DiabetesBio – Détails, épisodes et analyse

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DiabetesBio

American Diabetes Association

Sciences

Fréquence : 1 épisode/27j. Total Éps: 35

DiabetesBio co-hosts Darleen Sandoval (University of Colorado), Kirk Habegger (University of Alabama-Birmingham), and Kevin Williams (UT Southwestern) interview authors of editor-selected biomedical research articles published in the journal Diabetes, the American Diabetes Association's flagship research publication.

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Scientific Sessions Reviewed by ADA Podcast Co-Hosts! In this special episode, the co-hosts of DiabetesBio, Diabetes Care “On Air,” Diabetes Core Update, and Diabetes Day by Day discuss highlights from the ADA’s 2024 Scientific Sessions

Saison 1 · Épisode 10

vendredi 16 août 2024 • Durée 54:39

Welcome to a very special episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care “On Air,” acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care “On Air”; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care “On Air,” DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer.

This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the “bench-to-bedside” spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.)

Correction:
•Dr. Carmella Evans-Molina is from the Indiana University School of Medicine
•Dr. Lou Philipson is from the University of Chicago

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

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Inbal Caspi and Danwei Huangfu on glucose transporters in human glucostat, Deepthi Mallela discusses the genetics of bile acids and their association with diabetes, Bernard Thorens and David Hodson revisit a 1993 “Classic” on GLP-1, and more!

Saison 1 · Épisode 9

mardi 6 août 2024 • Durée 01:11:58

Welcome to the August 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2024 issue of Diabetes.

2:39: Darleen and Kirk are joined by Dr. Inbal Caspi and Dr. Danwei Huangfu, lead author and corresponding author, respectively, of the August Paper of the Month, entitled “Glucose Transporters Are Key Components of the Human Glucostat.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0508.

27:30: Kirk and Darleen host Dr. Deepthi P. Mallela, co-lead author of “Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0676.

50:21: In this month’s Sweet Talk segment, Kevin and Kirk engage in a scintillating discussion with Dr. Bernard Thorens and Dr. David J. Hodson, coauthors of a recent “Classics in Diabetes” feature, named “Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al.” This article is an editor-selected feature article and is freely accessible at . The original “Classics” article is freely accessible at .

Jordan Wright on the exocrine pancreas, Lisa Smeehuijzen on circulating monocytes for individuals with obesity and insulin resistance, Sweet Talk with this year’s Banting Medal winner, Rury Holman, and more!

Saison 1 · Épisode 8

vendredi 5 juillet 2024 • Durée 43:24

Welcome to the July 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2024 issue of Diabetes.

4:31: Darleen and Kirk are joined by Dr. Jordan J. Wright, first author of the Paper of the Month, entitled “Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0009.

17:23: Kirk and Darleen then chat with Dr. Lisa Smeehuijzen, first author of the article “Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0970.

20:26: In a very special Sweet Talk segment, Kevin is joined by cohosts Darleen and Kirk for an interview with Dr. Rury R. Holman, the winner of the 2024 Banting Medal for Scientific Achievement. More details about this award can be found at https://professional.diabetes.org/awards/banting-medal-scientific-achievement-award.

DeFronzo on a novel renal-hepatic axis in endogenous glucose production, arguments for and against the current model of glucose regulation of β-cell KATP channels from Rutter and Sweet (for) and Merrins and Kibbey (against), and more!

Saison 1 · Épisode 7

mercredi 12 juin 2024 • Durée 51:49

Welcome to the June 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2024 issue of Diabetes.

2:27: Darleen and Kirk are joined by Dr. Ralph A. DeFronzo, senior author of the article “Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects.” This article is freely accessible at https://doi.org/10.2337/db23-0457.

20:26: In this month’s Sweet Talk segment, Kevin and Kirk highlight this month’s Point-Counterpoint feature on whether a new model is needed on the regulation of β-cell KATP channels in glucose metabolism. First, they talk to Drs. Matthew J. Merrins and Richard G. Kibbey, authors of the Counterpoint, titled “Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!” This article is freely accessible at https://doi.org/10.2337/dbi23-0032.

35:00: Kevin next is joined by Drs. Guy A. Rutter and Ian R. Sweet, authors of the Point article, titled “Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?” This article is freely accessible at https://doi.org/10.2337/dbi23-0031.

Devi Kasinathan, Zheng Guo, and Dax Fu on autoimmune diabetes, Jennifer Lee and Rebecca Salzo on WIN ADA, Olga Gupta and Rana Gupta on a “Classic” article about regional adiposity, and more!

