In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions.

The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences?

B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment.

Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

0:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests

2:51 Autism and ADHD; Neurodiversity; and some problems in society

7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication

13:27 Autistic Phenotypes

19:01 ADHD Phenotypes

21:41 Specifiers and Lumping Contrasting Phenotypes

33:18 Medication and ODD (Oppositional Defiant Disorder) Rant

35:42 Autism conundrum with ADHD

38:45 Reviews/Ratings and Contact Info

Hopp: https://www.hopp.bio/fromthespectrum

X: https://twitter.com/rps47586

email: info.fromthespectrum@gmail.com

My guest today is Jonathan Mitchell. Jonathan is a senior citizen Autistic, Author of numerous novels and blogs, and stands up for the purpose of Autism. His blog, Autism Gadfly, provides perspectives of Autism otherwise not considered by the lay-public or researchers in Autism. Jonathan's views have been mentioned in Newsweek, NPR, Autism Daily Newscast, and HuffPost.

Jonathan was born in 1955 in Los Angeles. We discuss his experience at an early age including psychoanalytic therapy, psychological assessment, and troubles through education. Eventually, Jonathan and his family learned about Autism while on a trip to the East. Jonathan faced many challenges through his education in different schools beginning in kindergarten. However, Jonathan graduated from UCLA with a bachelors of arts in psychology.

We also discuss challenges in professional and personal life as an adult where he faced various barriers. In the early 2000s, when the internet allowed for different communication platforms, Jonathan began to call out things wrong in Autism. In addition, he carries a loud voice for a cure/treatment for Autism. Recently, you can find him on X as he continues to be a voice for the Autistic community.

The Mu Rhythm Bluff https://www.amazon.com/Mu-Rhythm-Bluff-Jonathan-Mitchell-ebook/dp/B00BQN84GM/ref=sr_1_1?crid=2UHATAWKAT5YA&dib=eyJ2IjoiMSJ9.eocnp6hSIjLZqAuzxnIcPw.vv03H-Vx-BeqtHx4_dYo4W6QomZdOkuZ4JEBPgbA-IQ&dib_tag=se&keywords=the+mu+rhythm+bluff&qid=1724157644&sprefix=the+mu+rhy%2Caps%2C104&sr=8-1

X: https://twitter.com/autismgadfly

Jonathan Mitchell website http://www.jonathans-stories.com

Wikipedia https://en.wikipedia.org/wiki/Jonathan_Mitchell_(writer)

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.

Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/

Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/

Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3Dtrue

Magnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284

Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysis

https://pubmed.ncbi.nlm.nih.gov/33400920/

Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/

(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives

(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)

(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic

(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light

(8:58) Magnocellular and Parvocellular

(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions

(22:20) Scientific Literatures

(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing

(30:07) Oxytocin and Dopamine

(31:08) Dopamine Receptors

(31:37) GABA

(33:57) Intranasal Oxytocin

(36:08) Take aways from Intranasal Literature

(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)

email: info.fromthespectrum@gmail.com

In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.

Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.

Dr. Catherine Lord:

https://www.semel.ucla.edu/autism/team/catherine-lord-phd

https://childmind.org/bio/catherine-lord-phd/

https://labs.dgsom.ucla.edu/lord/pages/our_team

The Lancet Commission https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01541-5/abstract

The Lancet https://pubmed.ncbi.nlm.nih.gov/30078460/

Nature Reviews Disease Primers https://pubmed.ncbi.nlm.nih.gov/31949163/

Autism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638

https://music.amazon.com/podcasts/d948fecc-8cfa-4203-8493-a12d2c9c92ed/episodes/bf7ce843-0dd2-4fe8-b800-82ea9cace96d/from-the-spectrum-finding-superpowers-with-autism-autism-and-education

The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/

(0:00) Intro

(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum

(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments

(16:36) Gaps in the Autism Assessment

(23:15) The Challenges with Understanding the Spectrum of Autism

(29:32) Updates on the Lancet Commission and Profound Autism

(35:19) Barriers with Autism and the Medical Field

(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)

(44:25) The Future of Autism and Helping Autistics Across the Life Span

(51:03) Reviews/Ratings and Contact Info

email: info.fromthespectrum@gmail.com

In this episode, we explore three regions associated with social awareness- the medial Prefrontal Cortex, the Anterior Cingulate Cortex, and the Insula. We review the functions of each, the interactions between each region, and the inputs and bi-directional connections to some crucial areas of the brain. In large part, we will review adaptive responses and cover some scientific literature on these regions and the implications to Autism.

https://molecularautism.biomedcentral.com/articles/10.1186/s13229-024-00593-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354837/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766703/#:~:text=Schematic%20structure%20of%20different%20regions,and%20infralimbic%20cortex%20(IL).

https://www.cell.com/neuron/fulltext/S0896-6273(12)01108-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627312011087%3Fshowall%3Dtrue

https://www.nature.com/articles/s42003-024-06016-9

https://www.sciencedirect.com/science/article/pii/S0149763409000815?via%3Dihub#aep-section-id15

https://www.tandfonline.com/doi/full/10.1080/17470919.2023.2242095

https://www.sciencedirect.com/science/article/abs/pii/S0006322308011578

(0:00) Intro; mPFC, ACC, and Insula

(3:26) mPFC, Excitation / Inhibition; CNTNAP2, SHANK3, Neuroligin, and PTEN

(7:42) Functions of mPFC and a primary dive into Adaptive Responses; Neuromodulators

(13:52) ACC

(15:23) the mPFC and ACC lead the way

(19:29) Scientific Studies on Theory of Mind Task and Sensory Processing

(21:52) Insula

(26:49) Scientific Study: Eye Gaze, Social Attention, Social Cognition, Observational Learning

(30:11) Social and Nonsocial Studies- different areas for Autistics versus Non-Autistic

(32:38) A study using 6-week-old Infants, attentional biases and sensorimotor and different brain areas

(35:05) Wrap Up

email: info.fromthespectrum@gmail.com

In this episode, we discuss biology of anxiety, responses from anxiety, and common situations causing anxiety with Autism. The stress response system of the body is very finite and the nervous system reflexively responds based on what it knows. A few biological components of anxiety include the amygdala, bed nucleus of the stria terminalis (BNST), and the spine. Common responses to anxiety include avoidance, shifts in physiology, and valance, or how we feel about the situation. To end, we have a lengthy discussion on some common sources of anxiety.

Biology and Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690364/

Deisseroth on Anxiety https://www.youtube.com/watch?v=UtCeIefq_PM

Deisseroth on Autism and Anxiety https://www.youtube.com/watch?v=4oiKOX2lCmE

Physiological Sighs https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00474-8

Jack Feldman https://bioscience.ucla.edu/people/jack-feldman/

David Spiegel https://med.stanford.edu/profiles/david-spiegel

Joseph LeDoux https://as.nyu.edu/faculty/joseph-e-ledoux.html

(0:00) Intro; Comorbid Tendency and the DSM

(2:56) Anxiety's role

(3:42) Biology and responses of Anxiety; Amygdala and Bed Nucleus of the Stria Terminalis; Avoidance, Physiology, Valance

(7:48) Avoidance (Action)- Hypothalamus

(9:11) Brief notes on Cortex

(11:36) Back to the Hypothalamus

(12:27) Physiology/Breathing (Body)- Parabrachial Nucleus; Physiological Sigh; Brainstem, Spine, and Body

(17:48) Valance (Feelings)- Ventral Tegmental Area; direct or indirect exposure- it doesn't matter

(20:00) Dopamine, Neuroplasticity, Side note on Testosterone, Multiple words have the same meaning

(24:58) Common situations for Anxiety and Autism

(35:58) Wrap Up, Reviews and Ratings, Contact Info

In this episode, we cover Autism and employment- some Superpowers and some Superdeficits. We discuss different types of work that are easier and fit our abilities and cover some challenges in the workplace. Some challenges include the social dynamic and being misunderstood, which are driving forces and sources of burnout and avoidance. Remember the metabolic "bank" account and the Excitation/Inhibition discussion.

Brain Science and Sir Simon Baron-Cohen https://www.youtube.com/watch?v=gMxfq_QLuUU

Brain Science Podcast https://www.youtube.com/@BrainSciencePodcast

Pattern Seekers by Sir Simon Baron-Cohen https://www.amazon.com/Pattern-Seekers-Autism-Drives-Invention/dp/1541647149

Autistic Brain by Temple Grandin https://www.amazon.com/Autistic-Brain-Temple-Grandin/dp/0544227735

(0:00) Intro; Clip of Sir Simon Baron-Cohen on Brain Science with Dr. Ginger Campbell; Society's trap and time perception

(6:20) Autism and awareness; Do others see or understand our abilities

(9:12) The applying process and the interview- we hate look at me; Superdeficits are easier to remember; Honesty and accuracy and Employers don't have an accurate comparison

(12:39) Understanding the Autistic Brain

(14:25) Autistic Traits - some Superpowers

(21:20) Autistic Traits - some Superdeficits

(28:43) Good and Bad: Perfectionism- a tough balance

(30:42) Do things that you can do, you will do, and you love to do; The Nervous System just does; See Temple Grandin and Sir Simon Baron-Cohen on types of employment for different types of Autistic Brains

(31:38) Reviews and Ratings; Contact Information

In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction.

