Bringing Chemistry to Life – Détails, épisodes et analyse

Early in her career, Dr. Jessica Reiner realized that she cared more about ensuring the accuracy of the measurements she was making than making the measurements themselves. This realization, combined with experience in working with PFAS, led to her current role as Research Chemist at the National Institute of Standards and Technology (NIST).

Join us to hear an insider’s perspective on the PFAS topic, with a deep dive into the analytical methods used to detect, quantify, and identify PFAS species. Jessica and her team use LC-MS, anion exchange chromatography, and other orthogonal methods in their work and they focus on creating, validating, and maintaining reference materials (RM) and standard reference materials (SRM) that are used to help ensure that PFAS measurements are accurate and comparable with those made in other laboratories around the world. From challenges around defining a PFAS, to creating a stable, ultra-low concentration standard, to detecting ultra-high concentrations PFAS, Jessica provides an ace analytical chemist’s perspective grounded in the metrology of it all.

As always, and in addition to the great science, you’ll get to learn about Jessica’s personal career path, the ups and downs of her work, and hear her advice for career development. 

Related episodes: 

• Season 4, Ep.2: The father of green chemistry
• Season 2, Ep.7: Fresh urban water
• Season 1, Ep.3: There’s chemistry in the air!

Bonus content!

• Access bonus content curated by this episode’s guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.
• View the video of this episode on www.thermofisher.com/chemistry-podcast.

A free thank you gift for our listeners! 

• Request your free Bringing Chemistry to Life t-shirt on our episode website.
• Use code 0chemRcks in August, and BCTLisn3R in September.

We read every email so please share your questions and feedback with us! 

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Bioconjugation of antibodies to drugs via chemical linkers is how antibody drug conjugates (ADCs) are made. We’re joined by Matt Giese, Senior Scientist at Vector Laboratories, who talks us through the complex chemistry options and biodesign considerations that have to be considered and balanced when making a successful ADC.

How does one build the skillset to work in biodesign of ADCs you might ask? Well, Matt’s career path might not provide a clearcut roadmap like you might hope. That’s because Matt started his career as an auto mechanic, moved into art, went back to auto mechanics, worked as baggage handler and as a construction worker, all before ever finding chemistry. If you think that’s a convoluted path, just wait to hear about his academic and professional work journeys.  

You’ll revel in following this journey, and in the lessons and diverse skills learned along the way. Join us to hear it yourself, from who might just be the most interesting man in chemistry!

Related episodes:

• Season 5, Ep.7: The life-altering impact of one chemist’s sabbatical
• Season 2, Ep.1: Chemistry: a modern American dream
• Season 3, Ep.5: On the COVID pill and other process chemistry tales

Bonus content!

• Access bonus content curated by this episode’s guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.
• View the video of this episode on www.thermofisher.com/chemistry-podcast.

A free thank you gift for our listeners! 

• Request your free Bringing Chemistry to Life t-shirt on our episode website.
• Use Podcast Code: LabRatsRul3 in July or OchemRcks in August.

We read every email so please share your questions and feedback with us! 

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Protein biology has always been grounded in the relationship between structure and function but how we determine structure has changed dramatically. While it’s still common to crystallize a protein for X-ray diffraction and then back calculate its structure, supercomputing-powered, AI-driven tools have revolutionized approaches to getting a protein structure and engineer proteins for uses such as biocatalysis. Amazing right, but how? By using wet lab data to train and then compute, protein structure based on their sequence alone, which is why talking with this episode’s guest is so interesting. 

In this episode, Dr. Ahir Pushpanath, Enzyme Technology Innovation Lead at Basecamp Research, explains his passion for gaming as the reason he got interested in this unique computational approach to chemical catalysis. He takes us through the field’s fascinating history, recent breakthroughs, and their immense potential. You’ll hear about the intersection of his personal mission to provoke a bio-revolution with his company’s mission to combine nature and AI. 

Today at Basecamp Research, Ahir and his team are working to remove global bias from protein-specific AI training sets by collecting samples and data from diverse locations, but their primary focus is to understand the why of protein evolution. Ultimately, they hope to someday be able to help make a protein for every conceivable function by incorporating environmental pressure aspects into their sequence/structure/function AI models.

Related episodes: 

• S4 : E3 Chemistry, Computers, and Humans
• S2: E5 Questioning the limits of Moore’s law

Other episodes on catalysis:

• S3:E2 Making impossible molecules
• S2:E1 Chemistry: a modern American dream
• S2: E3  Rethinking catalysis

Bonus content!

• Access bonus content curated by this episode’s guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.
• View the video version of this episode on www.thermofisher.com/chemistry-podcast.

A free thank you gift for our listeners! 

• Visit the episode website and request your free Bringing Chemistry to Life t shirt.
• Use Podcast Code:  2023wrap in December 2023 or Ba++ery in January 2024.

We read every email so please share your questions and feedback with us! 

