BroadEye: An Ophthalmology Podcast – Détails, épisodes et analyse

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BroadEye: An Ophthalmology Podcast

Bruno Fernandes and Shawn Maloney

Forme & Santé

Fréquence : 1 épisode/19j. Total Éps: 85

Authentic conversations about the knowledge gaps in ophthalmology and eye care, with guests hailing from ophthalmology and optometry clinics, vision research labs, industry, private companies, and the low vision community.

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Données mises à jour le 04/07/2026

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29/10/2024
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Inside the FDA: Reflections from Dr. Wiley Chambers on Ophthalmic Drug Development

Épisode 85

samedi 26 juillet 2025 • Durée 01:03:45

In this week’s episode of the BroadEYE Podcast, hosts Dr. Shawn Maloney and Dr. Carlos Quezada-Ruiz sit down with Dr. Wiley Chambers, recently retired Deputy Director of the Division of Ophthalmology at the U.S. Food and Drug Administration (FDA). With over 36 years at the FDA, Dr. Chambers offers a rare insider’s perspective on regulatory science, ophthalmic drug development, and the evolution of clinical trial oversight.

This episode explores:

How ophthalmology regulation has changed over the decades
Common pitfalls in pre-IND meetings and what smart innovators do differently
Lessons learned from reviewing countless drug and biologic applications
The future of FDA guidance in areas like rare disease, gene therapy, and digital endpoints

Dr. Chambers also shares personal reflections on mentorship, scientific integrity, and his transition out of federal service after a distinguished career.

About Our Guest Dr. Wiley Chambers served as a lead ophthalmic reviewer at the U.S. FDA from 1987 until his retirement in 2023. As Deputy Director of the Division of Ophthal

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From Tactile Tech to Radical Inclusion: A Conversation with Dr. Joshua Miele

Épisode 84

mardi 15 juillet 2025 • Durée 51:59

In this episode of the BroadEYE Podcast, we welcome inventor, researcher, and MacArthur Fellow Dr. Joshua Miele. Known for his pioneering work in accessible technology for blind users, Dr. Miele shares his journey from early advocacy to his role at Amazon’s Lab126, where he continues to develop tools that redefine independence and equity in the built and digital worlds.

Explore Dr. Joshua Miele’s work, projects, and writings on his personal site, MieleLab, which highlights his innovations in accessible design and disability inclusion. You can visit it here: www.mielelab.com

Joining as co-host is Victoria Nolan—a decorated Paralympian, accessibility advocate, and BroadEYE regular. With lived experience navigating vision loss, Victoria brings deep empathy and clarity to the discussion, drawing out the personal and systemic forces that shape accessibility work today.

Together, they explore:

The real meaning of inclusion, and why accessibility must be baked in—not bolted on.
Dr. Miele’s development of tactile maps, screen readers, and accessible media interfaces.
How institutions can move from compliance to genuine cultural transformation.

Dr. Miele also reflects on the resilience required to challenge ableist assumptions and the power of disabled leadership in tech innovation. His message is clear: access is not about charity—it’s about justice.

About Our Guests

Dr. Joshua Miele is a blind scientist, designer, and advocate for accessibility. Currently a Principal Accessibility Researcher at Amazon, he has developed technologies that empower blind and visually impaired people to navigate cities, classrooms, and digital spaces. He is a 2021 MacArthur “Genius Grant” recipient and a prominent voice for disability rights and design justice.

Want to learn more? Pick up Dr. Miele’s powerful memoir, “Connecting the Dots: From the Blind Side”, now available on Amazon.

Victoria Nolan is a Canadian Paralympic rower, author, and passionate advocate for inclusion. Diagnosed with retinitis pigmentosa in her youth, she went on to compete internationally in rowing, including two Paralympic Games. Today, she is an influential public speaker and ambassador for breaking down barriers for people with vision loss.

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Behind the Research: A Candid Conversation with Prof. Margaret Chang

Épisode 83

jeudi 19 juin 2025 • Durée 44:26

In this episode of the BroadEYE Podcast, host Sean Maloney is joined by guest co-host Dr. Carlos Quezada-Ruiz for a deep and inspiring conversation with Dr. Margaret Chang, one of the leading figures in retina research and innovation.