Antipsychotics https://www.marketresearchfuture.com/reports/antipsychotic-drugs-market-2784#:~:text=The%20antipsychotic%20drugs%20market%20size,period%20(2023%20%2D%202030).

Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618

Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/

Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html

Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s

(0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment

(7:00) The Prescription Era; Medication first Paradigm

(10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning;

(13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not?

(13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism;

(14:39) Subject Switching and Criteria B conflict

(17:14) If you have met one child with Autism, you have met one child with Autism

(17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience;

(23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics;

(27:00) Art was fine, other subjects were not fine; Details to General versus General to Details;

(27:58) High School personal experiences; Pathway to Success > General Education;

(29:52) Did I graduate, or Not?

(31:56) SAT

(32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses)

(36:34) Education Arrangement; Taking Notes is challenging

(39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information

Criteria B is Autism. Hans Aspergers called the children with the syndrome "little professors." This is Autism. Our routines and fixated interests. Autism gives us the ability to be comfortable within ourselves, and this accelerates our abilities, our Superpowers. How will society handle these so-called "differences" and the conflict within the so-called "normal" people?

In this episode, we expand to real-life examples of Criteria B components and review some personal experiences.

Dopamine Nation (Pleasure and Pain SeeSaw) https://www.annalembke.com

https://www.templegrandin.com/templegrandinbooks.html

(0:00) Intro; Autism is Criteria B, how will society handle "differences," those differences create conflict in others, stimulus-response, conflict, and comfort

(4:44) Routines (B2) and Plans, Exact Planning, Plan versus Actual Time and Execution, Reality meets our Visualized Thinking; Pleasure and Pain SeeSaw; More Relationship Struggles Implicated by Criteria B,

(9:01) Punctual- for others and ourselves; Bias yourself into Action; Understanding the need for Breaks; Others take the easy way out; get Sunlight for our Biology

(12:34) Personal Experience and a Glimpse into an Autistic Thought; Traffic Spacing

(16:33) Researching Items and Fixated Interests (B3); personal experience; Hans Aspergers and his Little Professors- This is Autism!

(20:40) Other examples- Pant Sizes and Alpha instead of Numerical, Restaurant Rant, Never Underestimate a Human's Capacity to Think; Don't try to change Autism because it is offends you- offends your expectations and beliefs

(23:12) Reviews and Ratings and Contact Information

Don't try to change an Autistic Person because they are "different" than you.

In this episode, we explore more examples of Criteria A- Deficits in Social Communication and Interaction. Yay, more DSM-5-TR. Can you fit in, or not? Are you like the so-called "normal" people, or not? This episode is highlighted by personal experiences and examples. Plus, I have three jokes. The examples and episode is not exhaustive, however, I try to capture some of the conditions on the spectrum. There are lots of examples in our social world that just does not make sense, and we like to say, "that does not make sense."

See Jack Kruse, Quantum Engineering 45

(0:00) Introduction; Crude Symptoms intend to capture the Spectrum; Can you fit in, or not? Are you like the so-called normal people, or not?

(2:08) Facts and Reality over Make-Believe; Methodical and Seeing Bottlenecks in Society- I hate "that's just the way it is"; Traffic; Names- Landon?, Associations; Repeating things- I hate, "like I said."

(7:09) "This does not make Sense"; Romantic Interests and Joke 1; Verbal Responses; Task-Switching from Fixated Interests; Sound Blends

(11:44) Social Media Use- Strange; Eye-Contact- Humans say we need to do it, and We are not Birds; Leaving Social Gatherings and Joke 2, the gathering will gather without me

(15:32) High-Fives = Stereotypy?; I hate Favors- favors create conflict; Henry David Thoreau; Self-Checkout Lanes and Autism, Neuroplasticity and Preference; Emotional Empathy

(20:04) Debriefing and Understanding; Supplementing Relationships and Visual Thinking; Joke 3 and Fixated Interests and Perfect Intensity- the DSM can have it's "abnormal" label; Echolalia; Fitting In and Modeling as a Blueprint

(26:03) Wrap-Up; Don't try to change an Autistic Person because They are "different" than you; Contact Information

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.

Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.

https://www.nature.com/articles/s41398-023-02317-5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/

https://www.nature.com/articles/s41398-018-0155-1

https://www.nature.com/articles/nature10360

https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmed

https://www.nature.com/articles/s41380-022-01506-w

(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena

(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum

(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation

(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical

(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I

(22:25) Wrap-up and understanding Autism, and Contact Info

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.

See Dr. Jack Kruse Quantum Engineering 45

Email: info.fromthespectrum@gmail.com

Hans Asperger called the children "little professors"- This is Autism.

In this episode, we explore criteria B.3, which is the core of Autism. Donald Triplett's father's first sentence to Leo Kanner- He seems self-satisfied.

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

Erwin Schrödinger https://en.wikipedia.org/wiki/Erwin_Schrödinger

0:00 Intro, Erwin Schrödinger and Leo Kanner; Light gives Life to Cells

2:29 B.3

5:15 Hans Asperger, Autist

7:19 Leo Kanner

8:31 Paths to Superpowers; Autism and Education; Medicine and Charles Sidney Burwell

13:50 Personal Experiences; Vietnam War; B.2 complications with B.3

15:22 Baseball Game and Probability

16:52 Adult Examples

17:55 1950s and Novel- example of Abnormal B.3; Thinking in Pictures and Supplementing Relationships

21:29 Disruptions from unplanned or outside interference; Medication Approach and Warning

23:36 Unusual Objects; ADHD prep; Finding interests in Life

26:31 Check-Out lanes and Autism; Self-Satisified- This is Autism

28:53 Circumscribed

31:36 Perseverative; The Nervous System

35:44 Bible; Inner-focus using B.3 as a Superpower and directing focus

39:16 Dogs and Snakes

39:50 Autistic Phenotype and B.3 at the Center

40:30 Reviews/Ratings and Contact Info

X: https://twitter.com/rps47586

Hopp: https://hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary.

Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdf

PTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue

16p11.2, Serotonin, and Possible Social Deficit Rescues

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/

https://www.nature.com/articles/s41586-018-0416-4

https://www.nature.com/articles/s41386-021-01091-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/

Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/

Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/

SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3

Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/

https://www.sciencedirect.com/science/article/pii/S0092867414006734

(0:00) Introduction; Excitation and Inhibition;

(3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should?

(10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;

(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;

(19:24) Back to 16p11.2 and Cortical Development;

(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;

(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;

(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC

(29:25) Wrap Up and Contact Information

email: info.fromthespectrum@gmail.com

In today's episode, we discuss Criteria A in the DSM-5-TR, which involves social communication and interaction. We discuss various aspects of the social world including unpredictableness, sensory processing being overwhelmed from the rapid firehose of information, being a student in a classroom, empathy, and are Autistic's being changed instead of cultivated into their own unique gifts (or Superpowers).

Autism and Empathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484273/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804307/

More from CNTNAP-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/

https://www.cell.com/fulltext/S0092-8674(11)01010-5

Sir Simon Baron-Cohen https://www.psychol.cam.ac.uk/people/simon-baron-cohen

Temple Grandin https://www.templegrandin.com

Deisseroth on Socialness https://www.youtube.com/watch?v=gOWnf1BpkGs

DSM (don't get hitched on this book) https://www.psychiatry.org/psychiatrists/practice/dsm

(0:00) Introduction;

(2:12) A1; don't change others just because; joining conversation; unpredictableness, protection, sensory processing and sounds blending; firehose of information;

(15:11) A2; don't change others just because pt. 2 and ABA therapy; interests are easier for all; challenges in the classroom and mental effort;

(21:09) A3; challenges with play as a child; strict rule adherence; imaginative play, even when good, is bad; fits and tantrums; speech and peers; empathy- emotional versus cognitive- ASD is better at emotional empathy; supplementing relationships later in life with small talk; relationships are hard!

(31:32) Leo Kanner correction- Nervous Child, not Pathology- Pathology section in Nervous Child;

(31:54) Final Thoughts; contact information and reaching out to me

Email- info.fromthespectrum@gmail.com

In this episode, we discuss criteria B from the DSM-5-TR. Criteria B are known as Restricted and Repetitive Behaviors. In addition, we discuss how criteria B implicates criteria A, or the social communication and interaction aspects of Autism.