• Email helloBCTL@thermofisher.com

Electricity undeniably changed the world and enabled countless other technologies. Now, via storage and mobile access to electrical energy, batteries are positioned to further enable us as a species. So, it is the perfect time to get to know battery technology innovator and entrepreneur, Dr. Simon Engelke, Founder and Chair of Battery Associates, as he shares his passion for sustainable battery innovation. Any battery enthusiast will feel recharged by this electrifying conversation about the past, present, and future of battery technology.  

As a child, Simon was fascinated with energy sources and storage and recalls playing with the fuel cell toy car from his father. In his teens, he indulged his entrepreneurial spirit by starting his first small company. Fast forward through his globally sourced academic training, always focused on electrochemistry and battery-related research, to find Simon leading a company at the forefront of the battery community and technology.  

In our conversation, Simon touches on battery fundamentals; how they work, how they’re produced, the various types, and the work involved in optimizing various components, as well as the geopolitical aspects of batteries. We got this insider to school us on how they’ve evolved, what’s next in battery technology and what’s needed from the global community to responsibly realize the potential that battery technology represents. 

Season 5 of Bringing Chemistry to Life starts now! 

Related episodes: 

• S1 : E6 One person’s waste is another's treasure
• S2 : E8 Sustainability as an entrepreneurial choice
• S3 : E10 On solid state materials, electrochemistry and the importance of roots
• S4 : E2  The Father of Green Chemistry
• S4 : E8 The electrifying chemistry of the nitrogen cycle

Bonus content!

• Access bonus content curated by this episode’s guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more. 
• View the video version of this episode on www.thermofisher.com/chemistry-podcast. 

A free thank you gift for our listeners! 

• Visit the episode website and request your free Bringing Chemistry to Life t shirt. 
• Use Podcast Code:  AlwysL3rning in November 2023, 2023wrap in December 2023. 

About Your Host

Paolo Braiuca grew up in the North-East of Italy and holds a PhD in Pharmaceutical Sciences from nearby esteemed University of Trieste, Italy. He developed expertise in biocatalysis during his years of post-doctoral research in Italy and the UK, where he co-founded a startup company. With this new venture, Paolo’s career shifted from R&D to business development, taking on roles in commercial, product management, and marketing. He has worked in the specialty chemicals, biotechnology, and pharmaceutical markets in Germany and the UK, where he presently resides.

He is currently the Director of Global Market Development in the Laboratory Chemicals Division at Thermo Fisher Scientific™ which put him in the host chair of the Bringing Chemistry to Life podcast. 

A busy father of four, in what little free time he has, you’ll find him inventing electronic devices with the help of his loyal 3D-printer and soldering iron. And if you ask him, he’ll call himself a “maker” at heart. 

We read every email so please share your questions and feedback with us! 

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Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!

Visit https://thermofisher.com/bctl and use the code S4_BCTL in August, StyTun3d in September, BrgChem2Lif in October, or AlwysL3rning in November, to register for your free Bringing Chemistry to Life T-shirt. 

Chemistry is often perceived as inaccessible and challenging, but there is one fundamental chemical construct that everybody knows – the periodic table of the elements. The periodic table is a chemical icon, that has transcended the boundaries of the chemical sciences to somehow become familiar, almost a staple in several aspects of everyday life. It is the foundation of every chemist’s knowledge, but not many understand its deeper meaning, let alone its history and philosophical significance. 

This is an exciting and unusual episode with one of the biggest names in chemistry, Eric Scerri, historian and scientist and the biggest living expert of the periodic table of the elements. 

The history and philosophy of chemistry are not common topics for Bringing Chemistry to Life, but this is an intriguing discussion that provides a deeper meaning and context to scientific research and chemistry in particular. In what may be our most thought-provoking episode yet we explore the relationship between chemistry and physics and revisit concepts that have been lost by modern scientists. We discuss what an element really is and the fundamental discoveries and progress that have been made over the years to influence chemical understanding and the periodic table. All this can explain how modern science really works and perhaps how we can teach it better. 

Our greatest season finale yet!

We read every email so please share your questions and feedback with us! 

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Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!

Visit https://thermofisher.com/bctl and use the code PaoloRKS in July, or S4_BCTL in August, to register for your free Bringing Chemistry to Life T-shirt. 

Some chemists just see the world around them in a different way. Where you see a pen, they see the polymer structure of its plastic body and the complex formulation of the ink. Where you see a building, they see the composite materials that make it and think about how the nano-scale structure of those materials define their macroscopic properties. Where you see a juicy burger, they see the proteins and complex chemicals that make its taste and texture so attractive.

In a nutshell, this is how Cate Levey sees the world around her. It’s a fascinating perspective that has taken her professional path down some paths less traveled. Engineered wood products, plant-based meat products, and carbon-negative aggregate for concrete have nothing to do with each other if you don’t look at things the way she does. To her they are they are all composite materials, where understanding and altering the chemistry at the nano, or sub-nano scale allows her to alter macroscopic functional properties to make amazing things happen. It’s where chemistry meets material science and where the science can really change the world around us.

