLL

References:

ASCO Annual Meeting

ASCO Annual Meeting

Pasupuleti SK, et al. J Clin Invest. 2023;doi:10.1172/JCI163968.

Press Release

Woyach JA, et al. Abstract 7500. Presented at: ASCO Annual Meeting 2023; June 2-6, 2023; Chicago.

Neurology Edition: Top Headlines for Week of June 26, 202329 Jun 202300:10:19

In this edition, Leqembi shows benefits in early Alzheimer’s, sex before bed has more positive impact on sleep, clearer guidelines needed on melatonin use in children and more.

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FDA committee says Leqembi shows benefits in early Alzheimer’s

Sex before bed has more positive impact on sleep vs. medication in adults with insomnia

Increased education, clearer guidelines needed on melatonin use in children

FDA approves Elevidys for pediatric Duchenne muscular dystrophy

CMS announces plan for Medicare coverage of approved Alzheimer's drugs

References:

Kirsch D, et al. How well does sexual activity improve sleep when compared with pharmacologic sleep aids? Presented at: SLEEP; June 3-7, 2023; Indianapolis.

Owens J. Navigating the challenges in talking to patients and families about melatonin. Presented at: SLEEP; June 3-7, 2023; Indianapolis.

Press Release

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Press Release

Leukemia Edition: Top Headlines for Week of June 12, 202315 Jun 202300:13:50

In this edition, prior authorization linked delay in prescription fills; disparities in access to specialized cancer centers; ‘new potential treatment option’ for advanced chronic lymphocytic leukemia and more.

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Prior authorization policies linked to 2-week delay in anticancer-drug prescription fills

AYAs with rare leukemia face disparities in access to specialized cancer centers

Liso-cel CAR-T ‘new potential treatment option’ for advanced chronic lymphocytic leukemia

Benefits of ivosidenib regimen for IDH1-mutant AML increase with longer follow-up

Childhood cancer survivors at increased risk for sleep concerns decades after diagnosis

References:

Daniel LC. Sleep in long-term childhood cancer survivors compared to siblings: A report from the Childhood Cancer Survivor Study. Presented at: SLEEP; June 3-7, 2023; Indianapolis.

De Botton S, et al. Abstract 7012. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Kyle MA, et al. Abstract 1504. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Muffly L, et al. Abstract 7008. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Siddiqi T, et al. Abstract 7501. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Lung Cancer Edition: Top Headlines for Week of June 5, 202308 Jun 202300:13:24

In this edition, surgery confers higher 5-year survival rates than radiotherapy; first-line combination extends PFS in lung cancer subgroup; pembrolizumab improves outcomes in early-stage resectable lung cancer, and more.

Read the full coverage here:

Surgery confers higher 5-year survival rates than radiotherapy in early-stage lung cancer

First-line combination extends PFS in lung cancer subgroup

Pembrolizumab improves outcomes in early-stage resectable lung cancer

Chemotherapy after first-line EGFR TKI fails to extend survival in advanced NSCLC

Severe myelosuppression common after chemotherapy for small cell lung cancer

References:

Hart L, et al. Cancer Med. 2023;doi:10.1002/cam4.5738.

Kanda S, et al. Abstract LBA9009. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Press Release

Udelsman B, et al. Abstract 275. Presented at: American Association for Thoracic Surgery Annual Meeting; May 6-9, 2023; Los Angeles.

Wakelee H, et al. Abstract LBA100. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago.

Leukemia Edition: Top Headlines for Week of May 29, 202301 Jun 202300:11:41

In this edition, cross-border partnership takes on survival gap for children with leukemia; ‘paradigm shift’ in transfusion-dependent myelodysplastic syndrome; FDA approves Ayvakit for mastocytosis and more.

Read the full coverage here:

Cross-border partnership takes on ‘huge survival gap’ among children with leukemia

Luspatercept ‘a paradigm shift’ in transfusion-dependent myelodysplastic syndrome

FDA approves Ayvakit for indolent systemic mastocytosis

Novel leukemia treatment signals ‘new era in CAR T-cell therapy’

Functional precision medicine-guided approach benefits pediatric patients with cancer

References:

Acanda de la Rocha AM, et al. Abstract LB358. Presented at: American Association of Cancer Research Annual Meeting; April 14-19, 2023; Orlando.

Appelbaum J, et al. Abstract 3092. Presented at: American Society of Gene & Cell Therapy Annual Meeting; May 16-20, 2023; Los Angeles.

Aristizabal P, et al. Abstract 1502. Presented at: ASCO Annual Meeting; June 2-6, 2022; Chicago.

Garcia-Manero G, et al. Abstract 7003. Scheduled for presentation at: ASCO Annual Meeting; June 2-6, 2022; Chicago.

Press Release

Neurology Edition: Top Headlines for Week of May 23, 202325 May 202300:09:13

In this edition, FDA approves supplemental new drug application for Rexulti, early amyloid PET provides high diagnostic confidence, Leqembi reduced biomarkers of Alzheimer’s and more.