Projections https://www.amazon.com/Projections-Story-Human-Emotions/dp/B08LDWC2L6/ref=sr_1_4?crid=1GPPI5ZOFM2OS&dib=eyJ2IjoiMSJ9.nkY0ZQ0_m001QwcD7GiPwEwRdZitzaWU2NDjvRw_-xiCyiXLlyVfEZSzmonDa2coKQXiPSas9JLw1NeXBBjVh-I5pYHXvMVnLvB9vFwniO7QRoSLMGL3Idst8j8oqskuyPjy1UlNxZR23U_Ch22UJLU033T0wsMJNyZE6FcDepX8XAZAlXqeWXAHRXYD6jhVQLF771sNzRg3o_tKPJBoDr7GF0TWaaX5Nl7Mynmvvc4.Yfa8m249WY_xvl2E3TGObX7BoDhrJ_nU9R8d0ezWL34&dib_tag=se&keywords=projections&qid=1711134807&sprefix=projections%2Caps%2C100&sr=8-4

Peter Attia and Karl Deisseroth https://youtu.be/4oiKOX2lCmE?si=Ru7W7cPpDDxtE8Qr

Future Treatment possibilities https://youtu.be/eeySrgKev2g?si=IbX5h6qG5ddBPeO5

Leo Kanner https://psycnet.apa.org/record/1943-03624-001

Meet My Autistic Brain Episode https://podcasts.apple.com/us/podcast/meet-my-autistic-brain/id1548001224?i=1000629007371

APA's DSM-5-TR https://www.psychiatry.org/psychiatrists/practice/dsm

(But don't get hitch on this book)

Time Scales

Introduction (0:00)

A Brief History (1:29)

Similar Disorders (or Phenomena) (2:25)

Levels of Autism; Criteria A and B; Superpowers and Superdeficits (5:16)

Criteria B; B1 Stereotyped or Repetitive Motor Movements, Use of Objects, or Speech; Stimming; Echolalia Example (9:40)

B2 Insistence on Sameness, Inflexible Adherence to Routines, or Ritualized Patterns of Verbal or Non-Verbal Behavior; Rigid Thinking Patterns and Gray Areas cause Problems; BEE MOVIE example (16:24)

B3 Highly Restricted, Fixated Interests that are "Abnormal" in Intensity or Focus; Find your Interests and Superpowers and Do That; Vietnam War; Memorization, Accelerated Learning and Personal Example (22:37)

B4 Hyper or Hyperactivity to Sensory Input or Unusual Interests in Sensory Aspects of the Environment; Complications with Eye-Contact and Keeping Up; Sensory Processing Phenomena; Visualization and the Eyes (32:47)

There is no question Mothers that have children with Autism are incredible. You are loved and appreciated.

In this episode, we explore typical topics with Autism research and try to understand the purpose. Autism research is confounding, and maybe, lacks direction. We offer a research suggestion based on the most plausible cause of Autism- the new modern day environmental factor- Artificial Light. Remember, Autism just shows up, so it makes sense to send the mother and father back to an environment pre-Autism.

Quantum Biology https://www.patreon.com/DrJackKruse/posts

Photobiological Implications of Folate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/

B9 (folate) and B12 (cobalamin) are Photoreceptors, too.

0:00 Autism Research Direction and missing the beginning; Is it Click-Bait?; Confounding

3:30 Changes in Light and the Full Spectrum; the number of Genes involved with Autism Research

5:07 Genetic Variants, Copy Number, Duplications, Deletions

7:04 Gene-Envrionment Interaction; MTHFR; Methylation, Myelin

13:03 Brain Connectivity and Neurobiology

13:55 Socio-Environmental/Socioeconomic; Robert Sapolsky

14:25 Early Diagnosis and Bio-markers

14:47 Comorbid Conditions

16:05 Personalized Interventions

16:27 Medications and the PROFIT MILL

18:36 Today's Purpose; Parental Melanin, Artificial Light, and nnEMF

19:30 Research Idea with 3 Groups and Returning the Environment before Autism magically shows up

25:17 Shift-Work Warning

26:20 Back to Autism; Amish

29:07 Reviews/Ratings, Contact Info

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Hopp: hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.

Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.

Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496

Su study: https://www.nature.com/articles/s41564-024-01739-1

Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/

Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9

Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/posts

(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions

(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems

(6:22) POMC; HPA; Stress example

(8:19) Common Autism problems in the GI

(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation

(14:09) Melanin/POMC; Clock-Timing; Omentum

(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut

(19:04) Vitamin D Receptors and more Clock-Timing

(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids

(24:33) Avoiding UV Light implications

(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data

(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles

(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD

(38:27) Reviews/Ratings and Contact Info

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Email: info.fromthespectrum@gmail.com

In this episode, we explore Autism developing in the embryo. We will review a couple Scientific papers discussing specific time frames of development within the embryo based on each trimester and specific cellular abnormal processes occurring. We will connect previous biological and environmental components and how it influences the creation of Autism and previous episodes of From the Spectrum podcast.

Remember in the Cause of Autism episode- Light, Water, Magnetism, Periodic Elements, Vitamins, and Proteins because they are involved. During the episode, we review risk-genes and how this could be the wrong direction for Autism research. As a counter, I provide where research and funding needs to focus- pregnancy.

Cause of Autism https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496

Eric Courchesne https://profiles.ucsd.edu/eric.courchesne

Prenatal Origins of ASD: The When, What, and How of ASD Development https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223620300515%3Fshowall%3Dtrue

The ASD Living Biology: from cell proliferation to clinical phenotype https://www.nature.com/articles/s41380-018-0056-y

Leukocytes and Melanin Pigmentation https://core.ac.uk/download/pdf/81931995.pdf

mTOR and PTEN https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/

Cancer Drug for "Autism" https://neurosciencenews.com/asd-cognition-cancer-pharmacology-26481/

0:00 Autism and the Embryo; Review of previous developmental milestones, and the processes and "ingredients" used in our Biology

5:45 Cellular processes; ASD Living Biology; becoming the complex living organism

8:17 1st Trimester: Proliferation, neurogenesis, migration

8:46 2nd Trimester: Neurite overgrowth, synaptogenesis and synaptic function

9:12 3rd Trimester: Neural networks

9:33 Epoch 1 and 2

13:04 Scientific Literature; risk-genes; send research and funding to pregnancy

17:57 Abnormal brain development in the embryo

21:39 Excitation and the risk-genes and consequences to the Nervous System

24:36 Be cautious of research direction; MEDICATION and MEDICAL PARADIGM RANT

29:32 Connecting Light and Abnormal Development across the Body- Example Melanin and Leukocytes

33:12 Recap on the Past 3 episodes

36:00 Reviews/Ratings and Contact Info

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Email: info.fromthespectrum@gmail.com

In this episode, we explore some critical dates and understanding of Autism. We will time travel from 1911 to 2024 with a goal of understanding why the sharp increase in Autism diagnosis of late. We review the closeness of schizophrenia and the separation from schizophrenia. In addition, we will review Autism becoming a separate diagnosis in the DSMs from the 1980s and review the closeness of Vaccines and Assessment Standardization that parallels this time. Hopefully, some consideration about the rates of Autism are presented.

Top Revenue Business Types- Not good. https://www.ibisworld.com/united-states/industry-trends/biggest-industries-by-revenue/

Bayh-Dole Act https://www.govinfo.gov/content/pkg/USCODE-2011-title35/html/USCODE-2011-title35-partII-chap18.htm

How Autism became Autism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757918/#bibr56-0952695113484320

Eugon Bleuler DEMENTIA PRAECOX OR THE GROUP OF SCHIZOPHRENIAS https://philpapers.org/archive/BLEDPO-2.pdf

Dr. Catherine Lord https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000659246090

(0:00) Intro, Classifications, Symptoms, Schizophrenia, DSM, Assessments, Vaccines and Bayh-Dole Act

(3:21) 1911; Twilight Peaks; Psychoanalysis; Eugon Bleuler; Early Autism

(10:37) 1959- Separating from Schizophrenia; Generational Lineage; Visual Imagery; Communication Problems are noticed

(14:21) The DSM and the Development of Autism Diagnosis

(17:32) Assessments becoming Standardized

(20:22) Vaccines and the Bayh-Dole Act of 1980; Vaccine Schedule and Centralized Medicine and Revenue

(25:06) 1980s-2000 emergence of Diagnosis and Assessments; Rates of Autism and Explainations

(30:03) Reviews/Ratings and Contact Info

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Email info.fromthespectrum@gmail.com

Autism just magically shows up.

"... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse

(Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uA

Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXs

Tryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079rev

Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567

0:00 Introduction & Framing Podcast blends science, personal experience, and opinion to explain autism. Autism “appeared” around 1938 (Kanner/Asperger), with rates rising sharply. Parallels to post-1880s conditions (Alzheimer’s 1906, diabetes, obesity, ADHD) linked to electrification.

5:30 Central Thesis: Light as the Common Environmental Factor Light is the key environmental change. Pre-1880s: sunlight/fire (red/IR-rich). Modern: blue-heavy artificial light. Disrupts vitamin A/B/D, amino acids, water, melanin, melanopsin, POMC.

12:00 Cellular & Mitochondrial Mechanisms Blue light dehydrates cells, disrupts TCA cycle and ATP production. Mitochondria need red/NIR for oxygen-to-water conversion; blue causes hypoxia/stress. Universal cellular vulnerability explains issues without added toxins.

19:00 Neuroplasticity & Autism as Adaptation Autism as extreme neuroplasticity adapting to light stress, like blind individuals repurposing visual cortex.

22:00 Lifespan Symmetry: Autism Dementia Autism and dementia rates mirror across lifespan. Both show early retinal damage. Artificial light at night exploded post-1940s, enabling 24/7 life at biological cost.