Saison 1 · Épisode 6

lundi 6 mai 2024 • Durée 53:36

Welcome to the May 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2024 issue of Diabetes.

5:06: Darleen and Kirk are joined by Drs. Devi Kasinathan, Zheng Guo, and Dax Fu, authors the May Paper of the Month, “Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice.” This article can be freely accessed at https://doi.org/10.2337/db23-0568.

20:14: Next, Kirk and Darleen highlight one of the ADA’s membership engagement groups, the Women’s Interprofessional Network of the ADA (WIN ADA), by chatting with Drs. Jennifer Lee and Rebecca Scalzo, the current cochairs of WIN ADA. They discuss the history and growth of WIN ADA, which is a members-only network for female clinicians, scientists, educators, and other health professionals in diabetes. Learn more about WIN ADA, including how to join, at https://professional.diabetes.org/membership/win-ada.

36:45: For the Sweet Talk segment, Kevin is joined by Drs. Olga T. Gupta and Rana K. Gupta, authors of May’s “Classics in Diabetes” article. The classic article they focus on is 1985’s “The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913,” by Ohlson et al. Kevin and his guests discuss the evolving concepts of regional adiposity and diabetes and other chronic disorders. Their “Classics” article is freely available at , and the 1985 classic by Ohlson et al. can be found at .

Sebastian Kalamajski on genetic aspects of adiposity-related traits; Yuval Dor on DNA methylation–based assessment of pancreas and islet cells; and Carmella Evans-Molina on the role of calcium in regulating insulin secretion.

Saison 1 · Épisode 5

mardi 2 avril 2024 • Durée 59:57

Welcome to the April 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2024 issue of Diabetes.

2:55: To kick things off, Darleen and Kirk are joined by Dr. Sebastian Kalamajski (Lund University), senior author of “Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function.” This article can be freely accessed at https://doi.org/10.2337/db23-0531.

15:16: Darleen and Kirk chat with Dr. Yuval Dor (The Hebrew University of Jerusalem), senior author of “DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets.” This study can be freely accessed at https://doi.org/10.2337/db23-0704.

42:50: Darleen introduces a very special guest for this month’s Sweet Talk, Dr. Carmella Evans-Molina. She is the director of the Center for Diabetes and Metabolic Diseases at Indiana University School of Medicine, and she was awarded the 2023 Outstanding Scientific Achievement Award by the American Diabetes Association. Darleen and Kevin raise many topics in this conversation with Dr. Evans-Molina, from her focus on the role of calcium in regulating insulin secretion to the importance of serendipity and collaboration in scientific research to her recent hobby of learning to play the piano.

Bonus Sweet Talk episode with Christopher Newgard and Louis Philipson about the ADA’s Pathway to Stop Diabetes initiative, Céline E. Riera on her Pathway award-winning research, and more!

Saison 1 · Épisode 4

jeudi 7 mars 2024 • Durée 41:15

Welcome to the special Sweet Talk March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. Our host is Dr. Kevin Williams.

1:00 Sweet Talk, part 1. Kevin introduces the guests for the first part of Sweet Talk, Dr. Christopher Newgard from Duke University Medical Center and Dr. Louis Philipson from the University of Chicago School of Medicine. They are co-chairs of the American Diabetes Association’s Pathway to Stop Diabetes Mentor Advisory Group. The Pathway program seeks to identify and support exceptional young scientists in the field of diabetes research. Drs. Newgard and Philipson explain the history of the program, expand on the importance of mentorship for young scientists, and relate challenges faced by the program, from funding cuts to the COVID-19 pandemic.

18:56 Sweet Talk, part 2. To wrap up the episode, Kevin brings in Dr. Céline E. Riera, recipient of a Pathway to Stop Diabetes initiator award in 2015. Dr. Riera is the author of a thought-provoking Perspective article in the March 2024 issue of Diabetes that is based on her award-winning research. This article can be freely accessed at https://doi.org/10.2337/db23-0706.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

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Harry Cutler and David James on using a dual tracer test to identify insulin resistance in mice, Lori Sussel on PTPN2 regulation of metabolic flux, a preview of a special Sweet Talk episode this month, and more!

Saison 1 · Épisode 3

jeudi 7 mars 2024 • Durée 40:24

Welcome to the March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2024 issue of Diabetes.

1:15 Before getting underway with this week’s interviews, Kirk gives a quick shout-out to March’s Paper of the Month: “High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans,” by Gray et al. Although they only mention it in passing, Kirk does offer a ringing endorsement: “It’s excellent work, and all things glucagon are good.” This article is freely available at https://doi.org/10.2337/db23-0201.