From the start, Dr. Quezada-Ruiz sets the tone, describing Dr. Chang as not only a scientific leader but also a mentor, friend, and advocate for meaningful innovation. Their conversation ranges from early inspirations and pivotal career decisions to her ongoing efforts in bridging clinical research and real-world impact.

Dr. Chang shares candid thoughts on what drives her work at the intersection of patient care and technology, how she evaluates opportunities in translational research, and what keeps her motivated in the ever-evolving field of retina. Her reflections offer a rare glimpse into the mindset of a researcher who blends vision, rigor, and humility.

Whether you're a clinician, student, or someone curious about the future of ophthalmology, this episode offers both inspiration and actionable insight.

About Our Guest Dr. Margaret Chang is an internationally recognized retina specialist and researcher. With a career spanning academia, clinical practice, and biotech innovation, she is known for her leadership in translating science into practice. A sought-after speaker and advisor, Dr. Chang continues to influence the field through both groundbreaking research and mentorship.

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Pushing the Frontiers of Inherited Retinal Disease Trials with Prof. Michel Michaelides

Épisode 82

lundi 2 juin 2025 • Durée 47:39

In this episode of the BroadEye Podcast, hosts Shawn Maloney and Dr. Bruno Fernandes welcome Prof. Michel Michaelides, one of the most active clinical researchers in ophthalmology today. Prof. Michaelides leads a large inherited retinal disease clinic—seeing 30–40 children and adults each week—and splits her time between patient care, advanced imaging research, and steering more than ten ongoing clinical trials.

Why This Matters Inherited retinal diseases affect hundreds of thousands worldwide, and for most there is still no approved treatment. Over the past two years, we’ve seen multiple Phase 1/2 gene-therapy trials move into registrational studies, alongside novel antioxidant approaches and AI-driven biomarkers. Today’s conversation cuts through the jargon to give you a clear picture of where the field stands—and where it’s headed.

Key Takeaways

Beyond RPE65: While Luxturna paved the way, newer AAV-based therapies for X-linked RP (RPGR) and other targets are now in Phase 2 and Phase 3 trials, with early data showing promising safety and efficacy.
Imaging & Function: Prof. Michaelides is pioneering next-generation retinal imaging devices and novel functional assays to capture meaningful changes in vision—critical for shortening trial timelines.
Antioxidant Strategies: High-dose N-acetylcysteine trials are under way, offering a non-viral approach to slow photoreceptor degeneration across multiple genetic subtypes.
AI in Stratification: Machine-learning algorithms on retinal scans can help predict progression rate and identify the best candidates for specific therapies, improving both trial design and patient outcomes.
Balancing Dose & Safety: Finding the sweet spot between transgene expression and immune activation remains a core challenge—Prof. Michaelides shares lessons learned from dose-escalation cohorts.
Phase 3 & Beyond: With over a hundred patients enrolled in pivotal studies, we’re closing in on potential approvals—but long-term follow-up and real-world evidence will determine ultimate impact.

Revolutionizing Retinal Gene Therapy with Dr. Arshad Khanani

Épisode 81

jeudi 29 mai 2025 • Durée 21:04

In this latest episode of the BroadEye podcast, hosts Shawn Maloney and Dr. Bruno Fernandes sit down with Dr. Arshad M. Khanani, MD, MA, FASRS, a pioneer in vitreoretinal gene-therapy trials and Managing Partner at Sierra Eye Associates. Dr. Khanani shares front-line insights into how genetic medicines are reshaping treatment for inherited and degenerative retinal diseases, highlighting both the promise and the practical challenges of bringing one-time therapies to patients.

Why Gene Therapy Matters Today Recent years have seen the first US approvals of in-vivo retinal gene therapies, beginning with voretigene neparvovec (Luxturna) for RPE65-mediated inherited retinal dystrophy in December 2017. These one-off treatments offer durable vision improvements where none existed before, but they also raise questions of long-term safety, vector delivery, and equitable access.