26:00 Light Spectra Compared Sun: 250–3100 nm, 43–47% red/IR. Incandescent/fire: warm/red-dominant. LEDs: blue peak (460–480 nm). Indoor dim vs. outdoor bright. Vitamin D inverse with autism; lower rates near equator.

31:00 Wavelength-Specific Benefits

37:00 The Unsung Hero Melanin absorbs all light to power biology and protect vs. stress/toxins. Neuromelanin links to Parkinson’s; autism raises Parkinson’s risk 3x.

48:00 Tryptophan → Serotonin → Melatonin Pipeline UVB activates tryptophan → serotonin → melatonin (95% mitochondrial). Blue light causes radicals, disrupts cells. Serotonin modulates development, sensory, gut

58:00 Rapid brain growth needs optimal light. Autism disrupts cell migration, speech/motor/sensory. GABA switch vulnerable.

1:07:00 B-Vitamins & UVB-dependent; blue disrupts folate/B12 for DNA methylation.

1:14:00 Autism rise coincides with electrification. More sunlight in pregnancy could reduce risk

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In this episode, we discuss Autism with Dr. Leanna Hernandez. Dr. Hernandez is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and director of the Hernandez Lab. She is a member of UCLA’s Center for Autism Research and Treatment, Center for Neurobehavioral Genetics, and the Brain Research Institute, and serves as Co-Director of the Genetics, Genomics, and Informatics Core for UCLA’s Intellectual and Developmental Disabilities Research Center.

Hernandez Lab https://www.hernandezlabucla.org

Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism https://www.nature.com/articles/mp2016209

Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity https://www.nature.com/articles/s41398-020-0750-9

Oxytocin and Vasopressin and the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273 https://www.youtube.com/watch?v=DAtmC-s1_e0

(0:00) Intro; Dr. Leanna Hernandez

(2:24) Autistic Phenotypes

(4:13) Dr. Hernandez education journey into Autism and the Hernandez Lab

(9:03) 2017 Paper Oxytocin Receptor Gene, Common Genetic Variance, Single Nucleotide Polymorphisms (SNP), and Reward and Social Processing and the Nucleus Accumbens (NAc)

(15:10) Differences in Brain Connectivity between Autistics and Non-Autistics

(20:06) Social Cognition, Boy Bias in Autism; GENDAAR Consortium and Sex- and Diagnosis-Differences

(21:48) GENDAAR

(22:45) Boys versus Girls Connectivity involving the NAc with and without Autism

(25:38) Different Connectivity correlated with Different ADOS scores for Repetitive Behaviors

(26:35) Female Protective Effect for Autism; Camouflaging/Masking

(30:19) The Assessment process for Girls and the Oxytocin Receptor Gene Sex Differences and Socialness and understanding the Boy Bias

(32:48) Current Research and a Genome Wide approach and Polygenic Risk Scores

(35:10) Oxytocin and Excitation/Inhibition

(37:08) Sharing Information and Current Research

(41:45) The Future of Autism Research

(45:48) Reviews/Ratings and Contact Info

email: info.fromthespectrum@gmail.com

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We expand on a critical network discussed in the Autism and Adaptive Responses episode. The biology that gives us Autism, gives us a condition the outside world is chaotic. The trade off is our inner world is comfortable. See criteria B.3.

The Salience Network is used to determine what we send our attention to as we orient ourselves with the outside world. You can see this in Autism versus Non-Autism. Autistics orient to single objects or single interests more than multiple objects or interests. That's Criteria B of Autism- Restricted, Repetitive Interests, Behaviors, or Activities.

In Autism, the Salience Network connects to different regions compared to Non-Autism, and this is shown at Six-Weeks-Old. And, this implicates our Social Attention and Social Motivation. Remember Hans Aspergers called the children "little professors" because Autism provides a path of Superpowers based on those fixated interests that are "abnormal in intensity or focus."

Covered Here. Also, we prepare for another discussion with a leading scientist from UCLA.

Study on Six-Week-Old https://www.nature.com/articles/s42003-024-06016-9

GENDAAR https://pubmed.ncbi.nlm.nih.gov/34050743/

(0:00) Intro; Human's Capacity to Think; the Salience Network and the NAc

(2:56) Insula

(4:47) Defining the Salience Network and Salience Detection; getting "hijacked" and metabolic bank account

(7:42) the Biology that gives us Autism causes a Chaotic outside world

(9:00) Returning to Six-week-olds and the Salience Network

(10:28) The Prefrontal Cortex and Human Cortex quiets things so we can properly evaluate things

(13:52) Salience Connections of six-week-olds; social attention at 3-12 months; Autistic traits at 12 months

(17:40) Sex-and-Diagnosis Differences; GENDAAR study using 8-17 year olds; Salience Network and Sensorimotor and Repetitive Behaviors

(20:47) Second Key Finding and possible cause of Boys Bias with Autism

(21:30) The Nucleus Accumbens- Reward Hub; Two Parts; shell and core

(25:20) Preparing for a future episode

(30:27) Reviews/Ratings and Contact Info

Facebook https://www.facebook.com/fromthespectrum.podcast

Email: info.fromthespectrum@gmail.com

In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons.

Jack Kruse https://www.patreon.com/DrJackKruse/posts

Glycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.

Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycle

Oxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation

0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration

4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)

6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS)

8:25 Glycolysis

10:03 Citric Acid cycle

12:02 OXPHOS

13:51 Cytochrome I

15:07 Cytochrome II

16:08 Cytochrome III

17:10 Cytochrome IV and creating water

19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism

29:20 Cytochrome V and ATPase; Chromophores

33:56 Evolution and losing electrons; Autism and modern health complications

37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies

40:23 Reviews/Ratings and contact info

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Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.

He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.

Dr. Frye shares many figures during the conversation so the listener can follow along.

Dr, Richard Frye https://drfryemdphd.com

CV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdf

Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter

Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub

Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495

0:00 Dr. Richard Frye

6:13 Intro into mitochondria & energy production, various disease & dysfunction

11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics

16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain

20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine

26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria

30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation

34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression

42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis

45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)

54:54 Future Research

59:58 Wrap up, Reviews/Ratings

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email: info.fromthespectrum@gmail.com

For today, just a brief introduction to research beginning at UT-Austin, University of Texas at Austin, led by Dr. Francisco Gonzalez-Lima. The study is called: Effects of Transcranial Infrared Light Stimulation on Symptoms of Autism Spectrum Disorder. In the link below, it is Study #2.

Dr. Francisco Gonzalez-Lima https://dellmed.utexas.edu/directory/francisco-gonzalez-lima

Research Link (Study #2) https://labs.la.utexas.edu/gonzalez-lima/participate-in-our-research/

Research Team https://labs.la.utexas.edu/gonzalez-lima/team/

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email: info.fromthespectrum@gmail.com

In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process.

A valuable consideration is the roles our eyes have on brain development, which we cover as well.

Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/

Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6

Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669

Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/care

Rudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037

The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e0

0:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins

5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin

7:06 Melanin and Melanopsin through the body and biochemistry

8:39 Fruit Tree Example from Dr. Kruse

9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution

14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following

17:21 Gaze Attention

18:02 Joint Attention

19:12 Studies on Infants; Pierce et al, 2019

25:00 Wen et al, 2022

27:03 Keehn et al, 2024 and Early Autism Evaluations (EAE)

29:25 Rudling et al, 2024

32:15 Wrap-Up/Final Thoughts

34:55 Reviews/Ratings, Contact Info

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email: info.fromthespectrum@gmail.com

For today's episode, we discuss Autism with Dr. Yehezkel Ben-Ari. Dr. Ben-Ari is a pioneer in the field of human development with over five decades of academic and private research. He has over 520 publications with a strong passion for early detection and treatment of brain disorders. His work includes studying Human Development, Autism, Epilepsy, Parkinson's, and Brain Tumors. He is a leader in how science understands the roles GABA and Chloride during early development and the NCCK1 importer and KCC2 exporter during the Excitation/Inhibition shift.

In 1986, he led INSERM Neurobiology and Pathophysiology of Development before shifting to Start-Up private investigation in 2008. He is the founder of Neurocholre, B & A Biomedical, B & A Oncomedical, INMED, and IBEN. Recently, Dr. Ben-Ari has made wonderful contributions towards Autism identification in the Placenta using the work of "Neuroarchaeology" and Machine Learning. Dr. Ben-Ari is the recipient of many awards including Grand Prix de l'INSERM, Grand Prix European Society of Epilepsy, and Grand Prix Gagne Van Heck Belgian National Scientific Research (FNRS), to name a few. His book, The First 1000 Days, will soon have an English version. Treating Autism with Bumetanide is available now.