2:44 Darleen announces that the March DiabetesBio is actually two episodes. The first part features Darleen and Kirk interviewing authors of the feature articles of the month, and the second part is devoted to Sweet Talk with Kevin. In this special episode, Kevin delves into the ADA’s Pathway to Stop Diabetes initiative with two of the initiative’s key members and one of the initiative’s award-winning researchers.

4:30 Darleen and Kirk interview Mr. Harry B. Cutler and Dr. David E. James, first and last authors of “Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia.” They discuss the use of a dual tracer test and describe insights into tissue-specific insulin action. They also raise an interesting question: Could it be that the popular belief that peripheral insulin resistance leads to hyperinsulinemia is inaccurate? This article can be freely accessed at .

Satya Dash on erythritol and cardiometabolic disease; Jeffrey Hodgin and Alan Attie on genetic analysis of obesity-induced diabetic nephropathy in BTBR mice; and revisiting Frans Schuit’s 1998 “Classic in Diabetes” on glucagon biology

Saison 1 · Épisode 2

mardi 6 février 2024 • Durée 01:07:03

Welcome to the February 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2024 issue of Diabetes.

2:25: To kick things off, Darleen and Kirk are joined by Dr. Satya Dash of University Health Network and the Banting & Best Diabetes Centre, University of Toronto. Dr. Dash is the senior author of “Erythritol as a Potential Causal Contributor to Cardiometabolic Disease: A Mendelian Randomization Study.” Do low-calorie sweeteners possibly contribute to cardiometabolic disease? Listen to hear about the results of Dr. Dash’s study. This article can be freely accessed at https://doi.org/10.2337/db23-0330.

14:52: Next, the Big 10 is well represented when Darleen and Kirk meet with Drs. Jeffrey Hodgin (University of Michigan) and Alan Attie (University of Wisconsin) to discuss their fascinating collaboration on their “Genetic Analysis of Obesity-Induced Diabetic Nephropathy in BTBR Mice.” Drs. Hodgin and Attie’s study can be freely accessed at https://doi.org/10.2337/db23-0444.

36:51: Sweet talk! Kevin introduces the first installment of the journal’s “Classics in Diabetes” series. This new format brings timeless articles into the spotlight and showcases their value for today’s scientists. The first installment, “GPCR Promiscuity Reshapes Islet Physiology” (), was co-authored by Associate Editor and and appears in the September 2023 issue of the journal. This commentary explores the work of Dr. Schuit, its implications for the understanding of diabetes, and how it laid the foundation for a rethinking of a traditional role of glucagon. Here, in this enlightening discussion, Dr. Schuit takes us through the historical context that led to the hypothesis and conclusions of his January 1998 classic, “Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors” (), and Dr. Campbell explains how rediscovering the concepts and findings of Dr. Schuit’s work has informed his current research. Drs. Schuit and Campbell conclude the discussion by sharing their thoughts on glucagon research and diabetes treatment.

Introducing DiabetesBio! A chat with editor David D’Alessio, discussing fatty acids and GDF15 with “Paper of the Month” author Gregory Steinberg, and remembering Daniel Porte Jr.

Saison 1 · Épisode 1

vendredi 29 décembre 2023 • Durée 37:08

Welcome to the premiere episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In each episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams will discuss the latest and greatest content in Diabetes. The team kicks off this first episode with some brief introductions before passing the mic to Diabetes editor-in-chief David D’Alessio (5:35), who shares his experiences as the editor of the journal and describes new initiatives involving the journal.

15:35: In addition, Dave and the team discuss the legacy and contributions of Daniel Porte Jr. Dan passed away at the age of 91 in May 2023, and he is the subject of a “Profiles in Progress” remembrance by Steven Kahn et al. in the January 2024 issue of Diabetes: https://doi.org/10.2337/db23-0787.

20:42: Darleen and Kirk then interview Dr. Gregory Steinberg of McMaster University. Dr. Steinberg is the senior author of “Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.” This article, which can be freely accessed at https://doi.org/10.2337/db23-0495, is the editor-selected Paper of the Month for the January 2024 issue of Diabetes.

31:49: In the “Sweet Talk” segment, Darleen and Kirk wrap up the episode by reviewing several interesting articles in January 2024 issue of Diabetes. Studies highlighted in this segment include:

M.W. Pataky et al. Divergent Skeletal Muscle Metabolomic Signatures of Different Exercise Training Modes Independently Predict Cardiometabolic Risk Factors. https://doi.org/10.2337/db23-0142
K. Motomura et al. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure. https://doi.org/10.2337/db23-0212

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