Dr. Khanani’s Journey With over a decade leading surgical trials in sustained-delivery and viral-vector therapies, Dr. Khanani has overseen early human work on next-generation agents—including subretinal injections of AAV vectors and novel capsid designs. He describes lessons learned from Phase 1 safety studies through global registrational trials, emphasizing iterative “vector evolution” to boost efficacy and minimize inflammation.

Key Takeaways

Vector Optimization: Directed-evolution platforms are accelerating discovery of capsids that target photoreceptors more precisely, reducing off-target toxicity.
Durability vs. Dose: Striking the right balance between transgene expression and immune activation remains central—higher doses don’t always equal better outcomes.
Regulatory Pathways: While Luxturna set a precedent, streamlined FDA and EMA guidance on trial endpoints and real-world evidence will shape the next wave of approvals.
Cost & Access: Innovative payment models (e.g., outcomes-based installment plans) are emerging to address the multi-hundred-thousand-dollar price tags of these therapies.

Global Advocacy for the Blind with Marc Workman, CEO of World Blind Union

Épisode 80

mercredi 23 avril 2025 • Durée 48:07

Join hosts Dr. Shawn Maloney and Dr. Bruno Fernandes on the BroadEYE Podcast as they sit down with Marc Workman, CEO of the World Blind Union. In this engaging episode, Marc shares insights into the WBU’s mission to advocate for blind and partially sighted individuals globally, from influencing UN policies to empowering local organizations. Dive into discussions on accessibility, the transformative potential of AI, and the impact of the Marrakesh Treaty. Marc also opens up about his personal journey with retinitis pigmentosa and the challenges of global travel as a blind advocate. A must-listen for anyone interested in disability advocacy and inclusive technology!

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NAC Attack Clinical Trial: Exploring Antioxidants and Retinitis Pigmentosa with Dr. Peter Campochiaro

Épisode 79

mardi 8 avril 2025 • Durée 46:16

In this episode of the BroadEYE Podcast, hosts Shawn Maloney and Dr. Bruno Fernandez dive into a fascinating discussion with Dr. Peter Campochiaro, a clinician-scientist at Johns Hopkins’ Wilmer Eye Institute, about the potential of N-acetylcysteine (NAC) as a treatment for retinitis pigmentosa (RP).

Dr. Campochiaro shares how his research journey began with unexpected findings in mouse models, revealing how excess oxygen in the retina—caused by the loss of rod photoreceptors in RP—leads to oxidative stress that damages surviving cone cells. This discovery paved the way for the NAC Attack clinical trial, a phase 3 study exploring whether NAC, a potent antioxidant, can slow cone degeneration and preserve vision in RP patients.

The conversation covers the science behind NAC, its safety profile, and why it was chosen over other antioxidants like glutathione or CoQ10. Shawn, who lives with late-stage RP, brings a personal perspective, while Bruno, an ophthalmologist, digs into the broader implications for retinal diseases. Dr. Campochiaro also addresses practical challenges, like NAC’s over-the-counter availability versus its regulated use, and cautions against self-medication without medical supervision.

The episode offers hope for RP patients while emphasizing the importance of awaiting trial results, expected in a couple of years, to confirm NAC’s efficacy and long-term safety.

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Leading with Vision: Angela Bonfanti's Journey to Transforming Accessibility at CNIB

Épisode 78

mardi 28 janvier 2025 • Durée 43:29

In this episode, we sit down with Angela Bonfanti, the first female CEO and President of the Canadian National Institute for the Blind (CNIB). Angela shares her personal and professional journey, the challenges and opportunities of leading a 106-year-old organization, and her vision for improving accessibility and inclusion for individuals with vision loss in Canada.