Dr. Yehezkel Ben-Ari https://www.inmed.fr/en/evenement/en-yehezkel-ben-ari

Neurochlore https://www.neurochlore.fr/en/

Machine Learning https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994821/

Excitatory Actions of GABA https://www.nature.com/articles/nrn920

GABA https://journals.physiology.org/doi/full/10.1152/physrev.00017.2006

Neuro-Archaeology https://pubmed.ncbi.nlm.nih.gov/18951639/e

Books: https://www.amazon.com/s?k=yehezkel+ben-ari&crid=1LZK6JWEBG4NC&sprefix=yehezkel+ben-ari%2Caps%2C196&ref=nb_sb_noss

0:00 Dr. Yehezkel Ben-Ari

3:08 Understanding Autism: Origins and Early Detection

8:08 The Roles of Machine Learning Data Analysis in Identification

14:56 The Impact of Environment and Autism

23:18 Treatment Approaches and Efficacy, Bumetanide, and NKKC1 Inhibitors

31:04 Challenges in Autism Research, including the Genetic Debate, Medical Paradigms, and Decision-Makers

38:00 Future Direction and Innovative Research, Autism in the Placenta and the Environment during Pregnancy

53:56 Wrap Up / Reviews and Ratings, Contact Info

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Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In this episode, we discuss Autism and the Default Mode Network. According to Lisa Feldman-Barrett, the Default Mode Network has many names because it has been discovered, named, rediscovered, and renamed many times. I do not disagree with the Science regarding Autism and the Default Mode Network. However, I disagree with the Interpretation of the Data. This IS our Default; our preferred state; the core of the Autistic Phenotype.

After listening to this episode and understanding B.3, you can understand MOST of Autism. The only reason you cannot understand ALL of Autism from these two episodes is the amount of Phenotypes branching off of B.3 and our Default Mode. Autism IS preference for ALONENESS and SAMENESS. This minimizes sensations and distractions that interfere with our internal world. This state is NOT abnormal, how society interferes with it makes it abnormal.

If you want more Autistics to ACHIEVE, then understand your interaction, interference, and interpretation of what YOU think Autism is, and that delta determines how much we are prevented in life. This, of course, becomes slightly different the more profound the Autistic Phenotype is with that specific person.

In this episode, we will explore the different brain regions and the goals of these regions as it relates to our phenotypes. We will get into some "Thinking in Picture" and thinking styles. This will be a good time because of a future guest on From the Spectrum Podcast discussing Autism and Creativity. This is exciting for me.

Lisa Feldman-Barrett Core System (DMN) https://lisafeldmanbarrett.com/2017/02/05/core-systems/

0:41 Research at UT-Austin and the Importance of the INFRARED LIGHT study with Autism

5:48 Autism and the Default Mode Network (DMN); Buzzword in Science

7:19 Humans and our Prediction Machine and Sensory Processing; Innate or Learned; Oxytocin in the Autistic Phenotype;

9:36 History of DMN (from Lisa Feldman-Barrett) and the many names; Core Systems

11:58 medial Prefrontal Cortex (covered in many episodes); roles, E/I, connectivity, Internal Calculators

14:45 Posterior Cingulate Cortex (PCC); Self-Referential Thinking, Memory, Attention, Task-Switching and the harms of calling it ADHD

18:03 Angular Gyrus; Language, Sensory Processing "Bee Movie" example, Mental Images, Narratives, Empathy

21:12 Supplementing Relationships

23:36 Sensation-Perception

24:30 Precuneus; Self-Awareness, Episodic Memory, Prediction and Strategic Planning

25:52 Social Cognition; Social Cues and Skills

27:50 Autism and Anxiety- Avoidance, Breathing (Physiology), and Valence (how we feel)

28:48 Internal Calculators; Metabolic Bank Account and Demands

29:26 the DMN is a Misnomer and the Default (tendency, phenotype) of the Autistic

33:04 Reviews/Ratings, Contact Info

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today’s episode, we discuss Autism with J.D. Barker. J.D. is a New York Times and International Best-Selling Author. His debut novel, Forsaken, caught the attention of legendary Author, Stephen King, who allowed Barker to use one of his characters from Needful Things for Barker’s debut novel. His writing career took off with The Fourth Monkey, which drew widespread attention, leading to a series of auctions and pre-empts for its publishing rights globally. Barker's style often involves intricate plots that blend psychological depth with supernatural or crime elements, appealing to fans of both horror and thriller genres.

Barker's work expanded when he was approached by Bram Stoker's family to co-author a prequel to Dracula, titled Dracul, utilizing previously unpublished notes by Stoker. Barker is a frequent co-author with legendary writer, James Patterson. Listen to how Barker can create such vivid imagination with the characters he creates. In addition, Barker shares critical information on how he navigates such a prolific and successful writing career, often managing many projects with great efficiency. This episode provides critical insights on how the Autistic Phenotype can strive with their unique superpowers.

J.D. Barker https://jdbarker.com/books/heavy-are-the-stones/

J.D Barker and Christine Daigle's upcoming book in November, Heavy Are the Stones https://www.amazon.com/Heavy-Are-Stones-J-D-Barker-ebook/dp/B0D5RKLYPC/ref=sr_1_1?crid=2TRLN3LUMCEFA&dib=eyJ2IjoiMSJ9.FJj1OgrpA4iJyLa9pHJ9ZQ.GiVjyydPJtKVpMdmN0HupggAyTd0GcjUBJ9l5UUA6xM&dib_tag=se&keywords=heavy+are+the+stones+jd+barker&qid=1728672013&sprefix=jd+barker+heavy%2Caps%2C119&sr=8-1

J.D. Barker Books https://www.amazon.com/s?k=JD+Barker&crid=18DBO8RHA8T05&sprefix=jd+barker%2Caps%2C111&ref=nb_sb_noss_1

X: https://x.com/jdbarker

0:00 JD Barker

2:49 Early Years of Creativity, Books, & Understanding Autism; Trying to Fit-In; Following Rules, Black and White thinking versus Gray

11:43 Superpowers of Writing as a Reflection, Creativity, & Intelligence of the Inner World

15:00 Superpowers of Autism by Creating Catalogs: Patterns, Visual & Thinking in Pictures, & Creating Characters

20:42 Balancing Life with Autism

23:51 The Writing Bout; the Importance of Managing Energy to avoid Burnout

35:42 Focusing on the Process, not the Outcome

39:35 Stephen King's Blessing & Approval of Forsaken; the journey to meet King

41:44 James Patterson Collaborations

43:25 Bram Stoker & the Prequel to Dracula, Dracul; Superpower of the Autistic Brain example

46:11 Recognizing Autism in Children

49:11 Future work

52:42 Review/Ratings & Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In this episode, we discuss Autism with Nicole Rincon, PA-C from Rossignol Medical Center. Nicole Rincon is a board-certified Physician Assistant (PA-C) who specializes in Pediatric Special Needs, MAPS (Medical Academy of Pediatric Special Needs), Integrative, and Functional Medicine. At Rossignol Medical Center, she is actively involved in patient care, research, and educational content. Nicole adopts valuable holistic and patient-centered care approaches in her practice.

Nicole also brings a deeply personal perspective to the discussion as a mother of children with regressive Autism. This personal journey has fueled her motivation to explore the complexities of Autism, leading her to Rossignol Medical Center. Prior to this, Nicole spent years in medical weight management, focusing on nutritional counseling and wellness supplementation. This background provides her with unique insights into the metabolic, gastrointestinal, and environmental factors influencing Autism.

Disclaimer: This is not Medical Advice

Nicole Rincon https://www.nicolerincon.com/nicole-rincon

Rossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/

TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdf

TACA Talks: https://www.nicolerincon.com/videos

X: https://x.com/NicoleRinconPA

Publications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles

0:00 Nicole Rincon

2:07 Nicole's Personal and Professional Journey into Medicine and Autism; "Who's the guy in Charge?"

12:30 Understanding Autism Trough Research and Interventions; Regression; Omegas and Toxins

21:56 Functional Medicine Approach to Autism; Rossignol Medical Center

25:07 Introduction to various Folate factors, Folate Receptor Antibodies, and Methylation

30:36 The Role of Mitochondrial Dysfunction and the many Comorbid Conditions of Autism (Autism and X, Y, Z)

36:02 Collaborative Approach at Rossignol Medical Center; Research Insights and Opportunities from Nicole's multiple roles

42:22 Challenges with the Current Medical Paradigm

44:09 Maternal Health and its Impact on Autism

48:34 Investigating Autism Beyond Vaccines

50:59 The Role of Light and Environment in Human Biology; Electrons and Magnetism

53:26 Introduction to Nicole's Comprehensive Evaluation from a Functional Medicine Approach; Understanding the Patient and Upstream Dysfunctions

1:02 Multifactorial Approach

1:05 The Future of Medicine, integrating Functional and Patient Center Care

1:13 Reviews/Ratings and Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

Relationships are challenging.

In this episode, we explore some of the Autistic phenotype challenges in relationships. We discuss symptoms from criteria A are external and criteria B are internal, and how criteria B complicates the symptoms in criteria A. In addition, Autism is a comparison to social-norms, and this is a problem. Some environments/relationships discussed include peer-to-peer, romantic, and parent-child. To begin, we explain the mechanisms behind the speaker-receiver and the use of conveying speech in socialness.

Before we begin, we cover a brief explanation of Speaker-Receiver and human communication.