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FDA approves supplemental new drug application for Rexulti to treat Alzheimer's agitation

Early amyloid PET provides high diagnostic confidence for adults with cognitive impairment

Leqembi reduced biomarkers of Alzheimer’s, slowed cognitive decline at 18 months

FDA grants 510(k) clearance for self-directed EEG headset

Oral Bruton’s tyrosine kinase inhibitor reduced brain lesions in phase 2 MS trial

References:

Altomare D, et al. JAMA Neurol. 2023;doi:10.1001/jamaneurol.2023.0997.

Press Release

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Press Release

Van Dyck CH, et al. A study to confirm safety and efficacy of lecanemab in participants with early Alzheimer’s disease (Clarity AD). Presented at: American Academy of Neurology annual meeting; April 22-27, 2023; Boston.

Leukemia Edition: Top Headlines for Week of May 15, 202318 May 202300:15:04

In this edition, we bring you a deep dive on a collaboration that aims to accelerate better treatments for pediatric cancers.

Read the full coverage here:

Collaboration aims to ‘truly accelerate better treatments’ for pediatric cancers

References:

Dharia NV, et al. Nat Med. 2021;doi:10.1038/s41588-021-00819-w.

Lung Cancer Edition: Top Headlines for Week of May 8, 202311 May 202300:12:06

In this edition, tumor mutational burden linked to immunotherapy response; toripalimab regimen extends EFS in stage III NSCLC; phase 3 study designed for increasing trial diversity, and more.

Read the full coverage here:

Tumor mutational burden may be linked to immunotherapy response in advanced cancers

Perioperative toripalimab regimen extends EFS in resectable stage III NSCLC

Phase 3 study of lung cancer regimen designed to be a model for increasing trial diversity

Smoking cessation before lung cancer diagnosis significantly reduces excess mortality risk

Pembrolizumab active in diffuse malignant peritoneal mesothelioma

References:

Aggarwal C, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.11181.

Lu S, et al. Abstract 425126. Presented at: ASCO Plenary Series: April 2023 Session; April 20, 2023.

Marmarelis ME, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.2526.

Pragmatica-Lung Study, a streamlined model for future cancer clinical trials, begins enrolling patients (NCI press release). Published April 12, 2023. Accessed April 12, 2023.

Wang X, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.11966.

Leukemia Edition: Top Headlines for Week of May 1, 202304 May 202300:12:33
Neurology Edition: Top Headlines for Week of April 24, 202327 Apr 202300:10:08

In this edition, trichloroethylene may be ‘invisible’ cause of PD, ravulizumab reduces clinical deterioration in generalized myasthenia gravis and more.

Read the full coverage here:

Trichloroethylene may be ‘invisible and highly preventable’ cause of Parkinson’s disease

DEA petitioned to de-schedule dual orexin receptor antagonist insomnia medications

Ravulizumab reduces clinical deterioration in patients with generalized myasthenia gravis

FDA places partial clinical hold on initiation of new patients in evobrutinib study

FDA advisory committees rule in favor of Rexulti for agitation associated with Alzheimer’s

References:

Dorsey ER, et al. J Parkinsons Dis. 2023;doi:10.3233?JPD-225047.

Mantegazza R, et al. Poster 148: Ravulizumab reduces clinical deteriorations in patients with generalized myasthenia gravis: Results from the CHAMPION MG study. Presented at: Muscular Dystrophy Association Clinical & Scientific Conference; March 19-22, 2023; Dallas.

Press Release

Press Release

Press Release

Leukemia Edition: Top Headlines for Week of April 17, 202320 Apr 202300:12:11

In this edition, elevated cardiotoxicity risk for Black patients after chemotherapy; CV risk factor disparities in childhood cancer survivors; neural network helps identify potential targets for cancer drugs and more.

Read the full coverage here:

Black patients may be at elevated cardiotoxicity, HF risk after chemotherapy

CV risk factor disparities in childhood cancer survivors similar to general population

Neural network helps identify many more potential targets for cancer drugs

Blood or marrow transplant survivors at high risk for malignant neoplasms in the GI tract

Optimizing CV health behaviors may lower risk for CVD and cancer

References:

Gebeyehu W, et al. Original Research Abstract 56. Presented at: American College of Cardiology’s Advancing the Cardiovascular Care of the Oncology Patient conference; April 14-16, 2023; Washington, D.C. (hybrid meeting).

McDonald A, et al. JAMA Oncol. 2023;doi:10.1001/jamaoncol.2022.6569.

Meller A, et al. Nat Commun. 2023;doi:10.1038/s41467-023-36699-3.

Noyd DH, et al. JACC CardioOncol. 2023;doi:10.1016/j.jaccao.2023.01.011.

van Sloten T, et al. JACC CardioOncol. 2023;doi:10.1016/j.jaccao.2022.11.015.

Leukemia Edition: Top Headlines for Week of April 10, 202313 Apr 202300:15:11
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