Cate explains some of her groundbreaking work, but also offers a fresh perspective on how to pursue a career in science, following a true passion, and taking unbeaten paths.

We read every email so please share your questions and feedback with us! 

• Email helloBCTL@thermofisher.com

Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!

Visit https://thermofisher.com/bctl and use the code PaoloRKS in July to register for your free Bringing Chemistry to Life T-shirt. 

Moving from a linear economy, where things are made, used and discarded, to a circular one, based on recycling and reuse, is one of the most important and difficult challenges for our society. Cracking this problem and moving to a more sustainable way of living, while maintaining or even improving living standards, is key for the future of our planet.

With Matthew Liu, we go back to topics discussed in Episode 6 of Season 1 to look at one of the most important chemical elements, nitrogen. Reducing atmospheric nitrogen to nitrates is fundamental to our modern world. Nitrogen reduction makes possible to feed billions of people globally and it provides some of the most fundamental building blocks of modern chemistry. At the same time, it is one of the most energy-intense industrial processes, and its products, while essential and beneficial, eventually become environmental pollutants at the end of their lifecycle. 

An old technology might be the key to change this landscape. Electrochemistry is going through a renaissance and it’s a very promising tool to recover nitrogen and put it back into the economic circle. In our discussion with Matthew we discuss some breakthrough and novel electrochemical approaches, electrocatalysis in particular, and how they can impact the economy of developed and under-developed countries.

We read every email so please share your questions and feedback with us! 

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Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!

Visit https://thermofisher.com/bctl and use the code CoolCh3mShirt in June to register for your free Bringing Chemistry to Life T-shirt. 

We embrace this rare opportunity to sit and chat freely with someone who has lived and breathed the technical and business sides of the chemicals market for the last 40 years. Simon Pearce is a Senior Product Manager in Thermo Fisher Scientific and a man of a thousand stories. 

Join us for this entertaining and eye-opening journey into the origins of chemical diversity, a bit of history on the British chemicals market, and a first-hand account of changes and constants in the work over time. We cover a lot of ground in this interview, from the early days of compound screening libraries, to the mindset of managing a complex product portfolio. We speak about serendipity, the power of making the most of opportunities, and how chemistry looks different when framed by business requirements. As it’s often the case, it’s about humans interacting with each other, the people behind science, and the people behind the market. It doesn’t get more “Bringing Chemistry to Life” than that.

We read every email so please share your questions and feedback with us! 

• Email helloBCTL@thermofisher.com

Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!

Visit https://thermofisher.com/bctl and use the code Scienc3Fwd in May to register for your free Bringing Chemistry to Life T-shirt. 

The modern revolutions of electronics and biotechnology are changing the world in dramatic ways. The incredible progress of electronics is changing the world external to our body, while biotechnology/genetics is promising to change it “internal” to our bodies. While these two revolutions have not quite met, chemistry is what could link them up. 

Imagine completely novel materials for interfacing electronics and the human body in a harmonious way. Be bold and open to new ideas, such as organic electronics with little or no use of semiconductors. Bio-electronics that can self-assemble, biodegrade after use, and leave no toxic trace behind. Imagine what this could mean for new generations of medical devices, diagnostic medicine, as well as robotics and other applications.

Exploring these ideas takes an inquisitive, enthusiastic, and creative polymer chemist with ambition, vision, a passion for science communication, and an incredible drive to succeed. Helen Tran is all of this and more. She speaks about her science and her desire to give back as much, or more, than she has received. Hear her views on the importance of mentorship and how having fun doing meaningful work remains a simple, powerful way to achieve something meaningful in life.

We read every email so please share your questions and feedback with us! 

• Email helloBCTL@thermofisher.com

Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the guest content sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!

Visit https://thermofisher.com/bctl and use the codes below to register for your free Bringing Chemistry to Life T-shirt (April = BCTLshirt, May = Scienc3Fwd). 

Among the various chemical disciplines we have discussed so far, astrochemistry is by far the most surprising. And Chris Shingledecker is a surprisingly charming member of this relatively new and growing scientific niche. He’s managed to naturally balance his passions for chemistry, born from a chemical set received as a gift in his childhood, and for astronomy, that grew in him during middle school. This is a great story of someone who took his education and professional path in his own hands and gave it the shape he wanted to follow his interests and passions. 

Chris is now living the excitement of a new science. So many things to understand and explain given such fast progress in the field. We learn about what a young discipline astrochemistry is, where until three or four decades ago it was thought chemistry could not occur in outer space, and hear how Chis and his colleagues are quickly showing that chemistry beyond the boundaries of planet Earth is in fact extremely rich, diverse, and complex. 

This is a fascinating discussion about the story and the future of astrochemistry, a jump into new ideas about the origins of life on our planet and hypothetical other worlds. 

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