Dr. Theresa Regan episode https://youtu.be/aUhIreFd5sw

Autism and Adaptive Responses https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000658438095

What is Autism: Criteria A https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000651048705

The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273

(0:00) Intro; Speaker-Receiver explanation when conveying speech

(3:55) Unpredicableness in socialness; black and white thinking and context-dependent and adaptive responses; Metabolic energy/resources; Oxytocin and Serotonin

(7:10) Biology that gives us Autism gives us complications to socialness and relationships; Sex-differences and socialness

(8:40) Criteria A is external, Criteria B is internal; Sensory-Processing

(10:32) B.2 and B.3 implicates socialness

(16:58) Direct social interactions

(22:26) Autism versus social norms; Romantic relationships

(26:51) Do Autistics outgrow Autism?

(28:04) Parenting

(31:30) Cohabitating

(32:28) Wrap Up

(32:45) Reviews/Ratings and contact info

Links: hopp.bio/fromthespectrum

X: https://twitter.com/rps47586

Email: info.fromthespectrum@gmail.com

For today's episode, we speak with Dr. Theresa Regan, PhD & CAS, about adolescents and adults with Autism. Dr. Regan is a neuropsychologist with over 25 years of experience serving adolescents, adults, and seniors in hospital settings. She is a Certified Autism Specialist and the Director of the OSF HealthCare Adult Diagnostic Autism Clinic. Dr. Regan has conducted over 1,000 assessments on adolescents and adults with Autism. Her expertise in brain-behavior relationships, adult and geriatric medical conditions, and autism has provided her with a unique set of qualifications for serving adults with autism.

In addition to her clinical work, Dr. Regan is the author of Understanding Autism and the host of the podcast "Autism in the Adult." During the episode, Dr. Regan shares valuable tools and protocols for Autistics as we learn to navigate various responsibilities such as employment and relationships. Her role as a neuropsychologist offers her insights into alternative approaches beneficial for both Autistics and their friends, family, as well as in employment and educational settings.

Dr. Theresa Regan https://www.adultandgeriatricautism.com

OSF Healthcare https://www2.osfhealthcare.org/providers/theresa-regan-1602000

Autism in the Adult https://open.spotify.com/show/2POoTBvzgPr0yIkU7dmw2m?si=31381356153f4903&nd=1&dlsi=8f401dc6fce54bb5

Understanding Autism https://www.amazon.com/dp/B098KQKZT7?binding=kindle_edition&ref_=ast_author_bsi

0:00 Dr. Theresa Regan

1:42 Journey into Psychology and Autism

7:20 Understanding Autism in Adults

13:39 The Role of Self-Knowledge in Relationships

19:47 Challenges faced by Adults with Autism

25:32 Tools and Protocols for Regulation

31:48 Navigating Employment

37:54 The Importance of Self-Care and Balance

43:35 Resources and Future Direction

55:18 Reviews/Rating and Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today's episode, Nicole Rincon, PA-C, returns to discuss the risks associated with Autism development. The conversation spans from before conception through to after birth. We'll explore how factors related to the mother can influence autism risk, and we'll look at specific tests and signs in the body (labs and biomarkers) that have been linked to Autism. Additionally, we'll cover environmental influences, dietary considerations, acute medical conditions and medications, seasonal patterns, and various other aspects to be mindful of.

By the end of the episode, we hope you'll gain valuable insights to consider as you navigate pregnancy. Our goal is to educate listeners, especially those who are pregnant or planning to conceive, about these potential risk factors, equipping them with the knowledge to make informed decisions or to be more aware during these pivotal times.

Nicole Rincon https://www.nicolerincon.com/nicole-rincon

Rossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/

TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdf

TACA Talks: https://www.nicolerincon.com/videos

X: https://x.com/NicoleRinconPA

Publications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles

Other Resources:

Autism and the Embryo, and expanding Artificial Light as a possible cause of Autism

https://www.youtube.com/watch?v=NOVp4mIroug

(See 18:36)

https://www.youtube.com/watch?v=OtA-aMN7ziY

DISCLAIMER: THIS IS NOT MEDICAL ADVICE.

0:00 Nicole Rincon

1:00 Understanding Pre-Pregnancy Risks

4:02 Maternal Risks Factors for Autism

6:53 Environmental Factors for Autism

9:56 Alternatives to Common Medications

12:58 The Role of Light & Seasonal Factors

16:02 Serotonin & Autism

18:56 Inflammation & Mitochondria

22:08 Infections & Antibiotics

25:08 Lab Work & Biomarkers for Maternal Health

27:46 Tyrosine, Thyroid, & Iodine; Depression, Fatigue

31:07 Folate & Methylation in Pregnancy; Autoimmune; Pregnancy Complications

40:40 Amino Acids; Dietary Types & Autism; Personal Diets

49:00 Eating Seasonally & Locally

51:01 Post-Pregnancy Nutrition

54:00 Breastfeeding versus Formula Feeding; Environmental Factors & Toxins, Plastics, Water

1:00 The Role of Sunlight on Human Biology; Leptin & Hormones, Metabolism Accountant; Red Light

1:02 Sun and Sunscreen; Beta-Endorphins, Cannabinoids, Hormones

1:07 Concluding Thoughts on Health & Family

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today's episode, Dr. Eric Weiss, MD, explains an exciting medical approach for Autism. Dr. Weiss, who holds board certification in Plastic and Reconstructive Surgery, is a notable figure in regenerative medicine. Dr. Weiss is a Veteran of the U.S. Navy. Dr. Weiss attended Duke University Medical School for his medical degree, completed his General Surgery Residency at the University of California, San Francisco (UCSF), and did his Plastic Surgery Residency at the University of Miami. He has a special interest in using regenerative therapies to address autism.

Dr. Eric Weiss recounts his journey into innovative medical practices, moving away from conventional pharmaceutical treatments. As a father to Marston, his dedication to exploring treatments for autism stems from personal experience. Throughout his story, his enthusiasm for natural healing methods is evident. By the end of this episode, listeners should gain insight into a thoroughly researched medical intervention that's gaining traction in the autism community.

Dr. Eric Weiss, MD: https://northfloridastemcells.com

Dr. Eric Weiss, MD: https://linktr.ee/neflps

Educating Marston: https://www.educatingmarston.com

Disclaimer: This is not Medical Advice.

0:00 Dr. Eric Weiss, MD

1:55 Dr. Weiss's Medical Journey

5:01 Intersection of Autism and Stem Cell Research

12:09 Personal Experience as a Parent with Autism

15:58 Understanding Umbilical Cord Blood Treatment

22:39 The Process of Umbilical Cord Blood Donation

25:55 The Science behind Stem Cell Healing

32:31 Future of Regenerative Medicine

34:24 Natural Healing and Lifestyle, Not Big Pharma

36:56 Mitochondrial Function & Energy Production

39:09 The Impact of Light on Health

41:07 Understanding Inflammation & Modern Disease

44:30 Stem Cell Therapy: Mechanisms & Effects

48:41 The Future of Medicine: Beyond Pharmaceuticals

54:14 Professional Transition into Stem Cell and Regenerative Therapy

58:05 Exploring Cytokines & Interleukins; Patterns of Disease; Dr. Weiss's Contact Info

1:07 Reviews/Ratings; Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. (Part 2 on Asperger's "little professors" next). The two-part series intends to remember the phenotypes that appeared and became known as Autism.

It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype.

Leo Kanner: Autistic Disturbances of Affective Contact http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

0:00 Intro

0:45 Erwin Schrödinger Quote; Quantum Physics; Missing link in Medicine

2:56 Kanner's Autistic Disturbances of Affective Contact; Demographics

3:52 Ages; Boys versus Girls; Phenotypes; Family History

6:26 Important consideration of Family History- electricity and nnEMF; general observation and important phenotypes

9:30 Anticipatory Motor Adjustment; Reflexes; Sensory and Adaptive Responses

13:32 Monotonous Repetitions; Sameness

15:26 Spelling and Language

18:20 Commands and Intrusions

18:57 Autism, not Autism and ADHD; Intense Fixations & Neuroplasticity; Default Mode Network; Sameness

24:00 Oblivious to Others; Inattentive- It's not ADHD, it's Autism

27:39 Changes & More on Sameness & Repetitions

30:10 Rote Memory; Gastrointestinal: Timelines and Milestones

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. The two-part series intends to remember the phenotypes that appeared and became known as Autism and Asperger's.

It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype.

If the children described by Asperger in Autistic Psychopathy in Childhood were alive today, they would receive a smorgasbord of diagnosis.

Introduction to the Podcast (00:00:00 - 00:00:41,320):

Asperger's Work and Concept of Autism (00:00:41,320 - 00:02:21,040):

Historical Context and Asperger vs. Kanner (00:02:21,040 - 00:05:10,520):

Case Study: Fritz V. (00:05:45,080 - 00:11:25,920):

• Detailed case study of Fritz, highlighting social integration issues, motor delays, superior speech, and behavioral challenges.
• Discussion on how modern medicine might label Fritz with multiple diagnoses.