About the Guest

Angela Bonfanti, the CEO and President of CNIB, is a trailblazer in the accessibility and inclusion space. With over 13 years of dedicated service at CNIB in various leadership roles, Angela became the organization’s leader in 2023, marking her 13th anniversary with the institute. She brings a deeply personal connection to her work, having grown up witnessing her father's journey with vision loss due to Retinitis Pigmentosa. Angela's leadership is defined by her commitment to systemic change, grassroots advocacy, and empowering individuals with vision loss through innovative programs and community-driven solutions.

About the CNIB

The Canadian National Institute for the Blind (CNIB) is Canada’s leading organization dedicated to empowering people impacted by blindness and vision loss. Established in 1918, CNIB supports individuals across the country with programs focusing on education, employment, accessibility, and advocacy. From guide dog training to groundbreaking virtual services, CNIB aims to create a world without barriers for people living with vision loss. Under Angela Bonfanti's leadership, the CNIB continues to advance its mission of inclusivity and accessibility through collaboration and innovative strategies.

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Revolutionizing Retinal Gene Therapy: A Conversation with Dr. Carlos Quezada-Ruiz

Épisode 77

jeudi 16 janvier 2025 • Durée 49:44

Dr. Carlos Quezada-Ruiz is a Vitreoretinal Surgeon and Assistant Professor of Ophthalmology at the Instituto de Oftalmologia Fundación Conde de Valenciana’s Retina Department in Mexico City. He also serves as the Senior Vice President of Clinical Research and Development and Therapeutic Area Head (Ophthalmology) at 4DMT, leading early- and late-stage clinical development teams focused on treating neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and geographic atrophy (GA).

In addition to his active clinical practice, Dr. Quezada-Ruiz has spent the past decade as a Drug Developer, beginning at Genentech–Roche. There, he worked on the Ophthalmology management team as Group Medical Director of Clinical Science (Product Development). During his tenure, he led the design, execution, and analysis of U.S. and global registrational trials for multiple retinal diseases, including the nAMD global clinical development program for VABYSMO, resulting in U.S. and worldwide approvals. He also led the global clinical science team for SUSVIMO, supporting its initial global filing, FDA approval, and launch in nAMD; successfully navigated the U.S. voluntary recall and commercial relaunch; and oversaw the phase 3 DR/DME registrational program through execution, readout, and filing with the FDA in early 2024. Previously, Dr. Quezada-Ruiz led Medical Affairs efforts for the U.S. launch of Lucentis Prefilled Syringe (PFS) and the myopic choroidal neovascularization indication for LUCENTIS.

Furthermore, Dr. Quezada-Ruiz contributed to diversity and inclusion strategies in the Ophthalmology Franchise—such as the AAO MOM program—and advanced personalized healthcare in retina at Genentech by helping design and develop predictive models that use machine learning and large language models to support both drug development and clinical practice.

Dr. Quezada-Ruiz is a Fellow of the American Society of Retina Specialists, with over 13 years of clinical practice and research in vitreoretinal diseases and surgery. He earned his M.D. from Universidad Autónoma de Coahuila in his hometown of Torreón, Mexico. He completed fellowships in Vitreoretinal Surgery, Ocular Pathology Research, and Vitreoretinal Surgery Research at Universidad Nacional Autónoma de México, McGill University, and the California Retina Research Foundation, respectively. In 2023, he completed an Executive Education program (CIBE) at Columbia Business School.

Leading Change in Eye Health - A Conversation with Jason Menzo (FFB)

Saison 2 · Épisode 76

dimanche 10 novembre 2024 • Durée 45:23

In this episode, we sit down with Jason Menzo, CEO of the Foundation Fighting Blindness, to discuss his unique journey from the pharmaceutical industry to leading one of the world’s most impactful organizations in eye health. Jason shares insights on his career transition into the nonprofit sector and his commitment to advancing the Foundation’s mission. We explore groundbreaking initiatives like My Retina Tracker, a resource bridging patients to clinical trials, and dive into the Foundation’s bold vision for future treatments, including the potential of eye transplants. Plus, hear how the Foundation is fueling innovation by investing in promising small eye care companies and funding research to combat inherited retinal diseases.

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BroadEye: An Ophthalmology Podcast – Détails, épisodes et analyse

Détails du podcast

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