Case Study: Harold L. (00:13:21,040 - 00:15:25,240):

• Description of Harold's struggles with school, social withdrawal, and the conflict between autistic capabilities and societal expectations.

Case Study: Ernest (00:17:37,960 - 00:21:00,160):

• Ernest's case with normal development but severe academic struggles, social withdrawal, and unique learning styles, suggesting individual teaching methods for autistics.

Case Study: Hellmuth L. (00:21:16,680 - 00:24:40,240):

• Helmuth's case with complications at birth, delayed development, obesity, and later sexual tendencies, linking these to environmental and light exposure changes.

Common Features Across Asperger's Cases (00:24:49,600 - 00:26:29,720):

• Summary of common traits observed across Asperger's 200 cases, including eye gaze issues, peripheral vision, and social interaction patterns.

Asperger's Insights on Autistic Intelligence (00:26:29,720 - 00:27:37,760):

• Discussion on the unique intelligence and original ideas in autistic children, introducing the concept of "Asperger's little professors."

Reflection on Autism as a Phenotype vs. Disorder (00:27:37,760 - 00:29:12,680):

Historical Figures and Autism (00:29:12,680 - 00:29:41,480):

• Speculation on whether historical geniuses might have had autistic traits, highlighting that autism could be viewed as a superpower in certain contexts.

Conclusion (00:29:41,480 - 00:30:42,800):

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In this brief episode, we discuss keeping up in the classroom during teacher lecture. Specifically, we discuss the delays in sensory processing, taking notes, visual thinking, and some challenges with keeping up. This is a pressing issue for Autistics, and in my opinion, education needs to do better for the Autistic phenotype.

Autism and Education https://youtu.be/zQpNtvS-tWw

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today's episode, we discussing transferring energy from the environment across our biology. We discuss a few quantum theories, atoms, molecules, water, DHA, and NF-kB. Life on Earth is driven by energy from the environment, and this could be missed with humans, and especially with developmental problems like Autism.

Water Podcast 1: Rubin, Kruse, Huberman https://www.youtube.com/watch?v=0lBAcUMGIeI&t=43s

Water Podcast 2: Gulhane and Kruse (Light changes the Physics of Water !) https://www.youtube.com/watch?v=l9Ubguvfpys

Water Podcast 3: Gulhane and Kruse https://www.youtube.com/watch?v=W5w0WainlMM

https://www.plefa.com/article/S0952-3278(12)00147-0/abstract

https://pmc.ncbi.nlm.nih.gov/articles/PMC5793004/#:~:text=Electrons%20exist%20in%20all%20matter,role%20in%20oxidation%2Dreduction%20reactions.

Quantum-coherent energy transfer: implications for biology and new energy technologies https://pmc.ncbi.nlm.nih.gov/articles/PMC3385675/#:~:text=In%20the%20simplest%20picture%2C%20quantum,transport%20at%20the%20molecular%20scale.

Quantum cognition: The possibility of processing with nuclear spins in the brain https://www.sciencedirect.com/science/article/abs/pii/S0003491615003243

Role of semiconductivity and ion transport in the electrical conduction of melanin https://www.pnas.org/doi/10.1073/pnas.1119948109

0:00 Intro

0:40 Quantum Biology, Coherence, Thermodynamics, Water, DHA, NF-kB, and transferring energy - Atoms & Molecules

2:00 Oxygen and CCO; Mitochondria

3:55 Quantum Biology; Environments influence Atoms & Molecules

5:50 Coherence & States; Light guides Life on Earth; Light provides Energy after it hits Matter

7:16 Modern Human Environments

7:41 Quantum Thermodynamics; Melanin, Electrons; Rules

9:03 Biophotons, Photons and Lux; Seasonal Impact

11:15 Electrons & Mitochondria; Real sources of Energy

12:00 Artificial Light versus 280nm-3100nm Light; Big Harma & GLP-1 sidebar

14:16 Autism and Loss of Biological Energy; changes in Light

15:43 Electrons in Biology; Water; Coherent Domains; Semiconductors

17:15 DHA; Electron Efficiency; Cells; Photoreceptors and Converting Energy and Developing Nervous Systems (plural)

19:20 Phylogeny of Oxytocin and DHA sidebar; pi-electons; DHA dictates DNA

22:40 Jack Kruse Quote

23:36 Cells, Tissues, & Synapses; Origins of Autism; DHA roles

26:14 Autism and X, Y, Z comorbid conditions (plural); definitions of Autism (modern versus origins), Criteria

29:23 DHA takeaways; efficiency

31:41 NF-kB; creating the womb and nervous systems; Autism and Orbitofrontal Cortex (OFC)

35:06 Reviews/Rating & Contact Info

These are comments about my opinion and experience with education- the classroom and the school day. There are many contrasts to the Autistic phenotype when it comes to the classroom and school day.

Autism and Education https://youtu.be/zQpNtvS-tWw

B.3 https://youtu.be/Ov_Bw--zzrQ

Kanner Kids https://youtu.be/FjELhG5FKzs

Asperger's Autistic Intelligence https://youtu.be/qygNL6wCrhg

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

For today’s episode, Dr. Hanna Stevens joins me to discuss early prenatal factors of early brain development. Dr. Stevens received an MD and PhD in Neuroscience from the University of Illinois. Dr. Hanna Stevens leads the Psychiatry and Early Neurobiological Development Lab at the University of Iowa Carver College of Medicine. Dr. Stevens is a distinguished Professor of Psychiatry and holder of the Ida P. Haller Chair.

Her work leads groundbreaking research into the molecular and cellular foundations of early brain development, and is pivotal in linking prenatal stress, environmental factors, and genetic influences on childhood behavior and the emergence of disorders. With a focus on the critical periods of pregnancy and early childhood, her research aims to revolutionize the diagnosis and treatment of conditions throughout the lifespan. By the end of this episode, we hope you receive valuable information about the Placenta, Womb, and Development.

Dr. Hanna Stevens https://medicine.uiowa.edu/psychiatry/profile/hanna-stevens

Iowa Healthcare https://uihc.org/childrens/providers/hanna-e-stevens

Psychiatry and Early Neurobiological Development Lab (PENDL) https://stevens.lab.uiowa.edu

Publications https://stevens.lab.uiowa.edu/publications

0:00 Dr. Hanna Stevens

2:00 Journey into Neuroscience and Psychiatry

8:13 Prenatal Development of Autism

14:02 The significance of NF-kB in Brain Development

23:10 Serotonin; Leukocytes as a window into our Biology; Cortisol

29:02 Steroid Hormones and Stress & Development

34:12 Methylation

40:00 Cell Proliferation & Migration in Fetal Development; Antioxidants

45:56 Oxidative Stress; Mitochondria; Antioxidants

48:30 Quantum Biology/Physics

** Me shaking my head at minute 48:50 is not intended at Dr. Stevens, but at myself because I tell myself not to keep going to the electrons and light for a Cause of Autism to guests

53:19 Future Research & Dorsal Striatum; Volume; Brain Development

1:00 Reviews/Rating; Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

My guest today is Dr. Kristen Lyall, ScD. Dr. Lyall received a Doctor of Science in Epidemiology from Harvard School of Public Health. During her postdoctoral training, she received training in Nutrient Science at Harvard and Pediatric Epidemiology at UC-Davis MIND Institute's Autism Research Training Program. Currently, Dr. Lyall is an Associate Professor at Drexel University's A.J. Drexel Autism Institute – Modifiable Risk Factors Program.

The overarching goal of the Modifiable Risk Factors program is to identify factors that can be changed to prevent or mitigate the adverse effects associated with Autism, thereby potentially improving outcomes for individuals and informing public health policy and practice. Dr. Lyall's expertise provides actionable tools for listeners to understand the environmental risks of Autism. By the end of the episode, we hope you gain insight into the identified modifiable risk factors for Autism.

Dr. Kristen Lyall: https://drexel.edu/autisminstitute/about/our-team/all-staff/Kristen-Lyall/

Dr. Lyall publications link: https://pubmed.ncbi.nlm.nih.gov/?term=Kristen%20Lyall&sort=pubdate

ECHO: https://echochildren.org

Fish not Supplements: https://echochildren.org/research-summaries/fish-but-not-supplements-consumed-in-pregnancy-associated-with-lower-rates-of-autism-diagnosis-and-related-traits-echo-cohort-study-finds/

Other Resources:

Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB (Autism is a loss of energy- electrons, photons, protons)

https://youtu.be/2-IA_gunXbw

0:00 Dr. Kristen Lyall

2:30 Her Journey into Epidemiology & Autism

7:50 The Role of Epidemiology & Autism

12:15 Modifiable Risk Factors

17:32 Dietary Influences on Autism Risk; Eat more FISH (DHA!)

22:53 Assessing Exposure & Risk Factors

32:35 Immune & Hormonal Factors in Autism; Cytokines & Inflammation

39:17 The Impact of Acute Events during Pregnancy

44:45 Air Pollution & its Effects in Neurodevelopment; Oxidative Stress

48:14 Current & Future Research; ECHO & EARLI

56:34 Reviews/Ratings, Contact Info

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In this episode, we discuss some difficulties with eye contact for the Autistic phenotype. Sensory processing and the rate of information comes fast, and this provides additional energy for an already challenging and exhaustive task. Humans are constantly extracting physical phenomena from the environment (sensations) and we process this information to inform our nervous systems (perceptions). Specifically in this episode, we discuss the differences between listening and speaking.

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A Year in Review from previous episodes.

00:00 - Intro

00:42 - Warning Against Comparing Rates; why comparing autism rates across different time periods is misleading due to changes in diagnostic criteria and definitions.

02:07 - Historical Context; the Bayh-Dole Act, DSM acceptance of Autism, and changes in vaccination schedules, affecting Autism definitions; Core Autism Characteristics

04:30 - Educational Challenges; Describes the typical school day's structure as potentially overwhelming for Autistic individuals due to frequent subject changes.

05:36 - Intense Focus; Autistic individuals might fixate on topics with abnormal intensity or focus, which is a hallmark of Autism.

08:40 - The biology of Autism allows us to be comfortable within ourselves; contrasting with societal expectations.

09:09 - Employment and Anxiety; Considers how the expectation to fit into social norms can lead to anxiety and challenges in employment for Autistic individuals.

10:10 - ADHD and Autism; Challenges the notion of coexisting ADHD and Autism,

14:26 - Early Detection; UCLA study on very young children showing altered salience network connectivity, hinting at early signs of Autism.

14:49 - Developmental Timing; emphasizes that Autism likely starts in the womb, suggesting prenatal development as a critical area for research.

15:14 - Neurodevelopmental Perspective; Autism as underdeveloped or abnormally developed cells, linking it to broader neurodevelopmental disorders.

16:03 - Comorbid Conditions: Explores the concept of Autism being associated with various other conditions due to shared developmental issues.

16:47 - Biological Processes: cellular proliferation, differentiation, and migration in the womb, crucial for brain development.

17:41 - Mitochondria and Autism

18:30 - Oxytocin & Autism; oxytocin as a molecule of interest, particularly its pathways and their implications for social behavior in Autism.

20:29 - Social Reward System; Explains how oxytocin and serotonin interaction in the brain contributes to the rewarding nature of social interaction, which might be lacking in Autism.

21:21 - Serotonin Synthesis; Details the synthesis of serotonin in both the GI tract and the brain, mentioning the enzymes involved and their significance.

22:34 - Tryptophan and Light; Discusses how light affects tryptophan, an amino acid precursor to serotonin, and its role in biological processes.

23:33 - Supplementing Relationships; Explores how visual thinking and movies can serve as a form of interaction for Autistic individuals, offering comfort or learning.

25:17 - Visual Learning; Highlights the concept of "thinking in pictures" and how it leads to accelerated learning or Autistic intelligence.

27:47 - Autistic Comfort and Societal Expectations; Advises against forcing Autistic individuals into societal norms that don't align with their natural inclinations, emphasizing understanding and acceptance

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The biology that gives us Autism allows us to be comfortable within ourselves.

Our biology orients the Autistic towards our internal state. This is more comfortable for the Autistic in comparison to the outside world. In this episode, we cover brain regions, networks, and internal calculators. All humans use these biological calculators. However, based on the living organisms unique structure of brain regions and networks (connections), it is easy to understand why people are different.

Epinephrine & Glia https://www.sciencedirect.com/science/article/pii/S009286741930621X

Other Resources:

Autism and Adaptive Responses https://youtu.be/Zj3_e6ZjCGk

Autism and Default Mode Network https://youtu.be/9CqyH4woB34

Autism and Salience Network https://youtu.be/9ZbTztb3al8

Autism and B.3 https://youtu.be/Ov_Bw--zzrQ

00:00 - Introduction

00:42 - Biology and Autistic Comfort

03:05 - Salience Network Explanation

05:06 - Attention Management in Autism

08:35 - Default Mode Network in Autism

09:47 - Introducing Internal Calculators & Neuromodulators; Neuroplasticity

10:52 - Biological Responses in Autistic Behavior

14:02 - Effort and Energy: The Role of Internal Calculators; Calculator for Effort vs. Outcome

17:07 - Social Interaction and Energy Use

20:23 - Dopamine and Internal Calculators; Reward Prediction Error as an Internal Calculator

25:18 - Internal Calculators and Societal Norms; Impact of Social Expectations on Internal Calculators; Neuroplasticity

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Understanding the roles of Thyroid with Autism & Parkinson's, and what is the missing link.

Research misses the link. Do not rely on research to connect these conditions and point to the real cause. Both, Autism and Parkinson's, have two major factors, 1) clocked timing and 2) A loss of, or a lack of, energy.

Two Questions are asked:

1) What do you think Neuromelanin is?

2) What do you think Light is?

Maternal health and preconception testing for Autism https://youtube.com/shorts/C2yhaPoWdIY

Iodine: https://youtube.com/shorts/q3dv-bslEwQ

Thyroid hormones and Autism https://youtube.com/shorts/SRnDzn4Uvgc

Impact of light on neurodevelopment and aging: Autism https://youtube.com/shorts/cLu53oVRRjI

Basal Ganglia: our go no go area for learning & habits https://youtube.com/shorts/YWc8AxuGHHM

Basal Ganglia: Motivation & Movements (you don't define Motivation, the nervous system does)

https://youtube.com/shorts/5agnRtSC95U

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Consider how the autistic phenotype might be judged. We spend more time in educational settings, but our interactions extend beyond these environments. Humans are social creatures, and we need to understand what individuals are trying to accomplish, especially in social settings. These two phenotypes show significant differences.

In this episode, we explore the Basal Ganglia. The basal ganglia are a group of subcortical nuclei that play a crucial role in orchestrating movement. They are involved in what's known as the 'Go, No-Go' decision-making process, where they help decide whether to initiate or suppress actions. This region is critical where motivation translates into action.

When discussing "motivations," we must be cautious; motivations aren't consciously defined by us but by our nervous system, which operates based on learned behaviors, habits, and neural pathways. The nervous system is designed to conserve energy by automating responses, which explains why it favors habit formation over constant conscious decision-making. It responds based on what it has learned, including connections, habits, and the rules established by our internal calculators.

General Description of the Basal Ganglia:

Inputs: Caudate Nucleus and Putamen

Relays: Globus Pallidus External (GPe) and Subthalamic Nucleus

Outputs: Globus Pallidus Internal (GPi) and Substantia Nigra Pars Reticulata (SNr)

Modulator: Substantia Nigra Pars Compacta (SNc)

00:00 - Defining the Autistic Phenotypes.

00:17 - Exploration of basal ganglia, focusing on the dorsal striatum.

00:40 - Explanation of connecting Autistic Phenotypes with behaviors and implications through biology.

01:00 - Detailed description of the basal ganglia's role in subcortical functions.

01:50 - Discussion on the relationship between eye and brain development.

02:18 - Explanation of basal ganglia's role in motivation and movement convergence.

03:02 - Insight into how the nervous system conserves energy and responds to known patterns.

03:52 - Explanation of why change is hard due to basal ganglia functions.

04:37 - paper on excitation-inhibition phenomena in autism.

05:07 - Genetic implications in autism: SHANK3, Neuroexcin, Neuroligin,

06:45 - Discussion on the enlargement of the dorsal striatum in autism.

08:07 - Identification of the caudate nucleus and putamen as inputs to the basal ganglia.

09:40 - Role of the putamen in motor skill acquisition and fine-tuning movements.

11:59 - Connection between the putamen and Autism-related motor behaviors like stimming.

13:30 - Discussion on Autistics preferring their inner world.

16:04 - Importance of the substantia nigra and dopamine in human function.

18:26 - Dopamine receptors and their roles in Autism.

20:03 - Subdivisions of the substantia nigra and their functions.

21:01 - Description of the globus pallidus and its role in basal ganglia circuits.

22:29 - Feedback loops involving the globus pallidus and subthalamic nucleus.

23:40 - Implications of delayed or inefficient signal loops in movement control.

24:57 - Role of the thalamus in processing sensations.

26:31 - Subthalamic nucleus as a major relay center for motor control.

28:47 - Linking Autism criteria with basal ganglia function.

30:20 - Coverage of all four criteria B symptoms related to Autism.

32:14 - Morphology of neural connections in Autism.

32:51 - Reviews and ratings.

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Autism just magically shows up.

In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases.

The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics.

"... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse

(Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uA

Tetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMI

Tetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4

Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXs

Tryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079rev

Autism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277

Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567

Regions of Interest:

Atoms,

Aromatic Amino Acids,

Artificial Light,

Chromophores,

Cytochromes,

Electromagnetic,

Embryo,

Folate Acid (and Folic Acid)

Sunlight,

Melanin (Neuromelanin),

Melanocytes,

Melanogenesis,

Melanopsin,

Mitochondria,

Neuroectoderm,

Neuroplasticity,

Periodic Elements,

Photoelectric Effect,

Pro-opiomelanocortin (POMC)

Proteins (wide-band gap semiconductors),

Serotonin,

Tryptophan Hydroxylase 1 and 2,

Vitamins A, b9 (Folate/Folic Acids), B12, and D,

Water

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